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| 1 | 中国婴幼儿接种吸附无细胞百白破灭活脊髓灰质炎和b型流感嗜血杆菌(结合)联合疫苗的安全性和免疫原性研究显示文摘目的比较吸附无细胞百白破灭活脊髓灰质炎和b型流感嗜血杆菌(结合)联合疫苗(DTaP—IPV//PRP~T联合疫苗)与吸附无细胞百白破联合疫苗(DTaP)、b型流感嗜血杆菌结合疫苗(Hib结合疫苗)、注射用灭活脊髓灰质炎疫苗(IPV)的免疫原性和安全性。方法受试者随机分为三组。试验组(A组和B组)分别于2、3、4月龄和3、4、5月龄接种DTaP—IPV//PRP~T联合疫苗,对照组(C组)于3、4、5月龄分别同时接种DTaP、Hib结合疫苗和IPV;3个组均在18~20月龄时加强接种一次。检测每种抗原的抗体滴度,并分别对A、B组与C组的血清保护率/血清转换率进行非劣效性检验。记录每次接种后的安全性数据,并评价疫苗的安全性。结果DTaP.IPV//PRP~T联合疫苗采用2、3、4月龄或者3、4、5月龄接种程序相对于DTaP、Hib结合疫苗和IPV在基础免疫及18~20月龄的加强免疫,对每种抗原的血清保护率/血清转换率均为非劣效;接种DTaP—IPV//PRP~T联合疫苗后安全性良好,并与对照疫苗相似。结论DTaP—IPV//PRP~T联合疫苗对中国婴幼儿具有很高的免疫原性和良好的安全性,并与对照疫苗具有可比性。 | 李艳萍 李凤祥 侯启明 李长贵 李亚南 陈福生 胡学忠 苏文斌 张庶民 方捍华 叶强 曾天德 刘陶宣 李秀必 黄运能 邓曼玲 李荣成 张燕平 Esteban Ortiz | 2011 | 中华流行病学杂志2011，32，8： | 24 |
| 2 | Current Trends in Pickering Emulsions: Particle Morphology and Applications显示文摘In recent years,Pickering emulsions and their applications have attracted a great deal of attention due to their special features,which include easy preparation and enhanced stability.In contrast to classical emulsions,in Pickering emulsions,solid microparticles or nanoparticles that localize at the interface between liquids are used as stabilizers,instead of surfactants,to enhance the droplet lifetime.Furthermore,Pickering emulsions show higher stability,lower toxicity,and stimuli-responsiveness,compared with emulsions that are stabilized by surfactants.Therefore,they can be considered attractive components for various uses,such as photocatalysis and the preparation of new materials.Moreover,the nanoparticle morphology strongly influences Pickering emulsion stability as well as the potential utilization of such emulsions.Here,we review recent findings concerning Pickering emulsions,with a particular focus on how the nanoparticles morphology(i.e.,cube,ellipsoid,nanosheet,sphere,cylinder,rod,peanut)influences the type and stability of such emulsions,and their current applications in different fields such as antibacterial activity,protein recognition,catalysis,photocatalysis,and water purification. | Danae Gonzalez Ortiz Celine Pochat-Bohatier Julien Cambedouzou Mikhael Bechelany Philippe Miele | 2020 | Engineering2020，6，4： | 22 |
| 3 | Epidemiological Evolution of Lung Cancer in the South of Spain from 1990 to 2010显示文摘Background: Changes in lung cancer has been characterized by the increase of cases among women and the increase in adenocarcinomas among other histological subtypes.Methods: Descriptive analysis of cases diagnosed with lung cancer in Hospital Virgen de las Nieves(Spain) from 1990 to 2010,based on five variables(age, sex, smoking, histology and pathological anatomy). The study establishes associations between these variables and compares the results with the literature.Results: 2,026 patients were diagnosed with lung cancer in this period; 1,838 were males(90.7%) and 188 women(9.3%); 1,892 patients(93.4%) were smokers or ex-smokers and 134(6.6%) had never smoked; the most frequent non-small cell histology types were squamous cell carcinoma and adenocarcinoma and it was the most frequent neoplasia in women and were associated with a lower tobacco consumption.Conclusion: The large majority of lung cancer cases is associated with a history of smoking tobacco and there are histopathological differences according to gender and cumulative tobacco smoke load. | Alberto Caballero Vázquez Ana Dolores Romero Ortiz Jose Manuel González de Vega San Román Raimundo García del Moral Bernardino Alcázar Navarrete | 2018 | 中国肺癌杂志2018，21，1： | 17 |
| 4 | Phase Ⅰ of cardiac rehabilitation:A new challenge for evidence based physiotherapy显示文摘Cardiac rehabilitation protocols applied during the inhospital phase(phaseⅠ)are subjective and their results are contested when evaluated considering what should be the three basic principles of exercise prescription:specificity,overload and reversibility.In this review,we focus on the problems associated with the models of exercise prescription applied at this early stage in-hospital and adopted today,especially the lack of clinical studies demonstrating its effectiveness.Moreover,we present the concept of'periodization'as a useful tool in the search for better results. | Rafael Michel de Macedo JoséRocha Faria-Neto Costantino Ortiz Costantini Dayane Casali Andrea Pires Muller Costantino Roberto Costantini Katherine Athayde Teixeira de Carvalho Luiz César Guarita-Souza | 2011 | World Journal of Cardiology2011，3，7： | 11 |
