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| 1 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 2 | Effects of yttrium on the sintering and microstructure of alumina-silicon carbide 'nanocomposites' 显示文摘 | ALEX M C IAN P S RICHARD I T STEVE G R | 2005 | J Am Ceram Soc2005，88，9： | 1 |
| 3 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 4 | Polyethylene Glycol-containing Polyurethanes for Biomedical Applications显示文摘 | Siska C Ngoc P L Etienne S Martyn D Alex S Rebecca G Stephen D Mike W Hugh W Simon C | 1998 | Polymer International1998，46，3： | 1 |
| 5 | Effect of the use of selected starter cultures on some quality,safety and sensorial properties of Dacia sausage,a traditional Romanian dry-sausage variety显示文摘 | SIMION A C VIZIREANU C ALEXE P | 2014 | Food Control2014，35，1： | 1 |
| 6 | Gefitinib plus best sup- portive care in previously treated patients with refractory advanced non-small-cell lung cancer:results from a ran- domised,placebo controlled,muhicentre study (Iressa Survival Evaluation in Lung Cancer)显示文摘 | Nick T Alex C Purvish P | 2005 | Lancet Oncol2005，366，9496： | 1 |
| 7 | Quadratus lumborum asymmetry and lumbar spine injury in cricket fast Bowlers显示文摘 | ALEX K M P JILL C | 2012 | J Sci Med Sport2012，15，5： | 1 |
| 8 | Genetic variation in IL28B and spontaneous clearance of hepatitis C virus显示文摘 | Thomas D L Thio C L Martin M P Qi Y Ge D O'Huigin C Kidd J Kidd K Khakoo S I Alex | | 0，，7265： | 1 |
| 9 | Electrowinning of cobalt from sulphate solutions 显示文摘 | SHARMAI G ALEX P BIDAYE A C SURIA K | 2005 | Hydrometallurgy2005，80，： | 1 |
| 10 | Cohort study of the pathogenesis and molecular epidemiology of catheter-related bloodstream infection in neonates with peripherally inserted central venous catheters显示文摘 | GARLAND J S ALEX C P SEVALLIUS J M | 2008 | Infect Control Hosp Epidemiol2008，29，3： | 1 |
| 11 | Spatial trends and historical deposition of polychlorinated biphenyls in Canadian midlatitude and Arctic lake sediments显示文摘 | Derek C G M Alex O Grift N P | 1996 | Environmental science and technology1996，30，12： | 1 |
| 12 | Solar photocatalytic thin film cascade reactor for treatment of benzoic acid containing wastewater显示文摘 | Alex H C Chan Chak K Chan John P Barford | 2003 | Water Research2003，37，： | 1 |
| 13 | Gefitinib plus best supportive care in previously treated patients with refractory advanced non - small - cell lung cancer: results from a randomized,placebo- controller, multicentre study( lressa survival evaluation in lung cancer) 显示文摘 | NIKE T ALEX C PURVISH P | 2005 | The Lancet2005，366，29： | 1 |
| 14 | Postharvest studies beyond fresh market eat-ing quality: Phytochemical antioxidant changes in peach and plumfruit during ripening and advanced senescence显示文摘 | ALEX F P LUIS C | 2011 | Postharvest Bi-ology and Technology2011，60，： | 1 |
| 15 | Spatial trends and historical deposition of polychlorinated biphenyls in Canadian midlatitude and Arctic lake sediments 显示文摘 | DEREK C G M ALEX O GRIFT N P | 1996 | Environmental Science and Technology1996，30，12： | 1 |
| 16 | Salicylic Acid Has Cell-Specific Effects on Tobacco mosaic virus Replication and Cell-to-Cell Movement显示文摘 | ALEX M M JOHN P C | 2002 | Plant Physiology2002，128，： | 1 |
| 17 | Solar photocatalytic thin film cascade reactor for treatment of benzoic acid containing wastewater显示文摘 | Alex H C Chan Chak K Chan John P Barford | 2003 | Water Research2003，37，5： | 1 |
| 18 | Autoantibodies against glucuronosyltransferases differ between viral hepatitis and autoimmune hepatitis显示文摘 | Obermayer Stranb P Alex B | 1996 | Gastroenterology1996，111，： | 1 |
| 19 | Electrowinning of cobalt from sulphate solutions 显示文摘 | SHARMA I G ALEX P BIDAYE A C SURI A K | 2005 | Hydrometallurgy2005，80，12： | 1 |
| 20 | High-power high-performance low-cost capacitor charge concept and implementation显示文摘 | Alex P Costel C Clifford S | 2010 | IEEE Transactions on PlasmaScience2010，38，10： | 1 |
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