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您的检索式：作者名="Alessandra Bitto"
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| 1 | Evidence for a role of mitogen-activated protein kinases in the treatment of experimental acute pancreatitis显示文摘Acute pancreatitis(AP) is an inflammatory disease characterized by acute inflammation and necrosis of the pancreatic parenchyma. AP is often associated with organ failure, sepsis, and high mortality. The pathogenesis of AP is still not well understood. In recent years several papers have highlighted the cellular and molecular events of acute pancreatitis. Pancreatitis is initiated by activation of digestive enzymes within the acinar cells that are involved in autodigestion of the gland, followed by a massive infiltration of neutrophils and macrophages and release of inflammatory mediators, responsible for the local and systemic inflammatory response. The hallmark of AP is parenchymal cell necrosis that represents the cause of the high morbidity and mortality, so that new potential therapeutic approaches are indispensable for the treatment of patients at high risk of complications. However, not all factors that determine the onset and course of the disease have been explained. Aim of this article is to review the role of mitogen-activated protein kinases in pathogenesis of acute pancreatitis. | Natasha Irrera Alessandra Bitto Monica Interdonato Francesco Squadrito Domenica Altavilla | 2014 | World Journal of Gastroenterology2014，20，44： | 2 |
| 2 | Genistein aglycone, a soy-derived isoflavone, improves skin changes induced by ovariectomy in rats 显示文摘 | Francesca Polito Herbert Marini Alessandra Bitto | 2012 | British Journal of Pharmacology2012，165，4： | 1 |
| 3 | High mobility group box - 1 expression correlates with poor outcome in lunginjury patients 显示文摘 | Alessandra Bitto Mario Barone Polito F | 2010 | Pharmacological Research2010，61，2： | 1 |
| 4 | Melanocortin MC4 receptor agonists counteract late inflammatory and apoptotic responses and improve neuronal functionality after cerebral is- ehemia显示文摘 | Luca Spaccapelo Alessandra Bitto Maria Galantucci | 2011 | European Journal of Pharmacology2011，670，23： | 1 |
| 5 | Evidence for using a dual COX 1/2 and 5-LOX inhibitor in neurodegenerative diseases显示文摘A complex network of factors contributes to neuroinflammation,such as infections,brain injuries and accumulation of toxic metabolites(Gendelman,2002).Eicosanoids and several cytokines are the main mediators of inflammatory process;in fact,when an inflammatory condition persists,it can be responsible for the progression of degenerative diseases,such | Natasha Irrera Alessandra Bitto | 2017 | Neural Regeneration Research2017，12，7： | 0 |
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