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| 1 | Inversion for the sea bottom acoustic parameters by using the group time delays and amplitude of normal mode显示文摘The group time delays and amplitudes of the normal mode are derived using the normal mode filter. The sea bottom sound speed, density and attenuation are inversely deduced by matching the group time delays and the amplitude of the normal mode. A genetic algorithm (GA) is used for optimization search in the parameter space. The inverted attenuation has the nonlinear frequency relationship a = 0.29f1.91 dB/m (the unit of frequency is kHz) in the frequency range 200 - 500 Hz. The theoretical transmission loss calculated using the deduced parameters matches the experiment data very well. | LI Zhenglin YAN Jin LI Fenghua GUO Lianghao(National Laboratory of Acoustics, Institute of Acoustics, Chinese Academy of Sciences Beijing 100080) | 2003 | Chinese Journal of Acoustics2003，22，2： | 15 |
| 2 | Bayesian localization in an uncertain ocean environment显示文摘In order to improve the ability to localize a source in an uncertain acoustic environment,a Bayesian approach,referred to here as Bayesian localization is used by including the environment in the parameter search space.Genetic algorithms are used for the parameter optimization.This method integrates the a posterior probability density(PPD) over environmental parameters to obtain a sequence of marginal probability distributions over source range and depth,from which the most-probable source location and localization uncertainties can be extracted.Considering that the seabed density and attenuation are less sensitive to the objective function of matched field processing,we utilize the empirical relationship to invert those parameters indirectly.The broadband signals recorded by a vertical line array in a Yellow Sea experiment in 2000 are processed and analyzed.It was found that,the Bayesian localization method that incorporates the environmental variability into the processor,made it robust to the uncertainty in the ocean environment.In addition,using the empirical relationship could enhance the localization accuracy. | LI Qianqian LI Zhenglin ZHANG Renhe | 2016 | Chinese Journal of Acoustics2016，35，1： | 8 |
| 3 | Detection of serum IgM and IgG for COVID-19 diagnosis显示文摘Dear Editor,Infection with the novel coronavirus(SARS-CoV-2,which is the virus responsible for the coronavirus disease 2019(COVID-19))was first reported in Wuhan,China on December 31,2019.The outbreak of COVID-19 remains ongoing and was linked to more than 80,000 infected patients and more than 3,000 deaths in China as of March 7,2020(Holshue et al.,2020). | Ling Zhong Junlan Chuan Bo Gong Ping Shuai Yu Zhou Yi Zhang Zhilin Jiang Dingding Zhang Xiaoqi Liu Shi Ma Yi Huang He Lin Qingwei Wang Lulin Huang Dan Jiang Fang Hao Juan Tang Chunqi Zheng Hua Yu Zhibin Wang Qi Jiang Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Jianghai Liu Junxi Tian Yu Xu Tengxiang Long Kaiju Xu Xingxiang Yang Yuping Liu Yi Shi Li Jiang Zhenglin Yang | 2020 | Science China(Life Sciences)2020，63，5： | 8 |
| 4 | Hydrogen sulfide, a signaling molecule in plant stress responses显示文摘Gaseous molecules, such as hydrogen sulfide(H_2S)and nitric oxide(NO), are crucial players in cellular and(patho)physiological processes in biological systems. The biological functions of these gaseous molecules, which were first discovered and identified as gasotransmitters in animals, have received unprecedented attention from plant scientists in recent decades. Researchers have arrived at the consensus that H_2S is synthesized endogenously and serves as a signaling molecule throughout the plant life cycle.However, the mechanisms of H_2S action in redox biology is still largely unexplored. This review highlights what we currently know about the characteristics and biosynthesis of H_2S in plants. Additionally,we summarize the role of H_2S in plant resistance to abiotic stress. Moreover, we propose and discuss possible redox-dependent mechanisms by which H_2S regulates plant physiology. | Jing Zhang Mingjian Zhou Heng Zhou Didi Zhao Cecilia Gotor Luis CRomero Jie Shen Zhenglin Ge Zhirong Zhang Wenbiao Shen Xingxing Yuan Yanjie Xie | 2021 | Journal of Integrative Plant Biology2021，63，1： | 8 |
