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| 1 | Diarrhoea-predominant irritable bowel syndrome distinguishable by 16S rRNA gene phylotype quantification显示文摘AIM:To study whether selected bacterial 16S ribosomal RNA(rRNA)gene phylotypes are capable of disting- uishing irritable bowel syndrome(IBS). METHODS:The faecal microbiota of twenty volunteers with IBS,subdivided into eight diarrhoea-predominant (IBS-D),eight constipation-predominant(IBS-C)and four mixed symptom-subtype(IBS-M)IBS patients,and fifteen control subjects,were analysed at three time-points with a set of fourteen quantitative real-timepolymerase chain reaction assays.All assays targeted 16S rRNA gene phylotypes putatively associated with IBS,based on 16S rRNA gene library sequence analysis. The target phylotypes were affiliated with Actinobac-teria,Bacteroidetes and Firmicutes.Eight of the target phylotypes had less than 95%similarity to cultured bacterial species according to their 16S rRNA gene sequence.The data analyses were made with repeated-measures ANCOVA-type modelling of the data and principle component analysis(PCA)with linear mixed-effects models applied to the principal component scores. RESULTS:Bacterial phylotypes Clostridium cocleatum 88%,Clostridium thermosuccinogenes 85%,Coprobacillus catenaformis 91%,Ruminococcus bromii-like, Ruminococcus torques 91%,and R.torques 93%were detected from all samples analysed.A multivariate analysis of the relative quantities of all 14 bacterial 16S rRNA gene phylotypes suggested that the intestinal microbiota of the IBS-D patients differed from other sample groups.The PCA on the first principal component(PC1),explaining 30.36%of the observed variation in the IBS-D patient group,was significantly altered from all other sample groups(IBS-D vs control, P=0.01;IBS-D vs IBS-M,P=0.00;IBS-D vs IBS-C, P=0.05).Significant differences were also observed in the levels of distinct phylotypes using relative values in proportion to the total amount of bacteria.A phy- lotype with 85%similarity to C.thermosuccinogenes was quantified in significantly different quantities among the IBS-D and control subjects(-4.08±0.90 vs -3.33±1.16,P=0.04)and IBS-D and IBS-M subjects (-4.08±0.90 vs-3.08±1.38,P=0.05).Furthermore,a phylotype with 94%similarity to R.torques was more prevalent in IBS-D patients'intestinal micro- biota than in that of control subjects(-2.43±1.49 vs -4.02±1.63,P=0.01).A phylotype with 93%simi- larity to R.torques was associated with control sam- ples when compared with IBS-M(-2.41±0.53 vs -2.92±0.56,P=0.00).Additionally,a R.bromii-like phylotype was associated with IBS-C patients in com- parison to control subjects(-1.61±1.83 vs-3.69± 2.42,P=0.01).All of the above mentioned phylotype specific alterations were independent of the effect of time. CONCLUSION:Significant phylotype level alterationsin the intestinal microbiotas of IBS patients were observed,further emphasizing the possible contribution of the gastrointestinal microbiota in IBS. | Anna Lyra Teemu Rinttil Janne Nikkil Lotta Krogius-Kurikka Kajsa Kajander Erja Malinen Jaana Mtt Laura Mkel Airi Palva | 2009 | World Journal of Gastroenterology2009，15，47： | 26 |
| 2 | Significant decrease in glomerular filtration rate at5years posttransplantation in the recipients of live donor kidneys50years of age or older显示文摘 | Jain N Airy M Kumari P | 2010 | Transplant Proc2010，42，5： | 1 |
| 3 | Significant decrease in glomerular filtration rate at 5 years posttransplantation in the recipients of live donor kidneys 50 years of age or older显示文摘 | Jain N Airy M Kumari P et al | 2010 | Transplant Proc2010，42，5： | 1 |
| 4 | Is reduced dermatoglyphic a-bridge count a reliable marker of developmental impairment inschizophrenia显示文摘 | Fearon P Lane A Airie M | 2001 | Schizophr Res2001，50，3： | 1 |
| 5 | The Fecal Microbiota of Irritable Bowel Syndrome Patients Differs Significantly From That of Healthy Subjects显示文摘 | Anna Kassinen Lotta Krogius-Kurikka Harri M?kivuokko Teemu Rinttil? Lars Paulin Jukka Corander Erja Malinen Juha Apajalahti Airi Palva | 2007 | Gastroenterology2007，，1： | 1 |
| 6 | High and increasing prevalence of inflammatory bowel disease in Finland with a clear North–South difference显示文摘 | Airi Jussila Lauri J. Virta Veikko Salomaa Juhani M?ki Antti Jula Martti A. F?rkkil? | 2013 | Journal of Crohn’s and Colitis2013，，7： | 1 |
| 7 | Impact of low salt concentration,salt quality on natural large-scale sauerkraut fermentation显示文摘 | Britta Viander Maarit Mki Airi palva | 2003 | Food Microbiology2003，20，： | 1 |
| 8 | Effectiveness of brief intervention and contact for suicide attempters: a randomized controlled trial in five countries显示文摘 | Fleischmann Alexandra Bertolote José M Wasserman Danuta De Leo Diego Bolhari Jafar Botega Neury J De Silva Damani Phillips Michael Vijayakumar Lakshmi V?rnik Airi Schlebusch Lourens Thanh Huong Tran Thi | 2008 | World Health Organization. Bulletin of the World Health Organization2008，，： | 1 |
| 9 | Effects of chest physical therapy on lung function in children recovering from acute severe asthma显示文摘 | Asher MI Douglas C Airy M | 1990 | Pediatr Pulmonol1990，9，3： | 1 |
| 10 | The diagnostic value of video capsule endoscopy显示文摘 | Heidi Niemenmaa Tuula M?kel? Airi Jussila Ilkka Krekel? Markku Voutilainen Hans Bj?rkn?s Alpo Hirvioja Katri Kaukinen Pekka Collin | 2010 | European Journal of Internal Medicine2010，，5： | 1 |
| 11 | Composition and temporal stability of gastrointestinal microbiota in irritable bowel syndrome – a longitudinal study in IBS and control subjects显示文摘 | Jaana M?tt? Liisa Maunuksela Kajsa Kajander Airi Palva Riitta Korpela Anna Kassinen Maria Saarela | 2006 | FEMS Immunology & Medical Microbiology2006，，2： | 1 |
| 12 | Significant decrease in glomerular filtration rate at 5 years posttransplantation in the recipients of live donor kidneys 50 years of age or older显示文摘 | Jain N Airy M Kumari P | 2010 | Transplant Proc2010，42，5： | 1 |
| 13 | Significant decrease in glomerular filtration rate at 5 years posttransplantation in the recipients of live donor kidneys 50 years of age or older显示文摘 | Jain N Airy M Kumari P | 2010 | Transplant Proc2010，42，5： | 1 |
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