| 5 | Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction显示文摘瞄准:与可勃起的机能障碍(编辑) 在无力的男人检验朝鲜红人参(KRG ) 的处理功效。方法:对中等编辑温和或温和的介绍的 60 个病人的一个总数在一个双窗帘被注册,功效 ofKRG 和安慰剂在被比较的控制安慰剂的学习。病人收到了任何一个 KRG 或安慰剂的 1 000 mg (3 次日报) 。结果:在治疗以后的可勃起的功能(IIEF-5 ) 分数的国际索引的五条款的版本在治疗前与那相比在 KRG 组是显著地更高的(从 16.4 ± 2.9 ~ 21.0 ± 6.3, P <
0.0001 ) 。相反,在在安慰剂组的治疗前后没有差别(从 17.0 ± 3.1 ~ 17.7 ± 5.6, P >
0.05 ) 。在 theKRG 组, 20 个病人(66.6%) ,报导改进勃起,在全球功效问题重要(P <
0.01 ) ;在安慰剂组,没有意义。问题上的分数 2 (刚硬) , 3 (穿入) , 4 和 5 (维护) ,当那些问题在 12 星期每治疗以后被回答时,比为安慰剂的那些为 KRG 是显著地更高的(P <
0.01 ) 。在 KRG 组的 Whenthe 分数与在治疗以后的安慰剂组相比,在全部的分数(IIEF-5 分数) 有重要改进在为对待 KRG 的组询问 3 和 5 (P <
0.001 并且 P <
0.0001,分别地) 。在治疗以后的浆液睾丸激素, prolactine 和胆固醇的层次不是统计上重要的在 KRG 和安慰剂组之间不同(P >
0.05 ) 。结论:我们 KRG 能是为对待男编辑的侵略途径的一种有效选择的数据表演。 | Enrico de Andrade Alexandre A. de Mesquita Joaquim de Almeida Claro Priscila M. de Andrade Valdemar Ortiz Mário Paranhos Miguel Srougi | 2007 | Asian Journal of Andrology2007，9，2： | 7 |
| 6 | An extended treatment protocol with pegylated interferon and ribavirin for hepatitis C recurrence after liver transplantation显示文摘AIM: To evaluate the efflicacy and tolerability of an extended treatment protocol and to determine the predictors of sustained virological response (SVR) after liver transplantation (LT).METHODS: Between August 2005 and November 2008, patients with recurrent hepatitis C virus (HCV) after LT were selected for treatment if liver biopsy showed at least grade 2 inflammation and/or stage 2 flibrosis. All patients were to receive pegylated interferon (PEG)/regimens combining ribavirin (RBV) for an additional 48 wk after HCV undetectability.RESULTS: Extended protocol treatment was initiated in thirty patients. Overall, 73% had end of treatmentresponse and 60% had SVR. Nineteen patients completed treatment per protocol, of them, sixteen (84%) had end of treatment response, and fourteen (74%) achieved SVR. Both early virological response and 24-week virological response were individually associated with SVR but this association was not signif icant on multivariate analysis. Eleven patients (37%) discontinued therapy due to adverse effects. Cytopenias were the most common and most severe adverse effect, and required frquent growth factor use, dose adjustments and treatment cessations. The risk of rejection was not increased.CONCLUSION: Recurrent HCV after LT can be safely treated with extended virological responseguided therpy using PEG/RBV, but requires close monitoring for treatment-related adverse effects, particularly cytopenias. | Nikroo Hashemi Victor Araya Kashif Tufail Laxmi Thummalakunta Eyob Feyssa Ashaur Azhar Mumtaz Niazi Jorge Ortiz | 2011 | World Journal of Hepatology2011，3，7： | 7 |
| 7 | Assessment of Iron Bioavailability in Ten Kinds of Chinese Wheat Flours Using an in vitro Digestion/Caco-2 cell Model显示文摘Objective To compare iron bioavailability (Fe BV) from ten selected kinds of Chinese wheat flours in order to provide scientific basis for further human trials and enable plant breeding programs to screen biofortified wheat cultivars. Methods An in vitro digestion/Caco-2 cell model was used to assess Fe BV of ten flour samples from six leading Chinese wheat cultivars and the stability of Fe BV in one cultivar was studied across three growing environments. Results Significant differences were observed in both Fe BV and Fe bioavailability per gram of food (Fe BVPG) among cultivars (P<0.01) grown at the same location with the same flour extraction rate. Zhongyou 9507 and Jingdong 8 had Fe BV 37%-54% and Fe BVPG 103%-154% higher than the reference control. In the Anyang