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| 1 | Maintenance of remission with infliximab in inflammatory bowel disease: Effi cacy and safety long-term follow-up显示文摘AIM: To evaluate the safety and efficacy of a long- term therapy with infliximab in Crohn’s disease (CD) and ulcerative colitis (UC) patients retrospectively. METHODS: The medical charts of 50 patients (40 CD and 10 UC), who received after a loading dose of 3 infl iximab infusions scheduled re-treatments every 8 wk as a maintenance protocol, were reviewed. RESULTS: Median (range) duration of treatment was 27 (4-64) mo in CD patients and 24.5 (6-46) mo in UC patients. Overall, 32 (80%) CD and 9 (90%) UC patients showed a sustained clinical response or remission throughout the maintenance period. Three CD patients shortened the interval between infusions. Eight (20%) CD patients and 1 UC patient underwent surgery for flare up of disease. Nine out of 29 CD and 4 out of 9 UC patients, who discontinued infliximab scheduled treatment, are still relapse-free after a median of 16 (5-30) and 6.5 (4-16) mo following the last infusion, respectively. Ten CD patients (25%) and 1 UC patient required concomitant steroid therapy during maintenance period, compared to 30 (75%) and 9 (90%) patients at enrolment. Of the 50 patients, 16 (32%) experienced at least 1 adverse event and 3 patients (6%) were diagnosed with cancer during maintenance treatment. CONCLUSION: Scheduled infl iximab strategy is effective in maintaining long-term clinical remission both in CD and UC and determines a marked steroid sparing effect. Long-lasting remission was observed following infliximab withdrawal. | Renato Caviglia Mentore Ribolsi Marina Rizzi Sara Emerenziani Maria Laura Annunziata Michele Cicala | 2007 | World Journal of Gastroenterology2007，13，39： | 14 |
| 2 | Diagnostic accuracy of fluorine-18-fluorodeoxyglucose positron emission tomography in gallbladder cancer: A meta-analysis显示文摘AIM: To meta-analyze published data about the diagnostic accuracy of fluorine-18-fluorodeoxyglucose(18F-FDG) positron emission tomography(PET) and PET/computed tomography(PET/CT) in the evaluation of primary tumor in patients with gallbladder cancer(GBCa).METHODS: A comprehensive literature search of studies published through 30 th June 2014 regarding the role of 18F-FDG PET and PET/CT in the evaluation of primary gallbladder cancer(GBCa) was performed. All retrieved studies were reviewed. Pooled sensitivity and specificity of 18F-FDG PET or PET/CT in the evaluation of primary GBCa were calculated. The area under the summary receiving operator characteristics curve(AUC) was calculated to measure the accuracy of these methods. Sub-analyses considering the device used(PET vs PET/CT) were carried out.RESULTS: Twenty-one studies comprising 495 patients who underwent 18F-FDG PET or PET/CT for suspicious GBCa were selected for the systematic review. The meta-analysis of 13 selected studies provided the following results: sensitivity 87%(95%CI: 82%-92%),specificity 78%(95%CI: 68%-86%). The AUC was 0.88. Improvement of sensitivity and specificity was observed when PET/CT was used.CONCLUSION: 18F-FDG-PET and PET/CT demonstrated to be useful diagnostic imaging methods in the assessment of primary tumor in GBCa patients,nevertheless possible sources of false-negative and false-positive results should be kept in mind. PET/CT seems to have a better diagnostic accuracy than PET alone in this setting. | Salvatore Annunziata Daniele Antonio Pizzuto Carmelo Caldarella Federica Galiandro Ramin Sadeghi Giorgio Treglia | 2015 | World Journal of Gastroenterology2015，21，40： | 8 |
| 3 | Efficacy and tolerability of high and low-volume bowel preparation compared:A real-life single-blinded large-population study显示文摘BACKGROUND Low-volume preparations for colonoscopy have shown similar efficacy compared to high-volume ones in randomized controlled trials(RCT).However,most RCTs do not provide data about clinical outcomes including lesions detection rate.Moreover,real-life comparisons are lacking.AIM To compare efficacy(both in terms of adequate bowel preparation and detection of colorectal lesions)and tolerability of a high-volume(HV:4 L polyethylene glycol,PEG)and a low-volume(LV:2 L PEG plus bisacodyl)bowel preparation in a real-life setting.METHODS Consecutive outpatients referred for colonoscopy were prospectively enrolled between 1 December 2014 and 31 December 2016.Patients could choose either LV or HV preparation,with a day-before schedule for morning colonoscopies and a split-dose for afternoon procedures.Adequate bowel preparation according to Boston Bowel Preparation Scale(BBPS),clinical outcomes including polyp detection