|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Regulation of TGF-β signaling by Smad7显示文摘转变生长因素(TGF )- 是调整象细胞生长,区别, apoptosis,移植,细胞粘附,和免疫者那样的许多细胞的过程的多种的 cytokine 反应。在表明小径的听说得好的古典 TGF- , TGF- 激活经由它象 TRII 和 ALK5/TRI 那样的二房间表面受体发信号的 Smad,导致调停 Smad 的 transcriptional 规定。另外, TGF- 可以也激活象激活 mitogen 的蛋白质 kinase 一样的另外的发信号的小径, PI3K,等等。发信号 TGF- 细微地在不同层次被调整。包括 Smad6 和 Smad7,禁止的 Smads 是由否定反馈环发信号的 TGF-/bone 形态基因的蛋白质(BMP ) 的关键管理者。他们能与激活的类型形成稳定的建筑群我受体并且从而堵住 R-Smads,或成员 ubiquitin E3 ligases 的 phosphorylation 例如 Smurf1/2,导致激活的类型的 ubiquitination 和降级我受体。而且,这些禁止的 Smad 蛋白质也禁止由与 transcriptional 抑压者交往,或破坏 TGF 的形成在原子核发信号的 TGF-/BMP,例如 histone deacetylases, Hoxc-8,和 CtBP -- 导致的功能的 Smad-DNA 建筑群。Smad7 被不同刺激接着调整,包括 TGF- , IFN- , TNF- 象一样紫外并且 TPA,并且调停在 TGF- 之间的串音和另外的发信号的小径。Smad7 表示的解除管制与各种各样的人的疾病被联系了,例如织物纤维变性,煽动性的疾病以及 carcinogenesis。Smad7 的 Overexpression 被显示了反对 TGF -- 调停的纤维变性, carcinogenesis,和发炎,建议 Smad7 的一个治疗学的潜力治疗这些疾病。 | Xiaohua Yan Ziying Liu Yeguang Chen | 2009 | Acta Biochimica et Biophysica Sinica2009，41，4： | 42 |
| 2 | Origin of gray-green sandstone in ore bed of sandstone type uranium deposit in north Ordos Basin显示文摘Dongsheng sandstone-type uranium deposit is located in the northern part of Ordos Basin, occurring in the transitional zones between gray-green and gray sandstones of Jurassic Zhiluo Formation. Sandstones in oxidized zone of the ore bed look gray-green, being of unique signature and different from one of ordinary inter-layered oxidation zone of sandstone-type uranium deposits. The character and origin of gray-green sandstones are systematically studied through their petrology, mineralogy and geochemistry. It is pointed out that this color of sandstones is originated from secondary oil-gas reduction processes after paleo-oxidation, being due to acicular-leaf chlorite covering surfaces of the sandstone grains. To find out the origin of gray-green sandstone and recognize paleo-oxidation zones in the ore bed are of not only theoretical significance for understanding metallogenesis of this kind of sandstone-type uranium deposit, but also very importantly practical significance for prospecting for similar kind of sandstone-type uranium deposit. | LI ZiYing FANG XiHeng CHEN AnPing OU GuangXi XIAO XinJian SUN Ye LIU ChiYang WANG Yi | 2007 | Science China Earth Sciences2007，50，z2： | 20 |
| 3 | Origin and Superposition Metallogenic Model of the Sandstone-type Uranium Deposit in the Northeastern Ordos Basin,China显示文摘这份报纸从铀来源,移植和免职的方面在东北 Ordos 盆应付沙岩类型铀存款的 metallogenic 模特儿。一个重叠 metallogenic 模型与油气体减小和热改革的重叠由于复杂的铀矿化作用过程被建立了。 | LI Ziying CHEN Anping FANG Xiheng OU Guangxi XIA Yuliang SUN Ye | 2008 | Acta Geologica Sinica(English Edition)2008，82，4： | 19 |
| 4 | Numerical modeling of the anomalous post-rift subsidence in the Baiyun Sag,Pearl River Mouth Basin显示文摘The Baiyun Sag is the deepest sag in the Pearl River Mouth Basin in northern continental margin of South China Sea,with the maximum sediment thickness over 12.5 km above the basement including >6.5 km sediments above the 30 Ma breakup unconformity.According to the theoretical models for the rifted basins,the post-rift subsidence is driven solely by the thermal contraction and can be calculated as the function of the lithospheric stretching factor.A method combining the forward modeling and reverse backstripping was designed to estimate lithospheric stretching factor.Using the 2D forward modeling based on the flexural cantilever model,we simulated the multi-rifting process of the Baiyun Sag with constrain of the backstripped profiles.By doing this the lithospheric stretching factor was obtained,and then the theoretical post-rift subsidence was calculated.The calculated theoretical subsidence was much smaller than the observed subsidence given by backstripping.Along the 1530 line in the Baiyun Sag,the anomalous post-rift subsidence is over 2 km in the sag center,and varies slightly to the north and south edges of the sag.This suggests that the anomalous post-rift subsidence continues beyond the sag both in the continental shelf to the north and in the continental slope to the south.The sensitivity tests in the forward modeling process indicate that only the use of low-angle faults (≤13°) can we simulate the shape of the backstripped profile. | LIAO Jie ZHOU Di ZHAO ZhongXian ZHANG YunFan XU ZiYing | 2011 | Science China Earth Sciences2011，54，8： | 14 |