environment, Zhongyou 9507 had a higher wheat flour-Fe level and Fe BVPG. Differences in Fe BV were detected in cultivars with different flour extraction rates. Conclusion Zhongyou 9507 and Jingdong 8 were identified as the most promising cultivars for further evaluation of efficacy by using human subjects. The growing environments had no effect on Fe BV, but did have a significant effect on Fe BVPG. Fe bioavailabilities in low-extraction (40%) flours were higher than those in high-extraction (78%) flours. | LEI Ji ZHANG Yong CHEN Xiang Gui ZHANG Ming Qiu BAI Lin HUANG Cheng Yu Ortiz Monasterio IVAN | 2012 | Biomedical and Environmental Sciences2012，25，5： | 5 |
| 8 | Small intestinal bacterial overgrowth in inactive Crohn's disease:Influence of thiopurine and biological treatment显示文摘AIM:To investigate the influence of thiopurines and biological drugs on the presence of small intestinal bacterial overgrowth(SIBO) in patients with inactive Crohn's disease(CD).METHODS:This was a prospective study in patients with CD in remission and without corticosteroid treatment,included consecutively from 2004 to 2010.SIBO was investigated using the hydrogen glucose breath test.RESULTS:One hundred and seven patients with CD in remission were included.Almost 58%of patients used maintenance immunosuppressant therapy and 19.6%used biological therapy.The prevalence of SIBO was16.8%.No association was observed between SIBO and the use of thiopurine Immunosuppressant(12/62patients),administration of biological drugs(2/21 patients),or with double treatment with an anti-tumor necrosis factor drugs plus thiopurine(1/13 patients).Half of the patients had symptoms that were suggestive of SIBO,though meteorism was the only symptom that was significantly associated with the presence of SIBO on univariate analysis(P<0.05).Multivariate analysis revealed that the presence of meteorism and a fistulizing pattern were associated with the presence of SIBO(P<0.05).CONCLUSION:Immunosuppressants and/or biological drugs do not induce SIBO in inactive CD.Fistulizing disease pattern and meteorism are associated with SIBO. | Cristina Sánchez-Montes Vicente Ortiz Guillermo Bastida Ester Rodríguez María Yago Belén Beltrán Mariam Aguas Marisa Iborra Vicente Garrigues Julio Ponce Pilar Nos | 2014 | World Journal of Gastroenterology2014，20，38： | 4 |
| 9 | Mechanisms of chemotherapy resistance in ovarian cancer显示文摘Ovarian cancer is one of the most lethal gynecologic cancers.The standard therapy for ovarian cancer has been the same for the past two decades,a combination treatment of platinum with paclitaxel.Recently,the FDA approved three new therapeutic drugs,two poly(ADP-ribose)polymerase inhibitors(olaparib and niraparib)and one vascular endothelial growth factor inhibitor(bevacizumab)as maintenance therapies for ovarian cancer.In this review,we summarize the resistance mechanisms for conventional platinum-based chemotherapy and for the newly FDA-approved drugs. | Mylena Ortiz Emma Wabel Kerry Mitchell Sachi Horibata | 2022 | Cancer Drug Resistance2022，5，2： | 4 |
| 10 | 叶酸与甲酰四氢叶酸用于减少甲氨蝶呤治疗副作用(摘要)显示文摘1 背景 甲氨蝶呤用于治疗许多风湿病,其短期疗效已被证实。但毒性使不少患者不能从中受益,其中叶酸缺乏可增加其毒性。类风湿关节炎患者常有叶酸缺乏,经甲氨蝶呤治疗后叶酸储备就进一步减少。甲氨蝶呤的胃肠道和血液学副作用都与叶酸缺乏有关,可以预见,叶酸补充疗法将有助改善低剂量甲氨蝶呤治疗的副作用。对此,已有不少试验开展,并提出不同的副作用减少率。 | Ortiz Z SheaB Suarez Almazor M Moher D Wells G Tugwell P 姚如愚 | 2001 | 循证医学2001，1，1： | 4 |
| 11 | Pathogenesis of glomerular haematuria显示文摘Haematuria was known as a benign hallmark of some glomerular diseases, but over the last decade, new evidences pointed its negative implications on kidney disease progression. Cytotoxic effects of oxidative stress induced by hemoglobin, heme, or iron released from red blood cells may account for the tubular injury observed in human biopsy specimens. However, the precise mechanisms responsible for haematuria remain unclear. The presence of red blood cells(RBCs) with irregular contours and shape in the urine indicates RBCs egression from the glomerular capillary into the urinary space. Therefore glomerular haematuria may be a marker of glomerular filtration barrier dysfunction or damage. In this review we describe some key issues regarding epidemiology and pathogenesis of haematuric diseases as well as their renal morphological findings. | Claudia Yuste Eduardo Gutierrez Angel Manuel Sevillano Alfonso Rubio-Navarro Juan Manuel Amaro-Villalobos Alberto Ortiz Jesus Egido Manuel Praga Juan Antonio Moreno | 2015 | World Journal of Nephrology2015，4，2： | 3 |
