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| 1 | Hypofractionated stereotactic rad iotherapy alone without whole-brain irradiation for patien ts with solitary and oligo brain metastasis using noninvasive fixation of the skull显示文摘To evaluate the efficacy and toxicity of hypofractionated stereotactic radiotherapy(HSRT)using noninvasive fixation of the sk ull on solitary or oligo brain metastatic p atients as an alternative to stereotactic radiosurgery(SRS)using invasive fixation.The subjects were 87patients who had 4or fewer brain meta stases(50solitary,37oligometastases).Treatment was conducted on 159meta stases by using a linac-based stereotactic system.T he median isocentric dose was 35Gy in4fractions.Whole-brain irradiati on was not applied as an initial treatment.For the salvage treatmen t of metachronous brain metastases,repeat HSRT or whole-brain irradiation was applied.The actuarial1-year local tumor control rate was 81%.Treatment-related complicatio ns were observed in 4patients in the e arly period(<3months)and in 2patients in the late period.T he median survival period was 8.7mon ths.Metachronous brain metastases occurred in 30patients,and none of the 18patients who were eligible for salvage HSRT refused to re ceive it again.Hypofractionated stereotactic radiotherapy achieved tumor control and survival equivalent to those of SRS reported i n the literature.The results suggested that HSRT could be an alternative for solitary or oligo br ain metastatic patients with less to xicity and less invasiveness compared to | Aoyama H Shirato H Onimaru R Kagei K Ikeda J Ishii N Sawamura Y Miyasaka K | 2003 | 癌症2003，22，7： | 12 |
| 2 | 超重和肥胖的全球趋势及其与心血管疾病发生率之间的关系显示文摘虽然超重和肥胖的全球发病率逐日上升,但在不同地区、国家和性别中的发病趋势仍存在差异。据世界卫生组织报道,全球多个地区由体质量指数(body mass index,BMI)≥25kg/m2定义的超重/肥胖发生率几乎接近一半人口,有的甚至超过了一半,如美洲(61.1%),欧洲(54.8%)和东地中海地区(46.0%),然而,在非洲(26.9%),东南亚(13.7%)和西太平洋地区(25.4%),超重/肥胖发生率较低。 | 刘莉 叶鹏 Yatsuya H Li Y Hilawe EH Ota A Wang C Chiang C Zhang Y Uemura M Osako A Ozaki Y Aoyama A Circ J | 2014 | 中华高血压杂志2014，22，12： | 8 |
| 3 | Stereotactic radiosurgery pluswhole - brain radiation therapy vs stereotactic radiosurgery alonefor treatment of brain metastases : a randomized controlled trial显示文摘 | Aoyama H Shirato H Tago M | 2006 | J Am Med Assoc2006，295，： | 1 |
| 4 | Vapor-liquid coex- istence curve in the critical region and the critical tempera- tures and densities of difluoromethane and pentafluoroeth- ane 显示文摘 | Kuwabara S Aoyama H Sato H | 1995 | J Chem Eng Data1995，40，1： | 1 |
| 5 | Isolation and characterization of norfloxacin-resistant mutants of Esehefichia eoli K- 12显示文摘 | Hirai K Aoyama H Suzue S | 1986 | Antimicrob Agents Chemother1986，30，2： | 1 |
| 6 | LM03 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in nenrohlastoma显示文摘 | Aoyama M Ozaki H Inuzuka D | 2005 | Cancer Res2005，65，11： | 1 |
| 7 | In situ-gelling gellan formulations as vehicles for oral drug delivery 显示文摘 | Miyazaki S Aoyama H Kawasaki N | 1999 | J Controlled Release1999，60，23： | 1 |
| 8 | Ankle brachial pres-sure index but not brachial-ankle pulse wave velocity is astrong predictor of systemic atherosclerotic morbidity andmortality in patients on maintenance hemodialysis显示文摘 | Tanaka M Ishii H Aoyama T | 2011 | Atherosclerosis2011，219，2： | 1 |
| 9 | Association of cardiac valvular calcifications and C-reactive protein with cardiovascular mortality in incident hemodialysis patients: a Japanese cohort study显示文摘 | Takahashi H Ishii H Aoyama T | 2013 | Am J Kidney Dis2013，61，： | 1 |
| 10 | Structures of two new flavonoids and effects of licorice phenolics on vancomycin-resistant Enterococcus species显示文摘 | Eerdunbayaer Orabi M A Aoyama H | 2014 | Molecules2014，19，4： | 1 |
| 11 | Develop- ment of a magnetostrictive torque sensor for milling process- monitoring 显示文摘 | OHZEKI H MASHINE A AOYAMA H | 1999 | J ManufSciEng1999，121，4： | 1 |
| 12 | Determination of formaldehyde in textites using a dif-fuse sampler显示文摘 | Naruse H Aoyama M | 1995 | BuH Environ Contam Toxicol1995，55，6： | 1 |
| 13 | Ankle brachial pressure index but not brachial-ankle pulse wave velocity is a strong predictor of systemic atherosclerotic morbidity and mortality in patients on maintenance hemodialysis显示文摘 | Tanaka M Ishii H Aoyama T | 2011 | Atherosclerosis2011，219，2： | 1 |
| 14 | Design and implementation of a fully distributed ultrasonic positioning system显示文摘 | Minami M Morikawa H Aoyama T | 2007 | Electronics and Communications in Japan Part 32007，90，6： | 1 |
| 15 | Simple and straight- forward construction of a mouse gene knockout vector using in vitro transposition reactions显示文摘 | Aoyama M Agari K Sunwada G H | 2005 | Nucleic Acids Res2005，33，： | 1 |
| 16 | A Case of Adventitial Cystic Dis- ease of the Popliteal Artery Progressing Rapidly after Percutaneous Ultrasound - guided Aspiration显示文摘 | Seo H Fujii H Aoyama T | 2014 | Ann Vase Dis2014，7，4： | 1 |
| 17 | Germinoma in Siblings:Case Reports显示文摘 | Aoyama I Kondo A Ogawa H | 1994 | Surg Neurol1994，41，4： | 1 |
| 18 | High speed magnetic resonance imaging for four-dimensional treatment planning of conformal radiotherapy of moving body tumours显示文摘 | Shimizu S Shirato H Aoyama H | 2000 | Int J Radiat Oncol Biol Phys2000，48，2： | 1 |
| 19 | ARR1,a transcription factor forgenes immediately responsive to cytokinins显示文摘 | SAKAI H HONMA T AOYAMA T | 2001 | Science2001，294，： | 1 |
| 20 | Plasma activated sintering transient sintering process control for rapid consolidation of powders 显示文摘 | YAMAZAKI K RISBUD S H AOYAMA H | 1996 | Journal of Materials Processing Technology1996，56，14： | 1 |
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