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| 1 | Comparative review of vertebroplasty and kyphoplasty显示文摘The aim of this review is to compare the effectiveness of percutaneous vertebroplasty and kyphoplasty to treat pain and improve functional outcome from ver-tebral fractures secondary to osteoporosis and tumor conditions. In 2009, two open randomized controlled trials published in the New England Journal of Medicine questioned the value of vertebroplasty in treating ver-tebral compression fractures. Nevertheless, the prac-tice of physicians treating these conditions has barely changed. The objective of this review is to try to clarify the most important issues, based on our own experi-ence and the reported evidence about both techniques, and to guide towards the most appropriate choice of treatment of vertebral fractures, although many ques-tions still remain unanswered. | Ferno Ruiz Santiago Alicia Santiago Chinchilla Luis Guzmán álvarez Antonio Luis Pérez Abela Maria del Mar Castellano García Miguel Pajares López | 2014 | World Journal of Radiology2014，6，6： | 30 |
| 2 | Recombinant streptokinase vs phenylephrine-based suppositories in acute hemorrhoids, randomized, controlled trial(THERESA-3)显示文摘AIM: To compare the efficacy and safety of recombinant streptokinase(rSK) and phenylephrine-based suppositories in acute hemorrhoidal disease.METHODS: A multicenter(14 sites), randomized(1:1), open, parallel groups, active controlled trial was done. After inclusion, subjects with acute symptoms of hemorrhoids, who gave their written, informed consent to participate, were centrally randomized to receive, as outpatients, rSK(200000 IU) or 0.25% phenylephrine suppositories, which had different organoleptic characteristics. Treatment was administered by the rectal route, one unit every 6 h during 48 h for rSK, and up to a maximum of 5 d(20 suppositories) for phenylephrine. Evaluations were performed at 3, 5 and 10 d postinclusion. The main end-point was the 5th-day complete clinical response(disappearance of pain and edema, and ≥ 70% reduction of the lesion size). Time to response and need for thrombectomy were secondary efficacy variables. Adverse events were evaluated too. RESULTS: 5thday complete response rates were 83/110(75.5%) and 36/110(32.7%) with rSK and phenylephrine suppositories, respectively. This 42.7% difference(95%CI: 30.5-54.2) was highly significant(P < 0.001). The advantage was detected since the early 3rdday evaluation(37.3% vs 6.4% for the rSK and active control groups, respectively; P < 0.001) and was kept even at the late 10thday assessment(83.6% vs 58.2% for rSK and phenylephrine, respectively; P < 0.001). Time for complete response was significantly shorter(P = 0.031; log-rank test) in the rSK group(median: 4.9 d; 95%CI: 4.8-5.0) with respect to the active control(median: 9.8 d; 95%CI: 9.8-10.0). Thrombectomy was necessary in 1/59 and 8/57 patients with baseline thrombosis in the rSK and phenylephrine groups, respectively(P = 0.016). There were no adverse events attributable to the experimental treatment. CONCLUSION: rSK suppositories showed a significant advantage over a widely used over-the-counter phen-ylephrine preparation for the treatment of acute hemorrhoidal illness, with an adequate safety profile. | Francisco Hernández-Bernal Georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-lvarez Roselin Valle-Cabrera Ana Aguilera-Barreto Pedro A López-Saura | 2014 | World Journal of Gastroenterology2014，20，6： | 4 |
| 3 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 4 | Conservative management of perforated duodenal diverticulum: A case report and review of the literature显示文摘Duodenal diverticula are a relatively common condition. They are asymptomatic, unless they become complicated, with perforation being the rarest but most severe complication. Surgical treatment is the most frequently performed approach. We report the case of a patient with a perforated duodenal diverticulum, which was diagnosed early and treated conservatively with antibiotics and percutaneous drainage of secondary retroperitoneal abscesses. We suggest this method could be an acceptable option for the management of similar cases, provided that the patient is in good general condition and without septic signs. | David Martínez-Cecilia Alvaro Arjona Sánchez Manuel Gómez álvarez Eva Torres Tordera Antonio Luque Molina Victor Valentí Azcárate Javier Briceo Delgado Francisco Javier Padillo Pedro López-Cillero Sebastián Rufián Pea | 2008 | World Journal of Gastroenterology2008，14，12： | 2 |
