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| 1 | 25-羟维生素D和甲状旁腺激素与高血压的相关性显示文摘有研究证实,维生素D缺乏和甲状旁腺激素(PTH)过高与高血压的发生密切相关。维生素D缺乏不仅可以影响肾素血管紧张素系统及PTH水平,而且可以直接参与血管炎性反应,影响高血压的发生发展。PTH可以通过促进血管炎性反应及血管钙化等参与高血压的进展。目前还没有前瞻性研究同时评估维生素D和PTH水平与高血压发病的关系。该研究分析多民族动脉粥样硬化研究的前瞻性数据,发现低水平25羟维生素D[25(OH)D]和高水平PTH与高血压发病相关,特别是在肥胖人群中。但在校正混杂因素后,25(OH)D水平与高血压发病的相关性无统计学意义,而PTH水平与高血压发病仍然相关。鉴于维生素D缺乏和PTH过量在人群中是普遍现象,该研究对于更好地了解高血压发病机制,在人群中开展高血压预防工作有重要意义。 | van Ballegooijen AJ Kestenbaum B Sachs MC de Boer IH Siscovick DS Hoofnagle AN Ix JH Visser M Brouwer IA 练桂丽 叶鹏 | 2014 | 中华高血压杂志2014，22，6： | 10 |
| 2 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 3 | Selecting suitable solid organ transplant donors: Reducing the risk of donor-transmitted infections显示文摘Selection of the appropriate donor is essential to a successful allograft recipient outcome for solid organ transplantation. Multiple infectious diseases have been transmitted from the donor to the recipient via transplantation. Donor-transmitted infections cause increased morbidity and mortality to the recipient. In recent years, a series of high-profile transmissions of infections have occurred in organ recipients prompt-ing increased attention on the process of improving the selection of an appropriate donor that balances the shortage of needed allografts with an approach that mitigates the risk of donor-transmitted infection to the recipient. Important advances focused on improving donor screening diagnostics, using previously excluded high-risk donors, and individualizing the selection of allografts to recipients based on their prior infection history are serving to increase the donor pool and improve outcomes after transplant. This article serves to review the relevant literature surrounding this topic and to provide a suggested approach to the selection of an appropriate solid organ transplant donor. | Christopher S Kovacs Jr Christine E Koval David van Duin Amanda Guedes de Morais Blanca E Gonzalez Robin K Avery Steven D Mawhorter Kyle D Brizendine Eric D Cober Cyndee Miranda Rabin K Shrestha Lucileia Teixeira Sherif B Mossad | 2014 | World Journal of Transplantation2014，4，2： | 7 |
| 4 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 5 | Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection显示文摘 | Maria Van der Sluis Barbara A.E. De Koning Adrianus C.J.M. De Bruijn Anna Velcich Jules P.P. Meijerink Johannes B. Van Goudoever Hans A. Büller Jan Dekker Isabelle Van Seuningen Ingrid B. Renes Alexandra W.C. Einerhand | 2006 | Gastroenterology2006，，1： | 3 |
| 6 | CD 64 distinguishes macrophages from dendritic cells in the gut and reveals the T h1‐inducing role of mesenteric lymph node macrophages during colitis显示文摘 | Samira Tamoutounour Sandrine Henri Hugues Lelouard Béatrice de Bovis Colin de Haar C. Janneke van der Woude Andrea M. Woltman Yasmin Reyal Dominique Bonnet Dorine Sichien Calum C. Bain Allan McI. Mowat Caetano Reis e Sousa Lionel F. Poulin Bernard Malisse | 2012 | Eur J Immunol2012，，12： | 2 |
| 7 | Comparison of exercise electrocardiography and dobutamine echocardiography with invasively assessed myocardial fractional flow reserve in evaluation of severity of coronary arterial narrowing显示文摘 | Bartunek J Van Schuerbeeck E De Bruyne B | | Am J Cardiol0，1，： | 2 |
| 8 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 9 | Effects of rock fragments on physical degradation of cultivated soils by rainfall 显示文摘 | Van Wesemael B Poesen J de Figueiredo T | 1995 | Soil and Tillage Research1995，33，： | 1 |
| 10 | Apoptosis in developing anthers and the role of ABA in this process during androgenesis in Hordeum vulgate L显示文摘 | WANG M HOEKSTRA S VAN BERGEN S LAMERS GEM OPPEDIJK B J VAN DER HEUDEN M W DE PRIESTER W SCHILPEROORT RA 1 | 1999 | Plant Mol Biol1999，39，： | 1 |
| 11 | Early prediction of endocrine therapy effect in advanced breast cancer patients using ^99mTc-depreotide scintigraphy 显示文摘 | VAN DEN BOSSCHE B VAN BELLE S DE WINTER F | 2006 | J Nucl Med2006，47，11： | 1 |
| 12 | Studies on pore systems in catalysts: Ⅶ, description of the pore dimensions of carbon blacks by the t methodl显示文摘 | DE BORE J H LINSEN B G VAN DER P T | 1965 | Journal of Catalysis1965，4，： | 1 |
| 13 | Claiming more: The increased voluminosity of patent applications and its determinants 显示文摘 | Van Zeebroeck N van Pottelsberghe de la Potterie B Guellec D | 2009 | Research Policy2009，38，6： | 1 |
| 14 | A review of current evidence with continuous glucose monitoring in patients with diabetes显示文摘 | de Block C Manuel-y-Keenoy B van Gaal L | 2008 | J Diabetes Sci Technol2008，2，4： | 1 |
| 15 | ML estimation of time and frequency offset in OFDM systems显示文摘 | J J van de Beek M Sandell P O Bφrjesson | 1997 | IEEE Trans Signal Processing1997，45，7： | 1 |
| 16 | Vascular permeability factor gene is expressed differentially in normal tissues,macrophages and tumors显示文摘 | Berse B Brown L F van de Water L | 1992 | Mol Biol Cell1992，3，2： | 1 |
| 17 | Stability of Ground and Precipitated CaCO3 Suspensions in the Presence of Polyethylene Oxide and Kraft Lignin显示文摘 | Cechova M Alince B T G M van de Ven | 1998 | Collids and Surfaces A:Physicochemical and Engineering Aspects1998，，141： | 1 |
| 18 | The effect of estrogen receptor genotype on litter size and placental traits at term in F2 crossbred gilts 显示文摘 | Van Rens B T de Groot P N Van Der L T | 2002 | Theriogenology2002，57，6： | 1 |
| 19 | Visualization of differential gene expression using a novel method of RNA fingerprinting based on AFLP: Analysis of gene expression during potato tuber development显示文摘 | Bachem C W B Van der Hoeven R S de Bruijn S M | 1996 | Plant J1996，9，： | 1 |
| 20 | Patterns of interdependence in work teams: A two-level investigation of the relations with job and team satisfaction 显示文摘 | Van Der Vegt G S Emans B J M Van De Vliert E | 2001 | Personnel Psychology2001，54，1： | 1 |
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