| 12 | Integrating fossils in a molecular-based phylogeny and testing them as calibration points for divergence time estimates in Menispermaceae显示文摘The phylogeny of extant Menispermaceae (Ranunculales) is reconstructed based on DNA sequences of two chloroplast genes (rbcL and atpB) from 94 species belonging to 56 genera. Fossilized endocarps represent 34 genera. The positions of these are inferred using 30 morphological characters and the molecular phylogeny as a backbone constraint. Nine of the thirteen nodes that are each dated by a fossil are used as calibration points for the estimates of molecular divergence times. BEAST is used to estimate stem age (121.2 Myr) and crown age (105.4 Myr) for Menispermaceae. This method does not require an input tree topology and can also account for rate heterogeneity among lineages. The sensitivity of these estimates to fossil constraints is then evaluated by a cross-validation procedure. The estimated origin for Menispermaceae is dated to the mid-Jurassic if the customary maximum age of 125 Myr for eudicots is not implemented. All constraints when used alone failed to estimate node ages in some parts of the tree. Fossils from the Palaeocene and Eocene impose strict constraints. Likewise, the use of Prototinomiscium as a dating constraint for Menispermaceae appears to be a conservative approach. | Frederic M.B. JACQUES Wei WANG Rosa Del C. ORTIZ Hong-Lei LI Zhe-Kun ZHOU Zhi-Duan CHEN | 2011 | Journal of Systematics and Evolution2011，49，1： | 3 |
| 13 | High Helicobacter pylori Resistance to Metronidazole and Clarithromycin in Brazilian Children and Adolescents显示文摘 | Silvio K. Ogata Anita P. Ortiz Godoy Francy R. da Silva Patricio Elisabete Kawakami | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，6： | 3 |
| 14 | Can Biochar Protect Labile Organic Matter Against Mineralization in Soil?显示文摘Biochar could help to stabilize soil organic(SOM) matter, thus sequestering carbon(C) into the soil. The aim of this work was to determine an easy method i) to estimate the effects of the addition of biochar and nutrients on the organic matter(SOM)mineralization in an artificial soil, proposed by the Organization for Economic Co-operation and Development(OECD), amended with glucose and ii) to measure the amount of labile organic matter(glucose) that can be sorbed and thus be partially protected in the same soil, amended or not amended with biochar. A factorial experiment was designed to check the effects of three single factors(biochar, nutrients, and glucose) and their interactions on whole SOM mineralization. Soil samples were inoculated with a microbial inoculum and preincubated to ensure that their biological activities were not limited by a small amount of microbial biomass, and then they were incubated in the dark at 21℃ for 619 d. Periodical measurements of C mineralized to carbon dioxide(CO_2) were carried out throughout the 619-d incubation to allow the mineralization of both active and slow organic matter pools. The amount of sorbed glucose was calculated as the difference between the total and remaining amounts of glucose added in a soil extract. Two different models, the Freundlich and Langmuir models, were selected to assess the equilibrium isotherms of glucose sorption. The CO_2-C release strongly depended on the presence of nutrients only when no biochar was added to the soil. The mineralization of organic matter in the soil amended with both biochar and glucose was equal to the sum of the mineralization of the two C sources separately. Furthermore, a significant amount of glucose can be sorbed on the biochar-amended soil, suggesting the involvement of physico-chemical mechanisms in labile organic matter protection. | giovanna b.melas oriol ortiz josep m.alacaiz | 2017 | Pedosphere2017，27，5： | 3 |
