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| 1 | Genome sequences of five Sitopsis species of Aegilops and the origin of polyploid wheat B subgenome显示文摘Common wheat(Triticum aestivum,BBAADD)is a major staple food crop worldwide.The diploid progenitors of the A and D subgenomes have been unequivocally identified;that of B,however,remains ambiguous and controversial but is suspected to be related to species of Aegilops,section Sitopsis.Here,we report the assembly of chromosome-level genome sequences of all five Sitopsis species,namely Aegilops bicornis,Ae.longissima,Ae.searsii,Ae.sharonensis,and Ae.speltoides,as well as the partial assembly of the Amblyopyrum muticum(synonym Aegilops mutica)genome for phylogenetic analysis.Our results reveal that the donor of the common wheat B subgenome is a distinct,and most probably extinct,diploid species that diverged from an ancestral progenitor of the B lineage to which the still extant Ae.speltoides and Am.muticum belong.In addition,we identified interspecific genetic introgressions throughout the evolution of the Triticum/Aegilops species complex.The five Sitopsis species have various assembled genome sizes(4.11-5.89 Gb)with high proportions of repetitive sequences(85.99%-89.81%);nonetheless,they retain high collinearity with other genomes or subgenomes of species in the Triticum/Aegilops complex.Differences in genome size were primarily due to independent post-speciation amplification of transposons.We also identified a set of Sitopsis genes pertinent to important agronomic traits that can be harnessed for wheat breeding.These newly assembled genome resources provide a new roadmap for evolutionary and genetic studies of the Triticum/Aegilops complex,as well as for wheat improvement. | Lin-Feng Li Zhi-Bin Zhang Zhen-Hui Wang Ning Li Yan Sha Xin-Feng Wang Ning Ding Yang Li Jing Zhao Ying Wu Lei Gong Fabrizio Mafessoni Avraham A.Levy Bao Liu | 2022 | Molecular Plant2022，15，3： | 5 |
| 2 | Biliary Strictures in 130 Consecutive Right Lobe Living Donor Liver Transplant Recipients: Results of a Western Center显示文摘 | S. A.Shah D. R.Grant I. D.McGilvray P. D.Greig M.Selzner L. B.Lilly N.Girgrah G. A.Levy M. S.Cattral | 2006 | American Journal of Transplantation2006，，1： | 2 |
| 3 | Adult Living Liver Donors have Excellent Long‐Term Medical Outcomes: The University of Toronto Liver Transplant Experience显示文摘 | L.Adcock C.Macleod D.Dubay P. D.Greig M. S.Cattral I.McGilvray L.Lilly N.Girgrah E. L.Renner M.Selzner N.Selzner A.Kashfi R.Smith S.Holtzman S.Abbey D. R.Grant G. A.Levy G.Therapondos | 2010 | American Journal of Transplantation2010，，2： | 1 |
| 4 | Measurable cardinals and the continuum hypothesis显示文摘 | A.Levy R.M.Solovay | | 0，，： | 1 |
| 5 | Convective Heat Transfer by Turbulent Melt Flow Excited by Travelling Magnetic Field at the Inductive Heating显示文摘We examine a convective dissipation-free heat transfer in melts under the action of a stationary component of electromagnetic body force induced by frequency-modulated travelling magnetic field.The influence of MHD parameters of turbulent flow on the transfer process is studied. | A.Kapusta A.Levy B.Mikhailovich | 2012 | Journal of Iron and Steel Research(International)2012，19，S2： | 0 |
| 6 | Programmed death 1 (PD-1) and ligand (PD-L1) inhibitors in head and neck squamous cell carcinoma: A meta-analysis显示文摘Background: PD-1 and PD-L1 inhibitors have emerged as promising treatments for patients with head and neck squamous cell carcinoma (HNSCC).Methods: Systematic review and meta-analysis of PD-1 and PD-L1 inhibitors in HNSCC. Outcomes: median overall survival (mOS), median progression-free survival (mPFS), Response Evaluation Criteria in Solid Tumors (RECIST) and treatment-related adverse events (TRAEs).Results: Eleven trials reported data on 1088 patients (mean age: 59.9 years, range: 18-90). The total mOS was 7.97 months (range: 6.0-16.5). Mean mPFS for all studies was 2.84 months (range: 1.9-6.5). PD-1 inhibitors had a lower rate of RECIST Progressive Disease than PD-L1 inhibitors (42.61%, 95% confidence interval [CI]: 36.29-49.06 vs. 56.79%, 95% CI: 49.18-64.19,P < 0.001). The rate of TRAEs of any grade (62.7%, 95% CI: 59.8-65.6) did not differ.Conclusions: Meta-analysis shows the efficacy of PD-1 and PD-L1 inhibitors in HNSCC and suggests a possible difference in certain RECIST criterion between PD-1 and PD-L1 inhibitors. Future work to investigate the clinical significance of these findings is warranted. | Dylan A.Levy Jaimin J.Patel Shaun A.Nguyen W.Nicholas Jungbauer David M.Neskey Ezra E.W.Cohen Chrystal M.Paulos John A.Kaczmar Hannah M.Knochelmann Terry A.Day | 2022 | World Journal of Otorhinolaryngology-Head and Neck Surgery2022，8，3： | 0 |