| 5 | The origin, diversification and adaptation of a major mangrove clade (Rhizophoreae) revealed by whole-genome sequencing显示文摘Mangroves invade some very marginal habitats for woody plants—at the interface between land and sea.Since mangroves anchor tropical coastal communities globally, their origin, diversification and adaptation are of scientific significance, particularly at a time of global climate change. In this study, a combination of single-molecule long reads and the more conventional short reads are generated from Rhizophora apiculata for the de novo assembly of its genome to a near chromosome level. The longest scaffold, N50 and N90 for the R. apiculata genome, are 13.3 Mb, 5.4 Mb and 1.0 Mb, respectively. Short reads for the genomes and transcriptomes of eight related species are also generated. We find that the ancestor of Rhizophoreae experienced a whole-genome duplication ~70 Myrs ago, which is followed rather quickly by colonization and species diversification. Mangroves exhibit pan-exome modifications of amino acid(AA) usage as well as unusual AA substitutions among closely related species. The usage and substitution of AAs, unique among plants surveyed, is correlated with the rapid evolution of proteins in mangroves. A small subset of these substitutions is associated with mangroves' highly specialized traits(vivipary and red bark) thought to be adaptive in the intertidal habitats. Despite the many adaptive features, mangroves are among the least genetically diverse plants, likely the result of continual habitat turnovers caused by repeated rises and falls of sea level in the geologically recent past. Mangrove genomes thus inform about their past evolutionary success as well as portend a possibly difficult future. | Shaohua Xu Ziwen He Zhang Zhang Zixiao Guo Wuxia Guo Haomin Lyu Jianfang Li Ming Yang Zhenglin Du Yelin Huang Renchao Zhou Cairong Zhong David E. Boufford Manuel Lerdau Chung-I Wu Norman C. Duke Suhua Shi | 2017 | National Science Review2017，4，5： | 7 |
| 6 | A modified warping operator based on BDRM theory in homogeneous shallow water显示文摘In this paper,a modified warping operator for homogeneous shallow water based on the Beam-Displacement Ray-Mode(BDRM)theory is presented.According to the BDRM theory,the contribution of the beam displacement and the time delay to the group velocity can be easily considered in a shallow water waveguide.A more accurate dispersion formula is derived by using the cycle distance formula to calculate the group velocity of normal modes.The derived dispersion formula can be applied to the homogeneous shallow water waveguide.Theoretically,the formula is related to the phase of the reflection coefficient and suitable for various bottom models.Furthermore,based on the derived dispersion relation,the modified warping operator is developed to obtain linear modal structures.For the Pekeris model,the formulae for the phase of the reflection coefficient are derived in this work.By taking account of the effect of the bottom attenuation on the reflection coefficient,the formula for the phase of the reflection coefficient including the bottom attenuation is obtained for the Pekeris model with a lossy bottom.Performance and accuracy of different formulae are evaluated and compared.The numerical simulations indicate that the derived dispersion formulae and the modified warping operator are more accurate. | NIU HaiQiang ZHANG RenHe LI ZhengLin | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，3： | 6 |
