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| 1 | 1995-2005年青海省棘球蚴病流行病学调查分析显示文摘目的分析1995-2005年青海省人与动物棘球蚴病的流行病学调查结果。方法人群棘球蚴病感染情况以Bu-ELISA、EM18-ELISA和B超、X线进行检查和评价。动物棘球蚴病/棘球绦虫感染调查采用解剖学方法和寄生虫学方法。结果①女性人群的血清阳性率和患病率显著高于男性人群(14.41%和4.81%、10.22%和3.25%);随年龄增长,人群血清阳性率和患病率升高(见表5);以牧民、喇嘛的血清阳性率和患病率最高(17.73%和9.33%、18.56%和10.0%)。②青海省人与动物棘球蚴病/棘球绦虫的血清阳性率和感染/患病率以青南高原的果洛、玉树、黄南三州最高(见表1、7、8),祁连山地和河湟谷地的海南、海北两州次之,海东地区、西宁及柴达木盆地的海西州较低。③青海省是以囊型棘球蚴病/细粒棘球绦虫为主的囊型和泡型棘球蚴病的混合流行区,并在其南部发现存在石渠棘球绦虫的动物感染。结论青海省棘球绦虫的生活史循环链十分复杂,家养动物相互之间、野生动物相互之间、家养动物和野生动物之间均参与其中。 | 王虎 张静宵 Schantz P M Akira Ito P S craig 吴献洪 韩秀敏 | 2006 | 中国人兽共患病学报2006，22，12： | 37 |
| 2 | 包虫病手术患者1312例流行病学资料分析显示文摘目的了解青藏高原包虫病的分布特点。方法对1992-2006年的1312例包虫病手术患者的相关资料进行分析。结果囊型和泡型包虫病均有分布。患者主要集中于21~50岁,20岁以下的患者相对较少,以藏族为主。囊型包虫病分布于四川省甘孜州和阿坝州的17个县以及青海省果洛州的5个县,而泡型包虫病同时分布于其中的大部分地区。结论囊型和泡型包虫病同时流行于四川省的西北部和青海省的东南部。 | 仁真 李调英 廖万明 陈兴旺 赵晓东 肖宁 喻晓慧 张西春 Akira Ito 邱加闽 Patrick Giraudoux Philip S Craig | 2008 | 寄生虫病与感染性疾病2008，6，3： | 8 |
| 3 | Priorities for research and control of cestode zoonoses in Asia显示文摘Globally,cestode zoonoses cause serious public health problems,particularly in Asia.Among all neglected zoonotic diseases,cestode zoonoses account for over 75%of global disability adjusted life years(DALYs)lost.An international symposium on cestode zoonoses research and control was held in Shanghai,China between 28th and 30th October 2012 in order to establish joint efforts to study and research effective approaches to control these zoonoses.It brought together 96 scientists from the Asian region and beyond to exchange ideas,report on progress,make a gap analysis,and distill prioritizing settings with a focus on the Asian region.Key objectives of this international symposium were to agree on solutions to accelerate progress towards decreasing transmission,and human mortality and morbidity caused by the three major cestode zoonoses(cystic echinococcosis,alveolar echinococcosis,and cysticercosis);to critically assess the potential to control these diseases;to establish a research and validation agenda on existing and new approaches;and to report on novel tools for the study and control of cestode zoonoses. | Ning Xiao Jia-Wen Yao Wei Ding Patrick Giraudoux Philip S Craig Akira Ito | 2013 | Infectious Diseases of Poverty2013，2，1： | 6 |
| 4 | CuPd催化剂调节中间反应能垒提高电催化CO_(2)生成二碳产物的选择性显示文摘过度的碳排放已造成了严重的全球环境问题,电催化CO_(2)还原是一种利用间歇性过剩电能将CO_(2)转化为有价值的化学物质的有效策略.在多种CO_(2)还原产物中,二碳(C2)产物(如乙烯、乙醇)因其比一碳产物(如甲酸、甲烷、甲醇)具有更高的能量密度而备受关注.Cu是唯一能用电化学方法将CO_(2)转化为多碳产物的单金属催化剂.如何提高Cu基催化剂上CO_(2)还原为C2产物的效率已引起了极大关注.电催化还原CO_(2)生成C2产物有两个重要步骤:一是参与碳碳偶联反应的CO*中间体的量(*代表中间体吸附在基底表面),二是碳碳偶联步骤的能垒.对于Cu单金属催化剂,虽然其表面碳碳偶联步骤的能垒相对较低,但是Cu对CO_(2)的吸附能力和CO_(2)*加氢能力并不高,导致在Cu表面不能生成足量的CO*中间体参与碳碳偶联反应,因而对C2产物的选择性和活性并不理想.与Cu单金属催化剂相反,在Pd单金属催化剂表面,CO*中间体的形成具有超快的反应动力学,但是CO*易在Pd表面中毒且后续碳碳偶联步骤的能垒极高,使其表面不能生成C2产物.为了充分发挥Cu(碳碳偶联步骤能垒较低)和Pd(CO*形成具有超快反应动力学)的双重优势,本文构建了一种紧密的CuPd(100)界面,以调节中间反应能垒,从而提高C2产率.密度泛函理论(DFT)计算表明,CuPd(100)界面增强了CO_(2)的吸附,且降低了CO_(2)*加氢步骤的能垒,从而能够催化生成更多的CO*中间体参与碳碳偶联反应.且CuPd(100)界面上CO_(2)还原为C2产物的电位决定步骤能垒为0.61 eV,低于Cu(100)表面的(0.72 eV).