| 5 | Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome显示文摘The trillions of microorganisms in the gut microbiome have attracted much attention recently owing to their sophisticated and widespread impacts on numerous aspects of host pathophysiology.Remarkable progress in large-scale sequencing and mass spectrometry has increased our understanding of the influence of the microbiome and/or its metabolites on the onset and progression of extraintestinal cancers and the efficacy of cancer immunotherapy.Given the plasticity in microbial composition and function,microbial-based therapeutic interventions,including dietary modulation,prebiotics,and probiotics,as well as fecal microbial transplantation,potentially permit the development of novel strategies for cancer therapy to improve clinical outcomes.Herein,we summarize the latest evidence on the involvement of the gut microbiome in host immunity and metabolism,the effects of the microbiome on extraintestinal cancers and the immune response,and strategies to modulate the gut microbiome,and we discuss ongoing studies and future areas of research that deserve focused research efforts. | Ziying Zhang Haosheng Tang Peng Chen Hui Xie Yongguang Tao | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 11 |
| 6 | Outline of Uranium Resources Characteristics and Metallogenetic Regularity in China显示文摘Uranium,as one of twenty-six kinds of important minerals in China,is strategic resource and energy mineral,which has been thoroughly investigated in the project of National Potential Evaluation of Uranium Resource.During the implementation of this project,the authors summarized the metallogenic regularity of uranium resource in China systematically,through the researches of geological characteristics of uranium resource,uranium deposits type(genetic and prediction type),temporal and spatial distribution,and metallogenic series.Based on the investigation of present situation and progress in uranium exploration,this paper proposes the uranium deposits in China should be divided into 4 classes,9 types,21 subtypes in genetic,and 50 types in prediction;suggests to divide China into 29 uranium metallogenic belts and 20 uranium prospective area,and constructs 20uranium-polymetallic metallogenic series,through summarizing temporal and spatial distribution characteristics and metallogenic regularity of uranium deposits in China.The above research is beneficial to the comprehensive understanding of regional uranium metallogenic regularity,and will direct the uranium exploration in the future. | CAI Yuqi ZHANG Jindai LI Ziying GUO Qingyin SONG Jiye FAN Honghai LIU Wusheng QI Fucheng ZHANG Minglin | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 11 |
