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| 1 | Simple hematological predictors of AF recurrence in patients undergoing atrial fibrillation ablation显示文摘Backgound Red cell distribution width(RDW) and neutrophil-to-lymphocyte ratio(NLR) are simple hematologic indices that have been used to predict adverse outcomes in different clinical settings. The aim of our study is to determine whether RDW and NLR can predict atrial fibrillation(AF) recurrence in patients undergoing AF ablation. Methods Consecutive patients, without known hematological disorders, who underwent AF catheter ablation between January 2014 and April 2017 were enrolled into this study. Blood samples were taken one day before and five hours after the ablation procedure. Results A total of 346 patients(224 males(65%), mean age: 59 ± 11 years old) were included. After a mean follow up of 26.2 ± 12.1 months, 80(23.1%) patients experienced late AF recurrence(defined as any recurrence after the blanking period of three months), while 97(28%) patients experienced early AF recurrence during the blanking period. Univariate analysis showed that early arrhythmia recurrence, type of AF and NLR after the procedure were significantly associated with late AF recurrence, while early arrhythmia recurrence and NLR remained significant in multivariate analysis. RDW was not associated with late AF recurrence. None of the parameters above predicted early arrhythmia recurrence. Conclusions Simple and inexpensive hematological indices such as NLR should be evaluated for their ability to predict AF recurrence in patients undergoing catheter ablation in larger prospective studies. | George Bazoukis Konstantinos P Letsas Konstantinos Vlachos Athanasios Saplaouras Dimitrios Asvestas Konstantinos Tyrovolas Aikaterini Rokiza Eirini Pagkalidou Gary Tse Stavros Stavrakis Antonios Sideris Michael Efremidis | 2019 | Journal of Geriatric Cardiology2019，16，9： | 4 |
| 2 | Headache:An unusual presentation of acute myocardial infraction显示文摘Acute myocardial infarction should be diagnosed as early as possible for the appropriate management to salvage ischemic myocardium. Accurate diagnosis is typically based on the typical symptoms of angina. Headache is an unusual symptom in patients with acute myocardial infraction. We report a patient with ST-segment elevation acute myocardial infarction who presented to the emergency department complaining of severe occipital headache without chest discomfort. | Dimitrios Asvestas Konstantinos Vlachos Anastasios Salachas Konstantinos P Letsas Antonios Sideris | 2014 | World Journal of Cardiology2014，6，6： | 3 |
| 3 | Mechanisms of drug-induced proarrhythmia in clinical practice显示文摘Drug-induced proarrhythmia represents a great challenge for those involved in the development of novel pharmaceuticals and in the regulatory bodies for drug approval as well as for the prescribing clinicians.Our understanding of the mechanisms that underlie druginduced proarrhythmia has grown dramatically over the last two decades.A growing number of cardiac and non-cardiac agents have been shown to alter cardiac repolarization predisposing to fatal cardiac arrhythmias such as ventricular tachycardia or ventricular fibrillation and sudden cardiac death.These agents may induce the phenotype of long QT syndrome and less commonly of short QT syndrome and Brugada syndrome(BS).Although,genetic susceptibility underlie drug-induced proarrhythmia in certain cases,current data are limited regarding this topic.The present review surveys the current published literature on the mechanisms and the offending medical agents that predispose to drug-induced long QT syndrome,short QT syndrome and BS.Drug-induced proarrhythmia should be considered as a predictor of sudden cardiac death and should prompt critical re-evaluation of the risks and benefits of the suspicious medication.Survivors of drug-induced proarrhythmia and family members require careful examination and possibly genetic testing for the presence of a channelopathy.Treating physicians are advised to follow the lists of agents implicated in drug-induced proarrhythmia in order to minimize the risk of arrhythmia and sudden cardiac death. | Arkadia Konstantopoulou Spyros Tsikrikas Dimitrios Asvestas Panagiotis Korantzopoulos Konstantinos P Letsas | 2013 | World Journal of Cardiology2013，5，6： | 2 |
