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| 1 | 硝酸甘油介入^(99)Tc^m-tetrofosminSPECT与^(18)F-FDG PET显像评估心肌活力比较显示文摘目的比较硝酸甘油介入^(99)Tc^m-tetrofosmin SPECT 心肌血流灌注显像与^(18)F-FDG PET 心肌代谢显像评估心肌活力的价值。方法既往有心肌梗死史伴左心功能不全经冠状动脉造影确诊为冠心病的患者36例,行二日法静息和硝酸甘油介入^(99)Tc^m-tetrofosmin SPECT 显像,并在1周内再行^(18)F-FDG PET 心肌代谢显像及静息超声心动图检查。将左心室分成13个节段,分析超声心动图室壁运动,并分析相同节段^(99)Tc^m-tetrofosmin 与^(18)F-FDG 的相对摄取比值,以^(99)Tc^m-tetrofosmin 摄取比值55%,^(18)F-FDG 摄取比值50%为判断心肌活力有无的阈值。以 k 统计比较3种方法的一致性。结果超声心动图示131个节段呈无运动或反向运动。^(99)Tc^m-tetrofosmin 静息显像示其中78个节段(60%)心肌有活力,53个节段(40%)无活力。该53个节段中14个(26%)在硝酸甘油介入后可见再填充,余39个节段无改变。在^(18)F-FDG PET 显像中,硝酸甘油介入显像再填充节段的心肌放射性摄取明显增高。再填充节段与无填充节段比较,心肌 FDG 摄取分别为(76±15)%和(58±17)%,差异有统计学意义(P<0.01)。硝酸甘油介入显像中,92个心肌节段(70%)有活力,39个无活力。tetrofosmin静息显像评估心肌活力与 FDG PET 显像比较,k 值为0.35,而硝酸甘油介入^(99)Tc^m-tetrofosmin SPECT与^(18)F-FDG PET 显像结果比较,k 值为0.53。结论硝酸甘油介入^(99)Tc^m-tetrofosmin SPECT 显像可提高对心肌活力的检测能力,与^(18)F-FDG PET 心肌代谢显像有很好的一致性。 | 何薇 Alberto Cuocolo | 2007 | 中华核医学杂志2007，27，5： | 6 |
| 2 | Exercise training early after acute myocardial infarction reduces stress-induced hypoperfusion and improves left ventricular function显示文摘 | Francesco Giallauria Wanda Acampa Francesca Ricci Alessandra Vitelli Giorgio Torella Rosa Lucci Giuseppina Prete Emilia Zampella Roberta Assante Giuseppe Rengo Dario Leosco Alberto Cuocolo Carlo Vigorito | 2013 | European Journal of Nuclear Medicine and Molecular Imaging2013，，3： | 1 |
| 3 | The Diagnosis of Nonfunctioning Pheochromocytoma The Role of I-123 MIBG Imaging显示文摘 | SIMONE MAUREA SECONDO LASTORIA ALBERTO CUOCOLO LUIGI CELENTANO MARCO SALVATORE | | Clinical Nuclear Medicine0，，： | 1 |
| 4 | Role of nuclear cardiology for guiding device therapy in patients with heart failure显示文摘Heart failure is a dynamic condition with high morbidity and mortality and its prognosis should be reassessed frequently, particularly in patients for whom critical treatment decisions may depend on the results of prognostication. In patients with heart failure, nuclear cardiology techniques are useful to establish the etiology and the severity of the disease, while fewer studies have explored the potential capability of nuclear cardiology to guide cardiac resynchronization therapy(CRT) and to select patients for implantable cardioverter defibrillators(ICD). Left ventricular synchrony may be assessed by radionuclide angiography or gated singlephoton emission computed tomography myocardial perfusion scintigraphy. These modalities have shown promise as predictors of CRT outcome using phase analysis. Combined assessment of myocardial viability and left ventricular dyssynchrony is feasible using positron emission tomography and could improve conventional response prediction criteria for CRT. Preliminary data also exists on integrated positron emission tomography/computed tomography approach for assessing myocardial viability, identifying the location of biventricular pacemaker leads, and obtaining left ventricular functional data, including contractile phase analysis. Finally, cardiac imaging with autonomic radiotracers may be useful in predicting CRT response and for identifying patients at risk for sudden cardiac death, therefore potentially offering a way to select patients for both CRT and ICD therapy. Prospective trials where imaging is combined with image-test driven therapy are needed to better define the role of nuclear cardiology for guiding device therapy in patients with heart failure. | Mario Petretta Andrea Petretta Teresa Pellegrino Carmela Nappi Valeria Cantoni Alberto Cuocolo | 2014 | World Journal of Meta-Analysis2014，2，1： | 1 |
| 5 | Effect of Adenosine on Cerebral Blood Flow as Evaluated by SinglePhoton Emission Computed Tomography in Normal Subjects and in Patients With Occlusive Carotid Disease A Comparison With Acetazolamide显示文摘 | Alfredo Postiglione Alberto Cuocolo | 1995 | Stroke1995，26，： | 1 |