| 5 | Sensory, physical, chemical and microbiological changes in aquacultured meagre ( Argyrosomus regius ) fillets during ice storage显示文摘 | M.D. Hernández M.B. López A. álvarez E. Ferrandini B. García García M.D. Garrido | 2008 | Food Chemistry2008，，1： | 2 |
| 6 | Measurement and simulation of climate inside Almería-type greenhouses using computational fluid dynamics显示文摘 | Molina-Aiz F D Valera D L álvarez A J | 2004 | Agricultural and Forest Meteorology2004，125，： | 1 |
| 7 | Gut glucose metabolism in rainbow trout:implications in glucose homeostasis and glucosensing capacity显示文摘 | Polakof S lvarez R Soengas J L | 2010 | American Journal of Physiology-Regulatory Integrative and Comparative Physiology2010，299，1： | 1 |
| 8 | Sensory, physical, chemical and microbiological changes in aquacultured meagre ( Argyrosomus regius ) fillets during ice storage显示文摘 | M.D. Hernández M.B. López A. álvarez E. Ferrandini B. García García M.D. Garrido | 2008 | Food Chemistry2008，，1： | 1 |
| 9 | Repetitive control of tubular heat exchangers显示文摘 | A′LVAREZ J D YEBRA L J BERENGUEL M | 2007 | Journal of Process Control2007，17，9： | 1 |
| 10 | A study of oxy-coal combustion with steam addition and biomass blending by thermogravimetric analysis显示文摘 | Gil M V Riaza J (A)lvarez L | | 0，，01： | 1 |
| 11 | Meticillin-resistant Staphylococcus au-reus with a novel mecA homologue in human and bovinepopulations in the UK and Denmark:a descriptive study显示文摘 | García-ǒlvarez L | 2011 | Lancet Infect Dis2011，11，8： | 1 |
| 12 | Effect of the vent hole geometry and welding on the static strength of galvanized RHS K-joints by FEM and DOE显示文摘 | J.J. del Coz Díaz M.A. Serrano López C. López-Colina Pérez F.P. álvarez Rabanal | 2012 | Engineering Structures2012，，： | 1 |
| 13 | Nonlinear System Identification with Composite Relevance Vector Machines显示文摘 | Camps-Valls G Martínez-Ramón M Rojo-álvarez J L | 2007 | IEEE Signal Processing Letters2007，14，4： | 1 |
| 14 | The Effect of Market Orientation on Buyer - seller Relationship Satisfaction 显示文摘 | Sanzo M J Santos M L Va'zquez R A'lvarez LI | 2003 | Induslrial Marketing Management2003，32，4： | 1 |
| 15 | Application of aluminium toxicity indices to soils under various forest species显示文摘 | Lvarez E A Ferna ndez-Marcos M L Monterroso C | 2005 | Forest Ecology and Management2005，211，3： | 1 |
| 16 | Analytical approximate solutions for conservative nonlinear oscillators by modified ra- tional harmonic balance method 显示文摘 | BELENDEZ A GIMENO E LVAREZ M L | 2010 | International Journal of Computer Mathematics2010，87，7： | 1 |
| 17 | Genetic polymorphisms of tumour necrosis factor alpha ( TNF ‐α) promoter gene and response to TNF ‐α inhibitors in Spanish patients with inflammatory bowel disease显示文摘 | R. López‐Hernández M. Valdés J. A. Campillo P. Martínez‐Garcia H. Salama G. Salgado F. Boix M. R. Moya‐Quiles A. Minguela A. Sánchez‐Torres M. Miras A. Garcia F. Carballo M. R. álvarez‐López M. Muro | 2014 | Int J Immunogenet2014，，1： | 1 |
| 18 | A systematic review of microvascular invasion in hepatocellular carcinoma:diagnostic and prognostic variability显示文摘 | Rodríguez-Perálvarez M Luong TV Andreana L | 2013 | Annals Surg Oncolo2013，20，1： | 1 |
| 19 | Quality characteristics of pork burger added with albedo-fiber powder obtained from yellow passion fruit ( Passiflora edulis var. flavicarpa ) co-products显示文摘 | Jairo H. López-Vargas Juana Fernández-López José ángel Pérez-álvarez Manuel Viuda-Martos | 2014 | Meat Science2014，，2： | 1 |
| 20 | Comparison ofethinyl2estradiol p lus cyp roterone acetate versus metform in effects onclassic metabolic cardiovascular risk factors in w omen w ith thepolycystic ovary syndrome显示文摘 | L uque R M A lvarez B F B otella C J I | 2007 | J C lin EndocrinolM etab2007，92，24： | 1 |
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