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| 1 | A natural clouding agent from orange peels obtained using polygalacturonase and cellulase 显示文摘 | Alexandre E B Robert C S F Olga M B | 2005 | Food Chemistry2005，92，1： | 1 |
| 2 | Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models显示文摘Background:We recently demonstrated an endolysosomal accumulation of theβ-secretase-derived APP C-terminal fragment(CTF)C99 in brains of Alzheimer disease(AD)mouse models.Moreover,we showed that the treatment with theγ-secretase inhibitor(D6)led to further increased endolysosomal APP-CTF levels,but also revealed extracellular APP-CTF-associated immunostaining.We here hypothesized that this latter staining could reflect extracellular vesicle(EV)-associated APP-CTFs and aimed to characterize theseγ-secretase inhibitor-induced APPCTFs.Methods:EVs were purified from cell media or mouse brains from vehicle-or D6-treated C99 or APPswedish expressing cells/mice and analyzed for APP-CTFs by immunoblot.Combined pharmacological,immunological and genetic approaches(presenilin invalidation and C99 dimerization mutants(GXXXG))were used to characterize vesicle-containing APP-CTFs.Subcellular APP-CTF localization was determined by immunocytochemistry.Results:Purified EVs from both AD cell or mouse models were enriched in APP-CTFs as compared to EVs from control cells/brains.Surprisingly,EVs from D6-treated cells not only displayed increased C99 and C99-derived C83 levels but also higher molecular weight(HMW)APP-CTF-immunoreactivities that were hardly detectable in whole cell extracts.Accordingly,the intracellular levels of HMW APP-CTFs were amplified by the exosomal inhibitor GW4869.By combined pharmacological,immunological and genetic approaches,we established that these HMW APP-CTFs correspond to oligomeric APP-CTFs composed of C99 and/or C83.Immunocytochemical analysis showed that monomers were localized mainly to the trans-Golgi network,whereas oligomers were confined to endosomes and lysosomes,thus providing an anatomical support for the selective recovery of HMW APP-CTFs in EVs.The D6-induced APP-CTF oligomerization and subcellular mislocalization was indeed due toγ-secretase blockade,since it similarly occurred in presenilin-deficient fibroblasts.Further,our data proposed that besides favoring APP-CTF oligomerization by preventing C99 proteolysis,γ-secretase inhibiton also led to a defective SorLA-mediated retrograde transport of HMW APP-CTFs from endosomal compartments to the TGN.Conclusions:This is the first study to demonstrate the presence of oligomeric APP-CTFs in AD mouse models,the levels of which are selectively enriched in endolysosomal compartments including exosomes and amplified byγ-secretase inhibition.Future studies should evaluate the putative contribution of these exosome-associated APP-CTFs in AD onset,progression and spreading. | Inger Lauritzen Anaïs Bécot Alexandre Bourgeois Raphaëlle Pardossi-Piquard Maria-Grazia Biferi Martine Barkats Fréderic Checler | 2019 | Translational Neurodegeneration2019，8，1： | 1 |
| 3 | Polymer-layered silicate-carbon nanotube nanocom posites: unique nanofiller synergistic effect显示文摘 | PEETERBROECK S ALEXANDRE M NAGY J B | 2004 | Compos Sci Technol2004，64，15： | 1 |
| 4 | 2015, Microbial community structure mediates response of soil C decomposition to litter addition and warming 显示文摘 | COURTNEY A C Alexandre B M Evelyn S K | 2015 | Soil Biology and Biochemistry2015，80，： | 1 |
| 5 | 3D reconstruction of cultural heritages:challenges and advances on precise mesh integration显示文摘 | Jurandir de O S J Alexandre V Olga R P B | 2012 | Computer Vision and Image Understanding2012，116，12： | 1 |
| 6 | Induction of Transglutaminase 2 by a Liver X Receptor/Retinoic Acid Receptor α Pathway Increases the Clearance of Apoptotic Cells by Human Macrophages显示文摘 | Cédric Rébé Magalie Raveneau Angélique Chevriaux Daniela Lakomy Anne-Laure Sberna Annie Costa Ginette Bessède Anne Athias Eric Steinmetz Jean Marc A. Lobaccaro Georges Alves Alexandre Menicacci Sébastien Vachenc Eric Solary Philippe Gambert David Masson | 2009 | Circulation Research2009，，4： | 1 |
| 7 | 1-n-Butyl-3- methylimidazolium tetrachloro-indate (BMI · InCl4 ) as a media for the synthesis of biodiesel from vegetable oils 显示文摘 | BRENNO A D S N MELQUIZEDEQUE B A ALEXANDRE A M L | 2007 | Journal of Catalysis2007，249，1： | 1 |
| 8 | Functionalization of diamond nanoparticles using'click'chemistry显示文摘 | ALEXANDRE B SABINE S LIONEL M | 2010 | Langmuir Article2010，26，13： | 1 |
| 9 | Neuroimaging studies of cognitive remediation in schizophrenia:A systematic and critical review显示文摘AIM To examine the effects of cognitive remediation therapies on brain functioning through neuroimaging procedures in patients with schizophrenia.METHODS A systematic, computerised literature search was conducted in the PubM ed/Medline and PsychI nfo databases. The search was performed through February 2016 without any restrictions on language or publication date. The search was performed using the following search terms: [('cogniti*' and 'remediation' or 'training' or 'enhancement') and('fMRI' or 'MRI' or 'PET' or 'SPECT') and(schizophrenia or schiz*)]. The search was accompanied by a manual online search and a review of the references from each of the papers selected, and those papers fulfilling