| 6 | Effects of type 2 diabetes mellitus on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease显示文摘 | Caterina Marciano Maurizio Galderisi Paola Gargiulo Wanda Acampa Carmen D’Amore Roberta Esposito Enza Capasso Gianluigi Savarese Laura Casaretti Francesco Iudice Giovanni Esposito Giuseppe Rengo Dario Leosco Alberto Cuocolo Pasquale Perrone-Filardi | 2012 | European Journal of Nuclear Medicine and Molecular Imaging2012，，7： | 1 |
| 7 | Exercise training early after acute myocardial infarction reduces stress-induced hypoperfusion and improves left ventricular function显示文摘 | Francesco Giallauria Wanda Acampa Francesca Ricci Alessandra Vitelli Giorgio Torella Rosa Lucci Giuseppina Prete Emilia Zampella Roberta Assante Giuseppe Rengo Dario Leosco Alberto Cuocolo Carlo Vigorito | 2013 | European Journal of Nuclear Medicine and Molecular Imaging2013，，3： | 1 |
| 8 | Does protracted antiviral therapy impact on HCV-related liver cirrhosis progression?显示文摘AIM: To study the outcomes of patients with compensated hepatitis C virus-related cirrhosis. METHODS: Twenty-four grade A5 and 11 grade A6 of Child-Pugh classification cirrhotic patients with active virus replication, treated for a mean period of 31.3 ± 5.1 mo with moderate doses of interferon-alpha and ribavirin, were compared to a cohort of 36 patients with similar characteristics, without antiviral treatment. Salivary caffeine concentration, a liver test of microsomal function, was determined at the starting and thrice in course of therapy after a mean period of 11 ± 1.6 mo, meanwhile the resistive index of splenic artery at ultra sound Doppler, an indirect index of portal hypertension, was only measured at the beginning and the end of study. RESULTS: Eight out of the 24 A5- (33.3%) and 5 out of the 11 A6- (45.45%) treated-cirrhotic patients showed a significant improvement in the total overnight salivary caffeine assessment. A reduction up to 20% of the resistive index of splenic artery was obtained in 3 out of the 8 A5- (37.5%) and in 2 out of the 5 A6- (40%) cirrhotic patients with an improved liver function, which showed a clear tendency to decrease at the end of therapy. The hepatitis C virus clearance was achieved in 3 out of the 24 (12.5%) A5- and 1 out of the 11 (0.091%) A6-patients after a median period of 8.5 mo combined therapy. In the cohort of non-treated cirrhotic patients, not only the considered parameters remained unchanged, but 3 patients (8.3%) had a worsening ofthe Child-Pugh score (P = 0.001).CONCLUSION: A prolonged antiviral therapy with moderate dosages of interferon-alpha and ribavirin shows a trend to stable liver function or to ameliorate the residual liver function, the entity of portal hypertension and the compensation status at acceptable costs. | Giovanni Tarantino Antonio Gentile Domenico Capone Vincenzo Basile Marianna Tarantino Matteo Nicola Dario Di Minno Alberto Cuocolo Paolo Conca | 2007 | World Journal of Gastroenterology2007，13，36： | 0 |
| 9 | Cardiac hybrid imaging: novel tracers for novel targets显示文摘Non-invasive cardiac imaging has explored enormous advances in the last few decades.In particular,hybrid imaging represents the fusion of information from multiple imaging modalities,allowing to provide a more comprehensive dataset compared to traditional imaging techniques in patients with cardiovascular diseases.The complementary anatomical,functional and molecular information provided by hybrid systems are able to simplify the evaluation procedure of various pathologies in a routine clinical setting.The diagnostic capability of hybrid imaging modalities can be further enhanced by introducing novel and specific imaging biomarkers.The aim of this review is to cover the most recent advancements in radiotracers development for SPECT/CT,PET/CT,and PET/MRI for cardiovascular diseases. | Andrea Ponsiglione Raffaele Ascione Carmela Nappi Massimo Imbriaco Michele Klain Renato Cuocolo Alberto Cuocolo Mario Petretta | 2021 | Journal of Geriatric Cardiology2021，18，9： | 0 |
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