|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The roles of MAPKs in disease显示文摘印射响应许多 ligands 和房间刺激涉及大量的细胞的小径和功能的家族 ases transduce 信号。MAPK 的异常或不恰当的功能现在在从癌症到煽动性的疾病到肥胖和糖尿病的疾病被识别了。在许多房间类型, MAPK ERK1/2 被连接到细胞增殖。因为在地岬和 B-Raf 的变化,能激活 ERK1/2 串联,在许多人的肿瘤被发现, ERK1/2 被认为在一些癌症起一个作用。发信号的反常 ERK1/2 也在 polycystic 肾疾病被发现了,并且象 cardio-facio-cutaneous 症候群那样的严肃的发展混乱在 ERK1/2 串联的部件从变化产生。ERK1/2 在区分得好的房间是必要的并且在神经原并且在上皮的极性的维护被连接了到长期的 potentiation。另外, ERK1/2 为在胰腺的贝它房间的胰岛素基因抄写是重要的,它响应传播葡萄糖的增加生产胰岛素在有机体允许有效葡萄糖利用和存储。导致或镇压的营养素和荷尔蒙胰岛素分泌物以在贝它房间上反映能分泌的需求的一种方式激活或禁止 ERK1/2。在这和另外的规章的小径的骚乱可以导致对某些人的混乱的病原学的 ERK1/2 的贡献。 | Michael C Lawrence Arif Jivan Chunli Shao Lingling Duan Daryl Goad Elma Zaganjor Jihan Osborne Kathleen McGlynn Steve Stippec Svetlana Earnest Wei Chen Melanie H Cobb | 2008 | Cell Research2008，18，4： | 64 |
| 2 | Serum MiRNA as Predictive and Prognosis Biomarker in Advanced Stage Non-small Cell Lung Cancer in Indonesia显示文摘Background and objective Lung cancer is the most common cause of death in men in the world and in Indonesia where nonsmall cell carcinoma lung cancer(NSCLC) constitutes 85% of all lung cancer cases. The high mortality rate is due to a poor prognosis and is often diagnosed as having advanced stages. If it is known at the initial stage, the prognosis of lung cancer will be better. Prognosis can be predicted with a marker of prognostic biology, one of which is micro RNA(mi RNA). This study aims to prove that serum mi RNA can be predictive biological marker and prognosis in NSCLC patients in Indonesia.Methods This study was cohort retrospective among 52 subjects in 'Dharmais' Hospital National Cancer Center. Sample was obtained from patients’ serum. Mi R-34, mi R-148, mi R-155 and mi R-222 serum are measured through Real-Time PCR(q PCR). Data were analyzed and interpreted with descriptive analysis, bivariate analysis(Mann Whitney-U for two type of variables or Kruskal-Wallis for more than two type of variables. Kaplan-Meier analysis was used to know association between characteristic which are sociodemographic, performance status, clinico-pathology, and survival rate in mi RNA expression. Results From this study, mi RNA expression: mi R-34(46.15%), mi R-148(23.08%), mi R-155(40.38%) and mi R-222(32.69%). Performance status score was statistically significant correlation with mi R-148(P=0.049) and mi R-222(P=0.018). High mi R-34 is associated with multiple M1 b metastatic type(P=0.020), cancer cell type(adenocarcinoma, P=0.009) and adenocarcinoma epidermal growth factor receptor(EGFR) mutation(negative, P=0.031). There was a significant correlation between the high mi R-222 as a poor prognosis in advanced stage NSCLC with M1 b metastasis(Median Survival/MS: 27 d, P=0.049) and positive EGFR mutations(MS: 74 d, P=0.049) and correlation of mi R-155 with adenocarcinoma(MS: 69 d, P=0.034) and positive EGFR gene mutations(MS: 58 d, P=0.023).Conclusion High mi R-34 expression in advanced stage NSCLC is the predictive factor for multiple metastatic, adenocarcinoma cell type and adenocarcinoma negative EGFR mutation. High expression of mi R-155 and mi R-222 are poor prognoses, especially high mi R-222 found in metastasis M1 b and positive EGFR mutation and mi R-155 found in adenocarcinoma and positive EGFR gene mutations. Further studies regarding correlation between mi RNA and survival rate are needed. | Arif R HANAFI Achmad M JAYUSMAN Serafim ALFASUNU Ahmad H SADEWA Dibyo PRAMONO Didik S HERIYANTO Sofia M HARYANA | 2020 | 中国肺癌杂志2020，23，5： | 6 |
| 3 | Mycorrhiza and Phosphate Solubilizing Bacteria:Potential Bioagents for Sustainable Phosphorus Management in Agriculture显示文摘Phosphorus(P)is a critical nutrient that plays an essential role in improving soil fertility for optimum plant growth and productivity.It is one of the most deficient macro-nutrients in agricultural soils after nitrogen and is considered inadequate for plant growth and production.To P availability in soils,the farmers are applying huge amounts of synthetic P fertilizers that adversely affect the wider environment,groundwater,soil fertility and microbial population.Many beneficial microbes are known to release and supply soluble P for improving growth and yield of a variety of plants in a sustainable manner