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| 1 | The impact of next-generation sequencing on genomics显示文摘这篇文章考察基本概念,一般应用程序,和下一代的定序的潜在的影响(NGS ) genomics 上的技术,与当前可得到、可能的未来平台和生物信息学的特别参考。NGS 技术表明了能力以崭新的速度,从而创新的以前不能想象的科学成就和新奇生物应用定序 DNA。但是, NGS 生产的巨大的数据也为数据存储,分析,和管理答案提出重要挑战。先进生物信息的工具为 NGS 技术的成功的申请是必要的。是在整个这评论证实了, NGS 技术将在 genomic 研究和全部生物的地上有惹人注目的影响。与它由以前的 genomic 技术处理未解决的挑战 unconquered 的能力, NGS 是可能的解开人的染色体的复杂性以基因变化,其中一些可以为某普通的人被限制到易受影响的 loci,调节。genomics 上的 NGS 技术的影响将远到达并且多年多半改变这个领域来。 | Jun Zhang Rod Chiodini Ahmed Badr Genfa Zhang | 2011 | Journal of Genetics and Genomics2011，38，3： | 23 |
| 2 | Validation of a serum microRNA panel as biomarkers for early diagnosis of hepatocellular carcinoma post-hepatitis C infection in Egyptian patients显示文摘AIM To investigate the prospective importance of serum micro(mi)RNAs(mi R-125 b, mi R-138 b, mi R-1269, mi R-214-5p, mi R-494, mi R375 and mi R-145) as early biomarkers for the diagnosis of hepatitis C virus(HCV)-related hepatocellular carcinoma(HCC).METHODS Two-hundred and fifty HCV4 a patients, 224 HCV4 aHCC patients, and 84 healthy controls were enrolled in the study. Expression levels of mi R214-5p, mi R-125 b, mi R-1269 and mi R-375 were quantified using quantitative real-time PCR.RESULTS Expression of the selected mi RNAs in serum wassignificantly lower in HCC patients than in the healthy controls, except for mi R-1269 and mi R-494. There was a significant difference between HCC and HCV patients, in particular for HCC and late stage fibrosis, rather than HCV patients and early fibrosis. It is obvious that mi R-1269 was significantly upregulated in HCC cases compared to hepatic fibrosis cases. Each mi RNA can show HCC progression. Multivariate logistic regression analysis indicated that the tested panel of mi RNAs(mi R214-5p, mi R-125 b, mi R-1269 and mi R-375) represent accurate and specific indictors of HCC development.CONCLUSION This study presents a panel of mi RNAs with strong power as putative diagnostic and prognostic biomarkers for HCV-induced HCC. Moreover, mi R-214-5p and mi R-1269 could be considered as early biomarkers for tracking the progress of liver fibrosis to HCC. | Moustafa Nouh Elemeery Ahmed Noah Badr Marwa Anwar Mohamed Doaa Ahmed Ghareeb | 2017 | World Journal of Gastroenterology2017，23，21： | 20 |
| 3 | Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions显示文摘AIM To assess the levels of different immune modulators in patients with hepatocellular carcinoma(HCC),in relation to other hepatic diseases.METHODS Eighty-eight patients were included in the current study and represented patients with HCC(20),liver cirrhosis(28) and chronic hepatitis(CH;25),and normal controls(NC;15).Peripheral blood was isolated for immunophenotyping of active myeloid dendritic cells(m DCs;CD1 c and CD40),mature inactive myeloid cells(CD1 c and HLA),active plasmacytoid cells(p DCs;CD303 and CD40),mature inactive p DCs(CD30 and HLA),active natural killer(NK) cells(CD56 and CD161),active NK cells(CD56 and CD314) and inactive NK cells(CD56 and CD158) was done by flow cytometry.Serum levels of interleukin(IL)-2,IL-10,IL-12,IL-1β,interferon(IFN)-α,IFN-γ and tumor necrosis factor(TNF)-αR2 were assessed by ELISA.RESULTS Active m DCs(CD1 C+/CD40+) and inactive m DCs(CD1 c+/HLA+) were significantly decreased in HCC patients in relation to NC(P < 0.001).CD40+ expression on active p DCs was decreased in HCC patients(P < 0.001),and its level was not significantly changed among other groups.Inactive p DCs(CD303+/HLA+),inactive NKs(CD56+/CD158+) and active NKs(CD56+/CD161+) were not statistically changed among the four groups studied;however,the