| 7 | Genetic analysis and molecular mapping of a novel gene for zebra mutation in rice (Oryza sativa L.)显示文摘A novel zebra mutant,zebra-15,derived from the restorer line Jinhui10(Oryza sativa L. ssp. indica) treated by EMS,displayed a distinctive zebra leaf from seedling stage to jointing stage. Its chlorophyll content decreased(55.4%) and the ratio of Chla/Chlb increased(90.2%) significantly in the yellow part of the zebra-15,compared with the wild type. Net photosynthetic rate and fluorescence kinetic parameters showed that the decrease of chlorophyll content significantly influenced the photosynthetic efficiency of the mutant. Genetic analysis of F2 segregation populations derived from the cross of Xinong1A and zebra-15 indicated that the zebra leaf trait is controlled by a single recessive nuclear gene. Ninety-eight out of four hundred and eighty pairs of SSR markers showed the diversity between the Xinong1A and the zebra-15,their F2 population was then used for gene mapping. Zebra-15(Z-15) gene was primarily restricted on the short arm of chromosome 5 by 150 F2 recessive individuals,19.6 cM from marker RM3322 and 6.0 cM from marker RM6082. Thirty-six SSR markers were newly designed in the restricted location,and the Z-15 was finally located between markers nSSR516 and nSSR502 with the physical region 258 kb by using 1,054 F2 recessive individuals. | Qiushi Wang,Xianchun Sang,Yinghua Ling,Fangming Zhao,Zhenglin Yang,Yunfeng Li,Guanghua He Key Laboratory of Biotechnology and Crop Quality Improvement,Ministry of Agriculture Rice Research Institute,Southwest University,Chongqing 400716,China | 2009 | Journal of Genetics and Genomics2009，36，11： | 5 |
| 8 | Arrival time fluctuation of higher order normal modes caused by solitary internal waves显示文摘The sensitivities of the normal modes arrival time to solitary internal waves(IWs) are analyzed by using the SW06 environments.Simulation results show that the arrival time of mode 1 is relatively stable.But,there are some higher-order normal modes which arrive earlier than mode 1,and fluctuate with the appearance of solitary IWs.Explanation of the phenomenon is given based on ray theory.It is shown that,when thermocline falls down to some depths,those higher-order modes with a group of definite grazing angles mainly propagate above the thermocline and arrive earlier. | LI Zhenglin ZHANG Renhe Mohsen Badiey Jing Luo | 2013 | Chinese Journal of Acoustics2013，32，2： | 5 |
| 9 | An oscillation phenomenon of low frequency reverberation in the shallow water and its physical explanation显示文摘An oscillation phenomenon of the low frequency reverberation intensity was observed in several shallow water reverberation experiments. This phenomenon cannot be explained by the widely used incoherent reverberation theory. In this paper, to explain the observed oscillation phenomenon, a normal mode based coherent reverberation theory is presented. The theoretical analysis and numerical results show that modal interference can cause the regular oscillation phenomenon of the low frequency reverberation intensity, and the oscillation frequency is determined by the normal mode eigen-values. A new method to estimate the bottom sound speed based on the oscillation frequency of reverberation intensity was presented in this paper. The experimental results at three different sites indicate that the bottom sound speed estimated from the oscillation frequency of reverberation intensity agrees with that inverted from Matched Field Processing (MFP) well. | LI Fenghua LIU Jianjun LI Zhenglin ZHANG Renhe | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，4： | 5 |
| 10 | Anomalous sound propagation due to the horizontal variation of seabed acoustic properties显示文摘The sound propagation in shallow water is greatly influenced by the acoustic properties of seabed. An anomalous transmission loss was observed in an experiment, and a range dependent bottom model with horizontal variation of seabed acoustic property is proposed and could be well used to explain the anomalous phenomena. It is shown that the horizontal variation of bottom properties has a great effect on underwater sound propagation, and it should be given much attention in sound propagation and geoacoustic inversion problems. | LI Zhenglin ZHANG Renhe PENG Zhaohui LI Xilu | 2004 | Science China(Physics,Mechanics & Astronomy)2004，47，5： | 5 |