| 7 | Geologic field evidence for non-lithostatic overpressure recorded in the North American Cordillera hinterland,northeast Nevada显示文摘There is a long-standing discrepancy for numerous North American Cordillera metamorphic core complexes between geobarometric pressures recorded in the exhumed rocks and their apparent burial depths based on palinspastic reconstructions from geologic field data.In particular,metamorphic core complexes in eastern Nevada are comprised of well-documented~12-15 km thick Neoproterozoic-Paleozoic stratigraphy of Laurentia’s western passive margin,which allows for critical characterization of field relationships.In this contribution we focus on the Ruby Mountain-East Humboldt Range-Wood Hills-Pequop Mountains(REWP)metamorphic core complex of northeast Nevada to explore reported peak pressure estimates versus geologic field relationships that appear to prohibit deep burial.Relatively high pressure estimates of 6-8 kbar(23-30 km depth,if lithostatic)from the lower section of the Neoproterozoic-Paleozoic passive margin sequence require burial and or repetition of the passive margin sequence by 2-3×stratigraphic depths.Our observations from the least migmatized and/or mylonitized parts of this complex,including field observations,a transect of peak-temperature(T_(p))estimates,and critical evaluation of proposed thickening/burial mechanisms cannot account for such deep burial.From Neoproterozoic-Cambrian(€)rocks part of a continuous stratigraphic section that transitions~8 km upsection to unmetamorphosed Permian strata that were not buried,we obtained new quartz-in-garnet barometry via Raman analysis that suggest pressures of~7 kbar(~26 km).A T_(p)traverse starting at the same basal€rocks reveals a smooth but hot geothermal gradient of≥40℃/km that is inconsistent with deep burial.This observation is clearly at odds with thermal gradients implied by high P-T estimates that are all≤25℃/km.Remarkably similar discrepancies between pressure estimates and field observations have been discussed for the northern Snake Range metamorphic core complex,~200 km to the southeast.We argue that a possible reconciliation of longestablished field observations versus pressures estimated from a variety of barometry techniques is that the rocks experienced non-lithostatic tectonic overpressure.We illustrate how proposed mechanisms to structurally bury the rocks,as have been invoked to justify published high pressure estimates,are entirely atypical of the Cordillera hinterland and unlike structures interpreted from other analogous orogenic plateau hinterlands.Proposed overpressure mechanisms are relevant in the REWP,including impacts from deviatoric/differential stress considerations,tectonic mode switching,and the autoclave effect driven by dehydration melting.Simple mechanical arguments demonstrate how this overpressure could have been achieved.This study highlights that detailed field and structural restorations of the least strained rocks in an orogen are critical to evaluate the tectonic history of more deformed rocks. | Andrew V.Zuza Drew A.Levy Suzanne R.Mulligan | 2022 | Geoscience Frontiers2022，13，2： | 0 |
| 8 | Freestanding region-responsive bilayer for functional packaging of ingestible devices显示文摘Ingestible capsules have the potential to become an attractive alternative to traditional means of treating and detecting gastrointestinal(GI)disease.As device complexity increases,so too does the demand for more effective capsule packaging technologies to elegantly target specific GI locations.While pH-responsive coatings have been traditionally used for the passive targeting of specific GI regions,their application is limited due to the geometric restrictions imposed by standard coating methods.Dip,pan,and spray coating methods only enable the protection of microscale unsupported openings against the harsh GI environment.However,some emerging technologies have millimeter-scale components for performing functions such as sensing and drug delivery.To this end,we present the freestanding region-responsive bilayer(FRRB),a packaging technology for ingestible capsules that can be readily applied for various functional ingestible capsule components.The bilayer is composed of rigid polyethylene glycol(PEG)under a flexible pH-responsive Eudragit®FL 30 D 55,which protects the contents of the capsule until it arrives in the targeted intestinal environment.The FRRB can be fabricated in a multitude of shapes that facilitate various functional packaging mechanisms,some of which are demonstrated here.In this paper,we characterize and validate the use of this technology in a simulated intestinal environment,confirming that the FRRB can be tuned for small intestinal release.We also show a case example where the FRRB is used to protect and expose a thermomechanical actuator for targeted drug delivery. | Michael A.Straker Joshua A.Levy Justin M.Stine Vivian Borbash Luke A.Beardslee Reza Ghodssi | 2023 | Microsystems & Nanoengineering2023，9，3： | 0 |
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