本文采用了一种简便的湿化学法制备了CuPd(100)界面催化剂.X射线衍射和X射线光电子能谱测试以及扩展X射线吸收精细结构光谱结果表明,合成的是相分离的CuPd双金属催化剂,而非CuPd合金催化剂.同时高分辨透射电镜可以观察到清晰的CuPd(100)界面.由此可见,本文成功合成了CuPd(100)界面催化剂.程序升温脱附实验结果表明,CuPd(100)界面对CO_(2)和CO*的吸附比Cu强,结果与理论预测一致.气体传感实验结果表明,CuPd(100)界面CO_(2)*加氢能力比Cu强.为评估CuPd(100)界面催化剂的催化活性,进行了CO_(2)电化学还原实验.结果表明,在0.1 mol/L的KHCO3电解液中,CuPd(100)界面催化剂在‒1.4 VRHE下,C2产物的法拉第效率为50.3%±1.2%,是同电位下Cu催化剂的(23.6%±1.5%)的2.1倍,C2产物的选择性是Cu催化剂的2.4倍,且具有更高的电流密度和更大的电化学活性面积.本文通过调控中间反应能垒以合理设计铜基CO_(2)还原电催化剂提供了参考. | 朱莉 林翌阳 刘康 Emiliano Cortés 李红梅 胡俊华 Akira Yamaguchi 刘小良 Masahiro Miyauchi 傅俊伟 刘敏 | 2021 | Chinese Journal of Catalysis2021，42，9： | 4 |
| 5 | 臂间血压差与脑卒中的关系显示文摘为了检测同时测量的双臂血压差值是否可识别踝臂血压指数〈0.90的受试者,及是否能预测未来心血管事件,Hirofumi等收集来自10个队列的日本受试者13 317人的数据(基于一般人群的队列,既往有心血管事件病史的队列及有心血管病危险因素的队列)进行荟萃分析。 | 刘青 叶鹏 Hirofumi T Toshiaki O Toshiharu N Chisa M Kazuomi K Satoshi H Yoshikuni K Toyoshi I Yasutaka M Katsuhiko K Yasuharu T Motoyuki N Takayoshi O Hirotaka W Masanori M Mitsuru O Norihisa I Michinari N Tetsuo S Charalambos V Akira Y | 2018 | 中华高血压杂志2018，26，6： | 3 |
| 6 | Constitutive androstane receptor agonist, TCPOBOP,attenuates steatohepatitis in the methionine choline-deficientdiet-fed mouse显示文摘AIM:To ascertain whether constitutive androstane receptor(CAR)activation by 1,4-bis-2-(3,5,-dichloropyridyloxy)benzene(TCPOBOP)modulates steatohepatitis in the methionine choline-deficient(MCD)diet-fed animal.METHODS:C57/BL6 wild-type mice were fed the MCD or standard diet for 2 wk and were treated with either the CAR agonist,TCPOBOP,or the CAR inverse agonist,androstanol.RESULTS:Expression of CYP2B10 and CYP3A11,known CAR target genes,increased 30-fold and 45-fold,respectively,in TCPOBOP-treated mice fed the MCD diet.TCPOBOP treatment reduced hepatic steatosis(44.6 ± 5.4% vs 30.4 ± 4.5%,P < 0.05)and serum triglyceride levels(48 ± 8 vs 20 ± 1 mg/dL,P < 0.05)in MCD diet-fed mice as compared with the standard diet-fed mice.This reduction in hepatic steatosis was accompanied by an increase in enzymes involved in fatty acid microsomal ω-oxidation and peroxisomal β-oxidation,namely CYP4A10,LPBE,and 3-ketoacyl-CoA thiolase.The reduction in steatosis was also accompanied by a reduction in liver cell apoptosis and inflammation.In contrast,androstanol was without effect on any of the above parameters.CONCLUSION:CAR activation stimulates induction of genes involved in fatty acid oxidation,and ameliorates hepatic steatosis,apoptosis and inflammation. | Edwina S Baskin-Bey Akira Anan Hajime Isomoto Steven F Bronk Gregory J Gores | 2007 | World Journal of Gastroenterology2007，13，42： | 3 |
| 7 | Optical and SuperDARN radar observations of duskside shock aurora over Zhongshan Station显示文摘We present observations of a duskside shock aurora occurred on 21 April 2001 by the SuperDARN radar at Syowa Station and the all-sky camera at Zhongshan Station (ZHS) in Antarctica when the radar was operated in fast-scan mode covering the ZHS region. With the two independent data sets, we examine ionospheric plasma convection and aurora arising from a sudden impulse (SI) event associated with an interplanetary shock. During the transient