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| 1 | Chiari畸形Ⅰ合并神经源性吞咽功能障碍的临床特征(英文)显示文摘目的:成年Chiari畸形Ⅰ型(chiari malformation typeⅠ,CMⅠ)患者中神经源性吞咽障碍的发生率并不少见,临床上罕有关于食管高分辨率测压(high-resolution manometry,HRM)技术对CMⅠ患者吞咽功能的精确评价的报道。本研究拟通过HRM量化评价CMⅠ患者吞咽功能,初步探讨影响吞咽功能的可能相关因素及其机制。方法:共纳入北京大学第三医院2010年1月至2015年7月收治的42例经临床和MRI检查、确诊不合并寰枢椎脱位的CMⅠ患者,将患者分为吞咽障碍组20例和不合并吞咽障碍组22例。所有患者均接受HRM检查,收集所有患者的临床、影像学资料和HRM评价参数,并做统计学分析。结果:(1)合并吞咽障碍的女性CMⅠ患者比例明显高于不合并吞咽障碍组(14/20 vs.8/22,P=0.029),吞咽障碍组后组颅神经损伤的其他症状(包括声音嘶哑、咽部感觉减退、患侧面部感觉减退及汗液分泌减少等)发生率明显高于不合并吞咽障碍对照组(15/20 vs.5/22,P=0.01)。(2)HRM显示吞咽障碍组食管上括约肌(upper esophageal sphincter,UES)松弛比高于对照组(75.3%vs.63.1%,P=0.023),UES上缘亦高于对照组(17.2 cm vs.15.7 cm,P=0.005)。(3)吞咽障碍组MRI影像上延髓或上颈部的脊髓空洞比例明显高于对照组(17/20 vs.7/22,P=0.001)。结论:CMⅠ患者的吞咽障碍经常与后组颅神经损伤、共济失调和阳性锥体束征相关,HRM显示平均UES松弛比例的差异亦有可能与延髓或上颈髓的脊髓空洞症有关,CMⅠ中的吞咽障碍的机制可能是由于神经源性咽肌运动障碍所导致,吞咽障碍病因学检查应包括CMⅠ畸形鉴别诊断。 | 于涛 李军 王琨 葛颖 Alice Chu Jiang 段丽萍 王振宇 | 2017 | 北京大学学报(医学版)2017，49，2： | 3 |
| 2 | Investigation on the Consumption Values of Hong Kong People on Tie Products显示文摘This study aims at investigating the consumption values of Hong Kong people on necktie. Based on the Sheth-Newman-Gross Model of consumption values on consumers’ choice decision as conceptual framework, results from the focus group interview, a questionnaire was designed and adopted for conducting the survey. Data collected from 245 respondents were analysed using the Factor Analysis to review the important elements of consumers’ decision of purchasing tie products. Implications on the results on the Functional value were reviewed and discussed in details. Interesting elements such as fabric hand-feel were also identified as influential associated in Hong Kong consumers’ selection of necktie. Since, both fibre content and fabric handle were also found as major selection criteria for fabric materials, the study was focused on the analysis of functional value of the product and further extended to study the handle preference for Hong Kong customers, in which a subjective handle assessment of a wide range of tie fabrics being newly developed and introduced in the market was conducted and objective fabric physical and mechanical properties were measured. Important fabric handle attributes that influence the consumers’ preference on tie fabrics were identified and their objective translation by fabric physical and mechanical properties were also obtained. The investigation provides decision support to necktie manufacturers and retailers through scientific and quantitative recommendations for product development of tie products and material selection. | Sarah Mei-yi Leung Alice Wai-ching Chu Kit-lun Yick | 2004 | Journal of Donghua University(English Edition)2004，21，2： | 1 |
| 3 | Reliability allocation problem in a series-parallel system 显示文摘 | Alice Yalaoui Chengbin Chu Eric Chatelet | 2005 | Reliability Engineering and System Safety2005，90，1： | 1 |
| 4 | iStent inject? and cataract surgery for mild-to-moderate primary open angle glaucoma in Japan: a cost-utility analysis显示文摘AIM: To evaluate the cost-utility of iStent inject;with cataract surgery vs cataract surgery alone in patients with mild-to-moderate primary open angle glaucoma(POAG) in the Japanese setting from a public payer’s perspective.METHODS: A Markov model was adapted to estimate the cost-utility of iStent inject;plus cataract surgery vs cataract surgery alone in one eye in patients with mild-tomoderate POAG over lifetime horizon from the perspective of Japanese public payer. Japanese sources were used for patients’ characteristics, clinical data, utility, and costs whenever available. Non-Japanese data were validated by Japanese clinical experts. RESULTS: In the probabilistic base case analysis, iStent inject;with cataract surgery was found to be cost-effective compared with cataract surgery alone over a lifetime horizon when using the ￥5 000 000/quality-adjusted life year(QALY)willingness-to-pay threshold. The incremental cost-utility ratio(ICUR) was estimated to be ￥1 430 647/QALY gained and the incremental cost-utility ratio(ICER) was estimated to be ￥12 845 154/blind eye avoided. iStent inject;with cataract surgery vs cataract surgery alone was found to increase costs(￥1 025 785 vs ￥933 759, respectively) but was more effective in increasing QALYs(12.80 vs 12.74) and avoiding blinded eyes(0.133 vs 0.141). The differences in costs were mainly driven by costs of primary surgery(￥279 903 vs ￥121 349). In the scenario analysis from a societal perspective, which included caregiver burden, iStent inject;with cataract surgery was found to dominate cataract surgery alone.CONCLUSION: The iStent inject;with cataract surgery is a cost-effective strategy over cataract surgery alone from the public payer’s perspective and cost-saving from the societal perspective in patients with mild-to-moderate POAG in Japan. | Ataru Igarashi Kyoko Ishida Nobuyuki Shoji Alice Chu Heather Falvey Ru Han Maki Ueyama Yoshie Onishi | 2022 | International Journal of Ophthalmology(English edition)2022，15，6： | 1 |
