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| 1 | Body-mass index correlates with severity and mortality in acute pancreatitis: A meta-analysis显示文摘BACKGROUND Obesity rates have increased sharply in recent decades. As there is a growing number of cases in which acute pancreatitis(AP) is accompanied by obesity, we found it clinically relevant to investigate how body-mass index(BMI) affects the outcome of the disease.AIM To quantify the association between subgroups of BMI and the severity and mortality of AP.METHODS A meta-analysis was performed using the Preferred Reporting Items for Systematic Review and Meta-Analysis(PRISMA) Protocols. Three databases(PubMed, EMBASE and the Cochrane Library) were searched for articles containing data on BMI, disease severity and mortality rate for AP. Englishlanguage studies from inception to 19 June 2017 were checked against our predetermined eligibility criteria. The included articles reported all AP cases with no restriction on the etiology of the disease. Only studies that classified AP cases according to the Atlanta Criteria were involved in the severity analyses. Odds ratios(OR) and mean differences(MD) were pooled using the random effects model with the DerSimonian-Laird estimation and displayed on forest plots. The meta-analysis was registered in PROSPERO under number CRD42017077890.RESULTS A total of 19 articles were included in our meta-analysis containing data on 9997 patients. As regards severity, a subgroup analysis showed a direct association between AP severity and BMI. BMI < 18.5 had no significant effect on severity;however, BMI > 25 had an almost three-fold increased risk for severe AP in comparison to normal BMI(OR = 2.87, 95%CI: 1.90-4.35, P < 0.001). Importantly,the mean BMI of patients with severe AP is higher than that of the non-severe group(MD = 1.79, 95%CI: 0.89-2.70, P < 0.001). As regards mortality, death rates among AP patients are the highest in the underweight and obese subgroups. A BMI < 18.5 carries an almost two-fold increase in risk of mortality compared to normal BMI(OR = 1.82, 95%CI: 1.32-2.50, P < 0.001). However, the chance of mortality is almost equal in the normal BMI and BMI 25-30 subgroups. A BMI >30 results in a three times higher risk of mortality in comparison to a BMI < 30(OR = 2.89, 95%CI: 1.10-7.36, P = 0.026).CONCLUSION Our findings confirm that a BMI above 25 increases the risk of severe AP, while a BMI > 30 raises the risk of mortality. A BMI < 18.5 carries an almost two times higher risk of mortality in AP. | Dalma Dobszai Péter Mátrai Zoltan Gyongyi Dezso Csupor Judit Bajor Balint Eross Alexandra Mikó Lajos Szakó Agnes Meczker Roland Hágendorn Katalin Márta Andrea Szentesi Péter Hegyi on behalf of the Hungarian Pancreatic Study Group | 2019 | World Journal of Gastroenterology2019，25，6： | 11 |
| 2 | Intralesional steroid is beneficial in benign refractory esophageal strictures:A meta-analysis显示文摘AIM To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal strictures.METHODS A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation combined with intralesional steroid injections. Following the data extraction, meta-analytical calculations were performed on measures of outcome by the randomeffects method of Der Simonian and Laird. Heterogeneity of the studies was tested by Cochrane's Q and I^2 statistics. Risk of quality and bias was assessed by the Newcastle Ottawa Scale and JADAD assessment tools.RESULTS Eleven articles were identified suitable for analyses, involving 343 patients, 235 cases and 229 controls in total. Four studies used crossover design with 121 subjects enrolled. The periodic dilation index(PDI) was comparable in 4 studies, where the pooled result showed a significant improvement of PDI in the steroid group(MD:-1.12 dilation/month, 95% CI:-1.99 to -0.25 P = 0.012; I^2 = 74.4%). The total number of repeat dilations(TNRD) was comparable in 5 studies and showed a non-significant decrease(MD:-1.17, 95%CI:-0.24-0.05, P = 0.057; I^2 = 0), while the dysphagia score(DS) was comparable in 5 studies and did not improve(SMD: 0.35, 95%CI:-0.38, 1.08, P = 0.351; I^2 = 83.98%) after intralesional steroid injection.CONCLUSION Intralesional steroid injection increases the time between endoscopic dilations of benign refractory esophageal strictures. However, its potential role needs further research. | László Szapáry Benedek Tinusz Nelli Farkas Katalin Márta Lajos Szakó Agnes Meczker Roland Hágendorn Judit Bajor Aron Vincze Zoltan Gyongyi Alexandra Mikó Dezso Csupor Péter Hegyi Balint Eross | 2018 | World Journal of Gastroenterology2018，24，21： | 7 |
