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| 1 | Adipokines,cytokines and body fat stores in hepatitis Cvirus liver steatosis显示文摘AIM: To identify patients with or without liver steatosis and its severity in treatment-na?ve patients affected by hepatitis C virus(HCV) infection.METHODS: We included 56 HCV infected patients, and assessed the amount of liver fat by histomorphometry, and its relationships with fat and lean mass at different parts of the body(by densitometry), hormones [insulin, homeostatic model assessment(HOMA)], adipokines(resistin, adiponectin, leptin), and cytokines(tumor necrosis factor α, interleukin-6).RESULTS: Although the intensity of liver steatosis is related to trunk fat mass and HOMA, 33% of patients showed no liver steatosis, and this finding was not related to body mass index or genotype. Besides trunkfat mass, no other factor was related to the presence or not of liver steatosis, or to the intensity of it, by multivariate analysis. Lean mass was not related to liver steatosis. Adiponectin levels were lower among patients. No differences were observed in leptin and resistin.CONCLUSION: Steatosis in HCV infection is common(67.2%), and closely related to trunk fat, and insulin resistance, but not with leg fat mass or adipokines. | emilio gonzález-reimers javier lópez-prieto geraldine quintero-platt ricardo pelazas-gonzález m remedios alemán-valls onán pérez-hernández m joséde-la-vega-prieto m angeles gómez-rodríguez candelaria martín-gonzález francisco santolaria-fernández | 2016 | World Journal of Hepatology2016，8，1： | 2 |
| 2 | S-adenosyl-methionine decreases ethanol-induced apoptosis in primary hepatocyte cultures by a c-Jun N-terminal kinase activity-independent mechanism显示文摘AIM:To determine the role of c-Jun N-terminal kinase(JNK)activity in ethanol-induced apoptosis and themodulation of this signaling cascade by S-Adenosyl-methionine(AdoMet).METHODS:Primary hepatocyte cultures werepretreated with 100 μmol/L SP600125,a selective JNKinhibitor,1 mL/L DMSO or 4 mmol/L AdoMet and thenexposed to 100 mmo/L ethanol.Hepatocyte apoptosiswas determined by the TUNEL and DNA ladder assays.JNK activity and its inhibition by SP600125 and AdoMetwere determined by Western blot analysis of c-junphosphorylation and Bid fragmentation.SP600125 andAdoMet effects on the apoptotic signaling pathway weredetermined by Western blot analysis of cytochrome crelease and pro-caspase 3 fragmentation.The AdoMeteffect on glutathione levels was measured by Ellman'smethod and reactive oxygen species(ROS)generationby cell cytometry.RESULTS:The exposure of hepatocytes to ethanolinduced JNK activation,c-jun phosphorylation,Bidfragmentation,cytochrome c release and pro-caspase 3cleavage;these effects were diminished by SP600125,and caused a significant decrease in ethanol-inducedapoptosis(P<0.05).AdoMet exerted an antioxidanteffect maintaining glutathione levels and decreasing ROSgeneration,without a significant effect on JNK activity,and prevented cytochrome c release and pro-caspase 3cleavage. CONCLUSION:The JNK signaling cascade is a keycomponent of the proapoptotic signaling pathwayinduced by ethanol.JNK activation may be independentfrom ROS generation,since AdoMet which exertedantioxidant properties did not have a significant effect onJNK activity.JNK pathway modulator agents and AdoMetmay be components of promising therapies for alcoholicliver disease(ALD)treatment. | Maria del Pilar Cabrales-Romero Lucrecia Márquez-Rosado Samia FatteI-Fazenda Cristina Trejo-Solis Evelia Arce-Popoca Leticia Alemán-Lazarini Saúl Villa-Trevineo | 2006 | World Journal of Gastroenterology2006，12，12： | 2 |
