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| 1 | Morphological changes in intraretinal microvascular abnormalities after anti-VEGF therapy visualized on optical coherence tomography angiography显示文摘Background:To examine the baseline morphological characteristics and alterations in intraretinal microvascular abnormalities(IRMAs)in response to anti-vascular endothelial growth factor(anti-VEGF)treatment,documented by optical coherence tomography angiography(OCTA)in diabetic eyes.Methods:In this retrospective study,IRMAs were evaluated with multimodal imaging(fundus photography,fluorescein angiography,OCTA)in treatment-naïve diabetic eyes before and after anti-VEGF treatment for diabetic macular edema(DME)and/or proliferative diabetic retinopathy(PDR)and compared to diabetic control eyes with similar diabetic retinopathy(DR)severity that did not receive anti-VEGF therapy.The morphological characteristics of IRMAs on enface OCTA imaging were graded by masked readers at baseline,then after anti-VEGF therapy in treated eyes or after observation in control eyes.Characterization of interval changes in an IRMA were based on the following parameters:branching,vessel caliber and area of adjacent capillary non-perfusion.Results:The treated group included 45 IRMA foci from 15 eyes of 11 patients,while the control group included 27 IRMA foci from 15 eyes of 14 patients.Following anti-VEGF treatment,enface OCTA demonstrated that 14 foci of IRMA(31%)demonstrated regression with normalization of appearance of the capillary bed,20 IRMAs(44%)remained unchanged,six IRMAs(13%)progressed with enlargement or development of new IRMAs and five IRMAs(11%)demonstrated complete obliteration defined as IRMA disappearance with advancing capillary drop-out.In the control group,17 IRMA(63%)remained stable,8 IRMAs(29.6%)progressed and 2 experienced total obliteration(7.4%).The difference in rank order between the two groups was statistically significant(p=0.022).Conclusions:In eyes with DR status post anti-VEGF therapy,foci of IRMAs have a variable course demonstrating one of four possible outcomes:regression,stabilit,progression or complete obliteration.In contrast,none of the untreated control diabetic eyes demonstrated regression of IRMAs,consistent with known progression of DR severity in high risk eyes.Morphologic evaluation of IRMAs with OCTA may help to monitor changes in retinal blood flow as well as the response to anti-VEGF treatment. | Osama A.Sorour Nihaal Mehta Caroline R.Baumal Akihiro Ishibazawa Keke Liu Eleni K.Konstantinou Sarah Martin Phillip Braun A.Yasin Alibhai Malvika Arya Andre J.Witkin Jay S.Duker Nadia K.Waheed | 2020 | Eye and Vision2020，7，1： | 4 |
| 2 | Prevalence and impact on survival of positive surgical margins in partial nephrectomy for renal cell carcinoma: a population‐based study显示文摘 | Ifeanyi Ani Antonio Finelli Shabbir M.H. Alibhai Narhari Timilshina Neil Fleshner Robert Abouassaly | 2013 | BJU Int2013，，： | 2 |
| 3 | Effect of diabetes mellitus and hyperglycemia on the proliferation of human Tenon's capsule fibroblasts:Implications for wound healing after glaucoma drainage surgery显示文摘 | Browning AC Alibhai A Mclntosh RS | 2006 | Wound Repair Regen2006，13，3： | 1 |
| 4 | The association be- tween patient age and prostate cancer stage and grade at diagnosis 显示文摘 | Alibhai SM Krahn MD Fleshner NE | 2004 | BJU Int2004，94，3： | 1 |
| 5 | Substitution of serine or threonine at position 473 of tissue-type plasminogen activator increases its stability in plasma显示文摘 | ALIBHAI M CHOW A M PAONI N F | 1996 | Thromb Haemost1996，75，1： | 1 |
| 6 | Short- term disruption of diurnal rhythms after murine myocardial infarction adversely affects long - term myocardial structure and function 显示文摘 | Alibhai FJ Tsimakouridze EV Chinnappareddy N | 2014 | Circ Res2014，114，11： | 1 |
| 7 | Unintended consequences of laparoscopic surgery on partial nephrectomy for kidney cancer显示文摘 | Abouassaly R Alibhai S M Tomlinson G Timilshina N Finelli A | 2010 | J Urol2010，183，46： | 1 |
| 8 | Dissecting the association between metabolic syndrome and prostate cancer risk: analysis of a large clinical cohort显示文摘 | Bhindi B Locke J Alibhai SM | 2015 | Eur Urol2015，67，1： | 1 |
| 9 | Teratogenicity of metals to chick embryos 显示文摘 | Gilani SH Alibhai Y | 1990 | Toxicol Environ Health1990，30，1： | 1 |
| 10 | Teratogenicity of metals to chick embryos 显示文摘 | Shamshad HG Alibhai Y | 1990 | Toxicol Environ Health1990，30，： | 1 |
| 11 | Meta-analysis: effect of prophylactic hematopoietic colony-stimulating factors on mortality and outcomes of infectious显示文摘 | Sung L Nathan PC Alibhai SMH | 2007 | Ann Intern Med2007，147，： | 1 |
| 12 | Prevalence and impact on survival of positive surgical margins in partial nephrectomy for re- nal cell carcinoma: a population-based study 显示文摘 | Ani I Finelli A Alibhai SM | 2013 | BJU Int2013，111，： | 1 |
| 13 | Substitution of Serine or Threonine at Position 473 of Tissue-type Plasminogen Activator Increases Its Stability in Plasma 显示文摘 | ALIBHAI M CHOW A M PAONI N F | 1996 | Thromb Haemost1996，75，1： | 1 |
| 14 | The effect of nerve-sparing surgery on patient-reported continence post-radical prostatectomy显示文摘 | TOREN P ALIBHAI SM MATTHEW A | 2009 | Can Urol Assoc J2009，3，6： | 1 |
| 15 | Closing down on glyphosate inhibition with a new structure for drug discovery显示文摘 | Stallings W C | 2001 | Proc Natl Acad Sci USA2001，98，： | 1 |
| 16 | Teratogenicity of metals to chick embryos显示文摘 | GILANI SH ALIBHAI Y | 1990 | Toxicol Environ Health1990，30，1： | 1 |
| 17 | Teratogenicity of metals to chick embryos显示文摘 | Gilani SH Alibhai Y | 1990 | Toxicol Environ Health1990，30，1： | 1 |
| 18 | Bioleaehing and bioprecipitation of nickel and iron from laterites 显示文摘 | Alibhai K Dudeney A W L Leak D J | 1993 | FEMS Microbiology Reviews1993，11，： | 1 |
| 19 | Meta-analysis: effect of prophylactic hematopoietic colony-stimulating factors on mortality and outcomes of infection显示文摘 | Sung L Nathan PC Alibhai SM | 2007 | Ann Intern Med2007，147，6： | 1 |
| 20 | Effect ofdiabetes mellitus and hyperglycemia on the proliferationof human Tenons capsule fibroblasts:implications forwound healing after glaucoma drainage surgery显示文摘 | Browning AC Alibhai A McIntosh RS | 2005 | WoundRepair Regen2005，13，3： | 1 |
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