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| 1 | The versatile functions of Sox9 in development,stem cells,and human diseases显示文摘The transcription factor Sox9 was first discovered in patients with campomelic dysplasia,a haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 expression during chondrogenesis.Since then,its role as a cell fate determiner during embryonic development has been well characterized;Sox9 expression differentiates cells derived from all three germ layers into a large variety of specialized tissues and organs.However,recent data has shown that ectoderm-and endoderm-derived tissues continue to express Sox9 in mature organs and stem cell pools,suggesting its role in cell maintenance and specification during adult life.The versatility of Sox9 may be explained by a combination of posttranscriptional modifications,binding partners,and the tissue type in which it is expressed.Considering its importance during both development and adult life,it follows that dysregulation of Sox9 has been implicated in various congenital and acquired diseases,including fibrosis and cancer.This review provides a summary of the various roles of Sox9 in cell fate specification,stem cell biology,and related human diseases.Ultimately,understanding the mechanisms that regulate Sox9 will be crucial for developing effective therapies to treat disease caused by stem cell dysregulation or even reverse organ damage. | Alice Jo Sahitya Denduluri Bosi Zhang Zhongliang Wang Liangjun Yin Zhengjian Yan Richard Kang Lewis L.Shi James Mok Michael J.Lee Rex C.Haydon | 2014 | Genes & Diseases2014，1，2： | 16 |
| 2 | Connectionist models of face processing:A survey显示文摘 | OMINIQUE V HERVE A ALICE JO | 1994 | Pattern Recognition1994，27，9： | 1 |
| 3 | Impact of thrombolysis, intra-aortic balloon pump counterpulsation, and their combination in cardiogenic shock complicating acute myocardial infarction: a report from the SHOCK Trial Registry显示文摘 | Timothy A Sanborn Lynn A Sleeper Eric R Bates Alice K Jacobs Jean Boland John K French Jo Dens Vladimir Dzavik Sebastian T Palmeri John G Webb Mark Goldberger Judith S Hochman | 2000 | Journal of the American College of Cardiology2000，，： | 1 |
| 4 | The programming of sexual phenotype in the homosporous fern Ceratopteris richardii显示文摘 | Jo Ann Banks Leslie Hickok Mary Alice Webb | 1993 | Int J Plante Sci1993，154，4： | 1 |
| 5 | Neoarchean atmospheric chemistry and the preservation of S-MIF in sediments from the São Francisco Craton显示文摘Sulfur mass-independent fractionation(S-MIF)preserved in Archean sedimentary pyrite is interpreted to reflect atmospheric chemistry.Small ranges in Δ^(33)S that expanded into larger fractionations leading up to the Great Oxygenation Event(GOE;2.45–2.2 Ga)are disproportionately represented by sequences from the Kaapvaal and Pilbara Cratons.These patterns of S-MIF attenuation and enhancement may differ from the timing and magnitude of minor sulfur isotope fractionations reported from other cratons,thus obscuring local for global sulfur cycling dynamics.By expanding the Δ^(33)S record to include the relatively underrepresented São Francisco Craton in Brazil,we suggest that marine biogeochemistry affected S-MIF preservation prior to the GOE.In an early Neoarchean sequence(2763–2730 Ma)from the Rio das Velhas Greenstone Belt,we propose that low δ^(13)Corg(<-30‰)and dampened Δ^(33)S(-0.4‰to-0.7‰)in banded iron formation reflect the marine diagenetic process of anaerobic methane oxidation.The overlying black shale(TOC up to 7.8%)with higher δ^(13)Corg(-33.4‰to-19.2‰)and expanded Δ^(33)S(2.3‰±0.8‰),recorded oxidative sulfur cycling that resulted in enhance preservation of S-MIF input from atmospheric sources of elemental sulfur.The sequence culminates in a metasandstone,where concomitant changes to more uniform δCorg(-30‰to--25‰),potentially associated with the RuBisCO I enzyme,and near-zero Δ^(33)S(-0.04‰to 0.38‰)is mainly interpreted as evidence for local oxygen production.When placed in the context of other sequences worldwide,the Rio das Velhas helps differentiate the influences of global atmospheric chemistry and local marine diagenesis in Archean biogeochemical processes.Our data suggest that prokaryotic sulfur,iron,and methane cycles might have an underestimated role in pre-GOE sulfur minor isotope records. | Alice Bosco-Santos William Patrick Gilhooly Ⅲ Paola de Melo-Silva Fotios Fouskas Amaury Bouyon João Gabriel Motta Mauricio Rigoni Baldim Wendell Fabricio-Silva Pascal Philippot Elson Paiva Oliveira | 2022 | Geoscience Frontiers2022，13，5： | 1 |
| 6 | Long lasting persistence of Bacillus thuringiensis seovar, israelensis larvicidal activity in Aedes aegypti (Diptera: Culicidae) breeding places is associated to bacteria recycling显示文摘 | Matia Alice Varjal de Melo-Santos Ana Paula de Araǘjo Eug8nia Maranhao Rios | 2009 | Biological Control2009，，49： | 1 |
| 7 | Genotoxic and recombinogenic activities of the two β-carboline alkaloids harman and harmine in Saccharomyces cerevisiae显示文摘 | Jane Marlei Boeira Alice Fialho Viana Jaqueline Nascimento Picada Jo?o Antonio Pêgas Henriques | 2002 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2002，，1： | 1 |
| 8 | National Carbon Capture Center:advancing fossil energy technology solutions显示文摘Introduction The National Carbon Capture Center is the primary carbon-capture research facility for the US Department of Energy(DOE).Through its role as a neutral test site,the centre is advancing technologies to reduce greenhouse-gas(GHG)emis-sions from fossil-fueled power plants,while also supporting the development of technology solutions for carbon-dioxide(CO_(2))utilization and direct air capture(DAC). | Jo Alice Driggers | 2020 | Clean Energy2020，4，3： | 0 |
| 9 | New In Vitro Studies on the Bioprofile of Genista tenera Antihyperglycemic Extract显示文摘The inhibition of a-glucosidase and glucose-6-phosphatase,two enzymes involved in the carbohydrate metabolism,is an important target to control glycaemia on individuals with type 2 diabetes.In this work we report for the first time the inhibition of both enzymes by the antihyperglycemic n-butanol extract from Genista tenera(Fabaceae).This extract decreased a-glucosidase and glucose-6-phosphatase activities to 0.97 and 80.25%,respectively,being more effective than acarbose,and phlorizin,the positive controls,which reduced enzymes activities only to 17.39 and 96.06%.Once inflammation and oxidative stress are related to diabetic impairments,the anti-inflammatory activity of the extract was also evaluated,through its inhibitory activity over COX-1 enzyme(47.5%inhibition).Moreover,after induction of oxidative stress by UV radiation,the viability of irradiated rat liver hepatoma cells exposed to the extract was significantly higher(67.82%)than that promoted by ascorbic acid,the positive control(45.05%).In addition,the stability of the extract under gastrointestinal conditions was evaluated by HPLC–DAD-ESI–MS/MS.Flavonoid diglycosides were identified as the main constituents of the extract,and no alterations in the chemical composition nor in the antioxidant activity were observed after in vitro digestion with artificial gastric and pancreatic juices. | Daniela Batista Pedro L.Falé Maria L.Serralheiro Maria E.Araújo Paulo J.A.Madeira Carlos Borges Isabel Torgal Margarida Goulart Jorge Justino Alice Martins Amélia P.Rauter | 2015 | Natural Products and Bioprospecting2015，5，6： | 0 |
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