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| 1 | Effect of topical 0.05% cyclosporine A on corneal endothelium in patients with dry eye disease显示文摘AIM:To determine the effect of topical 0.05%cyclosporine A(CsA) on corneal endothelium in patients with dry eye disease.·METHODS:Observational,prospective,case series study.Fifty-five eyes of 29 consecutive patients(9 males and 20 females;median age:66.8 years,interquartile range:61-73.2 years) with moderate-severe dry eye disease were evaluated.All patients were treated with topical 0.05% CsA ophthalmic emulsion twice a day in addition to lubricant eyedrops 5 times a day.The followup period was 12 months.Before treatment and at 3 and12 months post-treatment central corneal specular microscopy was performed.The endothelial cell density(ECD),coefficient of variation of cell size(CoV),and percentage of hexagonal cells(Hex %) were analyzed.·RESULTS:The median ECDs pre-treatment and at 3and 12 months post-treatment were 2 352.5/mm2(interquartile range,2 178-2548.5),2 364/mm2(interquartile range,2 174.25-2 657.5),and 2 366 cells/mm2(inter-quartile range,2 174.75-2 539.75),respectively(P =0.927,one way ANOVA).The median CoVs pre-treatment and at3 and 12 months post-treatment were 34.5(interquartile range,30-37),35(interquartile range,30-38),and 34(interquartile range,30.75-38.25),respectively(P =0.7193,one way ANOVA).The median Hex % values pre-treatment and at 3 and 12 months post-treatment were53(interquartile range,47-58),54(interquartile range,45.75-59),and 50.5(interquartile range,45.75-58),respectively(P =0.824,one way ANOVA).·CONCLUSION:Treatment of patients with dry eyedisease for 12 months with topical 0.05% CsA does not seem to cause substantial changes on corneal endothelium. | Consuelo Pérez-Rico Francisco Germain María Castro-Rebollo Agustín Moreno-Salgueiro Miguel ngel Teus | 2013 | International Journal of Ophthalmology(English edition)2013，6，4： | 6 |
| 2 | Efficacy and Safety of Anticoagulation on Patients With Cirrhosis and Portal Vein Thrombosis显示文摘 | María Gabriela Delgado Susana Seijo Ismael Yepes Linette Achécar Maria Vega Catalina ángeles García–Criado Juan G. Abraldes Joaquín de la Pe?a Rafael Ba?ares Agustín Albillos Jaume Bosch Juan Carlos García–Pagán | 2012 | Clinical Gastroenterology and Hepatology2012，，7： | 3 |
| 3 | Systemic effects of chronic obstructive pulmonary disease显示文摘 | AGUST A | 2007 | Proc Am Thorac Society2007，4，7： | 1 |
| 4 | Climate, niche, ticks, and models: what they are and how we should interpret them显示文摘 | Agustín Estrada-Pe?a | 2008 | Parasitology Research2008，，1： | 1 |
| 5 | Respiratory syncytial virus infection : a decade of contributions 显示文摘 | Val Blanco del Alfredo Jos e Mar f a Eiros Bouza Agust f n M? | 2012 | Le Infezioni in Medicina2012，，3： | 1 |
| 6 | Changes in the cooling rate and medium improve the vascular function in cryopreserved porcine femoral arteries显示文摘 | Montserrat Rigol Magda Heras Anna Martínez María Jesús Zurbano Elba Agustí Eulàlia Roig José Luís Pomar Ginés Sanz | 2000 | Journal of Vascular Surgery2000，，5： | 1 |
| 7 | Is the CAT questionnaire sensitive to changes in health status in patients with severe COPD exacerba- tions? 显示文摘 | Agust A Soler JJ Molina J | 2012 | COPD2012，9，5： | 1 |
| 8 | Corticosteroids in severe pneu-monia显示文摘 | Sibila O AgustíC Torres A | 2008 | Eur Respir J2008，32，3： | 1 |
| 9 | Microbiologic features and outcome of pneumonia in transplanted patients显示文摘 | Carlos Cervera Carlos Agustí María Angeles Marcos Tomás Pumarola Federico Cofán Miguel Navasa Félix Pérez-Villa Antonio Torres Asunción Moreno | 2006 | Diagnostic Microbiology & Infectious Disease2006，，1： | 1 |
| 10 | Global strategy for the diagnosis,management,and prevention of chronic obstructive pulmonary disease:GOLD executive summary显示文摘 | Vestbo J Hurd S S AgustíA G | 2013 | American journal of respiratory and critical care medicine2013，187，4： | 1 |
| 11 | The yin and yang of COPD:or balancing repair (yang)and inflammation (yin)显示文摘 | Soriano JB Agust í A | 2008 | Eur Respir J2008，32，6： | 1 |
| 12 | Linares-Solano Influence of potassium loading at different reaction temperatures on the NOx reduction process by potassium-containing coal pellets显示文摘 | Agustín Bueno-López Avelina García-García José Antonio Caballero and A | 2003 | Fuel2003，82，： | 1 |
| 13 | Subcellular localisation of VEGF in different pituitary cells. Changes of its expression in oestrogen induced prolactinomas显示文摘 | Jorge Humberto Mukdsi Ana Lucía De Paul Silvina Gutiérrez Félix Daniel Roth Agustín Aoki Alicia Inés Torres | 2005 | Journal of Molecular Histology (-)2005，，8： | 1 |
