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| 1 | Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 in patients with fatty liver diseases显示文摘AIM:To test the occurrence of the Pro12Ala mutation of the peroxisome proliferator-activated receptor-γ (PPARγ)2-gene in patients with non-alcoholic fatty liver disease (NAFLD) or alcoholic fatty liver disease (AFLD).METHODS:DNA from a total of 622 specimens including 259 blood samples of healthy blood donors and 363 histologically categorized liver biopsies of patients with NAFLD (n=263) and AFLD (n=100) were analyzed by Real-time polymerase chain reaction using allele-specific probes.RESULTS:In the NAFLD and the AFLD collective,3% of the patients showed homozygous occurrence of the Ala12 PPARγ2-allele,differing from only 1.5% cases in the healthy population.In NAFLD patients,a high incidence of the Ala12 mutant was not associated with the progression of fatty liver disease.However,we observed a significantly higher risk (odds ratio=2.50,CI:1.05-5.90,P=0.028) in AFLD patients carrying the mutated Ala12 allele to develop inflammatory alterations.The linkage of the malfunctioning Ala12-positive PPARγ2 isoform to an increased risk in patients with AFLD to develop severe steatohepatitis and fibrosis indicates a more prominent anti-inflammatory impact of PPARγ2 in progression of AFLD than of NAFLD.CONCLUSION:In AFLD patients,the Pro12Ala single nuclear polymorphism should be studied more extensively in order to serve as a novel candidate in biomarker screening for improved prognosis. | Johannes W Rey Andrea Noetel Aline Hardt Ali Canbay Hakan Alakus Axel zur Hausen Hans Peter Dienes Uta Drebber Margarete Odenthal | 2010 | World Journal of Gastroenterology2010，16，46： | 11 |
| 2 | Natural history of hepatic metastases from colorectal cancer-pathobiological pathways with clinical significance显示文摘Colorectal cancer hepatic metastases represent the final stage of a multi-step biological process.This process starts with a series of mutations in colonic epithelial cells,continues with their detachment from the large intestine,dissemination through the blood and/or lymphatic circulation,attachment to the hepatic sinusoids and interactions with the sinusoidal cells,such as sinusoidal endothelial cells,Kupffer cells,stellate cells and pit cells.The metastatic sequence terminates with colorectal cancer cell invasion,adaptation and colonisation of the hepatic parenchyma.All these events,termed the colorectal cancer invasion-metastasis cascade,include multiple molecular pathways,intercellular interactions and expression of a plethora of chemokines and growth factors,and adhesion molecules,such as the selectins,the integrins or the cadherins,as well as enzymes including matrix metalloproteinases.This review aims to present recent advances that provide insights into these cell-biological events and emphasizes those that may be amenable to therapeutic targeting. | Konstantinos A Paschos Ali W Majeed Nigel C Bird | 2014 | World Journal of Gastroenterology2014，20，14： | 10 |
| 3 | Liver transplantation for hepatocellular carcinoma:an update显示文摘BACKGROUND: Hepatocellular carcinoma (HCC) is a heterogeneous malignancy with multiple etiologies, high incidence, and high mortality. The standard surgical management for patients with HCC consists of locoregional ablation, surgical resection, or liver transplantation, depending on the background state of the liver. Eighty percent of patients initially presenting with HCC are unresectable, either due to the extent of tumor or the level of underlying hepatic dysfunction. While in patients with no evidence of cirrhosis and good hepatic function resection has been the surgical treatment of choice, it is contraindicated in patients with moderate to severe cirrhosis. Liver transplantation is the optimal surgical treatment. DATA SOURCES: PubMed search of recent articles (from January 2000 to March 2011) was performed looking for relevant articles about hepatocellular carcinoma and its treatment. Additional articles were identified by evaluating references from selected articles. RESULTS: Here we review criteria for transplantation, the types, indications, and role of locoregional therapy in treating the cancer and in