| 7 | Hyperthermic intraperitoneal chemotherapy for gastric cancer with peritoneal metastasis:A multicenter propensity scorematched cohort study显示文摘Objective:Systemic chemotherapy has limited efficacy in the treatment of peritoneal metastasis(PM)in gastric cancer(GC).Hyperthermic intraperitoneal chemotherapy(HIPEC)combined with complete cytoreductive surgery(CRS)has shown promising outcomes but remains controversial.The present study aimed to evaluate the safety and efficacy of HIPEC without CRS in GC patients with PM.Methods:This retrospective propensity score-matched multicenter cohort study included GC patients with PM treated with either chemotherapy alone(Cx group)or with HIPEC combined with chemotherapy(HIPEC-Cx group)in four Chinese high-volume gastric medical centers between 2010 and 2017.The primary outcomes were median survival time(MST)and 3-year overall survival(OS).Propensity score matching was performed to compensate for controlling potential confounding effects and selection bias.Results:Of 663 eligible patients,498 were matched.The MST in the Cx and HIPEC-Cx groups was 10.8 and 15.9 months,respectively[hazard ratio(HR)=0.71,95%confidence interval(95%CI),0.58-0.88;P=0.002].The 3-year OS rate was 10.1%(95%CI,5.4%-14.8%)and 18.4%(95%CI,12.3%-24.5%)in the Cx and HIPEC-Cx groups,respectively(P=0.017).The complication rates were comparable.The time to first flatus and length of hospital stay for patients undergoing HIPEC combined with chemotherapy was longer than that of chemotherapy alone(4.6±2.4 d vs.2.7±1.8 d,P<0.001;14.2±5.8 d vs.11.4±7.7 d,P<0.001),respectively.The median follow-up period was 33.2 months.Conclusions:Compared with standard systemic chemotherapy,HIPEC combined with chemotherapy revealed a statistically significant survival benefit for GC patients with PM,without compromising patient safety. | Ziying Lei Jiahong Wang Zhi Li Baozhong Li Jiali Luo Xuejun Wang Jin Wang MingchenBa Hongsheng Tang Qingjun He Quanxing Liao Xiansheng Yang Tianpei Guan Han Liang Shuzhong Cui | 2020 | Chinese Journal of Cancer Research2020，32，6： | 11 |
| 8 | Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer显示文摘5-methylcytosine (5mC ) 和它的氧化形式 5-hydroxymethylcytosine (5hmC ) 被建议了涉及 tumorigenesis。因为印射方法的广泛地使用的 5mC 的读出,定序的重亚硫酸盐(BS-seq ) ,是 5mC 的和, 5hmC 层次, 5mC/5hmC 模式和这二修正的关系仍然保持糟糕理解。由介绍真实 5mC (BS-seq 由帮助 Tet 的 BS-seq 改正了, TAB-seq ) 并且 5hmC (TAB-seq ) 在单个核苷酸的分辨率同时铺平,我们这里证明与匹配的正常纸巾相比没有在肾肿瘤的 5mC 的全球损失。相反地, 5hmC 全球性被失去在几乎所有肾肿瘤纸巾。在肿瘤纸巾的 5hmC 水平是为肾癌症的一个独立预示的标记,与与更短的全面幸存联系的 5hmC 的底层。而且,我们证明 5hmC 的损失与匹配的正常纸巾相比在肿瘤被连接到 hypermethylation,特别地在基因身体区域。惊人地,基因身体 hypermethylation 显著地与肿瘤相关的基因的 silencing 被联系。IDH1 的 Downregulation 作为在肾癌症位于 5hmC 损失下面的机制被识别。恢复 5hmC 层次稀释了肿瘤房间的侵略能力并且在一个异种皮移植模型压制了肿瘤生长。一起,我们的结果证明 5hmC 的损失在由改变 DNA methylation 模式的肾癌症是一个预示的标记和一个 oncogenic 事件。 | Ke Chen Jing Zhang Zhongqiang Guo Qin Ma Zhengzheng Xu Yuanyuan Zhou Ziying Xu Zhongwu Li Xiongjun- Ye Xuesong Li Bifeng Yuan Yuwen Ke Chuan He Liqun Zhou Jiang Liu WeiminCi | 2016 | Cell Research2016，26，1： | 10 |
| 9 | Deep Reinforcement Learning-Based Computation Offloading for 5G Vehicle-Aware Multi-Access Edge Computing Network显示文摘Multi-access Edge Computing(MEC)is one of the key technologies of the future 5G network.By deploying edge computing centers at the edge of wireless access network,the computation tasks can be offloaded to edge servers rather than the remote cloud server to meet the requirements of 5G low-latency and high-reliability application scenarios.Meanwhile,with the development of IOV(Internet of Vehicles)technology,various delay-sensitive and compute-intensive in-vehicle applications continue to appear.Compared with traditional Internet business,these computation tasks have higher processing priority and lower delay requirements.In this paper,we design a 5G-based vehicle-aware Multi-access Edge Computing network(VAMECN)and propose a joint optimization problem of minimizing total system cost.In view of the problem,a deep reinforcement learningbased joint computation offloading and task migration optimization(JCOTM)algorithm is proposed,considering the influences of multiple factors such as concurrent multiple computation tasks,system computing resources distribution,and network communication bandwidth.And,the mixed integer nonlinear programming problem is described as a Markov Decision Process.Experiments show that our proposed algorithm can effectively reduce task processing delay and equipment energy consumption,optimize computing offloading and resource allocation schemes,and improve system resource utilization,compared with other computing offloading policies. | Ziying Wu Danfeng Yan | 2021 | China Communications2021，18，11： | 9 |
