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| 1 | Would integrated Western and traditional Chinese medicine have more benefits for stroke rehabilitation? A systematic review and meta-analysis显示文摘Background Stroke is a major cause of death or long-term disability worldwide.Many patients with stroke receive integrative therapy consisting of Western medicine(WM)and routine rehabilitation in conjunction with Chinese medicine(CM),such as acupuncture and Chinese herbal medicine.However,there is no available evidence on the effectiveness of the combined use of WM and CM interventions in stroke rehabilitation.Aims The purpose of this meta-analysis is to evaluate the results of all individual studies to assess the combined use of CM and WM in stroke rehabilitation compared with WM only.Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were followed.MEDLINE,EMBASE,Cochrane and China National Knowledge Infrastructure(CNKI)were searched.The included outcomes were dependency,motor function,depression and swallowing function.Subgroup analysis was performed,and publication bias was assessed using funnel plots.Summary of review 58 studies and 6339 patients were included in the meta-analysis.Subgroup analysis revealed that combined therapy comprising both acupuncture and WM had a superior effect on improving dependency and swallowing function compared with standard WM therapy alone.Potential superiority of combined therapy comprising CM and WM in improving depression compared with standard WM therapy was also found.Conclusions Our results indicate that the combined use of CM and WM could be more efficacious in stroke rehabilitation compared with the use of WM therapy alone.However,most studies were short in duration(2 to 4 weeks)and prone to different types of biases,which prevents making any conclusion regarding the long-term effects and raises concerns regarding true efficacy in context of high likelihood of Hawthorn bias.So,more randomised controlled trials with more rigorous design and longer duration of treatment and follow-up need to be conducted to compare WM alone versus WM and CM combined. | Linda LD Zhong Ya Zheng Alexander Y Lau Norman Wong Liang Yao Xingyao Wu Tengteng Shao Zhenxing Lu Huijuan Li Chun Sum Yuen Jianwen Guo Suzanne Lo Janita Chau Kam Wa Chan Bacon Fung Leung Ng Zhaoxiang Bian Edwin Chau-leung Yu | 2022 | Stroke & Vascular Neurology2022，7，1： | 7 |
| 2 | Pegni- vacogin results in near complete FIX inhibition in acute coro- nary syndrome patients: RADAR pharmacokinetic and pharma- codynamic substudy显示文摘 | POVSIC TJ WARGIN WA ALEXANDER JH | 2011 | Eur Heart J2011，32，19： | 1 |
| 3 | Long-term outcome after an early invasive versus selective invasive treatment strategy in patients with non-ST-elevation acute coronary syndrome and elevated cardiac troponin T (the ICTUS trial): a follow-up study显示文摘 | Alexander Hirsch Fons Windhausen Jan GP Tijssen Freek WA Verheugt Jan Hein Cornel Robbert J de Winter | 2007 | The Lancet . 2007 (9564)2007，，9564： | 1 |
| 4 | Pathophysiol- ogy of pregnancy - induced hypertension 显示文摘 | Granger JP Alexander BT Bennett WA | 2001 | Am J Hyper- tens2001，14，62： | 1 |
| 5 | Magnetic resonance classification of lumbar intervertebral disc degeneration 显示文摘 | Christian WA Alexander M Marco Z | 2001 | Spine2001，26，12： | 1 |
| 6 | Retroperiloneal abscess显示文摘 | Altemeier WA Alexander JW | 1961 | Arch Surg1961，83，： | 1 |
| 7 | Congenital fistulas of the lower lip 显示文摘 | Soricelli DA Bell L Alexander WA | 1966 | Oral Surg Oral Med Oral Pathol1966，，4： | 1 |
| 8 | Penicillin prophylaxis of experimental staphylococcal wound infections显示文摘 | Alexander JW Altemeier WA | 1965 | Surg Gynecol Obstet1965，120，2： | 1 |
| 9 | Pathophysiology ofpregnancy induced hypertension显示文摘 | Grang er JP Alexander BJ Bennertt WA | 2001 | Am J Hypertens2001，14，： | 1 |
| 10 | Hypertension produced by reductions in uterine perfusion in the pregnant rat :role of tumor necrosis factor-alpha显示文摘 | LaMarca BD Bennett WA Alexander BT | 2005 | Hypertension2005，46，4： | 1 |
| 11 | Magnetic resonance classification of lumbar intervertebral disc degeneration显示文摘 | Christian WA Alexander M Marco Z | | 0，，： | 1 |
| 12 | Pathophysiology of pregnancy inducel hypertension显示文摘 | Granger JP Alexander BJ Bennertt WA | 2001 | Am J Hypertens2001，14，62： | 1 |
| 13 | Pathophysiology of pregnancy-induced hypertension显示文摘 | Granger JP Alexander BT Bennett WA | 2001 | Am J Hypertens2001，14，62： | 1 |
| 14 | Pathophysiology of pregnancy-induced hypertension显示文摘 | Granger JP Alexander BT Bennett WA | 2001 | Am J Hypertens2001，14，62： | 1 |
| 15 | Hyper- tension producd by reductions in uterine perfusion in the pregnant rat role of tumor necrosia factor-or 显示文摘 | Lamarca BB Bennett WA Alexander BT el al | 2005 | Hyperten- sion2005，46，4： | 1 |
| 16 | Candida glabrata fungemia in transplant patients reeeiving vorieonazole after flueonazole显示文摘 | Alexander BD Sehell WA Miller JA | 2005 | Transplantation2005，80，6： | 1 |
| 17 | Pathophysiology of pregnancy-induced hypertension 显示文摘 | Granger JP Alexander BT Bennett WA | 2001 | Am J Hypertens2001，14，62： | 1 |
| 18 | Pathophysiology of pregnancy induced hypertension 显示文摘 | GRANGER JP ALEXANDER BT BENNETY WA | 2001 | Am J Hypertens2001，14，62： | 1 |
| 19 | Magnetic resonance classification of lumbar intervertebral disc degeneration显示文摘 | Chrisitian WA Alexander M | 2001 | Spine2001，26，17： | 1 |
| 20 | Pathophsiology of pregnancy- induced hypertension显示文摘 | Granger JP Alexander BT Bennett WA | 2001 | Am J Hypertens2001，，： | 1 |
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