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| 1 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 2 | Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project显示文摘AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated children.METHODS:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to < 10,10 to < 15 and ≥ 15 years respectively compared to those < 5 years and 1.1 among girls compared to boys with P < 0.01. HBs Ag was positive in 0.11% and breakthrough infection was 0.36% and 0.39% depending on positivity of anti-HBc and DNA detection respectively. The prevalence of HBV infection was significantly higher among children aged ≥ 7 years(0.59%) compared to 0.07% among younger children with odds ratio equal to 8.4(95%CI:1.1-64.2) and P < 0.01.The prevalence was higher among girls(0.48%) than boys(0.29%) with P > 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory. | Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally | 2015 | World Journal of Hepatology2015，7，22： | 2 |
| 3 | Analysis of raw meats and fats of pigs using polymerase chain reaction for Halal authentication 显示文摘 | Aida A A Che Man Y B Wong C M V L | 2005 | Meat Science2005，69，： | 1 |
| 4 | Influence of third monomer on the crystal phase transition behavior of ethylene-tetrafluoroethylene copolymer显示文摘 | FUNAKI A ARAI K AIDA S | 2008 | Polymer2008，49，25： | 1 |
| 5 | Influence of deposition temperature on structural, optical and electrical properties of sputtered A1 doped ZnO thin films 显示文摘 | Mosbah A Aida M S | 2012 | J Alloy Compd2012，515，： | 1 |
| 6 | Substrate temperature influence on ZnS thin films prepared by ultrasonic spray显示文摘 | Daranfed W Aida M S Hafdallah A | 2009 | Thin Solid Films2009，518，4： | 1 |
| 7 | Characterization of a bacteriocin-like substance produced by a vaginal lactobacillus salivarius strain显示文摘 | Virginia S O Aida A P Maria E N | 1999 | Appl Environ Microbiol1999，65，5： | 1 |
| 8 | Performance evaluation model for scheduling in a global computing system显示文摘 | AIDA K TAKEFUSA A NAKADA H | 2000 | The International Journal of High Performance Computing Applications2000，14，3： | 1 |
| 9 | Carotenoid cleavage dioxygenase (CmCCD4a) contributes to white color formation in chrysanthemum petals显示文摘 | OHMIYA A KISHIMOTO S AIDA R | 2006 | Plant Physiol2006，142，： | 1 |
| 10 | Modeling the gain degradation of high concentration erbium-doped fiber amplifiers by introducing inhomogeneous cooperative up-conversion显示文摘 | Masuda H Takada A Aida K | 1992 | IEEE J Lightwave Technol1992，10，12： | 1 |
| 11 | Inhibition of the acid corrosion of steel by 4-amino-3-hydrazino-5-thio-1,2,4-triazoles 显示文摘 | Aida B Tadros Abd-el-Nabey B A | 1988 | Journal of Electroanalytical Chemistry1988，，2： | 1 |
| 12 | Camel milk amelio- rates steatohepatitis, insulin resistance and lipid peroxida- tion in experimental non-alcoholic fatty liver disease显示文摘 | Aida A Korish and Maha M Arafah | 2013 | Korish and Arafah BMC Complementary and Alternative Medicine2013，，： | 1 |
| 13 | The PINHEAD/ZWILLEgene acts pleiotropically in Arabidopsis development andhas overlapping functions with the ARGONAUTE1 gene 显示文摘 | Lynn K Fernandez A Aida M | 1999 | Development1999，126，46： | 1 |
| 14 | Molecular ordering of organic molten salts triggered by single-walled carbon nanotubes显示文摘 | Fukushima T Kosaka A Ishimura Y Yamamoto T Takigawa T Ishii N Aida T | 2003 | Science2003，300，： | 1 |
| 15 | Influence of the monomer sequential distribution on the mechanical properties and temperature dependence of an ethylene-tetrafluoroethylene copolymer in association with the phase-transition behavior显示文摘 | ARAI K FUNAKI A AIDA S | 2009 | Journal of Applied Polymer Science2009，114，3： | 1 |
| 16 | Apigenin decreases hemin-mediated heme oxygenase-1 induction显示文摘 | AIDA A YANG G WONG R | 2005 | Free Radical Biology & Medicine2005，39，： | 1 |
| 17 | Characterization of a bact eriocin-like substance produced by a vaginal Lactobacillus salivarius strain显示文摘 | VIRGINIA S O AIDA A P MARIA E N | 1999 | Appl Environ Microbiol1999，65，： | 1 |
| 18 | Kinetics of limonene epoxidation by hydrogen peroxide on PW-Amberlite显示文摘 | AIDA L V D P FARLAN T A CORREA C M D | 2002 | Journal of Molecular Catalysis A Chemical2002，185，12： | 1 |
| 19 | The PINHEAD/ZWILLE gene acts pleiotropically in Arabidopsis development and has overlapping functions with the ARGONAUTE1 gene显示文摘 | LYNN K FERNANDEZ A AIDA M | 1999 | Development1999，126，： | 1 |
| 20 | Carotenoid cleavage dioxygenase (CmCCD4a) contributes to white color formation in chrysanthemum petals显示文摘 | Ohmiya A Kishimoto S Aida R Yoshioka S Sumitomo K | 2006 | Plant Physiology2006，142，3： | 1 |
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