|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Downregulation of Hes1 expression in experimental biliary atresia and its effects on bile duct structure显示文摘AIM To analyze the expression and function of the notchsignaling target gene Hes1 in a rhesus rotavirusinduced mouse biliary atresia model. METHODS The morphologies of biliary epithelial cells in biliary atresia patients and in a mouse model were examined by immunohistochemical staining. Then, the differential expression of Notch signaling pathway-related molecules was investigated. Further, the effects of the si RNAmediated inhibition of Hes1 expression were examined using a biliary epithelial cell 3 D culture system.RESULTS Both immature(Ep CAM+) and mature(CK19+) biliary epithelial cells were detected in the livers of biliary atresia patients without a ductile structure and in the mouse model with a distorted bile duct structure. The hepatic expression of transcripts for most Notch signaling molecules were significantly reduced on day 7 but recovered to normal levels by day 14, except for the target molecule Hes1, which still exhibited lower m RNA and protein levels. Expression of the Hes1 transcriptional co-regulator, RBP-Jκ was also reduced. A 3 D gel culture system promoted the maturation of immature biliary epithelial cells, with increased expression of CK19+ cells and the formation of a duct-like structure. The administration of Hes1 si RNA blocked this process. As a result, the cells remained in an immature state, and no duct-like structure was observed.CONCLUSION Our data indicated that Hes1 might contribute to the maturation and the cellular structure organization of biliary epithelial cells, which provides new insight into understanding the pathology of biliary atresia. | Rui-Zhong Zhang Xin-Hao Zeng Ze-Feng Lin Ming-Fu Yan-Lu Tong Vincent CH Lui Paul KH Tam Jonathan R Lamb Hui-Min Xia Yan Chen | 2018 | World Journal of Gastroenterology2018，24，29： | 5 |
| 2 | Identification of α-gliadin genes in Dasypyrum in relation to evolution and breeding显示文摘 | LI G R LIU CH ZENG Z X JIA J Q ZHANG T ZHOU J P REN ZH L YANG Z J | 2009 | Euphytica2009，165，： | 1 |
| 3 | Efficacy of trivalent chromium on growth performance, carcass characteristics and tissue chromium in heat-stressed broiler chicks显示文摘 | Zha L Y ? Zeng J W ? Ch X W | 2009 | Journal of the Science of Food and Agriculture2009，89，10： | 1 |
| 4 | Podoeyte lesions in patients with obesity related glomerulopathy显示文摘 | Chen HM Liu ZH Zeng CH | 2006 | Am J Kidney Dis2006，48，5： | 1 |
| 5 | A muhicenter application and e- valuation of the Oxford classification of IgA nephropathy in adult Chinese patients 显示文摘 | Zeng CH Le W Ni Z | 2012 | Am J Kidney Dis2012，60，5： | 1 |
| 6 | Validation of the Oxford classi- fication of IgA nephropathy for pediatric patients from china显示文摘 | Le W Zeng CH Liu Z | 2012 | BMC Nephrol2012，27，13： | 1 |
| 7 | Etiology and clinical characteristics of membranous nephropathy in Chinese patients显示文摘 | Zeng CH Chen HM Wang RS | 2008 | Am J Kidney Dis2008，52，4： | 1 |
| 8 | Etiology and clinical characteristics of membranous nephropathy in Chinese patients显示文摘 | Zeng CH Chen HM Wang RS | 2008 | Am J Kidney Dis2008，52，4： | 1 |
| 9 | Biosynthetic human parathyroid hormane(1-34) effects on bone quality in aged ovariectomized rats显示文摘 | Sato M Zeng GQ Turner CH | 1997 | Endocrinology1997，138，： | 1 |
| 10 | The role of the CXCL12-CX-CR4/CXCR7 axis in the progression and metastasis of bone sarcomas (Review)显示文摘 | Liao YX Zhou CH Zeng H | 2013 | Int J Mol Med2013，32，6： | 1 |
| 11 | Etiology and clinicalcharacteristics of membranous nephropathy in Chinese pa-tients 显示文摘 | Zeng CH Chen HM Wang RS | 2008 | Am J Kidney Dis2008，52，4： | 1 |
| 12 | Amylin deposition in the kidney of patients with diabetic nephropathy显示文摘 | Gong W Liu ZH Zeng CH Peng A | 2007 | Kidney International2007，72，： | 1 |
| 13 | General Formulas for Obtaining the MLEs and the Asymptotic variancecovariance matrix in mapping quantitative trait loci when using the EM algorithm 显示文摘 | Kao CH and Z-B Zeng | 1997 | Biometrics1997，53，3： | 1 |
| 14 | Etiology and clinical characteristics of membranous nephropathy in Chinese patients显示文摘 | Zeng CH Chen HM Wang RS | 2008 | Am J Kidney Dis2008，52，4： | 1 |
| 15 | Vi- bration suppression control for AMB-supported motor driveline system using synchronous rotating frame transformation 显示文摘 | ZENG SH Q HAN B CH FENG R etal | 2015 | IEEE Transactions on Industrial Electronics2015，62，9： | 1 |
| 16 | Relationships between years of education and gray matter volume, metabolism and functional connectivity in healthy elders显示文摘 | Eider M. Arenaza-Urquijo Brigitte Landeau Renaud La Joie Katell Mevel Florence Mézenge Audrey Perrotin Béatrice Desgranges David Bartrés-Faz Francis Eustache Ga?l Chételat | 2013 | Neuroimage2013，，： | 1 |
| 17 | Association ofinterleukin-10 gene-592A/C polymorphism with the clinical andpathological diversity of lupus nephritis显示文摘 | Zhu LJ Liu ZH Zeng CH Chen ZH Yu C | 2005 | Clin Exp Rheumatol2005，23，6： | 1 |
| 18 | Eigenvalue-based spectrum sensing algorithms for cognitive radio显示文摘 | ZENG Y H LIANG Y CH | 2009 | IEEE Transac- tions on Communications2009，57，6： | 1 |
| 19 | Etiology and clinical characteristics of membranous nephropathy in Chinese patients显示文摘 | Zeng CH Chen HM Wang RS | 2008 | Am J Kidney Dis2008，52，4： | 1 |
| 20 | Triptolide reduces proteinuria in experimental membranous nephropathy and protects against C5b-9-induced podocyte injury in vitro显示文摘 | Chen ZH Qin WS Zeng CH | 2010 | Kidney Int2010，77，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员