| 5 | Reliability allocation problem in a series-parallel system显示文摘 | Yalaoui Alice Chu Chengbin Eric Chatelet | 2005 | Reliability Engineering and System Safety2005，90，1： | 1 |
| 6 | Reliability allocation problem in a series-parallel system 显示文摘 | Alice Yalaoui Chu Chengbin | 2005 | Reliability engineering & system safety2005，，90： | 1 |
| 7 | Reliability allocation problem in a series-parallel system显示文摘 | Alice Yalaoui Chengbin Chu Eric Chatelet | 2005 | Reliability Engineering & System Safety2005，90，1： | 1 |
| 8 | A novel therapeutic cytomegalovirus DNA vaccine in allogeneic haemopoietic stem-cell transplantation: a randomised, double-blind, placebo-controlled, phase 2 trial显示文摘 | Mohamed A Kharfan-Dabaja Michael Boeckh Marissa B Wilck Amelia A Langston Alice H Chu Mary K Wloch Don F Guterwill Larry R Smith Alain P Rolland Richard T Kenney | 2012 | The Lancet Infectious Diseases2012，，4： | 1 |
| 9 | Reliability allocation problem in a series-parallel system 显示文摘 | Alice Yalaoui Chu Chengbin Eric Chatelet | 2005 | Reliability Engineering & System Safety2005，90，1： | 1 |
| 10 | 中国香港地区老年痴呆患者的口腔健康状况显示文摘目的:比较中国香港地区痴呆患者组和健康对照组之间.刷牙习惯、静息状态下唾液流率以及口腔健康状况是否存在不同。材料和方法:经过样本量计算.需要纳入82位60岁以上的中国老年痴呆患者.能够配合牙周探诊操作并且加入日常管理中心。年龄、性别匹配全身健康的非痴呆老年人作为对照组。用调查问卷收集刷牙情况。此外.测量静息状态下的唾液流率.用龋失补指数DMFT指数和社区牙周指数(CPI)分别记录患龋情况和牙周状况。结果:招募了59名老年痴呆患者作为痴呆组.以及相同数目年龄、性别匹配的健康老年人作为对照组。他们的平均年龄为80岁(SD=7)。相对于对照组,老年痴呆患者较少每天刷牙两次(31%VS5%:P〈0.0001)。再者.唾液流率也较对照组低(0.30ml/m.nVS0.41m1/min:P=0.043)。龋患病率平均DMFT值(±SD)与对照组相似(223±8.2vs21.5±82.P=0.59)。牙周袋(CPI〉3)的患病率在两组中没有差异(78%vs74%.P=0.64)。结论:相较于对照组,较少的老年痴呆患者会每天刷牙两次。尽管他们静息状态下唾液分泌量减少.他们的龋发病率和重度牙周病的患病率与对照组相比没有统计学意义上的差异。 | Chun Hung Chu Alice Ng Alex M1.H. Chau Eeward C. M.Lo 池莉(译) 滕伟(审) | 2018 | 中国口腔医学继续教育杂志2018，21，4： | 0 |
| 11 | Hospital outcomes and early readmission for the most common gastrointestinal and liver diseases in the United States:Implications for healthcare delivery显示文摘BACKGROUND Gastrointestinal(GI)and liver diseases contribute to substantial inpatient morbidity,mortality,and healthcare resource utilization.Finding ways to reduce the economic burden of healthcare costs and the impact of these diseases is of crucial importance.Thirty-day readmission rates and related hospital outcomes can serve as objective measures to assess the impact of and provide further insights into the most common GI ailments.AIM To identify the thirty-day readmission rates with related predictors and outcomes of hospitalization of the most common GI and liver diseases in the United States.METHODS A cross-sectional analysis of the 2012 National Inpatient Sample was performed to identify the 13 most common GI diseases.The 2013 Nationwide Readmission Database was then queried with specific International Classification of Diseases,Ninth Revision,Clinical Modification codes.Primary outcomes were mortality(index admission,calendar-year),hospitalization costs,and thirty-day readmission and secondary outcomes were predictors of thirty-day readmission.RESULTS For the year 2013,the thirteen most common GI diseases contributed to 2.4 million index hospitalizations accounting for about$25 billion.The thirty-day readmission rates were highest for chronic liver disease(25.4%),Clostridium difficile(C.difficile)infection(23.6%),functional/motility disorders(18.5%),inflammatory bowel disease(16.3%),and GI bleeding(15.5%).The highest index and subsequent calendar-year hospitalization mortality rates were chronic liver disease(6.1%and 12.6%),C.difficile infection(2.3%and 6.1%),and GI bleeding(2.2%and 5.0%),respectively.Thirty-day readmission correlated with any subsequent admission mortality(r=0.798,P=0.001).Medicare/Medicaid insurances,≥3 Elixhauser comorbidities,and length of stay>3 d were significantly associated with thirty-day readmission for all the thirteen GI diseases.CONCLUSION Preventable and non-chronic GI disease contributed to a significant economic and health burden comparable to chronic GI conditions,providing a window of opportunity for improving healthcare delivery in reducing its burden. | Somashekar G Krishna Brandon K Chu Alecia M Blaszczak Gokulakrishnan Balasubramanian Hisham Hussan Peter P Stanich Khalid Mumtaz Alice Hinton Darwin L Conwell | 2021 | World Journal of Gastrointestinal Surgery2021，13，2： | 0 |
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