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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | Constitutive and tissue-specific differential expression of the cryIA(b)gene in transgenic rice plants conferring resistance to rice insect pest显示文摘 | Datta K Vasquez A Tu J M Tonizo L Alam M F Oliva N Abrigo E Cohen M Khush G S and Datta SK | | 0，，： | 1 |
| 3 | Risk of intracerebral hemorrhage in patients with cerebral microbleeds undergoing endovascular intervention显示文摘 | Soo YO Siu DY Abrigo J | 2012 | Stroke2012，43，6： | 1 |
| 4 | Separation of reduced and oxidized glu- tathione in a pharmaceutical preparation by ion-interaction re- versed-phase HPLC显示文摘 | Gennaro MC Abrigo C | 1992 | J Pharm Biomed Aria1992，10，1： | 1 |
| 5 | Constitutive and tissue-specific differential expression of the cryIA(b) gene in transgenic rice plants conferring resistance to rice insect pest显示文摘 | K. Datta A. Vasquez J. Tu L. Torrizo M. F. Alam N. Oliva E. Abrigo G. S. Khush S. K. Datta | 1998 | TAG Theoretical and Applied Genetics (-)1998，，1： | 1 |
| 6 | Electrospun nanofibers as dressings for chronic wound care : Advances, challenges, and future prospects 显示文摘 | Abrigo M McArthur S L Kingshott P | 2014 | Macromolecular Biuscience2014，14，6： | 1 |
| 7 | Transgenic insect-resistant maintainer line (IR68899B) for improvement of hybrid rice 显示文摘 | Alam MF Datta K Abrigo N | 1999 | Plant Cell Rep1999，18，： | 1 |
| 8 | Non-alcoholic fatty liver disease: Spectral patterns observed from an in vivo phosphorus magnetic resonance spectroscopy study显示文摘 | Jill M. Abrigo Jiayun Shen Vincent W.-S. Wong David K.-W. Yeung Grace L.-H. Wong Angel M.-L. Chim Anthony W.-H. Chan Paul C.-L. Choi Francis K.-L. Chan Henry L.-Y. Chan Winnie C.-W. Chu | 2013 | Journal of Hepatology2013，，： | 1 |
| 9 | Ion interaction reagent reversed-phase high-performance liquid chromatography determination of anti-tuberculosis drugs and metabolites in biological fluids 显示文摘 | Gennaro M C Calvino R Abrigo C | 2001 | J Chromatogr B Biomed Sci Appl2001，754，2： | 1 |
| 10 | Risk of intracerebral hemorrhage in patients with cerebral microbleeds undergoing endovascular intervention显示文摘 | Soo YO Siu DY Abrigo J | 2012 | Stroke2012，43，6： | 1 |
| 11 | The use of chiral interaction reagents in the separation of D-( - )- and L-( + )-ascorbic acid by ion interaction reversed-phase HPLC 显示文摘 | GENNARO M C ABRIGO C MARENGO E | 1990 | Chromatographia1990，20，56： | 1 |
| 12 | Transgenic insect resist- ant maintainer line (IR68899B) for improvement of hybrid rice显示文摘 | Alam M F Data K Abrigo E | 1999 | Plant Cell Rep1999，18，： | 1 |
| 13 | Transgenic insect-resistant maintainer line (IR68899B) for improvement of hybrid rice显示文摘 | M. F. Alam K. Datta E. Abrigo N. Oliva J. Tu S. S. Virmani S. K. Datta | 1999 | Plant Cell Reports (-)1999，，7： | 1 |
| 14 | Risk of intracerebral hemorrhagein patients with cerebral microbleeds undergoing endovascularintervention显示文摘 | Soo YO Siu DY Abrigo J | 2012 | Stroke2012，43，6： | 1 |
| 15 | tomographic angiography for with acute spontaneous intracerebral hemorrhage 显示文摘 | Wong GK Computed patients Siu DY Abrigo JM | 2012 | I Clin Neurosci2012，19，4： | 1 |
| 16 | Constitutive and tissue-specific differential expression of the cry1A(b) gene in transgenic rice plants conferring resistance to rice insect pest显示文摘 | Datta K Vasquez A Tu J Torrizo L Alam M F Oliva N Abrigo E Khush G S Datta S K | | 0，，1： | 1 |
| 17 | Effect of melt flow rate of polycarbonate and cobalt catalyst on properties of PET/PC(80/20 wt%)reactive blending显示文摘 | Mendes L C Abrigo R E R Ramos V D | | 0，，2： | 1 |
| 18 | Risk of intracerebral hemorrhage in patients with cerebral microbleeds undergo- ing endovascular intervention 显示文摘 | Soo YO Siu DY Abrigo J | 2012 | Stroke2012，43，6： | 1 |
| 19 | Separation of reduced and oxidized glutathione in a pharmaceutical preparation by ion-interaction reversed-phase HPLC显示文摘 | Gennaro MC Abrigo C | 1992 | J Pharm Biomed Anal1992，10，1： | 1 |
| 20 | Bioengineered‘golden’ indica rice cultivars with beta-carotene metabolism in the endosperm with hygromy-cin and mannose selection systems显示文摘 | Datta K Baisakh N Oliva N Torrizo L. Abrigo E. Tan J. Rai M. Rehana S. Al-Babili S. Beyer P. Potrykus I. Datta S.K | | 0，，02： | 1 |
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