shock compression, the aurora was quiescent without any optical emission at the preliminary impulse of the SI. About 7 min later, a new thin auroral arc with brighter emissions and a lifetime of~14 min expanded westward from the region above ZHS during the main impulse of the SI. SuperDARN radar line-of-sight measurements showed periodical oscillation in the flow direction with ultra-low-frequency waves having a period of~8 min during the shock compression. We suggest that downward field-aligned current during the preliminary impulse stage of the SI was the main driver of the first plasma flow reversal, and the subsequent new discrete auroral arc may be associated with field-aligned acceleration in the region of the main impulse related upward field-aligned currents. The ground magnetometer observations suggest that the oscillation of the ionospheric convection on the duskside was associated with field line resonance activity. | LIU Jianjun HU Hongqiao HAN Desheng LIU Yonghua ZHANG Qinghe Akira S Yukimatu | 2013 | Advances in Polar Science2013，24，1： | 2 |
| 8 | Microbial recognition by Toll-like receptor 显示文摘 | Takeda K Akira S | 2004 | J Dermatol Sci2004，34，2： | 1 |
| 9 | Inhibition of Toll-like receptor 4 with eritoran attenuates myocardial ischemia-reperfusion injury 显示文摘 | Akira S Albert CJ Masaki Y | 2006 | Circulation2006，114，： | 1 |
| 10 | Three case of malignant lymphoma of the breast显示文摘 | YASUHIRO S YUTAKA T AKIRA O | 2000 | Jpn J Clin Oncol2000，30，： | 1 |
| 11 | Gasless laparoscopic ovarian cystectomy during pregnancy:Comparison with laparotomy显示文摘 | Yamanaka A Ishihara T | 1999 | Am J Obstet Gynecol[J]1999，180，55： | 1 |
| 12 | Video-assisted neck surgery:endoscopic resection of thyroid tumors with a very minimal neck wound显示文摘 | Shimizu K Akira S Jasmi AY | 1999 | J Am Coll Surg1999，188，6： | 1 |
| 13 | Innate antiviral responses by means of TLRT-mediated recognition of single-stranded RNA显示文摘 | Diebold S S Kaisho T Hemmi H Akira S Reis e Sousa C | 2004 | Science2004，303，： | 1 |
| 14 | Toll-like receptors and innate immunity显示文摘 | Uematsu S Akira S | 2006 | J Mol Med2006，84，： | 1 |
| 15 | Video-assisted neck surgery:endoscopic resection of thyroid tumors with a very minimal neck wound显示文摘 | Shimizu K Akira S Jasmi AY | 1999 | J Am Coll Surg1999，188，6： | 1 |
| 16 | Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute al- lograft rejection显示文摘 | Goldstein D R Teasar B M Akira S | 2003 | J Clin Invest2003，111，10： | 1 |
| 17 | Toll-like receptors显示文摘 | Takeda K Kaisho T Akira S | 2003 | Annu rev im- munol2003，21，1： | 1 |
| 18 | Innate immunity to virus infection显示文摘 | Takeuchi O Akira S | 2009 | Immunol Rev2009，227，1： | 1 |
| 19 | Molecular magnetism: present and future 显示文摘 | Tadashi S Akira I | 1997 | Molecular Crystals and Liquid Crystals Science and Technology1997，，305： | 1 |
| 20 | Macrophage differentiation-specific expression of NF-IL6,a transcription factor for interleukin-6显示文摘 | Natsuka S Akira S Nishio Y | 1992 | Blood1992，79，2： | 1 |
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