rate(PDR),adenoma detection rate(ADR),advanced adenoma detection rate(AADR),sessile/serrated lesion detection rate(SDR)and cancer detection rate and self-reported tolerability of HV and LV were blindly assessed.RESULTS Total 2040 patients were enrolled and 1815(mean age 60.6 years,50.2%men)finally included.LV was chosen by 52%of patients(50.8%of men,54.9%of women).Split-dose schedule was more common with HV(44.7%vs 38.2%,P=0.005).High-definition scopes were used in 33.4%of patients,without difference in the two groups(P=0.605).HV and LV preparations showed similar adequate bowel preparation rates(89.2%vs 86.6%,P=0.098),also considering the two different schedules(HV split-dose 93.8%vs LV split-dose 93.6%,P=1;HV daybefore 85.5%vs LV day-before 82.3%,P=0.182).Mean global BBPS score was higher for HV preparations(7.1±1.7 vs 6.8±1.6,P<0.001).After adjustment for sex,age and indications for colonoscopy,HV preparation resulted higher in PDR[Odds ratio(OR)1.32,95%CI:1.07-1.63,P=0.011]and ADR(OR 1.29,95%CI 1.02–1.63,P=0.038)and comparable to LV in AADR(OR 1.51,95%CI 0.97-2.35,P=0.069),SDR and cancer detection rate.The use of standard-definition colonoscopes was associated to lower PDR(adjusted OR 1.59,95%CI:1.22-2.08,P<0.001),ADR(adjusted OR 1.71,95%CI:1.26–2.30,P<0.001)and AADR(adjusted OR 1.97,95%CI:1.09-3.56,P=0.025)in patients receiving LV preparation.Mean Visual Analogue Scale tolerability scored equally(7,P=0.627)but a≥75%dose intake was more frequent with LV(94.6%vs 92.1%,P=0.003).CONCLUSION In a real-life setting,PEG-based low-volume preparation with bisacodyl showed similar efficacy and tolerability compared to standard HV preparation.However,with higher PDR and ADR,HV should still be considered as the reference standard for clinical trials and the preferred option in screening colonoscopy,especially when colonoscopy is performed with standard resolution imaging. | Vincenzo Occhipinti Paola Soriani Francesco Bagolini Valentina Milani Emanuele Rondonotti Maria Laura Annunziata Flaminia Cavallaro Sara Vavassori Maurizio Vecchi Luca Pastorelli Gian Eugenio Tontini | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，12： | 4 |
| 4 | A Novel Automatic Classification System Based on Hybrid Unsupervised and Supervised Machine Learning for Electrospun Nanofibers显示文摘The manufacturing of nanomaterials by the electrospinning process requires accurate and meticulous inspection of related scanning electron microscope(SEM)images of the electrospun nanofiber,to ensure that no structural defects are produced.The presence of anomalies prevents practical application of the electrospun nanofibrous material in nanotechnology.Hence,the automatic monitoring and quality control of nanomaterials is a relevant challenge in the context of Industry 4.0.In this paper,a novel automatic classification system for homogenous(anomaly-free)and non-homogenous(with defects)nanofibers is proposed.The inspection procedure aims at avoiding direct processing of the redundant full SEM image.Specifically,the image to be analyzed is first partitioned into subimages(nanopatches)that are then used as input to a hybrid unsupervised and supervised machine learning system.In the first step,an autoencoder(AE)is trained with unsupervised learning to generate a code representing the input image with a vector of relevant features.Next,a multilayer perceptron(MLP),trained with supervised learning,uses the extracted features to classify non-homogenous nanofiber(NH-NF)and homogenous nanofiber(H-NF)patches.The resulting novel AE-MLP system is shown to outperform other standard machine learning models and other recent state-of-the-art techniques,reporting accuracy rate up to92.5%.In addition,the proposed approach leads to model complexity reduction with respect to other deep learning strategies such as convolutional neural networks(CNN).The encouraging performance achieved in this benchmark study can stimulate the application of the proposed scheme in other challenging industrial manufacturing tasks. | Cosimo Ieracitano Annunziata Paviglianiti Maurizio Campolo Amir Hussain Eros Pasero Francesco Carlo Morabito | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，1： | 3 |
| 5 | Association between glucose variability as assessed by continuous glucose monitoring (CGM) and diabetic retinopathy in type 1 and type 2 diabetes显示文摘 | Giovanni Sartore Nino Cristiano Chilelli Silvia Burlina Annunziata Lapolla | 2013 | Acta Diabetologica2013，，3： | 2 |
| 6 | Randomized Trial of Atorvastatin for Reduction of Myocardial Damage During Coronary Intervention: Results From the ARMYDA (Atorvastatin for Reduction of MYocardial Damage during Angioplasty) Study显示文摘 | Vincenzo Pasceri Giuseppe Patti Annunziata Nusca Christian Pristipino Giuseppe Richichi Germano Di Sciascio | 2004 | Circulation2004，，6： | 2 |