in P deficient soils.Thus,inoculation of these microbes,including arbuscular mycorrhizal fungi(AMF)and phosphate solubilizing bacteria(PSB)to soil to enhance crop production without harming the environment,is an alternative approach to chemical fertilizers.The combined role of AMF and PSB in P solubilization is not well understood and the application and mode of action of these microbial groups are often naive due to variation in the environment.Therefore,the current review article would develop a better understanding of the interactive role and mechanisms of AMF and PSB in improving P availability from both organic and inorganic sources in a sustainable crop production system.Finally,the current review would loop out further avenues for researchers interested to commercially produce effective AMF and PSB-based biofertilizers for sustainable management of phosphorus over a wide range of agricultural crops worldwide. | Fazli Wahid Muhammad Sharif Shah Fahad Amjad Ali Muhammad Adnan Rafiullah Shah Saud Subhan Danish Muhammad Arif Ali Niaz Ahmed Hüseyin Arslan Doğan Arslan Murat Erman Ayman EL Sabagh Fatemeh Gholizadeh Rahul Datta | 2022 | Phyton-International Journal of Experimental Botany2022，91，2： | 2 |
| 4 | Force-displacement model foranalysis of pulsed-GMAW显示文摘 | Arif N Lee J H Yoo C D | 2009 | Journal of Physics D:AppliedPhysics2009，42，3： | 1 |
| 5 | Comparative effectiveness of 10 antiepileptic drugs in older adults with epilepsy显示文摘 | Arif H Buchsbaum R Pierro J | 2010 | Arch Neurol2010，67，4： | 1 |
| 6 | Association of sequences in the coat protein/read through domain of potato mop-top virus with transmission of Spongospora subterranean显示文摘 | Reavy B Arif M Cowan G H at al | 1998 | Journal of General Virology1998，79，10： | 1 |
| 7 | Carotid plaque, a subclinical precursor of vascular events: the Northern Manhattan Study显示文摘 | Rundek T Arif H Boden-Albala B | 2008 | Neurology2008，70，： | 1 |
| 8 | Carotid plaque a subclinical precusor of vascular events:the Northern Manhattan Study显示文摘 | Rundek T Arif H Boden-Albala B | 2008 | Neurology2008，70，1： | 1 |
| 9 | Molecular markers for biodiversity analysis of wildlife animals: a brief review 显示文摘 | Arif 1 A Khan H A | 2009 | Animal Biodiversity andConservation2009，32，1： | 1 |
| 10 | Neuroimaging of tuberculous myelitis:analysis of ten cases and review of literature显示文摘 | Wasay M Arif H Khcalani B | 2006 | Neuroimaging2006，16，3： | 1 |
| 11 | Comparison and predictors of rash associated with 15 antiepileptic drugs显示文摘 | Arif H Buchsbaum R Weintraub D | 2007 | Neurology2007，68，20： | 1 |
| 12 | Arotid plaque, a subulinical precursor of vascular events The Northern Manhattan Study 显示文摘 | Rundek J Arif H Boden - Albala B | 2005 | Neurology2005，70，： | 1 |
| 13 | Modelling of globular transfer considering momentum flux in GMAW 显示文摘 | Arif N Lee J H Yoo C D | 2008 | Journal of Phys- ics D:Applied Physics2008，，41： | 1 |
| 14 | Effect of age and comedication on levetiracetam pharmacokineties and tolerability 显示文摘 | Hirsch J Arif H Buchsbaum R | 2007 | Epilepsia2007，48，7： | 1 |
| 15 | Patient-reported cognitive side effects of antiepileptic drugs:predictors and comparison of all commonly used antiepileptic drugs显示文摘 | Arif H Buchsbaum R Weintraub D | 2009 | Epilepsy Behay2009，14，1： | 1 |
| 16 | A preliminary study of dexamethasone against ischernia/reperfusion liver injury in rats显示文摘 | Amr A F Mahmoud H E Arif M U | | 0，，02： | 1 |
| 17 | Comparison and predictors of fash associated with 15 antiepileptic drugs 显示文摘 | ARIF H BUCHSBAUM R WEINTRAUB D | 2007 | Neurology2007，68，20： | 1 |
| 18 | Revisiting stabilized finite element methods for the advectivediffusive equation显示文摘 | FRANCA L P GUILLERMO H ARIF M | 2006 | Comput Meth Appl Mech Engr2006，195，1316： | 1 |
| 19 | Carotid plaque, a subclinical precursor of vascular events: The Northern Manhattan Study显示文摘 | T Rundek H Arif B Boden-Albala M S. Elkind M C. Paik R L. Sacco | 2008 | Neurology2008，，14： | 1 |
| 20 | Metal-based antibacterial and antifungal amino acid derived Schiff bases: their synthesis, characterization and in vitro biological activity 显示文摘 | Zahid H C Arif M Sarfraz M | 2007 | Appl Organometal Chem2007，21，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员