| 11 | Effects of sediment parameters on the low frequency acoustic wave propagation in shallow water显示文摘The integral expression for acoustic field due to a point source in shallow waterwhile sediment is either a liquid or a solid is derived. The synthetic full waveforms are simulatedusing real axis integration and FFF method. The effects of the seabed sediment parametersand center frequency of the source on the low frequency acoustic wave propagation in shallowwater are investigated. The conclusion is that the wave groups received in far field are thoseof the mode waves of the source center frequency. The possibility for inversely deducing thecompressional and shear sound speeds of sediment using the least square optimum through themeasured group velocities of a selected mode at different frequencies is discussed. | LI Zhenglin WANG Yaojun(The State Key Laboratory of Modern Acoustics, Nanjing University Nanjing 210093)MA Li GAO Tianfu(Institute of Acoustics, Academia Silica Beijing 100080) | 2000 | Chinese Journal of Acoustics2000，19，3： | 5 |
| 12 | Microelectronics-embedded channel bridging and signal regeneration of injured spinal cords显示文摘Due to the dificulty in spinal cord regeneration with biological methods,the microelectronic neural bridge,a new concept based on microelectronic technology,is presented.The microelectronic system has been realized in the forms of hybrid and integrated circuits.The integrated circuits forneural signal detection,stimulation,and regeneration are realized in a CMOS process.In animal experiments with 100 toads,48 rats,and 3 rabbits,nerve signals have been successfully detected from spinal cords and sciatic nerves,and functional electrical stimulation has been carried out for spinal cords and sciatic nerves.When the microelectronic system is bridged between the controlling and stimulated nerve,the relevant motion of legs and nerve signal waveforms,which are stimulated by the evoked or spontaneous nerve signal through such a system,have been observed.Therefore,the feasibility of the presented method was demonstrated. | Zhigong Wang Xiaosong Gu Xiaoying Lǔ Zhenglin Jiang Wenyuan Li Guangming Lǔ Yufeng Wang Xiaoyan Shen Xintai Zhao Huiling Wang Zhenyu Zhang Hongmei Shen Yang Wu Weixing Shen Jingyang Zhang Dong Chen Xiaoyi Mao Huaxiang Shen | 2009 | Progress in Natural Science:Materials International2009，19，10： | 5 |
| 13 | Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome显示文摘To unravel the genetic mechanisms of disease and physiological traits,it requires comprehensive sequencing analysis of large sample size in Chinese populations.Here,we report the primary results of the Chinese Academy of Sciences Precision Medicine Initiative(CASPMI)project launched by the Chinese Academy of Sciences,including the de novo assembly of a northern Han reference genome(NH1.0)and whole genome analyses of 597 healthy people coming from most areas in China.Given the two existing reference genomes for Han Chinese(YH and HX1)were both from the south,we constructed NH1.0,a new reference genome from a northern individual,by combining the sequencing strategies of PacBio,10×Genomics,and Bionano mapping.Using this integrated approach,we obtained an N50 scaffold size of 46.63 Mb for the NH1.0 genome and performed a comparative genome analysis of NH1.0 with YH and HX1.In order to generate a genomic variation map of Chinese populations,we performed the whole-genome sequencing of 597 participants and identified 24.85 million(M)single nucleotide variants(SNVs),3.85 M small indels,and 106,382 structural variations.In the association analysis with collected phenotypes,we found that the T allele of rs1549293 in KAT8 significantly correlated with the waist circumference in northern Han males.Moreover,significant genetic diversity in MTHFR,TCN2,FADS1,and FADS2,which associate with circulating folate,vitamin B12,or lipid metabolism,was observed between northerners and southerners.Especially,for the homocysteine-increasing allele of rs1801133(MTHFR 677T),we hypothesize that there exists a “comfort”zone for a high frequency of 677T between latitudes of 35–45 degree North.Taken together,our results provide a high-quality northern Han reference genome and novel population-specific data sets of genetic variants for use in the personalized and precision medicine. | Zhenglin Du Liang Ma Hongzhu Qu Wei Chen Bing Zhang Xi Lu Weibo Zhai Xin Sheng Yongqiao Sun Wenjie Li Meng Lei Qiuhui Qi Na Yuan Shuo Shi Jingyao Zeng Jinyue Wang Yadong Yang Qi Liu Yaqiang Hong Lili Dong Zhewen Zhang Dong Zou Yanqing Wang Shuhui Song Fan Liu Xiangdong Fang Hua Chen Xin Liu Jingfa Xiao Changqing Zeng | 2019 | Genomics, Proteomics & Bioinformatics2019，17，3： | 4 |