| 3 | Compared efficacy of preservation solutions on the outcome of liver transplantation:Meta-analysis显示文摘AIM To compare the effects of the four most commonly used preservation solutions on the outcome of liver transplantations.METHODS A systematic literature search was performed using MEDLINE, Scopus, EMBASE and the Cochrane Library databases up to January 31^(st), 2017. The inclusion criteria were comparative, randomized controlled trials(RCTs) for deceased donor liver(DDL) allografts with adult and pediatric donors using the gold standard University of Wisconsin(UW) solution or histidinetryptophan-ketoglutarate(HTK), Celsior(CS) and Institut Georges Lopez(IGL-1) solutions. Fifteen RCTs(1830 livers) were included; the primary outcomes were primary non-function(PNF) and one-year posttransplant graft survival(OGS-1). RESULTS All trials were homogenous with respect to donor and recipient characteristics. There was no statistical difference in the incidence of PNF with the use of UW, HTK, CS and IGL-1(RR = 0.02, 95%CI: 0.01-0.03, P = 0.356). Comparing OGS-1 also failed to reveal any difference between UW, HTK, CS and IGL-1(RR = 0.80, 95%CI: 0.80-0.80, P = 0.369). Two trials demonstrated higher PNF levels for UW in comparison with the HTK group, and individual studies described higher rates of biliary complications where HTK and CS were used compared to the UW and IGL-1 solutions. However, the meta-analysis of the data did not prove a statistically significant difference: the UW, CS, HTK and IGL-1 solutions were associated with nearly equivalent outcomes.CONCLUSION Alternative solutions for UW yield the same degree of safety and effectiveness for the preservation of DDLs, but further well-designed clinical trials are warranted. | Agnes Lilla Szilágyi Péter Mátrai Péter Hegyi Eszter Tuboly Daniella Pécz András Garami Margit Solymár Erika Pétervári Márta Balaskó Gábor Veres László Czopf Bastian Wobbe Dorottya Szabó Juliane Wagner Petra Hartmann | 2018 | World Journal of Gastroenterology2018，24，16： | 5 |
| 4 | Characterization of the inhibition of hepatitis C virus entry by in vitro-generated and patient-derived oxidized low-density lipoprotein显示文摘 | Westhaus S Bankwitz D Ernst S Rohrmann K Wappler I AgnéC Luchtefeld M Schieffer B Sarrazin C Manns M P Pietschmann T Ciesek S von Hahn T | 2013 | Hepatology2013，57，5： | 1 |
| 5 | New modalities of regional and global left ventricular function analysis:state of the art显示文摘 | Fedele F J rambaio lo P M agn G | | 0，，01： | 1 |
| 6 | Anemia and iron defi- ciencies among Long-Term renal transplant reeipients显示文摘 | Matthias L Josef K Agnes P | 2002 | J Am Soe Nephrol2002，13，3： | 1 |
| 7 | Differential expression of four members of the H+-ATPase gene family during dormancy of vegetative buds of peach trees显示文摘 | Frédéric Gévaudant Gilles Pétel Agnès Guilliot | 2001 | Planta2001，，4： | 1 |
| 8 | Reelin regulates postnatal neurogenesis and enhances spine hypertrophy and long-term potentiation显示文摘 | Lluís P Agnès G Carles B | 2010 | J Neurosci2010，30，13： | 1 |
| 9 | ZnAl-layer double hydroxides as photocatalysts for oxidation of phenol in aqueous solution显示文摘 | Agnes P Robert K Viktoria H | | 0，，： | 1 |
| 10 | The opgGlH and opgC genes of Rhodobacter sphaeroides form an operon that controls backbone synthesis and succinylation of osmoregulated periplastoic glueans 显示文摘 | Virginie C Evgueni G Agnes P | 2002 | Eur J Biochem2002，269，： | 1 |
| 11 | The reaction of barium manganate with acid and their precursors显示文摘 | LASZLO K AGNES K JANOS P | 1999 | Ind J Chem1999，，38： | 1 |
| 12 | Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors显示文摘 | Agnes R S Lee Y S Davis P | 2006 | J Med Chem2006，49，： | 1 |
| 13 | Single nucleotide polymorphisms for assessing genetic diversity in castor bean ( Ricinuscommunis L)显示文摘 | Jeffrey T F Gerard J A Agnes P C | 2010 | BMC Plant Biology2010，10，： | 1 |
| 14 | Polyphyletic emergence of linezolid -resistant staphylococci in the united states显示文摘 | Agnes W Shilpa P R Davida S | 2010 | Antimicrobial Chemother2010，54，2： | 1 |
| 15 | Impact of eoleopteran- active Bt corn on non-target nematode communities in soil and decomposing corn roots显示文摘 | Deborah A N Agnes W N M Galen P D | 2014 | Soil Biology & Biochemistry2014，76，： | 1 |
| 16 | Nondestructive estimation of shoot nitrogen in different rice genotypes显示文摘 | Jagdish K L Agnes T P Gloria C | 1998 | Agron J1998，90，： | 1 |
| 17 | A comparison of the effectsof problem - based learning and lecturing on the develop-ment of students' critical thinking 显示文摘 | Tiwari Agnes Lai P So M at el | 2006 | Medical Education2006，40，6： | 1 |
| 18 | Micro - sequential contour blasting - how does it influence the surrounding rock mass? 显示文摘 | AGNE P RUSTAN | 1998 | Engineering Geology1998，49，： | 1 |
| 19 | Intemet Development in Asia-Pacific: Spatial Patterns and Underlying Locational Factors显示文摘 | Becky P Y Loo Agnes Y P Wong | 2002 | Netcom2002，16，34： | 1 |
| 20 | The 'end of geography' in financial services? Local embeddedness and territorialization in the interest rate swaps industry显示文摘 | AGNES P | 2000 | Economic Geography2000，76，4： | 1 |
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