latter was increased in CH(P < 0.05).NKG2 D was statistically decreased in HCC,CH and cirrhosis(P < 0.001),and it was not expressed in 63%(12/20) of HCC patients.There was significant decrease of IL-2,IFN-α and IFN-γ(P < 0.001),and a significant increase in IL-10,IL-1β,and TNF-αR2(P <0.01,P < 0.001 and P < 0.001;respectively) in HCC patients.There was inverted correlation between IL-12 and IL-1β in HCC(r =-0.565,P < 0.01),with a strong correlation between p DCs(CD303+/CD40+) and NKs(CD56+/CD161+;r = 0.512,P < 0.05) as well as inactive m DCs(CD1 c+/HLA+) and inactive NK cells(CD56+/CD158+;r = 0.945,P < 0.001).CONCLUSION NKG2 D,CD40,IL-2 and IL-10 are important modulators in the development and progression of HCC. | Abdel-Rahman N Zekri Somaya El Deeb Abeer A Bahnassy Abeer M Badr Mona S Abdellateif Gamal Esmat Hosny Salama Marwa Mohanad Ahmed Esam El-dien Shimaa Rabah Assmaa Abd Elkader | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 4 | MicroRNA signature in patients with hepatocellular carcinoma associated with type 2 diabetes显示文摘BACKGROUND Nonalcoholic steatohepatitis-related cirrhosis is one of the liver complications in type 2 diabetes mellitus(T2DM)and reported to be a risk factor for developing hepatocellular carcinoma(HCC).A reliable screening biomarker of liver cirrhosis(LC)and HCC among T2DM patients is important to reduce the morbidity and mortality of this disease.MicroRNA(miRNA)is considered a key player in HCC and T2DM,and it might be a hidden culprit in diabetes-associated HCC,making it a promising reliable prognostic tool.AIM To investigate the signature of serum miRNAs as early biomarkers for the screening of HCC among diabetic patients.METHODS Expression profiles of miRNAs in serum samples of diabetic LC and diabetic HCC patients were assessed using Illumina sequencing;then,RT-qPCR was used to validate significantly altered miRNAs between the two groups.Candidate miRNAs were tested in serum samples of 200 T2DM patients,270 LC patients,200 HCC patients,and 225 healthy control subjects.Additionally,receiver operating characteristic(ROC)analysis,with area under the curve(AUC),was performed to assess the diagnostic performance of the screened miRNAs for discriminating HCC from LC and nonmalignant patients(LC+T2DM).RESULTS Expression of the sequenced miRNAs in serum was different in HCC vs LCpositive T2DM patients.Two miRNAs(miR-34a,miR-221)were significantly upregulated and five miRNAs(miR-16,miR-23-3p,miR-122-5p,miR-198,miR-199a-3p)were significantly down-regulated in HCC compared to LC patients.Analysis of ROC curve demonstrated that the combination of these seven miRNAs can be used as a reliable biomarker for detection of HCC in diabetic patients,as it could identify HCC with high diagnostic accuracy in diabetic LC patients(AUC=0.993)and in diabetic nonmalignant patients(AUC=0.961).CONCLUSION This study validates a panel of serum miRNAs that can be used as a reliable noninvasive screening biomarker of HCC among T2DM cirrhotic and noncirrhotic patients.The study recommends further research to shed light on a possible role of c-Met in T2DM-associated HCC via the miRNA regulatory pathway. | Moustafa Nouh Elemeery Marwa Anwar Mohamed Marwa Ahmed Madkour Mohammed Mohammed Shamseya Noha Mahmoud Issa Ahmed Noah Badr Doaa Ahmed Ghareeb Cheol-Ho Pan | 2019 | World Journal of Gastroenterology2019，25，42： | 3 |
| 5 | Characterization and Catalytic Activity of New Metal-organic Frameworks Resulted from Self-assembly of Ph3SnCI, K[Cu(CN)2] and Nitrogen Donor Ligands显示文摘 | Etaiw, Safaa El-din H. Elsherbiny, Abeer S. Badr El-din, Ahmed S. | 2011 | Chinese Journal of Chemistry2011，29，7： | 1 |