| 14 | Dynamic blood single-cell immune responses in patients with COVID-19显示文摘The 2019 coronavirus disease(COVID-19)outbreak caused by the SARS-CoV-2 virus is an ongoing global health emergency.However,the virus'pathogenesis remains unclear,and there is no cure for the disease.We investigated the dynamic changes of blood immune response in patients with COVID-19 at different stages by using 5'gene expression,T cell receptor(TCR),and B cell receptors(BCR)V(D)J transcriptome analysis at a single-cell resolution.We obtained single-cell mRNA sequencing(scRNA-seq)data of 341,420 peripheral blood mononuclear cells(PBMCs)and 185,430 donotypic T cells and 28,802 donotypic B cells from 25 samples of 16 patients with COVID-19 for dynamic studies.In addition,we used three control samples.We found expansion of dendritic cells(DCs),CD14+monocytes,and megakaryocytes progenitor cells(MP)/platelets and a reduction of naive CD4+T lymphocytes in patients with COVID-19,along with a significant decrease of CD8+T lymphocytes,and natural killer cells(NKs)in patients in critical condition.The type I interferon(IFN-I),mitogen-activated protein kinase(MAPK),and ferroptosis pathways were activated while the disease was active,and recovered gradually after patient conditions improved.Consistent with this finding,the mRNA level of IFN-I signal-induced gene IFI27 was significantly increased in patients with COVID-19 compared with that of the controls in a validation cohort that included 38 patients and 35 controls.The concentration of interferon-a(IFN-a)in the serum of patients with COVID-19 increased significantly compared with that of the controls in an additional cohort of 215 patients with COVID-19 and 106 controls,further suggesting the important role of the IFN-I pathway in the immune response of COVID-19.TCR and BCR sequences analyses indicated that patients with COVID-19 developed specific immune responses against SARS-CoV-2 antigens.Our study reveals a dynamic landscape of human blood immune responses to SARS-CoV-2 infection,providing clues for therapeutic potentials in treating COVID-19. | Lulin Huang Yi Shi Bo Gong Li Jiang Zhixin Zhang Xiaoqi Liu Jialiang Yang Yongquan He Zhilin Jiang Ling Zhong Juan Tang Chunfang You Qi Jiang Bo Long Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Shuqiang Wang Xingxiang Yang Zhenglin Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 4 |
| 15 | Genome-wide analysis identified 17 new loci influencing intraocular pressure in Chinese population显示文摘Intraocular pressure(IOP) is a major risk factor for glaucoma. Genetic determinants of intraocular pressure can provide critical insights into the genetic architecture of glaucoma and, as a result, open new avenues for therapeutic intervention. We performed a genome-wide association study and replication analysis of 8,552 Chinese participants. In the genome-wide association study, we identified 51 loci that surpassed the significance of P<9×10^(-7), and we formally replicated these loci. A combined discovery and replication meta-analysis identified 21 genome-wide loci that surpassed the genome-wide significance of P<5×10^(-8), including 4 previously reported loci: rs145063132(7 p21.2, ETV1/DGKB), rs548030386(7 q31.2, ST7 near CAV1/CAV2), rs7047871(9 p24.2, GLIS3), and rs2472494(9 q31.1, ABCA1/SLC44 A1). Of the 17 newly identified loci, five were reported to have ocular related phenotypes: PTCH2(rs7525308 in 1 p34.1), LRIF1/DRAM2(rs1282146 in 1 p13.3), COLEC11(rs201143466 in 2 p25.3),SPTBN1(rs4514918 in 2 p16.2), and CRK(rs11078446 in 17 p13.3). The genetic loci identified in this study not only increase our understanding of the genes involved in intraocular pressure but also provide important genetic markers to improve future genetic screening and drug discovery for intraocular pressure disorders. | Lulin Huang Yuhong Chen Ying Lin Pancy O.S.Tam Yilian Cheng Yi Shi Bo Gong Fang Lu Jialiang Yang Haixin Wang Yi Yin Yong Cao Dan Jiang Ling Zhong Bai Xue Jing Wang Fang Hao Dean-Yao Lee Chi-Pui Pang Xinghuai Sun Zhenglin Yang | 2019 | Science China(Life Sciences)2019，62，2： | 4 |