| 4 | Estimation of fractal dimension of images using a fixed mass approach显示文摘 | ASVESTAS P MATSOPOULOS GK NIKITA KS | 1999 | Pattern Recognition Letters1999，20，3： | 1 |
| 5 | Catheter ablation of persistent atrial fibrillation:The importance of substrate modification显示文摘Accumulating data have shown that elimination of atrial fibrillation(AF) sources should be the goal in persistent AF ablation. Pulmonary vein isolation, linear lesions and complex fractionated atrial electrograms(CFAEs) ablation have shown limited efficacy in patients with persistent AF. A combined approach using voltage, CFAEs and dominant frequency(DF) mapping may be helpful for the identification of AF sources and subsequent focal substrate modification. The fibrillatory activity is maintained by intramural reentry centered on fibrotic patches. Voltage mapping may assist in the identification of fibrotic areas. Stable rotors display the higher DF and possibly drive AF. Furthermore, the single rotor is usually consistent with organized AF electrograms without fractionation. It is therefore quite possible that rotors are located at relatively 'healthy islands' within the patchy fibrosis. This is supported by the fact that high DF sites have been negatively correlated to the amount of fibrosis. CFAEs are located in areas adjacent to high DF. In conclusion, patchy fibrotic areas displaying the maximum DF along with high organization index and the lower fractionation index are potential targets of ablation. Prospective studies are required to validate the efficacy of substrate modification in left atrial ablation outcomes. | Konstantinos P Letsas Michael Efremidis Nikolaos P Sgouros Konstantinos Vlachos Dimitrios Asvestas Antonios Sideris | 2015 | World Journal of Cardiology2015，7，3： | 1 |
| 6 | Contrast enhancement of images using Partitioned It-erated Function Systems显示文摘 | ECONOMOPOULOS T L ASVESTAS P A MATSOPOULOS G K | 2010 | Image and Vision Computing2010，28，1： | 1 |
| 7 | Automatic point correspondence using an artificial immune system optimization technique for medical image registration显示文摘 | DELIBASIS K K ASVESTAS P A MATSOPOULOS G K | 2011 | Computerized Medical Imaging and Graphics2011，35，1： | 1 |
| 8 | Abnormal P600 in heroin addicts with prolonged abstinence elicited during a working memory test显示文摘 | Papageorgiou C Liappas I Asvestas P | 2001 | Neuroreport2001，12，： | 1 |
| 9 | Estimation of fractal dimension of images using a fixed mass approach显示文摘 | ASVESTAS P MATSOPOULOS G K NIKITA K S | 1999 | Pattern Recognition Letters1999，20，3： | 1 |
| 10 | Estimation of fractal dimension of images using a fixed mass approach显示文摘 | ASVESTAS P MATSOPOULOS G K NIKITA K S | 1999 | Pattern Recognition Letters1999，20，3： | 1 |
| 11 | Computer-aided diagnosis of thyroid malignancy using an artificial immune system classifi- cation algorithm显示文摘 | DELIBASIS K K ASVESTAS P A MATSOPOU- LOS G K | 2009 | IEEE Transactions on Informa- tion Technology in Biomedicine2009，13，5： | 1 |
| 12 | An enzyme coupling proce- dure for the determination of lipoprotein activity显示文摘 | Victoratos P Asvesta S Arzoglou P L | 1990 | Anal Lett1990，23，： | 1 |
| 13 | Calculation of the impedance matrix inner integral to prescribed precision 显示文摘 | Asvestas J S Yankovich S P and Allen 0 E | 2010 | IEEE Transactions Antennas and Propagation2010，58，2： | 1 |
| 14 | A power differentiation method of fractal dimension estimation for 2-D signals显示文摘 | Asvestas P Matsopoulos G K Nikita K S | 1998 | Journal of Visual Communication and Image Representation1998，9，4： | 1 |
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