| 10 | The Discovery of Natural Native Uranium and Its Significance显示文摘This study analyzed the composition and uranium valence of pitchblendes sampled from the hydrothermal Guidong and Zhuguang uranium deposits of the middle Nanling metallogenic belt, Southern China using X-ray photoelectron spectroscopy(XPS).A revolutionary discovery is that the uranium not only exists in the forms of tetravalent and hexavalent uranium oxides, but also occurs in the form of native uranium.This is the first discovery of the existence of native uranium in nature.It greatly helps to reveal the origin of hydrothermal mineralization of uranium, and also has great significance for studying the thermal energy, formation and evolution of the earth. | LI Ziying HUANG Zhizhang LI Xiuzhen GUO Jian FAN Chou | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 8 |
| 11 | Bottom water temperature measurements in the South China Sea,eastern Indian Ocean and western Pacific Ocean显示文摘文章报道了一批新的海底底水温度(BWT)数据,其中南海(SCS)158个站位、东印度洋(EIO)30个站位及西太平洋(WPO)37个站位。基于这批新的BWT数据,获得南海和西太平洋海域底水温度与水深经验关系,可为地球物理和物理海洋提供准确、可靠的海底温度边界。这将有助于海底油气资源调查与评估。同时,这批实测数据表明:1)水深超过3500m的海域,其底水温度在南海约为2.47℃,比东印度洋(~1.34℃)和西太平洋(~1.60℃)稍微偏高。这与大洋传送带模式所预测的情况比较吻合。该模式认为:低温高盐的海水,从北大西洋格陵兰岛和冰岛附近海域下沉到深层,然后向南流动,再与南极洲周围海域的低温高盐海水一同向北进入印度洋和太平洋。而南海是一个相对比较封闭的热带边缘海,其内部海水与印度洋和菲律宾海交换有限,导致海水温度整体高于印度洋和太平洋。2)台西南盆地水深在2700~3000m的部分站位,其底水温高达约3.00℃,明显高于其周边同水深海域底水温度(平均值约为2.33℃)。这可能是台西南盆地海底水热活动导致的结果。3)在东印度洋和西太平洋水深超过4800m海域,底水温度随着水压增大稍有升高,其升高率分别为10.6mK·MPa^(-1)和12.0mK·MPa^(-1)。这与理论估算的深层底水绝热压力温度梯度范围较为吻合。这也意味着东印度洋和西太平洋深层底水,主要由绝热自压作用导致其温度随着深度的增大而升高。 | YANG Xiaoqiu SHI Xiaobin ZHAO Junfeng YU Chuanhai GAO Hongfang CHEN Aihua LU Yuanzheng CEN Xianrong LIN Weiren ZENG Xin XU Hehua REN Ziqiang ZHOU Shengqi XU Ziying SUN Jinlong KAMIYA Nana LIN Jian | 2018 | 热带海洋学报2018，37，5： | 8 |
| 12 | Timing of transplantation of autologous bone marrow derived mesenchymal stem cells for treating myocardial infarction显示文摘It is still unclear whether the timing of intracoronary stem cell therapy affects the therapeutic response in patients with myocardial infarction.The natural course of healing the infarction and the presence of putative homing signals within the damaged myocardium appear to favor cell engraftment during the transendothelial passage in the early days after reperfusion.However,the adverse inflammatory environment,with its high oxidative stress,might be deleterious if cells are administered too early after reperfusion.Here we highlight several aspects of the timing of intracoronary stem cell therapy.Our results showed that transplantation of bone marrow mesenchymal stem cells at 2 4 weeks after myocardial infarction is more favorable for reduction of the scar area,inhibition of left ventricular remodeling,and recovery of heart function.Coronary injection of autologous bone marrow mesenchymal stem cells at 2 4 weeks after acute myocardial infarction is safe and does not increase the incidence of complications. | CHEN YiHuan TENG XiaoMei CHEN WeiQian YANG JunJie YANG ZiYing YU YunSheng SHEN ZhenYa | 2014 | Science China(Life Sciences)2014，57，2： | 7 |