| 6 | Evaluation of oxidative stress markers and vascular risk factors in patients with diabetic peripheral neuropathy显示文摘 | Noha Ahmed El Boghdady Gamal Ali Badr | 2012 | Cell Biochem Funct2012，，4： | 1 |
| 7 | A Proof of Convergence for Ant Algorithms显示文摘 | Badr Amr Fahmy Ahmed | 2004 | Information Sciences (S0020-0255)2004，160，： | 1 |
| 8 | Down regulation of COX-2 is involved in hyperbaric oxygen treatment in a rat transient focal cerebral ischemia model显示文摘 | Wei Yin Ahmed E Badr George Mychaskiw John H Zhang | 2002 | Brain Research2002，，1： | 1 |
| 9 | A direct power control of a DFIG based-WECS during symmetrical voltage dips显示文摘The Wind Energy Conversion System(WECS)based Doubly Fed Induction Generator(DFIG)has experienced a rapid development in the world,which leads to an increasing insertion of this source of energy in the electrical grids.The sudden and temporary drop of voltage at the network can affect the operation of the DFIG;the voltage dips produce high peak currents on the stator and rotor circuits,without protection,the rotor side converter(RSC)will suffer also from over-current limit,consequently,the RSC may even be destroyed and the generator be damaged.In this paper a new Direct Power Control(DPC)method was developed,in order to control the stator powers and help the operation of the aero-generator during the faults grid;by injecting the reactive power into the network to contribute to the return of voltage,and set the active power to the optimum value to suppress the high peak currents.The DPC method was designed using the nonlinear Backstepping(BS)controller associated with the Lyapunov function to ensure the stability and robustness of the system.A comparison study was undertaken to verify the robustness and effectiveness of the DPC-BS to that of the classical vector control(VC)using Proportional-Integral(PI)correctors.All were simulated under the Simulink®software. | Sara Mensou Ahmed Essadki Tamou Nasser Badr Bououlid Idrissi | 2020 | Protection and Control of Modern Power Systems2020，5，1： | 1 |
| 10 | A Proof of Convergence for Ant Algorithms 显示文摘 | Amr Badr Ahmed Fahmy | 2004 | Information Sciences2004，160，： | 1 |
| 11 | Hyperbaric oxygenation prevented brain injury induced by hypoxia–ischemia in a neonatal rat model显示文摘 | John W Calvert Wei Yin Mona Patel Ahmed Badr George Mychaskiw Andrew D Parent John H Zhang | 2002 | Brain Research2002，，1： | 1 |
| 12 | Evaluation of oxidative stress markers and vascular risk factors in patients with diabetic peripheral neuropathy显示文摘 | Noha Ahmed El Boghdady Gamal Ali Badr | 2012 | Cell Biochem Funct2012，，4： | 1 |
| 13 | Risk factors for liver fibrosis among human immunodeficiency virus monoinfected patients using the FIB4 index in Morocco显示文摘AIM: To study the prevalence and risk factors of significant hepatic fibrosis in Moroccan human immunodeficiency virus(HIV) monoinfected patients.METHODS: We conducted a cross-sectional study among HIV monoinfected patients(negative for hepatitis B surface antigen and hepatitis C antibody). Clinical and laboratory data were collected from the data base of the Infectious Diseases Unit in Ibn Rochd Hospital Center [age, gender, duration of HIV infection, CD4 T lymphocyte count, HIV viral load, glycemia and current or prior use of antiretroviral and antiretroviral therapy(ART) duration]. The primary outcome was a FIB4score > 1.45. Multivariable logistic regression identifiedindependent risk factors for FIB4 > 1.45.RESULTS: A FIB4 score > 1.45 was identified in 96among 619(15.5%). HIV monoinfected patients followed up between September 