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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Exploiting the diversity of tomato:the development of a phenotypically and genetically detailed germplasm collection显示文摘A collection of 163 accessions,including Solanum pimpinellifolium,Solanum lycopersicum var.cerasiforme and Solanum lycopersicum var.lycopersicum,was selected to represent the genetic and morphological variability of tomato at its centers of origin and domestication:Andean regions of Peru and Ecuador and Mesoamerica.The collection is enriched with S.lycopersicum var.cerasiforme from the Amazonian region that has not been analyzed previously nor used extensively.The collection has been morphologically characterized showing diversity for fruit,flower and vegetative traits.Their genomes were sequenced in the Varitome project and are publicly available(solgenomics.net/projects/varitome).The identified SNPs have been annotated with respect to their impact and a total number of 37,974 out of 19,364,146 SNPs have been described as high impact by the SnpEeff analysis.GWAS has shown associations for different traits,demonstrating the potential of this collection for this kind of analysis.We have not only identified known QTLs and genes,but also new regions associated with traits such as fruit color,number of flowers per inflorescence or inflorescence architecture.To speed up and facilitate the use of this information,F2 populations were constructed by crossing the whole collection with three different parents.This F2 collection is useful for testing SNPs identified by GWAs,selection sweeps or any other candidate gene.All data is available on Solanaceae Genomics Network and the accession and F2 seeds are freely available at COMAV and at TGRC genebanks.All these resources together make this collection a good candidate for genetic studies. | Estefanía Mata-Nicolás Javier Montero-Pau Esther Gimeno-Paez Víctor Garcia-Carpintero Peio Ziarsolo Naama Menda Lukas A.Mueller JoséBlanca Joaquín Cañizares Esther van der Knaap María JoséDíez | 2020 | Horticulture Research2020，7，1： | 2 |
| 3 | Kinetic Study by Thermogravimetry显示文摘 | Van D W Herrden C V Hutjens F J | 1951 | Fuel1951，11，15： | 1 |
| 4 | Comparison of etanereept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis 显示文摘 | van der Heijde D Klareskog L Rodriguez-Valverde V | 2006 | Arthrtis Rheum2006，54，4： | 1 |
| 5 | Nanoparticle-filled silane films as chromate replacements for aluminium alloys显示文摘 | Palanivel V Zhu D Van Ooij W J | 2003 | Prog Org Coat2003，47，： | 1 |
| 6 | Changes in volatile production during an infection of potatoes by Erwinia carotovora显示文摘 | LYEW D Y VAN GARIEPY G S V RAGHAVAN A C | 2001 | Food Research International2001，34，： | 1 |
| 7 | Process mining for ubiquitous mobile systems: an overview and a concrete algorithm 显示文摘 | Ana K A d M Boudewijn F van D Wil M P v d A | 2004 | Ubiquitous Mobile Information and Collaboration Systems2004，3272，1： | 1 |
| 8 | Supply chain management in food chains:Im proving performance by reducing uncertainty显示文摘 | VAN D V BEULENS A J M WIT W D | 1998 | International Transactions in Operational Research1998，5，6： | 1 |
| 9 | 查看详情显示文摘 | Vlaskin V A Janssen N van Rijssel J Beaulac R Gamelin D R | | 0，，9： | 1 |
| 10 | Functional connectivity as revealed by spatial independent component analysis of fMRI measurements during rest显示文摘 | van de VEN V G FORMISANO E PRVULOVIC D | 2004 | Hum Brain Map2004，22，3： | 1 |
| 11 | Technical aspectsof myocardial SPECT imaging with technetium-99m sestamibi显示文摘 | Garcia E V Coke C D van Train K F | 1990 | Am J Cardiol1990，66，13： | 1 |
| 12 | Effect of nitrogen concentration on fructan metabolizing enzymes in young chicory plants (Cichorium intybus)显示文摘 | Van den Ende W Roover J D Laere A V | 1999 | Physiologia Plantarum1999，105，： | 1 |
| 13 | The Reverse Supply Chain显示文摘 | Guide J V D Luk N Van W | 2002 | Harvard Business Review2002，80，2： | 1 |
| 14 | In vitro effects of 2-methoxyestradiol on cell numbers, morphology, cell cycle pro- gression,and apoptosis induction in oesophageal carcinoma cells 显示文摘 | Thaver V Lottering M L van Papendorp D | 2009 | Cell Bioehem Funct2009，27，4： | 1 |
| 15 | Infectious bronchitis subpopulation in vaccinated chickens afterchallenge显示文摘 | Toro H Pennington D Gallardo R A van Santen V L | 2012 | Avian Dis2012，56，3： | 1 |
| 16 | Definition and classification of power system stability 显示文摘 | KUNDUR P PASERBA J AJJARAPU V ANDERSSON G BOSE A CANIZARES C HATZIARGYRIOU N HILL D STANKOVICA TAYLOR C van CUTSEM T VITTAL V | 2004 | IEEE Transactions on Power Systems2004，19，3： | 1 |
| 17 | Intrathoracic impedance monitoring, audible patient alerts, and outcome in patients with heart failure 显示文摘 | van Veldhuisen D J Braunschweig F Conraads V | 2011 | Circulation2011，124，16： | 1 |
| 18 | Age-associated defect in human TLR-1/2 function显示文摘 | van Duin D Mohanty S Thomas V | 2007 | J Immunol2007，178，2： | 1 |
| 19 | Interaction of O and OH radicals with a simple model system for lipids in the skin barrier: a reactive molecular dynamics investigation for plasma medicine 显示文摘 | PAAL J V d AERNOUTS S van DUIN A C T | 2013 | Joumal of Physics D: Applied Physics2013，46，39： | 1 |
| 20 | Esomeprazole 40 mg once a day in patients with functional dyspepsia: the randomized, placebo-controlled 'ENTER' trial 显示文摘 | van Zanten S V Armstrong D Chiba N | 2006 | Am J Gastroenterol2006，101，9： | 1 |
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