our inclusion criteria were also included.RESULTS A total of 101 studies were found, but only 18 of them fulfilled the inclusion criteria. These studies indicated that cognitive remediation improves brain activation in neuroimaging studies. The most commonly reported changes were those that involved the prefrontal and thalamic regions. Those findings are in agreement with the hypofrontality hypothesis, which proposes that frontal hypoactivation is the underlying mechanism of cognitive impairments in schizophrenia. Nonetheless,great heterogeneity among the studies was found. They presented different hypotheses, different results and different findings. The results of more recent studies interpreted cognitive recovery within broader frameworks, namely, as amelioration of the efficiency of different networks. Furthermore, advances in neuroimaging methodologies, such as the use of wholebrain analysis, tractography, graph analysis, and other sophisticated methodologies of data processing, might be conditioning the interpretation of results and generating new theoretical frameworks. Additionally, structural changes were described in both the grey and white matter, suggesting a neuroprotective effect of cognitive remediation. Cognitive, functional and structural improvements tended to be positively correlated.CONCLUSION Neuroimaging studies of cognitive remediation in patients with schizophrenia suggest a positive effect on brain functioning in terms of the functional reorganisation of neural networks. | Rafael Penadés Alexandre González-Rodríguez Rosa Catalán Bàrbara Segura Miquel Bernardo Carme Junqué | 2017 | World Journal of Psychiatry2017，7，1： | 1 |
| 10 | An energy-shaping approach to the design of excitation control of synchronous generators显示文摘 | Galaz M Ortega R Alexandre S B | 2003 | Automatica2003，39，1： | 1 |
| 11 | A domain swap approach reveals a role of the plant wall - associated kinase 1 ( WAK1 ) as a re- ceptor of oligogalacturonides 显示文摘 | Alexandre B Francesca S Alberto M | 2010 | PNAS2010，107，20： | 1 |
| 12 | Improving The Sift Descriptor With Smooth Derivative Filters 显示文摘 | Plinio M Alexandre B Jose S | 2009 | Pattern Recognition Let- ters2009，30，1： | 1 |
| 13 | The use of multiple tools for teaching medical biochemistry显示文摘 | Alexandre B S Renato M P Andre H O etal | 2008 | Adv Physiol Educ2008，32，： | 1 |
| 14 | Layered compounds based on molybdenum disulfide and ruthenium arene complexes显示文摘 | Alexandre S Golub Inna B Shumilova Yan V Zubavichus | 1997 | J Mater Chem1997，7，1： | 1 |
| 15 | Critical appraisal of the significance of intrathoracie anastomotic leakage after esophagectomy for cancer 显示文摘 | Whooley B P Law S Alexandrou A | 2001 | Am J Surg2001，181，3： | 1 |
| 16 | Myocardial performance index in female rats with myocardial infarction: relationship with ventricular function parameters by doppler echocardiography显示文摘 | Alexandre FC Andre B Roberto S | 2005 | J Am Soc Echocardiog2005，18，5： | 1 |
| 17 | Laser endoscopic microsurgery of laryngeal cancers显示文摘 | Moustapha S Olivier D Alexandre B | 2014 | Int Arch Otorhinolaryngol2014，18，1： | 1 |
| 18 | Emerging collective behavior and local properties of financial dynamics in a public investment game 显示文摘 | Roberto D S Ana L C B Alexandre T B | 2006 | Physica A : Statistical and Theoretical Physics2006，371，2： | 1 |
| 19 | Melatonin prevents oxidative stress,inflammatory activity,and DNA damage in cirrhotic rats显示文摘BACKGROUND Cirrhosis is an important health problem characterized by a significant change in liver parenchyma.In animals,this can be reproduced by an experimental model of bile duct ligation(BDL).Melatonin(MLT)is a physiological hormone synthesized from serotonin that has been studied for its beneficial properties,including its antioxidant potential.AIM To evaluate MLT’s effects on oxidative stress,the inflammatory process,and DNA damage in an experimental model of secondary biliary cirrhosis.METHODS Male Wistar rats were divided into 4 groups:Control(CO),CO+MLT,BDL,and BDL+MLT.MLT was administered(20 mg/kg)daily beginning on day 15 after biliary obstruction.On day 29 the animals were killed.Blood samples,liver tissue,and bone marrow were collected for further analysis.RESULTS BDL caused changes in biochemical and histological parameters and markers of inflammatory process.Thiobarbituric acid(0.46±0.01)reactive substance levels,superoxide dismutase activity(2.30±0.07)and nitric oxide levels(2.48±0.36)were significantly lower(P<0.001)n the groups that received MLT.DNA damage was also lower(P<0.001)in MLT-treated groups(171.6±32.9)than the BDL-only group(295.5±34.8).Tissue damage and the expression of nuclear factor kappa B,interleukin-1β,Nrf2,NQO1 and Hsp70 were significantly lower in animals treated with MLT(P<0.001).CONCLUSION When administered to rats with BDL-induced secondary biliary cirrhosis,MLT effectively restored the evaluated parameters. | Josieli R Colares Renata M Hartmann Elizângela G Schemitt Sandielly R B Fonseca Marilda S Brasil Jaqueline N Picada Alexandre S Dias Aline F Bueno Cláudio A Marroni Norma P Marroni | 2022 | World Journal of Gastroenterology2022，28，3： | 1 |
| 20 | Iterative minimization of H2 control performance criteria 显示文摘 | ALEXANDRE S B | 2008 | Automatica2008，44，3： | 1 |
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