| 7 | Relationships between lymphomas linked to hepatitis C virus infection and their microenvironment显示文摘The relationships between lymphomas and their microenvironment appear to follow 3 major patterns:(1)an independent pattern;(2)a dependent pattern on deregulated interactions;and(3)a dependent pattern on regulated coexistence.Typical examples of the third pattern are hepatitis C virus(HCV)-associated marginal zone lymphomas(MZLs)and mucosa-associated lymphoid tissue lymphomas.In these lymphomas,a regulated coexistence of the malignant cells and the microenvironmental factors usually occurs.At least initially,however,tumor development and cell growth largely depend on external signals from the microenvironment,such as viral antigens,cytokines,and cell-cell interactions.The association between HCV infection and B-cell lymphomas is not completely defined,although this association has been demonstrated by epidemiological studies.MZL and diffuse large B-cell lymphoma are the histotypes most frequently associated with HCV infection.Many mechanisms have been proposed for explaining HCV-induced lymphomagenesis;antigenic stimulation by HCV seems to be fundamental in establishing B-cell expansion as observed in mixed cryoglobulinemia and in B-cell lymphomas.Recently,antiviral treatment has been proved to be effective in the treatment of HCV-associated indolent lymphomas.Importantly,clinically responses were linked to the eradication of the HCV-RNA,providing a strong argument in favor of a causative link between HCV and lymphoproliferation. | Antonino Carbone Annunziata Gloghini | 2013 | World Journal of Gastroenterology2013，19，44： | 2 |
| 8 | Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis显示文摘 | Liu Weicheng Chen Yunzi Golan Maya Aharoni Annunziata Maria L Du Jie Dougherty Urszula Kong Juan Musch Mark Huang Yong Pekow Joel Zheng Changqing Bissonnette Marc Hanauer Stephen B Li Yan Chun | 2013 | Journal of Clinical Investigation2013，，9： | 2 |
| 9 | Colistin and Rifampicin Compared With Colistin Alone for the Treatment of Serious Infections Due to Extensively Drug-Resistant Acinetobacter baumannii: A Multicenter, Randomized Clinical Trial显示文摘 | Emanuele Durante-Mangoni Giuseppe Signoriello Roberto Andini Annunziata Mattei Maria De Cristoforo Patrizia Murino Matteo Bassetti Paolo Malacarne Nicola Petrosillo Nicola Galdieri Paola Mocavero Antonio Corcione Claudio Viscoli Raffaele Zarrilli Ciro Gal | 2013 | Clinical Infectious Diseases2013，，3： | 2 |
| 10 | Short-Term Effects of Air Pollution in a Cohort of Patients With Chronic Obstructive Pulmonary Disease显示文摘 | Annunziata Faustini Massimo Stafoggia Giovanna Cappai Francesco Forastiere | 2012 | Epidemiology2012，，6： | 2 |
| 11 | Antioxidant capacities, carotenoids and polyphenols evaluation of fresh and refrigerated peach and nectarine cultivars from Italy显示文摘 | Claudio Vaio Giulia Graziani Luigi Marra Annunziata Cascone Alberto Ritieni | 2008 | European Food Research and Technology2008，，4： | 2 |
| 12 | Microwave accelerated wittig reaction of stabilized phosphorus ylides with ketones under solvent-free conditions 显示文摘 | ALDO S TANCRED F ANNUNZIATA S | 1997 | Synlett1997，，1： | 1 |
| 13 | Immunophenotypic analysis enables the correct prediction of t(8;21)in acute myeloid leukemia 显示文摘 | Di-Noto R Annunziata M | 1998 | Br J Haematol1998，102，2： | 1 |
| 14 | Update on asthma control iv five European countries:results of a 2008 survey显示文摘 | Demoly P Gueron B Annunziata K | 2010 | Eur Respir Rev2010，19，116： | 1 |
| 15 | The IGF system显示文摘 | Annunziata M Granata R Ghigo E | 2011 | Acta Diabetol2011，48，1： | 1 |
| 16 | Nanoeneapsulation of essential oils to enhance their antimicrobial activity in foods 显示文摘 | DONSi F ANNUNZIATA M SESSA M | 2011 | LWT-Food Science and Technology2011，44，9： | 1 |
| 17 | Arsenic trioxide therapy for relapsed acute promyelocytic leukemia: a bridge to transplantation 显示文摘 | Leoni F Gianfaldoni G Annunziata M Fanci R Ciol- li S Nozzoli C | 2002 | Haematologica2002，87，5： | 1 |
| 18 | Update on asthma controlin five European countries:results of a 2008 survey显示文摘 | Demoly P Gueron B Annunziata K | 2010 | Eur RespirRev2010，19，116： | 1 |
| 19 | Arsenic trioxide therapy for relapsed acute promyelocytic leukemia:a bridge to transplantation显示文摘 | Leoni F Gianfaldoni G Annunziata M | 2002 | Haematologica2002，87，5： | 1 |
| 20 | Acetylsalicylic acid inhibits proliferation of human bone marrow stromal cells and matrix mineralization 显示文摘 | Guida L Annunziata M Passaro I | 2008 | lnt J lmmunopathol Pharmacol2008，21，4： | 1 |
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