| 16 | The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR显示文摘On January 22,2020,China National Center for Bioinformation(CNCB)released the 2019 Novel Coronavirus Resource(2019nCoVR),an open-access information resource for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-CoV-2 isolates,which are manually curated with value-added annotations and quality evaluated by an automated in-house pipeline.Of particular note,2019nCoVR offers systematic analyses to generate a dynamic landscape of SARS-CoV-2 genomic variations at a global scale.It provides all identified variants and their detailed statistics for each virus isolate,and congregates the quality score,functional annotation,and population frequency for each variant.Spatiotemporal change for each variant can be visualized and historical viral haplotype network maps for the course of the outbreak are also generated based on all complete and high-quality genomes available.Moreover,2019nCoVR provides a full collection of SARS-CoV-2 relevant literature on the coronavirus disease 2019(COVID-19),including published papers from PubMed as well as preprints from services such as bioRxiv and medRxiv through Europe PMC.Furthermore,by linking with relevant databases in CNCB,2019nCoVR offers data submission services for raw sequence reads and assembled genomes,and data sharing with NCBI.Collectively,SARS-CoV-2 is updated daily to collect the latest information on genome sequences,variants,haplotypes,and literature for a timely reflection,making 2019nCoVR a valuable resource for the global research community.2019nCoVR is accessible at http://gffzzdbc7b6aaae734bddsvww96uvqw5qv66np.ffgz.tsg.suse.edu.cn/ncov/. | Shuhui Song Lina Ma Dong Zou Dongmei Tian Cuiping Li Junwei Zhu Meili Chen Anke Wang Yingke Ma Mengwei Li Xufei Teng Ying Cui Guangya Duan Mochen Zhang Tong Jin Chengmin Shi Zhenglin Du Yadong Zhang Chuandong Liu Rujiao Li Jingyao Zeng Lili Hao Shuai Jiang Hua Chen Dali Han Jingfa Xiao Zhang Zhang Wenming Zhao Yongbiao Xue Yiming Bao | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 4 |
| 17 | Acoustic sound speed profile inversion based on orthogonal matching pursuit显示文摘The estimation of ocean sound speed profiles(SSPs)requires the inversion of an acoustic field using limited observations.Such inverse problems are underdetermined,and require regularization to ensure physically realistic solutions.The empirical orthonormal function(EOF)is capable of a very large compression of the data set.In this paper,the non-linear response of the sound pressure to SSP is linearized using a first order Taylor expansion,and the pressure is expanded in a sparse domain using EOFs.Since the parameters of the inverse model are sparse,compressive sensing(CS)can help solve such underdetermined problems accurately,efficiently,and with enhanced resolution.Here,the orthogonal matching pursuit(OMP)is used to estimate range-independent acoustic SSPs using the simulated acoustic field.The superior resolution of OMP is demonstrated with the SSP data from the South China Sea experiment.By shortening the duration of the training set,the temporal correlation between EOF and test sets is enhanced,and the accuracy of sound velocity inversion is improved.The SSP estimation error versus depth is calculated,and the 99%confidence interval of error is within±0.6 m/s.The 82%of mean absolute error(MAE)is less than 1 m/s.It is shown that SSPs can be well estimated using OMP. | Qianqian Li Juan Shi Zhenglin Li Yu Luo Fanlin Yang Kai Zhang | 2019 | Acta Oceanologica Sinica2019，38，11： | 4 |