| 13 | Long-term trends in fog and boundary layer characteristics in Tianjin,China显示文摘Long-term trends in fog episodes,vertical variations of atmospheric boundary structure,and air pollutant concentrations during two different heavy fog events in the Tianjin area were analyzed.The total amount of fog has increased since 1980 due to the stability of the boundary layer and an increase of pollutant emissions.The variation in the characteristics of the boundary layer and air pollutant concentrations were significantly different between the two fog processes(fog 1 and fog II).The onset of fog I was accompanied by a temperature inversion in the low atmosphere,and the average kinetic energy showed a clear diurnal trend and vertical variation,which increased with height.The dissipation of fog I was mainly due to turbulence.However,the atmospheric stratification was not stable in the lower layer before the onset of fog II.The diurnal and vertical changes in kinetic energy were very small,in which turbulent momentum at each measurement height tended to be zero.In the dissipation process of fog II,wind speed increased significantly.Surface PM_(2.)5 concentrations decreased,but the ratio of PM_(2.5) to PM_(10)increased from 0.66 to 0.82 until fog I dissipated.However,the concentration of PM2.5 did not decrease at the early stage of fog II,but the ratio of PM_(2.5) to PM_(10) PM_(2.5)/PM_(10) decreased to 0.21 when fog II dissipated.This study showed that there was a clear difference in the evolution of pollutant concentration for different pollutants and in different developing stages during the fog events.PM2.5 concentration accumulated faster than those of SO_2 and NO_x,and the PM_(2.5) cumulative rate was greater in the mid-term of the fog process. | Suqin Han Ziying Cai Yufen Zhang Jiao Wang Qing Yao Peiyan Li Xiangjin Li | 2015 | Particuology2015，13，3： | 7 |
| 14 | Effects of erythropoietin on the expression of tumor necrosis factor-alpha and Bax after facial nerve axotomy in rats显示文摘This study sought to evaluate the effect of high-dose erythropoietin (EPO;5 000 IU/kg) on the expression of tumor necrosis factor-alpha (TNF-α) and Bax in the facial nucleus after facial nerve transection in rats.A total of 42 Wistar rats of both genders were used in this study,and 40 rats were randomly divided into 2 groups:EPO group and model group.The EPO group was treated with EPO once a day for 5 days at a dose of 5 000 IU/kg body weight.The model group was treated with saline of the same amount.At day 3 after EPO (or saline) treatment,the right facial nerves of the 40 rats were transected at the level of the stylomastoid foramen,with the left sides untreated.The remaining 2 rats that did not undergo axotomy served as the control group.The surviving motor neurons in operated rats were counted in coronal paraffin sections of the facial nucleus.The expression of TNF-α and Bax in the facial nucleus was detected by immunohistochemical staining at days 3,7,14,21,and 28 after axotomy.At days 14,21,and 28 after facial nerve axotomy,a significantly greater proportion of facial motor neurons survived in the EPO group than in the model group.After axotomy,the expression of TNF-α and Bax increased in motor neurons in both the EPO and the model groups.TNF-α expression reached its peak level at day 14 after axotomy,while Bax expression reached its peak level at day 21.TNF-α expression was much lower in the EPO group than in the model group at all time points.No significant difference in Bax expression was found between the EPO and the model groups.These results indicate that high-dose EPO treatment attenuates the increase in TNF-α expression in the facial nucleus and reduces the loss of motor neurons after facial nerve transection in rats.However,high-dose EPO treatment has little effect on Bax expression. | Wei Zhang Shengyu Lue Ziying Yu Ming Bi Bin Sun | 2011 | Neural Regeneration Research2011，6，6： | 6 |