downstaging for possible later transplantation. We also summarize the contribution of immunosuppression and adjuvant chemotherapy in the management and prevention of HCC recurrence. Finally we discuss recent advances in imaging, tumor biology, and genomics as we delineate the remaining challenges for the diagnosis and treatment of this disease. CONCLUSIONS: Much can be improved in the diagnosis and treatment of HCC. A great challenge will be to improve patient selection to criteria based on tumor biology. Another will be to incorporate systemic agents post-operatively in patients at high risk for recurrence, paying close attention to efficacy and safety. The future direction of the effort in treating HCC will be to stimulate prospective trials, develop molecular imaging of lymphovascular invasion, to improve recipient selection, and to investigate biomarkers of tumor biology. | Ali Zarrinpar Fady Kaldas Ronald W Busuttil | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 8 |
| 4 | Synthesis, characterization and catalytic activity of ZSM-5 zeolites having variable silicon-to-aluminum ratios显示文摘 | Ali M A Brisdon B Thomas W J | 2003 | Applied Catalysis A: General2003，252，： | 1 |
| 5 | Detection of corrosion and cracking beneath paint using photonic techniques显示文摘 | Ali J H Wang W B Alfano R R | 2004 | Theoretical and Applied Fracture Mechanics2004，41，： | 1 |
| 6 | Association of Iron Deficiency Ane- mia in Children of 1-2 Years of Age with Low Birth Weight,Recurrent Diarrhoea or Recurrent Respiratory Tract Infection-A Myth or Fact?显示文摘 | Ali N S Zuberi R W | 2003 | J Pak Med Assoe2003，53，4： | 1 |
| 7 | Control of A fuel cell based Z source inverter 显示文摘 | JUNG J W ALI K H | 2007 | IEEE Transactions on Energy Conversion2007，22，2： | 1 |
| 8 | Quantitative regulation of the Flaveria Mel gene is controlled by the 3'untranslated region and sequences near the aminoterminus显示文摘 | Ali S Taylor W C | 2001 | Plant Mol Biol2001，，46： | 1 |
| 9 | A laboratory study of caustic flooding for two Alberta crude oils显示文摘 | Symonds R W P Farouq Ali S M Thomas S | 1991 | J Canada Petrol Technol1991，30，1： | 1 |
| 10 | Gas-sens- ing system using an array of coated quartz crystal micro- balances with a fuzzy inference system 显示文摘 | ALI Z O'HARE W T SARKODIE T | 1999 | Journal of Thermal Analysis and Calorimetry1999，55，2： | 1 |
| 11 | Swine influenza H1N1 virus induces acute inflammato- ry immune responses in pig lungs: a potential animal model for human H1N1 influenza virus显示文摘 | Khatri M Dwivedi V Krakowka S Manickam C Ali A Wang L Qin Z Renukaradhya G J Lee C W | 2010 | J Virol2010，84，11： | 1 |
| 12 | Identi- fication and inhibition of the Ice/Ced-3 protease nec- essary for mammalian apoptosis显示文摘 | Nicholson D W Ali A Thornberry N A | 1995 | Nature1995，376，： | 1 |
| 13 | Incidence and outcomes in acutekidney injury: a comprehensive population-based study 显示文摘 | Ali T Khan I Simpson W | 2007 | J Am Soc Nephro12007，18，4： | 1 |
| 14 | Mancozeb-induced genotoxicity and apoptosis in cultured human lymphocytes显示文摘 | Srivastava A K Ali W Singh R | 2012 | Life Sciences2012，90，2122： | 1 |
| 15 | Dual Doped High Tg White Organic Light Emitting Devices on Silicon显示文摘 | Ali T A Jones G W Howard W E | 2004 | SID2004，29，： | 1 |
| 16 | Analytical solutions for radial pressure distribution including the effects of the quadratic gradient term显示文摘 | Chakrabarty C Farouq Ali S M Tortike W S | 1993 | Water Resource Research1993，29，4： | 1 |
| 17 | Bioaugmentation of a Sequencing Batch Reactor with Pseudomonas Putida ONBA-17 and Its Impact on Reactor Bacterial Communities显示文摘 | Yu F B Ali S W Guan L B | 2010 | Journal of Hazardous Materials2010，176，13： | 1 |
| 18 | Comparison of surgical and interventional therapy of native and recurrent aortic coarctation regarding different age groups during childhood显示文摘 | Fruh S Knirsch W Ali DK | 2011 | Eur J Cardio Thorac2011，39，： | 1 |
| 19 | Differentially expressed miRNAs in the plasma may provide a molecular signature for aggressive pancreatic cancer显示文摘 | Ali S Almhanna K Chen W | | 0，，： | 1 |
| 20 | Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis显示文摘 | Nicholson D W Ali A Thornberry N A | 1995 | Nature1995，376，： | 1 |
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