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| 1 | Resonance-enhanced multi-octave supercontinuum generation in antiresonant hollow-core fibers显示文摘Ultrafast supercontinuum generation in gas-filled waveguides is an enabling technology for many intriguing applications ranging from attosecond metrology towards biophotonics,with the amount of spectral broadening crucially depending on the pulse dispersion of the propagating mode.In this study,we show that structural resonances in a gas-filled antiresonant hollow core optical fiber provide an additional degree of freedom in dispersion engineering,which enables the generation of more than three octaves of broadband light that ranges from deep UV wavelengths to near infrared.Our observation relies on the introduction of a geometric-induced resonance in the spectral vicinity of the ultrafast pump laser,outperforming gas dispersion and yielding a unique dispersion profile independent of core size,which is highly relevant for scaling input powers.Using a krypton-filled fiber,we observe spectral broadening from 200 nm to 1.7μm at an output energy of B 23μJ within a single optical mode across the entire spectral bandwidth.Simulations show that the frequency generation results from an accelerated fission process of solitonlike waveforms in a non-adiabatic dispersion regime associated with the emission of multiple phase-matched Cherenkov radiations on both sides of the resonance.This effect,along with the dispersion tuning and scaling capabilities of the fiber geometry,enables coherent ultra-broadband and high-energy sources,which range from the UV to the mid‐infrared spectral range. | Rudrakant Sollapur Daniil Kartashov Michael Zürch Andreas Hoffmann Teodora Grigorova Gregor Sauer Alexander Hartung Anka Schwuchow Joerg Bierlich Jens Kobelke Mario Chemnitz Markus A Schmidt Christian Spielmann | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 2 | Diagnostic value of diffusion-weighted MRI for imaging synovitis in pediatric patients with inflammatory conditions of the knee joint显示文摘Background Diffusion-weighted imaging(DWI)of synovitis has been suggested as a possible non-invasive alternative to contrast-enhanced T1w imaging(ce-T1w).We aimed to study DWI for diagnosing synovitis in the knee joint of pediatric patients,to quantify inter-observer agreement on DWI and ce-T1w and to calculate quantitative measures of synovial diffusivity and conspicuity.Methods Forty consecutive patients with known or suspected arthritis of the knee(25 girls,median age 12 years)underwent routine 1.5T MRI with ce-T1w and transverse DWI with b values 50 and 800 s/mm2.Mean apparent diffusion coefficient(ADC)values and signal intensity of inflamed synovium,joint effusion and muscle were measured with regions of interest retrospectively.Post-contrast T1 w images(diagnostic standard)and diffusion-weighted images at b=800 s/mm2 with ADC map were separately rated by three independent and blinded readers with different levels of expertise for the presence and degree of synovitis along with the level of diagnostic confidence.Results Thirty-one(78%)patients showed at least some synovial contrast enhancement,17(43%)children were diagnosed with synovitis on ce-T1w.Ratings by the 1st reader on ce-T1w and on DWI for synovitis showed very good agreement(kappa=0.90).Inter-observer agreement on DWI ranged from moderate to substantial with kappa values between 0.68 and 0.79(all P<0.001).Agreement and diagnostic confidence were generally lower in patients with mild and without synovial enhancement,compared to patients with synovitis.DWI yielded higher signal of inflamed synovium vs.muscle tissue,but lower signal vs.joint effusion,compared to ce-T1 w(all P<0.001).Conclusions Diffusion-weighted imaging is a promising,though reader-dependent alternative to contrast-enhanced imaging in patients with arthritis of the knee,based on our preliminary findings.It holds potential for increasing patient safety and comfort. | Mengxia Li Alexander Sauer Annette Holl-Wieden Thomas Pabst Henning Neubauer | 2020 | World Journal of Pediatrics2020，16，1： | 1 |
| 3 | Proton‐driven sucrose symport and antiport are provided by the vacuolar transporters SUC4 and TMT1/2显示文摘 | Alexander Schulz Diana Beyhl Irene Marten Alexandra Wormit Ekkehard Neuhaus Gernot Poschet Michael Büttner Sabine Schneider Norbert Sauer Rainer Hedrich | 2011 | The Plant Journal2011，，1： | 1 |
| 4 | Closed reduction and percutaneus Kirschner wire fixation for the treatment of dislocated calcaneal fractures: surgical technique, complications, clinical and radiological results after 2–10?years显示文摘 | Tim Alexander Walde B. Sauer J. Degreif H.-J. Walde | 2008 | Archives of Orthopaedic and Trauma Surgery2008，，6： | 1 |