| 15 | Platelet-rich plasma combined with injectable hyaluronic acid hydrogel for porcine cartilage regeneration: a 6-month follow-up显示文摘Based on our previous study,the utilization of an ultraviolet light photo-cross-linkable hyaluronic acid(HA)hydrogel integrated with a small molecule kartogenin-encapsulated nanoparticles obtained good reconstruction of osteochondral defects in a rabbit model,indicating the superiority of injectable hydrogel-based scaffolds in cartilage tissue engineering.Platelet-rich plasma(PRP),rich in various growth factors,proteins and cytokines,is considered to facilitate cartilage healing by stimulating cell proliferation and inducing chondrogenesis in cartilage defect site.The aim of this study was to test the therapeutic feasibility of autologous PRP combined with injectable HA hydrogel on cartilage repair.The focal cartilage defects with different critical sizes in the medial femoral condyle of a porcine model were used.At 6 months,the minipigs were sacrificed for assessment of macroscopic appearance,magnetic resonance imaging,micro-computed tomography,histology staining and biomechanics.The HA hydrogel combined with PRP-treated group showed more hyaline-like cartilage exhibited by macroscopic appearance and histological staining in terms of extracellular matrix and type II collagen without formation of hypertrophic cartilage,indicating its capacity to improve cartilage healing in the minipig model evaluated at 6 months,with full-thickness cartilage defect of 8.5mm diameter and osteochondral defect of 6.5mm diameter,5mm depth exhibiting apparent regeneration. | Wenqiang Yan Xingquan Xu Qian Xu Ziying Sun Qing Jiang Dongquan Shi | 2020 | Regenerative Biomaterials2020，7，1： | 6 |
| 16 | Degradation of lipid droplets by chimeric autophagy-tethering compounds显示文摘Degrading pathogenic proteins by degrader technologies such as PROTACs(proteolysis-targeting chimeras)provides promising therapeutic strategies,but selective degradation of non-protein pathogenic biomolecules has been challenging. | Yuhua Fu Ningxie Chen Ziying Wang Shouqing Luo Yu Ding Boxun Lu | 2021 | Cell Research2021，31，9： | 5 |
| 17 | s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand-foot skin reaction that can be reversed by nicotinamide显示文摘Hand-foot skin reaction(HFSR),among the most significant adverse effects of sorafenib,has been limiting the clinical benefits of this frontline drug in treating various malignant tumors.The mechanism underlying such toxicity remains poorly understood,hence the absence of effective intervention strategies.In the present study,we show that vascular endothelial cells are the primary cellular target of sorafenib-induced HFSR wherein soluble heparin-binding epidermal growth factor(s-HBEGF)mediates the crosstalk between vascular endothelial cells and keratinocytes.Mechanistically,s-HBEGF released from vascular endothelial cells activates the epidermal growth factor receptor(EGFR)on keratinocytes and promotes the phosphorylation of c-Jun N-terminal kinase 2(JNK2),which stabilizes sirtuin 1(SIRT1),an essential keratinization inducer,and ultimately gives rise to HFSR.The administration of s-HBEGF in vivo could sufficiently induce hyper-keratinization without sorafenib treatment.Furthermore,we report that HBEGF neutralization antibody,Sirtl knockdown,and a classic SIRTI inhibitor nicotinamide could all significantly reduce the sorafenib-induced HFSR in the mouse model.It is noteworthy that nicotinic acid,a prodrug of nicotinamide,could substantially reverse the sorafenib-induced HFSR in ten patients in a preliminary clinical study.Collectively,our findings reveal the mechanism of vascular endothelial cell-promoted keratinization in keratinocytes and provide a potentially promising therapeutic strategy for the treatment of sorafenib-induced HFSR. | Peihua Luo Hao Yan Xueqin Chen Ying Zhang Ziying Zhao Ji Cao Yi Zhu Jiangxia Du Zhifei Xu Xiaochen Zhang Su Zeng Bo Yang Shenglin Ma Qiaojun He | 2020 | Cell Research2020，30，9： | 5 |
