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| 1 | Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 in patients with fatty liver diseases显示文摘AIM:To test the occurrence of the Pro12Ala mutation of the peroxisome proliferator-activated receptor-γ (PPARγ)2-gene in patients with non-alcoholic fatty liver disease (NAFLD) or alcoholic fatty liver disease (AFLD).METHODS:DNA from a total of 622 specimens including 259 blood samples of healthy blood donors and 363 histologically categorized liver biopsies of patients with NAFLD (n=263) and AFLD (n=100) were analyzed by Real-time polymerase chain reaction using allele-specific probes.RESULTS:In the NAFLD and the AFLD collective,3% of the patients showed homozygous occurrence of the Ala12 PPARγ2-allele,differing from only 1.5% cases in the healthy population.In NAFLD patients,a high incidence of the Ala12 mutant was not associated with the progression of fatty liver disease.However,we observed a significantly higher risk (odds ratio=2.50,CI:1.05-5.90,P=0.028) in AFLD patients carrying the mutated Ala12 allele to develop inflammatory alterations.The linkage of the malfunctioning Ala12-positive PPARγ2 isoform to an increased risk in patients with AFLD to develop severe steatohepatitis and fibrosis indicates a more prominent anti-inflammatory impact of PPARγ2 in progression of AFLD than of NAFLD.CONCLUSION:In AFLD patients,the Pro12Ala single nuclear polymorphism should be studied more extensively in order to serve as a novel candidate in biomarker screening for improved prognosis. | Johannes W Rey Andrea Noetel Aline Hardt Ali Canbay Hakan Alakus Axel zur Hausen Hans Peter Dienes Uta Drebber Margarete Odenthal | 2010 | World Journal of Gastroenterology2010，16，46： | 11 |
| 2 | Effect of low molecular weight heparin (enoxaparin) on congenital cataract surgery显示文摘AIM: To assess the efficacy of intracameral enoxaparin (a low-molecular-weight heparin) infusion, in variable doses on postoperative inflammatory response in congenital cataract surgery.METHODS: It is a prospective, randomized controlled trial. Eighty eyes of 53 children with congenital cataract were enrolled in this study. Every eye had primary posterior capsulorrhexis and intraocular lens (IOL) implantation after lens aspiration. The eyes were divided into 4 equal groups. In group 1 balanced salt solution (BSS) without enoxaparin was used as an irrigation solution. Whereas in group 2, 3 and 4, 40mg, 20mg and 10mg enoxaparin in 500mL BSS was used respectively. The inflammatory response in the anterior chamber was compared among the groups with slit-lamp biomicroscopy.RESULTS: The mean follow-up period was (17.75±3.95) months in group 1, (18.00±5.15) months in group 2, (19.20±5.47) months in group 3 and (18.65±5.16) months in group 4. Mean number of inflammatory cells in the anterior chamber in group 1 was significantly higher than that of group 2, 3, 4 (P<0.001). There was fibrin formation in the anterior chambers of 3 eyes in group 1 and one eye in group 4. There was synechiae formation in 3 eyes of group 1 and one eye of group 4. There was no significant difference among the groups by means of fibrin or synechiae formation (P>0.05). There were IOL precipitates in 4 eyes of group 1 and 2 eyes of group 4. IOL precipitate formation was significantly higher in group 1 than that of group 2 and 3 in which there was no IOL precipitate (P=0.048). There was IOL subluxation in only one eye of group 1, 3 and 4 while no subluxation was observed in group 2 (P>0.05). There was no statistically significant difference detected about IOL subluxation occurance in all 4 groups (P>0.05). CONCLUSION: Complications of cataract surgery in congenital cataract patients associated with postoperative inflammatory response found to be decreased with the use of enoxaparin in intraocular infusion solutions. Furthermore according to our results the anti-inflammatory effect of enoxaparin was dose dependant. | Ihsan aa Alparslan Sahin Abdullah Kürsat Cingü Seyhmus Ari Fuat Alakus Yasin inar | 2012 | International Journal of Ophthalmology(English edition)2012，5，5： | 3 |
| 3 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 4 | Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations显示文摘 | Schmitz KJ Wohlschlaeger J Alakus H | 2007 | Virchows Arch2007，450，2： | 1 |