| 5 | Off-label-use of sulfur-hexafluoride in voiding urosonography for diagnosis of vesicoureteral reflux in children:A survey on adverse events显示文摘AIM To evaluate the risk profile of sulfur hexafluoride in voiding urosonography(VUS) based on a large cohort of children.METHODS Since 2011 sulfur hexafluoride(SH,SonoV ue?,Bracco,Italy) is the only ultrasound contrast available in the European Union and its use in children has not been approved.Within a 4-year-period,531 children with suspected or proven vesicoureteral reflux(f/m = 478/53; mean age 4.9 years; 1 mo-25.2 years) following parental informed consent underwent VUS with administration of 2.6 ± 1.2 mL SH in a two-center study.A standardizedtelephone survey on adverse events was conducted three days later.RESULTS No acute adverse reactions were observed.The survey revealed subacute,mostly self-limited adverse events in 4.1%(22/531).The majority of observed adverse events(17/22) was not suspected to be caused by an allergic reaction: Five were related to catheter placement,three to reactivated urinary tract infections,five were associated with perineal disinfection before voiding urosonography or perineal dermatitis and four with a common cold.In five patients(0.9%) hints to a potential allergic cause were noted: Perineal urticaria was reported in three interviews and isolated,mild fever in two.These were minor self-limited adverse events with a subacute onset and no hospital admittance was necessary.Ninety-six point two percent of the parents would prefer future VUS examinations with use of SH.CONCLUSION No severe adverse events were observed and indications of self-limited minor allergic reactions related to intravesical administration of SH were reported in less than 1%. | Alexander Sauer Clemens Wirth Isabel Platzer Henning Neubauer Simon Veldhoen Alexander Dierks Reinhard Kaiser Andreas Kunz Meinrad Beer Thorsten Bley | 2017 | World Journal of Clinical Pediatrics2017，6，1： | 1 |
| 6 | The local immune response to intraocular Toxoplasma re-challenge: Less pathology and better parasite control through Treg/Th1/Th2 induction显示文摘 | Arnaud Sauer Elise Rochet Ibtissem Lahmar Julie Brunet Marcela Sabou Tristan Bourcier Ermanno Candolfi Alexander W. Pfaff | 2013 | International Journal for Parasitology2013，，9： | 1 |
| 7 | Conventional and wavelet coherence applied to sensory-evoked electrical brain activity显示文摘 | Alexander Klein Tomas Sauer Andreas Jedynak | 2004 | IEEE Transactions on Biomedical Engineering2004，，： | 1 |
| 8 | Typical load profile-supported convolutional neural network for short-term load forecasting in the industrial sector显示文摘This paper investigates how existing forecasting models can be enhanced to accurately forecast the electric load at factory level,enabling industrial companies to shift consumption to times of low energy costs.The model architecture must outperform state-of-the-art models and be sufficiently robust for use in multiple factories with low effort for specific applications.Moreover,this work focuses on the processing of high-resolution input data available almost in real time from multiple submeters after the main meters.The theory of load forecasting and related works are summarized in a first step including the requirements of forecasting models applied at factory level.Based on existing models,a new hybrid machine-learning model is proposed,combining a decision tree-based typical load profiler with a convolutional neural network that extracts features from multidimensional endogenous inputs with measurements of the preceding two weeks for multi-step-ahead load forecasts updated almost in real time.Furthermore,a multi-model approach is presented for calculating bottom-up forecasts with submeter data aggregated to a main-meter forecast.In a case study,the forecasting accuracy of the hybrid model is compared to both base models and a seasonal naïve model calculating the load forecasts for three factories.The results indicate that the proposed typical-load-profile-supported convolutional neural network for all three factories achieves the lowest forecasting error.Furthermore,it is validated that a reduction in data transfer delay leads to better forecasts,as the forecasting accuracy is higher with near real time data than with a data transfer delay of one day.Thus,a model architecture is proposed for robust forecasting in digitalized factories. | Thilo Walser Alexander Sauer | 2021 | Energy and AI2021，5，3： | 0 |
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