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| 1 | Lack of Efficacy of Bevacizumab Plus Irinotecan in Children with Recurrent Malignant Glioma and Diffuse Brainstem Glioma:A Pediatric Brain Tumor Consortium Study显示文摘PURPOSE:A phase Ⅱ study of bevacizumab(BVZ) plus irinotecan(CPT-11) was conducted in children with recurrent malignant glioma(MG) and intrinsic brainstem glioma(BSG).PATIENTS AND METHODS:Eligible patients received two doses of BVZ | Gururangan S Chi SN Young Poussaint T Onar-Thomas A Gilbertson RJ Vajapeyam S Friedman HS Packer RJ Rood BN Boyett JM Kun LE | 2010 | 中国神经肿瘤杂志2010，8，2： | 7 |
| 2 | INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To characterize the efficacy of the dual FXR/TGR5 receptor agonist INT-767 upon histological endpoints in a rodent model of diet-induced and biopsy-confirmed non-alcoholic steatohepatitis(NASH).METHODS The effects of INT-767 on histological features of NASH were assessed in two studies using Lep^(ob/ob)(ob/ob) NASH mice fed the AMLN diet(high fat with transfat, cholesterol and fructose). In a proof-of-conceptstudy, Lep^(ob/ob)(ob/ob) NASH mice were first dosed with INT-767(3 or 10 mg/kg for 8 wk). A second ob/ob NASH study compared INT-767(3 and 10 mg/kg) to obeticholic acid(OCA)(10 or 30 mg/kg; 16 wk). Primary histological endpoints included qualitative and quantitative assessments of NASH. Other metabolic and plasma endpoints were also assessed. A comparative assessment of INT-767 and OCA effects on drug distribution and hepatic gene expression was performed in C57 Bl/6 mice on standard chow. C57 Bl/6 mice were orally dosed with INT-767 or OCA(1-30 mg/kg) for 2 wk, and expression levels of candidate genes were assessed by RNA sequencing and tissue drug levels were measured by liquid chromatography tandem-mass spectrometry.RESULTS INT-767 dose-dependently(3 and 10 mg/kg, PO, QD, 8 wk) improved qualitative morphometric scores on steatohepatitis severity, inflammatory infiltrates and fibrosis stage. Quantitative morphometric analyses revealed that INT-767 reduced parenchymal collagen area, collagen fiber density, inflammation(assessed by Galectin-3 immunohistochemistry) and hepatocyte lipid droplet area following INT-767 treatment. In a comparative study(16 wk), the FXR agonists OCA(10 and 30 mg/kg) and INT-767(3 and 10 mg/kg) both improved NASH histopathology, with INT-767 exerting greater therapeutic potency and efficacy than OCA. Mechanistic studies suggest that both drugs accumulate similarly within the liver and ileum, however, the effects of INT-767 may be driven by enhanced hepatic, but not ileal, FXR function. CONCLUSION These findings confirm the potential utility of FXR and dual FXR/TGR5 activation as disease intervention strategies in NASH. | Jonathan D Roth Michael Feigh Sanne S Veidal Louise KD Fensholdt Kristoffer T Rigbolt Henrik H Hansen Li C Chen Mathieu Petitjean Weslyn Friley Niels Vrang Jacob Jelsing Mark Young | 2018 | World Journal of Gastroenterology2018，24，2： | 7 |
| 3 | Low skeletal muscle mass is associated with non-alcoholic fatty liver disease in Korean adults: the Fifth Korea National Health and Nutrition Examination Survey显示文摘BACKGROUND: Sarcopenia and non-alcoholic fatty liver disease(NAFLD) share similar pathophysiological mechanisms, and the relationship between sarcopenia and NAFLD has been recently investigated. The study investigated whether low skeletal muscle mass is differentially associated with NAFLD by gender in Korean adults.METHODS: We conducted a cross-sectional analysis of the data from the Fifth Korea National Health and Nutrition Examination Survey. The skeletal muscle index(SMI) was obtained by the appendicular skeletal muscle mass divided by the weight. NAFLD was defined as a fatty liver index(FLI) ≥60 in the absence of other chronic liver disease.RESULTS: Among the included subjects, 18.3%(SE: 1.4%) in men and 7.0%(SE: 0.7%) in women were classified as having FLI-defined NAFLD. Most of the risk factors for FLI-defined NAFLD showed a significant negative correlation with the SMI in both genders. Multiple logistic regression analysis showed that low SMI was associated with FLI-defined NAFLD, independent of other metabolic and lifestyle parameters in both genders [males: odds ratio(OR)=1.35; 