1990 and September2012. Multivariate analysis showed that only a viral load > 75(OR = 2.23, 95%CI: 1.36-3.67), CD4 > 200cells/mm3(OR = 0.39, 95%CI: 0.21-0.72) and age at FIB4 index calculation(OR = 1.10, 95%CI: 1.07-1.13)were independently associated with the occurrence of FIB4 index(> 1.45). Gender, duration of HIV infection,glycemia, use of antiretroviral therapy and ART duration were not associated with significant fibrosis by FIB4.CONCLUSION: FIB4 score > 1.45 was found in 15.5%of Moroccan HIV monoinfected patients. Age, HIV viremia > 75 copies/mL and CD4 count > 200 cells/mm3are associated with liver fibrosis. Further studies are needed to explore mechanisms for fibrosis in HIV monoinfected patients. | Mohamed Tahiri Mustapha Sodqi Fatima Ez Zahra Lahdami Latifa Marih Hassan Lamdini Wafaa Hliwa Ahd Oulad Lahcen Wafaa Badre Fouad Haddad Abdelfetah Chakib Ahmed Bellabah Rhimou Alaoui Kamal Marhoum El Filali | 2013 | World Journal of Hepatology2013，5，10： | 1 |
| 14 | A proof of convergence for Ant algorithms显示文摘 | Amr Badr Ahmed Fahmy | 2004 | Information Sciences2004，，160： | 1 |
| 15 | The Lambert-G Family:Properties,Inference,and Applications显示文摘This study proposes a new flexible family of distributions called the Lambert-G family.The Lambert family is very flexible and exhibits desirable properties.Its three-parameter special sub-models provide all significantmonotonic and non-monotonic failure rates.A special sub-model of the Lambert family called the Lambert-Lomax(LL)distribution is investigated.General expressions for the LL statistical properties are established.Characterizations of the LL distribution are addressed mathematically based on its hazard function.The estimation of the LL parameters is discussed using six estimation methods.The performance of this estimation method is explored through simulation experiments.The usefulness and flexibility of the LL distribution are demonstrated empirically using two real-life data sets.The LL model better fits the exponentiated Lomax,inverse power Lomax,Lomax-Rayleigh,power Lomax,and Lomax distributions. | Jamal N.Al Abbasi Ahmed Z.Afify Badr Alnssyan Mustafa S.Shama | 2024 | Computer Modeling in Engineering & Sciences2024，140，7： | 0 |
| 16 | Improving CNN-BGRU Hybrid Network for Arabic Handwritten Text Recognition显示文摘Handwriting recognition is a challenge that interests many researchers around the world.As an exception,handwritten Arabic script has many objectives that remain to be overcome,given its complex form,their number of forms which exceeds 100 and its cursive nature.Over the past few years,good results have been obtained,but with a high cost of memory and execution time.In this paper we propose to improve the capacity of bidirectional gated recurrent unit(BGRU)to recognize Arabic text.The advantages of using BGRUs is the execution time compared to other methods that can have a high success rate but expensive in terms of time andmemory.To test the recognition capacity of BGRU,the proposed architecture is composed by 6 convolutional neural network(CNN)blocks for feature extraction and 1 BGRU+2 dense layers for learning and test.The experiment is carried out on the entire database of institut für nachrichtentechnik/ecole nationale d’ingénieurs de Tunis(IFN/ENIT)without any preprocessing or data selection.The obtained results show the ability of BGRUs to recognize handwritten Arabic script. | Sofiene Haboubi Tawfik Guesmi Badr M Alshammari Khalid Alqunun Ahmed S Alshammari Haitham Alsaif Hamid Amiri | 2022 | Computers, Materials & Continua2022，，12： | 0 |
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