| 18 | Morphological and physiological analysis of narrow and striped leaf 1(nsl1) mutant of rice(Oryza sativa L.) and the gene mapping显示文摘The shape and color of rice leaves are important agronomic traits that directly influence the proportion of sunlight energy utilization and ultimately affect the yield and quality.A new mutant exhibiting stable inheritance was identified as derived from ethyl methane sulfonate(EMS)-treated restorer Jinhui 10,tentatively named as narrow and striped leaf 1(nsl1).The nsl1 displayed pale white leaves at the seeding stage and then white striped leaves in parallel to the main vein at the jointing stage.Meanwhile,its leaf blades are significantly narrower than the control group of Jinhui 10.The chloroplast structures of cells in the white striped area of the nsl1 mutant break down,and the photosynthetic pigments are significantly lower than that of the wild type.Moreover,fluorescence parameters,such as F0,F v/F m,U psII,qp,and ETR,in the nsl1 mutant are significantly lower than those of the wild type,and the photosynthetic efficiency is also significantly decreased.These changes in leaf color and shape,together with physiological changes in the nsl1,result in smaller plant height and a decrease in the most important agronomic traits,such as the number of grains per panicle,grain weight,etc.Genetic analysis shows that the narrow and striped traits of the nsl1 mutant are controlled by a single recessive nuclear gene,which is located between InDel 16and InDel 12 in chromosome 3.The physical distance is204 kb.So far,no similar genes of such leaf color and shape in this area have been reported.This study has laid a solid foundation for the gene cloning and function analysis of NSL1. | Fangming Zhao Yong Zhang Yanru Wu Tongming Wang Ling Ma Zhenglin Yang Xia Wei Xianchun Sang Yinghua Ling Nan Wang Changwei Zhang Guanghua He | 2014 | Chinese Science Bulletin2014，59，9： | 3 |
| 19 | Tracking of Maneuvering Target in Glint Noise Environment显示文摘This paper presents a tracking algorithm for maneuvering target in the presence of glint noise. In radar target tracking system, because of the random wandering of the target position, the measurement noise is clearly non-Gaussian distribution, called as glint noise, which has a considerable influence on conventional linear estimates. In this paper, the glint noise is modeled via the mixture of Gaussian distribution and Laplace distribution, and tackled with two model sets. The tracking algorithm for maneuvering target is derived detailedly when the model sets is interacting in the presence of glint noise. The Monte Carlo simulation results express its better performance in comparison with the IMM algorithm. | ZUODongguang BIANShutan HANChongzhao ZHENGLin ZHUHongyan | 2005 | Chinese Journal of Electronics2005，14，3： | 3 |
| 20 | CD146 as a promising therapeutic target for retinal and choroidal neovascularization diseases显示文摘Blood vessel dysfunction causes several retinal diseases,including diabetic retinopathy,familial exudative vitreoretinopathy,macular degeneration and choroidal neovascularization in pathological myopia.Vascular endothelial growth factor(VEGF)-neutralizing proteins provide benefits in most of those diseases,yet unsolved haemorrhage and frequent intraocular injections still bothered patients.Here,we identified endothelial CD146 as a new target for retinal diseases.CD146 expression was activated in two ocular pathological angiogenesis models,a laser-induced choroid neovascularization model and an oxygeninduced retinopathy model.The absence of CD146 impaired hypoxia-induced cell migration and angiogenesis both in cell lines and animal model.Preventive or therapeutic treatment with anti-CD146 antibody AA98 significantly inhibited hypoxia-induced aberrant retinal angiogenesis in two retinal disease models.Mechanistically,under hypoxia condition,CD146 was involved in the activation of NFκB,Erk and Akt signalling pathways,which are partially independent of VEGF.Consistently,anti-CD146therapy combined with anti-VEGF therapy showed enhanced impairment effect of hypoxia-induced angiogenesis in vitro and in vivo.Given the critical role of abnormal angiogenesis in retinal and choroidal diseases,our results provide novel insights into combinatorial therapy for neovascular fundus diseases. | Bai Xue Ping Wang Wenzhen Yu Jing Feng Jie Li Rulian Zhao Zhenglin Yang Xiyun Yan Hongxia Duan | 2022 | Science China(Life Sciences)2022，65，6： | 3 |
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