| 5 | Clinic pathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer显示文摘 | Alakus H Grass G Hennecken J K | 2008 | Histol Histopathol2008，23，8： | 1 |
| 6 | Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer显示文摘 | Alakus H Afriani N Warnecke-Eberz U | 2010 | World J Surg2010，34，12： | 1 |
| 7 | Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer 显示文摘 | Alakus H Afriani N Warnecke-Eberz U | 2010 | World J Surg2010，34，12： | 1 |
| 8 | ERCC1 and XRCC1 Gene Polymorphisms predict response to neoadjuvant radiochemotherapy in esophageal cancer显示文摘 | Warnecke-Eberz U Vallbohmer D Alakus H | 2009 | J Gastrointest Surg2009，13，8： | 1 |
| 9 | Clinicopathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer显示文摘 | Alakus H Grass G Hennecken J K | 2008 | Histology and Histopathology2008，23，8： | 1 |
| 10 | ER- CC1 and XRCC1 gene polymorphisms predict response to neoadjuvant radiochemotherapy in esophageal cancer显示文摘 | Warnecke-Eberz U Vallb-hmer D Alakus H | 2009 | J Gastrointest Surg2009，13，8： | 1 |
| 11 | Clinic pathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer显示文摘 | Alakus H Grass G Hennecken J K | 2008 | Histol Histopathol2008，23，8： | 1 |
| 12 | Clinicopathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer 显示文摘 | Alakus H Grass G Hennecken JK | 2008 | Histol Histopathol2008，23，8： | 1 |
| 13 | GNAS1 T393C poly-morphism and survival in patients with sporadic colorectal cancer显示文摘 | Frey UH Alakus H Wohlschlaeger J | 2005 | Clin Cancer Res2005，11，14： | 1 |
| 14 | Activation of extracellular regulated kinases (ERK1/2)but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations显示文摘 | Schmitz KJ Wohlschlaeger J Alakus H | 2007 | Virchows Arch2007，450，2： | 1 |
| 15 | Clinicopathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer 显示文摘 | Alakus H Grass G Hennecken JK | 2008 | Histol Histopathol2008，23，8： | 1 |
| 16 | Neoadjuvant chemoradiotherapy for esophageal cancer:Impact on extracapsular lymph node involvement显示文摘AIM:To assess the effects of neoadjuvant chemoradiotherapy(CRT) on the presence of extracapsular lymph node involvement(LNI) and its prognostic value in patients with resected esophageal cancer.METHODS:Two hundred and ninety-eight patients with advanced esophageal cancer underwent esophagectomy between 1997 and 2006.One hundred and ninety patients(63.8%) were treated with neoadjuvant CRT prior to resection.A total of 986 metastatic LNs were examined.Survival of the patients was analyzed according to intra-and extra-capsular LNI.RESULTS:Five-year survival rate was 22.5% for the entire patient population.Patients with extracapsular LNI had a 5-year survival rate of 16.7%,which was comparable to the 15.8% in patients with infiltrated nodes of the celiac trunk(pM1lymph).In contrast to patients treated with surgery alone,neoadjuvant therapy resulted in signif icantly(P = 0.001) more patients with pN0/M0(51.6% vs 25.0%).In 17.6% of the patients with surgery alone vs 16.8% with neoadjuvant CRT,extracapsular LNI was detected.Neoadjuvant therapy does not reduce the occurrence of extracapsular LNI.CONCLUSION:Extracapsular LNI is an independent negative prognostic factor not influenced by neoadjuvant CRT.In a revised staging system for esophageal cancer,extracapsular LNI should be considered. | Ralf Metzger Elfriede Bollschweiler Uta Drebber Stefan P Mnig Wolfgang Schrder Hakan Alakus Martin Kocher Stephan E Baldus Arnulf H Hlscher | 2010 | World Journal of Gastroenterology2010，16，16： | 1 |
| 17 | Variable 18F-fluorodeoxyglucose uptake in gastric cancer is associated with different levels of GLUT-1 expression显示文摘 | Alakus H Batur M Schmidt M | 2010 | Nuclear Medicine Communications:June2010，31，6： | 1 |
| 18 | Clinicopathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer显示文摘 | Alakus H Grass G Hennecken J K | 2008 | Histol Histopathol2008，23，8： | 1 |
| 19 | Variable 18F-fluorodeoxyglucose uptake in gastric cancer is associated with different levels of GLUT-1 expression显示文摘 | Alakus H Batur M Schmidt M | | 0，，： | 1 |
| 20 | Extracapsular lymph node spread: a new prognostic factor in gastric cancer显示文摘 | Alakus H Holscher AH Grassg | 2009 | Cancer2009，116，2： | 1 |
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