| 14 | Stable NiO-CeO_(2) nanoparticles with improved carbon resistance for methane dry reforming显示文摘High surface area mixed oxide 8.7%NiO-CeO_(2) nanoparticles(122 m2/g;6-7 nm)were prepared using a reversed microemulsion method,and were tested for dry methane reforming(DRM).The catalytic activity of these nanoparticles remains stable under the severe conditions of DRM(700℃),and they show better carbon resistance than conventional NiO-CeO_(2) catalysts prepared without control of the size.The activity and selectivity of nanoparticles and reference catalyst are similar,but nanoparticles reduce the accumulation of carbon by 63%during the DRM tests,which is a key feature for this reaction.XPS and H_(2)-TPR suggest that the improved carbon resistance of the nanoparticles is due to the better interaction and cooperation between NiO and CeO_(2) mixed phases.In nanoparticles,the participation of cerium cations in the redox processes taking place during DRM stabilizes cationic species of nickel.On the contrary,the catalyst prepared without control of the size suffers segregation of Ni during DRM reaction,and segregated Ni explains the higher catalytic formation of carbon. | Andrea Cárdenas-Arenas Esther Bailón-García Dolores Lozano-Castelló Patrick Da Costa Agustín Bueno-López | 2022 | Journal of Rare Earths2022，40，1： | 1 |
| 15 | Clinical usefulness of adherence to gastro-esophageal reflux disease guideline by Spanish gastroenterologists显示文摘AIM:To investigate usefulness of adherence to gastroesophageal reflux disease(GERD) guideline established by the Spanish Association of Gastroenterology.METHODS:Prospective,observational and multicentre study of 301 patients with typical symptoms of GERD who should be managed in accordance with guidelines and were attended by gastroenterologists in daily practice.Patients(aged > 18 years) were eligible for inclusion if they had typical symptoms of GERD(heartburn and/or acid regurgitation) as the major complaint in the presence or absence of accompanying atypical symptoms,such as dyspeptic symptoms and/or supraesophageal symptoms.Diagnostic and therapeutic decisions should be made based on specific recommendations of the Spanish clinical practice guideline for GERD which is a widely disseminated and well known instrument among Spanish in digestive disease specialists.RESULTS:Endoscopy was indicated in 123(41%) patients:50 with alarm symptoms,32 with age > 50 years without alarm symptom.Seventy-two patients(58.5%) had esophagitis(grade A,23,grade B,28,grade C,18,grade D,3).In the presence of alarm symptoms,endoscopy was indicated consistently with recommendations in 98% of cases.However,in the absence of alarm symptoms,endoscopy was indicated in 33% of patients > 50 years(not recommended by the guideline).Adherence for proton pump inhibitors(PPIs) therapy was 80%,but doses prescribed were lower(half) in 5% of cases and higher(double) in 15%.Adherence regarding duration of PPI therapy was 69%;duration was shorter than recommended in 1%(4 wk in esophagitis grades C-D) or longer in 30%(8 wk in esophagitis grades A-B or in patients without endoscopy).Treatment response was higher when PPI doses were consistent with guidelines,although differences were not significant(95% vs 85%).CONCLUSION:GERD guideline compliance was quite good although endoscopy was over indicated in patients > 50 years without alarm symptoms;PPIs were prescribed at higher doses and longer duration. | Fermín Mearin Julio Ponce Marta Ponce Agustín Balboa Miguel A González Javier Zapardiel | 2012 | World Journal of Gastroenterology2012，18，35： | 1 |
| 16 | The effect of citric acid and microbial phytase on mineral utilization in broiler chicks显示文摘 | AGUSTIN B AGUST'IN V IGNAC10 A | 2003 | J Animal Feed Scieace and Technology2003，110，： | 1 |
| 17 | Systemic effects of chronic obstructive pulmonary disease显示文摘 | Agust AG Noguera A Sauleda J | 2003 | Eur Respir J2003，21，2： | 1 |
| 18 | The GOLD initiative 2011:a change of paradigm显示文摘 | Rodríguez-Roisin R Agustí A | | 0，，08： | 1 |
| 19 | Global strategy for the diagnosis,management,and prevention of chronic obstructive pulmonary disease:GOLD executive summary显示文摘 | Vestbo J Hurd S S AgustíA G | 2013 | Am J Respir Crit Care Med2013，187，4： | 1 |
| 20 | Development of hyperdynamic circulation and response to β‐blockers in compensated cirrhosis with portal hypertension显示文摘 | Càndid Villanueva Agustín Albillos Joan Genescà Juan G. Abraldes Jose L. Calleja Carles Aracil Rafael Ba?ares Rosa Morillas María Poca Beatriz Pe?as Salvador Augustin Joan Carles Garcia‐Pagan Oana Pavel Jaume Bosch | 2016 | Hepatology2016，，1： | 1 |
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