| 18 | A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer显示文摘Objective:To compare the efficacy and safety of hyperthermic intravesical chemotherapy(HIVEC)and intravesical chemotherapy(IVEC)in patients with intermediate and high risk nonmuscle-invasive bladder cancer(NMIBC)after transurethral resection.Methods:We included 560 patients diagnosed with primary or recurrent NMIBC between April 2009 and December 2015 at 1 of 6 tertiary centers.We matched 364 intermediate or high risk cases and divided them into 2 groups:the HIVEC+IVEC group[chemohyperthermia(CHT)composed of 3 consecutive sessions followed by intravesical instillation without hyperthermia]and the IVEC group(intravesical instillation without hyperthermia).The data were recorded in the database.The primary endpoint was 2-year recurrence-free survival(RFS)in all NMIBC patients(n=364),whereas the secondary endpoints were the assessment of radical cystectomy(RC)and 5-year overall survival(OS).Results:There was a significant difference in the 2-year RFS between the two groups in all patients(n=364;HIVEC+IVEC:82.42%vs.IVEC:74.18%,P=0.038).Compared with the IVEC group,the HIVEC+IVEC group had a lower incidence of RC(P=0.0274).However,the 5-year OS was the same between the 2 groups(P=0.1434).Adverse events(AEs)occurred in 32.7%of all patients,but none of the events was serious(grades 3–4).No difference in the incidence or severity of AEs between each treatment modality was observed.Conclusions:This retrospective study showed that HIVEC+IVEC had a higher 2-year RFS and a lower incidence of RC than IVEC therapy in intermediate and high risk NMIBC patients.Both treatments were well-tolerated in a similar manner. | Qiang Ruan Degang Ding Bin Wang Chaohong He Xuequn Ren Zhenhua Feng Zhigang Pang Jin Wang Xiangliang Zhang Hongsheng Tang Jiahong Wang Qingjun He Ziying Lei Quanxing Liao Jiali Luo Shuzhong Cui | 2021 | Cancer Biology & Medicine2021，18，1： | 4 |
| 19 | Microbial electro-fermentation for synthesis of chemicals and biofuels driven by bi-directional extracellular electron transfer显示文摘Electroactive bacteria could perform bi-directional extracellular electron transfer(EET)to exchange electrons and energy with extracellular environments,thus playing a central role in microbial electro-fermentation(EF)process.Unbalanced fermentation and microbial electrosynthesis are the main pathways to produce value-added chemicals and biofuels.However,the low efficiency of the bi-directional EET is a dominating bottleneck in these processes.In this review,we firstly demonstrate the main bi-directional EET mechanisms during EF,including the direct EET and the shuttle-mediated EET.Then,we review representative milestones and progresses in unbalanced fermentation via anode outward EET and microbial electrosynthesis via inward EET based on these two EET mechanisms in detail.Furthermore,we summarize the main synthetic biology strategies in improving the bi-directional EET and target products synthesis,thus to enhance the efficiencies in unbalanced fermentation and microbial electrosynthesis.Lastly,a perspective on the applications of microbial electro-fermentation is provided. | Ziying Gong Huan Yu Junqi Zhang Feng Li Hao Song | 2020 | Synthetic and Systems Biotechnology2020，5，4： | 4 |
| 20 | Uranium Metallogenic Regionalization and Resource Potential in China显示文摘This paper is comprehensively involved in main types of uranium deposits and their general metallogenic characteristics, metallogenic fields, provinces, regions and belts, and uranium resources potential evaluation. Generally speaking, there are favorable conditions and good uranium resources potential for uranium mineralization in China. | LI Ziying ZHANG Jindai JIAN Xiaofei CAI Yuqi GUO Qingyin ZHU Pengfei | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员