| 3 | Titania ultrafihration membrane:preparation,characterization and photocatalytic activity显示文摘 | ALEM A SARPOOLAKY H KESHMIRI M | 2009 | Journal of the European Ceramic Society2009，29，4： | 1 |
| 4 | Acupuncture in the rehabilitation of women after breast cancer surgery-a case series显示文摘 | Alem M Gurgel MS | | 0，，02： | 1 |
| 5 | Antioxidant and antimicrobial peptide fractions from squid and tuna skin gelatin显示文摘 | GUILL N G L PEZ CABALLERO M ALEM N A | 2010 | 2010，，： | 1 |
| 6 | Efficient polymer-based interpenetrated network photovoltaic cells显示文摘 | Alem S Bettignies R de Nunzi J M | 2004 | Appl Phys Lett2004，84，12： | 1 |
| 7 | Open-cell reaction bon- ded silicon nitride foams: Fabrication and characterization 显示文摘 | Alem A Pugh M D Drew R A L | 2014 | J Eur Ceram Soe2014，34，： | 1 |
| 8 | Poly (N-isopropylacrylamide) grafted into nanopores:ther mo-responsive behaviour in the presence of different salts显示文摘 | Alem H Jonas A M Demoustier-Champagne S | | 0，，03： | 1 |
| 9 | Soil moisture estimation from ERS/SAR data:toward an operational methodology显示文摘 | Le Hegarat-Mascle S Zribi M Alem F | 2002 | IEEE Transactions on Geoscience and Remote Sensing2002，40，12： | 1 |
| 10 | Effects of Head--supported Mass on Aircrew Health and Perfor- mance 显示文摘 | Alem N M Crowley J S Mcghee J S | 2006 | Aviation Space and Environmental Medicine2006，77，3： | 1 |
| 11 | Soil moisture estimation from ERS/SAR data:Toward an operational methodology显示文摘 | HEGARAT-MASCLE S L ZRIBI M ALEM F | 2002 | IEEE Transactions on Geoscience and Remote Sensing2002，40，12： | 1 |
| 12 | Experimental investigation of turbulent flow and convective heat transfer characteristics of alumina water nanofluids in fully developed flow regime 显示文摘 | HEYHAT M M KOWSARY F RASHIDI A M ALEM VARZANE ESFEHANI S AMROLLAHI A | 2012 | International Communications in Heat and Mass Transfer2012，39，8： | 1 |
| 13 | Increased risk of hip fracture among patients with end-stage renal disease显示文摘 | Alem A M Sherrard D J Gillen D L | 2000 | Kidney Int2000，58，1： | 1 |
| 14 | Acupuncture in the rehabilitation of women after breast cancer surgery-a case series显示文摘 | Alem M Gurgel MS | 2008 | Acupunct Med2008，26，2： | 1 |
| 15 | Computer-aided measurement of solid breast tnmor features on ultrasound images显示文摘 | Alemán-Flores M Alemán-Flores P Alvarez-León L | 2004 | Cvamia Mrnbia2004，117，3： | 1 |
| 16 | Memory T(H)2 cells induce alternatively activated macrophages to mediate protection againstnematode parasites显示文摘 | Anthony R M Urban JJ Alem F | | 0，，08： | 1 |
| 17 | Identification of ace-inhibitory peptides from squid skin collagen after in vitro gastrointestinal digestion 显示文摘 | Alem N A G Mez-Guill N M C MONTERO P | 2013 | Food Research International2013，54，1： | 1 |
| 18 | Controlled large-scale synthesis and magnetic properties of single crystal cobalt nanorods 显示文摘 | Aslam M Bhobe R Alem N | 2005 | Journal of Applied Physics2005，98，7： | 1 |
| 19 | Soil Moisture Estimation from ERS/SAR Data:Toward an Operational Methodology显示文摘 | LE HEGARAT-MASCLE S ZRIBI M ALEM F | 2002 | IEEE Transactions on Geoscience and Remote Sensing2002，40，12： | 1 |
| 20 | Prostaglandin production during growth of Candida albicans biofilms显示文摘 | Alem M A Douglas L J | 2005 | J Med Microbiol2005，54，11： | 1 |
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