95% confidence interval(CI): 1.17-1.54; females: OR=1.36; 95% CI: 1.18-1.55]. The magnitude of the association between FLI-defined NAFLD and low SMI was higher in middle aged to elderly males(OR=1.50; 95% CI: 1.22-1.84) than in males less than 45 years of age(OR=1.25; 95% CI: 1.02-1.52) and in premenopausal females(OR=1.50; 95% CI: 1.12-2.03) than in postmenopausal females(OR=1.36; 95% CI: 1.20-1.54).CONCLUSIONS: Low SMI is associated with the risk of FLIdefined NAFLD independent of other well-known metabolic risk factors in both genders. This association may differ according to age group or menopausal status. Further studies are warranted to confirm this relationship. | hee yeon kim chang wook kim chung-hwa park jong young choi kyungdo han anwar t merchant yong-moon park | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，1： | 7 |
| 4 | Putting things in place for fertilization: discovering roles for importin proteins in cell fate and spermatogenesis显示文摘Importin 蛋白质原来通过原子毛孔在蛋白质运输为他们的中央角色被描绘,唯一的细胞内部的入口到原子核。这个重要函数必须紧被调整由抄写因素和另外的原子蛋白质控制存取到 genomic DNA,到完成细胞的行为影响的适当调整房间命运。调停 Importin 的 nucleocytoplasmic 运输依靠他们货物的特定的识别,与到不同、重叠的蛋白质子集的每 importin 绑定。importin 功能的知识关于三个关键发展系统实质地膨胀了:胚胎的干细胞,肌肉房间和细菌排队。自从为调整 nucleocytoplasmic 运输的潜力被建议贡献精子发生,在十年,我们和其它证明了进原子核的渡船抄写因素执行的 importins 另外的角色,它控制房间命运。这评论从哺乳动物的精子发生的研究介绍关键调查结果揭示男富饶和不孕由产生的潜在的新小径。germline 开始的这些研究照亮 importin 蛋白质在管理细胞的区别的新方法,经由指导到不同细胞内部的分隔空间并且由决定细胞的压力回答的蛋白质包括。 | Kate L Loveland Andrew T Major Romaly Butler Julia C Young David A Jan Yoichi Miyamoto | 2015 | Asian Journal of Andrology2015，17，4： | 3 |
| 5 | Insulin-induced translocation of glucose transporters in rat hindlimb muscles显示文摘 | Klip A Ramlal T Young D A | 1987 | FEBS Lett1987，224，1： | 2 |
| 6 | The oxidative dehydrogenation of ethane over catalysts containing mixed oxides of molybdenum and vanadium显示文摘 | Thorsteinson E M Wilson T P Young F G | 1978 | J Catal1978，52，： | 2 |
| 7 | Surface treatment of titanium for adhesive bonding to polymer composites: a review显示文摘 | Molitor P Barron V Young T | 2001 | Internation Journal of Adhesion & Adhesives2001，21，： | 2 |
| 8 | The occurrence of sleep-disordered breathing among middle-aged adults 显示文摘 | Young T Palta M Dempsey J | 1993 | N Engl J Med1993，328，17： | 2 |
| 9 | Interleukin-1 beta mRNA expression in ischemic rat cortex显示文摘 | Liu T McDonnell PC Young PR | 1993 | Stroke1993，24，： | 2 |
| 10 | A comparison of residents’ attitudes towards tourism in 10 New Zealand destinations显示文摘 | RW Lawson J Williams T Young J Cossens | 1998 | Tourism Management1998，，3： | 2 |
| 11 | Phospholipid - stabilized nanoparticles of cyclosporine A by rapid expansion from supercritical to aqueous solution显示文摘 | YOUNG T J JOHNSTON K P PACE G W | 2004 | AAPS Pharm Sci Tech2004，5，1： | 1 |
| 12 | Complication of reperfusion in acute aortic artery occlusion following saddle embolization orginating from an atrial myxoma显示文摘 | Ali T Castro J Young CR | 2004 | Vascular2004，12，3： | 1 |
| 13 | Impact of ND-YAG laser drilled holes on the strength and stiffness of laminar flow carbon fibre reinforced composite panels显示文摘 | Young T O'Driscoll D | 2002 | Coznposite2002，33，1： | 1 |
| 14 | Fatty acid genotypes of Virginia-type peanut cultivars显示文摘 | Isleib T G Young C T Knauft D A | 1996 | Crop Sci1996，36，3： | 1 |
| 15 | Infrared spectroscopic investigation of hydroxyl in β-(Mg,Fe)2SiO4 and coexisting olivine: implications for mantle evolution and dynamics显示文摘 | Young T E Green H W Hofmeister A M | 1993 | Phys Chem Minerals1993，19，： | 1 |
| 16 | Neuroendocrine bases of monogamy 显示文摘 | Young L J Wang Z X Insel T R | 1998 | Trends Neurosci1998，21，2： | 1 |
| 17 | A Study of electrodeposits containing nickel and sulfur 显示文摘 | YOUNG W T KERSTEN H | 1937 | Trans Electrochem Soc1937，71，： | 1 |
| 18 | Comparison of a-amylase activities from different assay methods 显示文摘 | YOUNG J Y JUAN H RANDOLPH T H | 1987 | Biotechnol Bioeng1987，30，： | 1 |
| 19 | The occurrence of sleep-disordered breathing among middle-aged adults显示文摘 | Young T Palta M Dempsey J | 1993 | N Engl J Med1993，328，17： | 1 |
| 20 | Epidemiology of obstructive sleep apnea:a population health perspective显示文摘 | Young T Peppard PE Gottlieb DJ | 2002 | Am J Respir Crit Care Med2002，165，9： | 1 |
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