|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of genistein and equol on human and rat testicular 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase 3 activities显示文摘现在的学习的目的是在 3 尾 - hydroxysteroid 脱氢酶(3 尾 - HSD ) 和 17 尾 - hydroxysteroid 脱氢酶上调查 genistein 和 equol 的效果 3 (17 尾 - HSD3 ) 在里面人和老鼠睾丸微体。与二其它(细胞色素 P450 方面链劈开酶和细胞色素 P450 17 伪 - hydroxylase/17-20 lyase ) 一起,这些酶(3 尾 - HSD 和 17 尾 - HSD3 ) 催化把类固醇胆固醇变换成性荷尔蒙睾丸激素的反应。Genistein 禁止了 3 尾 - HSD 活动(0.2 渭 m ol L ? 1 pregnenolone ) 与一半最大的抑制或 87 卤的一半最大的禁止的集中(IC50 ) 15 (人) 并且 636 卤 155 nmol L ? 1 (老鼠) 。Genistein 在 3 尾 - HSD 活动的行动的模式为余因子 NAD+ 为底层 pregnenolonrge 和 noncompetitive 是竞争的。在 genistein 在未经触动的老鼠 Leydig 房间和睾丸微体之间的 3 尾 - HSD 抑制的力量没有差别。与它 3 尾 - HSD 的有势力抑制相对照, genistein 在人和老鼠上有更小的效果 17 尾 - HSD3 (0.1 渭 m ol L ? 1 androstenedione ) ,与 IC50 鈮 ? 100 渭 m ol L ? 1。在另一方面, equol 仅仅在 42% 禁止了人 3 尾 - HSD,并且没在老鼠纸巾在 3 尾 - HSD 和 17 尾 - HSD3 上有效果。这些观察暗示酱油 isoflavones 到的能力在 Leydig 房间调整雄激素生合成对在 Leydig 房间 3 尾 - HSD 活动的行动部分地到期。在血雄激素层次上给基于酱油的食物产品和他们的潜在的效果的增加的吸入,这些调查结果是极大地与公共健康相关。 | Guo-Xin Hu Bing-Hai Zhao Yan-Hui Chu Hong-Yu Zhou Benson T. Akingbemi Zhi-Qiang Zheng Ren-Shan Ge | 2010 | Asian Journal of Andrology2010，12，4： | 5 |
| 2 | Chapel Hill bisphenol A expert panel consensus statement:integration of mechanisms,effects in animals and potential to impact human health at current levels of exposure显示文摘 | vom Saal FS Akingbemi BT Belcher SM | 2007 | Reprod Toxicol2007，24，2： | 1 |
| 3 | Phthalate-induced leydig cell hyperplasia is associated with multiple endocrine disturbances 显示文摘 | Akingbemi B T Ge R Klinefelter G R | 2004 | Proceedings of the National Academy of Sciences of the United States of America2004，101，3： | 1 |
| 4 | Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: the case of bisphenol A显示文摘 | Myers JP vom Saal FS Akingbemi BT | 2009 | Environ Health Perspect2009，117，3： | 1 |
| 5 | Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary LH secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells显示文摘 | AKingbemi BT Sottas CM Koulova AI | 2004 | Endocrinology2004，145，2： | 1 |
| 6 | Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure 显示文摘 | Vom S F Akingbemi B T Belcher S M | 2007 | Reprod Toxicol2007，24，2： | 1 |
| 7 | Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data : the case of bisphenol A显示文摘 | Myers J P Vom S F Akingbemi B T | 2009 | Environ Health Perspeet2009，117，3： | 1 |
| 8 | Effects of dietary soybean and cowpea on gut morphology and faecal composition in creep and noncreep-fed pigs 显示文摘 | Makinde M O Umapthy E Akingbemi B T | 1996 | Zentralbl Veterinarmed A1996，43，2： | 1 |
| 9 | Inhibition of testicu- lar steroidoenesis by the xenoestrogen bisphenol A is associated with reduced pituitary lutein hormone secretion and decreased ste- roidogenic enzyme gene expression in rat Leydig cells 显示文摘 | Akingbemi BT Sottas CM Koulova AI | 2004 | Endo- crinology2004，145，2： | 1 |
| 10 | Chapel Hill bisphenol A expert panel consensus statement:integration of mechanisms,effects in animals and potential to impact human health at current levels of exposure显示文摘 | vom Saal F S Akingbemi B T Belcher S M | | 0，，02： | 1 |
| 11 | Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells显示文摘 | Akingbemi BT Sottas CM Koulova AI | 2004 | Endocrinology2004，145，： | 1 |
| 12 | Modulation of rat Leydig Cell steroidogenic function by di-(2-ethylhexyl) phthalate显示文摘 | Akingbemi BT Youker RT Sottas CM | 2001 | Biol Reprod2001，65，4： | 1 |
| 13 | Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances 显示文摘 | Akingbemi BT Ge R Klinefeher GR | 2004 | Proc Nad Acad Sci U S A2004，101，3： | 1 |
| 14 | Estrogen receptor-alpha gene deficiency enhances androgen biosynthesis in the mouse Leydig ceU 显示文摘 | AKINGBEMI B T GE R ROSENFELD C S | 2003 | Endocrinology2003，144，： | 1 |
| 15 | Inhibition of testicular steroidogenesis by the xenoestmgen bisphenol A is associated with reduced pituitary luteinizing hormone secre- tion and decreased steroidogenic enzyme gene expression in rat Leydig cells显示文摘 | Akingbemi BT Sottas CM Koulova AI | 2004 | Endocrinology2004，145，2： | 1 |
| 16 | Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances显示文摘 | Akingbemi BT Ge R Klinefelter GR | 2004 | Proc Natl Acad Sci USA2004，101，3： | 1 |
| 17 | Modulation of rat leydig cell steroidogenic function by di(2 - ethylhexyl) phthalate 显示文摘 | AKINGBEMI B T YOUBER R T SOTTAS C M | 2001 | Biol Reprod2001，651，： | 1 |
| 18 | Effects of methoxychlor and 2,2-b/s ( p-hydroxyphenyl )-1, 1, 1-trichloroethane on 3β- hydroxysteroid dehydrogenase and 1713-hydroxysteroid dehydrogenase-3 activities in human and rat testes 显示文摘 | Hu GX Zhao B Chu Y Li XH Akingbemi BT Zheng ZQ | 2010 | Int J Androl2010，33，： | 1 |
| 19 | Phthalate - induced leydig cell hyperplasiais associated with multiple endocrine disturbance 显示文摘 | AKINGBEMI B T KLINEFELTER G R ZIRKIN B R | 2004 | Proc Natl Acad Sci2004，101，： | 1 |
| 20 | Oestrogenic and antiandrogenic chemicals in the environment: effects on male reproductive health显示文摘 | Akingbemi B J Hardy MP | 2001 | Ann Med2001，33，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员