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| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | Pharmacogenetics of anticancer monoclonal antibodies显示文摘Pharmacogenetics is the study of therapeutic and adverse responses to drugs based on an individual’s genetic background.Monoclonal antibodies(mAbs)are a rapidly evolving field in cancer therapy,however a number of newly developed and highly effective mAbs(e.g.,anti-CTLA-4 and anti-PD-1)possess pharmacogenomic profiles that remain largely undefined.Since the first chemotherapeutic mAb Rituximab was approved in 1997 by the US Food and Drug Administration for cancer treatment,a broad number of other mAbs have been successfully developed and implemented into oncological practice.Nowadays,mAbs are considered as one of the most promising new approaches for cancer treatment.The efficacy of mAb treatment can however be significantly affected by genetic background,where genes responsible for antibody presentation and metabolism,for example,can seriously affect patient outcome.This review will focus on current anticancer mAb treatments,patient genetics that shape their efficacy,and the molecular pathways that bridge the two. | Dmitrii Shek Scott ARead Golo Ahlenstiel Irina Piatkov | 2019 | Cancer Drug Resistance2019，2，1： | 2 |
| 3 | Interaction of IFNL3 with insulin resistance,steatosis and lipid metabolism in chronic hepatitis C virus infection显示文摘Metabolic changes are inextricably linked to chronic hepatitis C(CHC).Recently polymorphisms in the IFNL3(IL28B)region have been shown to be strongly associated with spontaneous and treatment induced recovery from hepatitis C virus(HCV)infection.Further,circumstantial evidence suggests a link between IFNL3single nucleotide polymorphisms and lipid metabolism,steatosis and insulin resistance in CHC.The emerging picture suggests that the responder genotypes of IFNL3polymorphisms are associated with a higher serum lipid profile,and less frequent steatosis and insulin resistance.This review analyzes the current data regarding this interaction and its meaning for HCV pathogenesis and disease progression. | Mohammed Eslam David R Booth Jacob George Golo Ahlenstiel | 2013 | World Journal of Gastroenterology2013，19，41： | 2 |
| 4 | Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa-dependent manner显示文摘 | Ahlenstiel G Titerence R H Koh C | 2010 | Gastroenterology2010，138，1： | 1 |
| 5 | IL28B is associated with response to chronic hepatitis C interferon-αand ribavirin therapy显示文摘 | SUPPIAH V MOLDOVAN M AHLENSTIEL G | 2009 | Nature genetics2009，41，10： | 1 |
| 6 | IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy显示文摘 | Suppiah V Moldovan M Ahlenstiel G et at | 2009 | Nat Genet2009，41，10： | 1 |
| 7 | The natural killer cell response to HCV infec- tion显示文摘 | AHLENSTIEL G | 2013 | ImmuneNetw2013，13，5： | 1 |
| 8 | IL-28B is as-sociated with response to chronic hepatitis C interferon-alpha and ribavirin therapy显示文摘 | Suppiah V Moldovan M Ahlenstiel G | | 0，，： | 1 |
| 9 | IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy显示文摘 | Suppiah V Moldovan M Ahlenstiel G | | 0，，10： | 1 |
| 10 | IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy显示文摘 | SUPPIAH V MOLDOVAN M AHLENSTIEL G | 2009 | Nat Genet2009，41，10： | 1 |
| 11 | Actual endoscopic ver- sus predicted surgical mortality for treatment of advanced mucosal ne- oplasia of the colon 显示文摘 | Ahlenstiel G Hourigan LF Brown G | 2014 | Gatrointestinal Endoscopy2014，80，4： | 1 |
| 12 | IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy 显示文摘 | Suppiah V Moldovan M Ahlenstiel G Berg T Weltman M Abate ML Bassendine M Spengler U Dote GJ Powell E Riordan S Sheridan D Smedile A Fragomeli V Muller T Bahlo M Stewart GJ Booth DR George J | 2009 | Nat Genet2009，41，10： | 1 |
| 13 | Improved cold preservation of kidney tubular cells by means of adding hioflavonoids to organ preservation solutions 显示文摘 | Ahlenstiel T Burkhardt G Kohler H | 2006 | Transplantation2006，81，2： | 1 |
| 14 | Actual endoscopic versus predicted surgical mortality for treatment of advanced mu- cosal neoplasia of the colon 显示文摘 | Ahlenstiel G Hourigan LF Brown G | 2014 | Gatrointest Endosc2014，80，4： | 1 |
| 15 | IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy 显示文摘 | Suppiah V Moldovan M Ahlenstiel G | 2009 | Nat Genet2009，41，10： | 1 |
| 16 | IL-28B is associated with response to chronic hepatitis C interferon-2 and ribavirin therapy显示文摘 | Suppiah V Moldovan M Ahlenstiel G | 2009 | Nature2009，41，10： | 1 |
| 17 | The HLA-A2 Restricted T Cell Epitope HCV Core 35–44 Stabilizes HLA-E Expression and Inhibits Cytolysis Mediated by Natural Killer Cells显示文摘 | Jacob Nattermann Hans Dieter Nischalke Valeska Hofmeister Golo Ahlenstiel Henning Zimmermann Ludger Leifeld Elisabeth H. Weiss Tilman Sauerbruch Ulrich Spengler | 2005 | The American Journal of Pathology2005，，2： | 1 |
| 18 | IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy显示文摘 | Suppiah V M oldovan M Ahlenstiel G | 2009 | NatGenet2009，41，10： | 1 |
| 19 | Low-density lipoprotein receptor variants are associated with spontaneous and treatment-induced recovery from hepatitis C virus infection显示文摘 | Andreas Mas Marques Tobias Mueller Justus Welke Stefan Taube Christoph Sarrazin Manfred Wiese Juliane Halangk Heiko Witt Golo Ahlenstiel Ulrich Spengler Uwe Goebel Eckart Schott Viola Weich Beate Schlosser Hermann E. Wasmuth Frank Lammert Thomas Berg Ecka | 2009 | Infection, Genetics and Evolution2009，，5： | 1 |
| 20 | 肝脏是一个免疫器官显示文摘第163届Falk论坛2008年3月14—15日将在中国杭州举行,现将该论坛有关肝脏病的中文摘要介绍给读者,以供参考。若要索取全文资料,请致电深圳市康哲药业有限公司市扬部'优思弗产品事业部',0755-82416868。 | Golo Ahlenstiel 齐慧慧(译) | 2008 | 肝脏2008，13，1： | 1 |
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