| 15 | Affinity-Based Network Interfaces for Efficient Communication on Multicore Architectures显示文摘Improving the network interface performance is needed by the demand of applications with high communication requirements (for example, some multimedia, real-time, and high-performance computing applications), and the availability of network links providing multiple gigabits per second bandwidths that could require many processor cycles for communication tasks. Multicore architectures, the current trend in the microprocessor development to cope with the difficulties to further increase clock frequencies and microarchitecture efficiencies, provide new opportunities to exploit the parallelism available in the nodes for designing efficient communication architectures. Nevertheless, although present OS network stacks include multiple threads that make it possible to execute network tasks concurrently in the kernel, the implementations of packet-based or connection-based parallelism are not trivial as they have to take into account issues related with the cost of synchronization in the access to shared resources and the efficient use of caches. Therefore, a common trend in many recent researches on this topic is to assign network interrupts and the corresponding protocol and network application processing to the same core, as with this affinity scheduling it would be possible to reduce the contention for shared resources and the cache misses. In this paper we propose and analyze several configurations to distribute the network interface among the different cores available in the server. These alternatives have been devised according to the affinity of the corresponding communication tasks with the location (proximity to the memories where the different data structures are stored) and characteristics of the processing core. As this approach uses several cores to accelerate the communication path of a given connection, it can be seen as complementary to those that consider several cores to simultaneously process packets belonging to either the same or different connections. Message passing interface (MPI) workloads and dynamic web servers have been considered as applications to evaluate and compare the communication performance of these alternatives. In our experiments, performed by full-system simulation, improvements of up to 35% in the throughput and up to 23% in the latency have been observed in MPI workloads, and up to 100% in the throughput, up to 500% in the response time, and up to 82% in the requests attended per second have been measured in dynamic web servers. | Andrés Ortiz Julio Ortega Antonio F.Díaz Alberto Prieto | 2013 | Journal of Computer Science & Technology2013，28，3： | 3 |
| 16 | Laparoscopic versus open surgery for rectal cancer: results of a prospective multicentre analysis of 4,970 patients显示文摘 | J. Lujan G. Valero S. Biondo E. Espin P. Parrilla H. Ortiz | 2013 | Surgical Endoscopy2013，，1： | 3 |
| 17 | Surgical Treatment and Survival in Patients with Liver Metastases from Neuroendocrine Tumors: A Meta-Analysis of Observational Studies显示文摘 | Stefano Bacchetti Serena Bertozzi Ambrogio P. Londero Alessandro Uzzau Enrico Maria Pasqual Jorge Ortiz | 2013 | International Journal of Hepatology2013，，： | 3 |
| 18 | 从墨西哥经验看普惠金融显示文摘一、信息不对称导致了正规金融服务的供给不足普惠金融是当前促进经济增长和减少贫困的重要途径之一。据粗略统计,全球现有一半(约25亿)的成年人无法获得正规的金融服务。这一比例在高收入国家约为8%,在低收入国家更高。其中,非洲撒哈拉以南地区有80%的人口未获得正规金融服务,而东亚、南亚、 | Guillermo Ortiz 彭春辉 曹志鸿 | 2013 | 金融发展评论2013，，7： | 3 |
| 19 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 20 | Minimal hepatic encephalopathy: diagnosis, clinical significance and recommendations显示文摘 | María Ortiz Carlos Jacas Juan Córdoba | 2004 | Journal of Hepatology2004，，1： | 2 |
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