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| 1 | Inulin Can Alleviate Metabolism Disorders in ob/ob Mice by Partially Restoring Leptinrelated Pathways Mediated by Gut Microbiota显示文摘Inulin has been used as a prebiotic to alleviate glucose and lipid metabolism disorders in mice and humans by modulating the gut microbiota. However, the mechanism underlying the alleviation of metabolic disorders by inulin through interactions between the gut microbiota and host cells is unclear. We use ob/ob mice as a model to study the effect of inulin on the cecal microbiota by16 S rRNA gene amplicon sequencing and its interaction with host cells by transcriptomics. The inulin-supplemented diet improved glucose and lipid metabolism disorder parameters in ob/ob mice,alleviating fat accumulation and glucose intolerance. The a diversity of gut microbial community of ob/ob mice was reduced after inulin treatment, while the b diversity tended to return to the level of wild type mice. Interestingly, Prevotellaceae UCG 001(family Prevotellaceae) was obviously enriched after inulin treatment. A comparative analysis of the gene expression profile showed that the cecal transcriptome was changed in leptin gene deficiency mice, whereas the inulin-supplemented diet partially reversed the changes in leptin gene-related signaling pathways, especially AMPK signaling pathway, where the levels of gene expression became comparable to those in wild type mice.Further analysis indicated that Prevotellaceae UCG 001 was positively correlated with the AMPK signaling pathway, which was negatively correlated with markers of glycolipid metabolism disorders. Our results suggest that the inulin-supplemented diet alleviates glucose and lipid metabolism disorders by partially restoring leptin related pathways mediated by gut microbiota. | Xiaofeng Song Liang Zhong Na Lyu Fei Liu Boxing Li Yanan Hao Yong Xue Jing Li Yuqing Feng Yue Ma Yongfei Hu Baoli Zhu | 2019 | Genomics, Proteomics & Bioinformatics2019，17，1： | 12 |
| 2 | Reconstruction of a hybrid nucleoside antibiotic gene cluster based on scarless modification of large DNA fragments显示文摘Genetic modification of large DNA fragments(gene clusters) is of great importance in synthetic biology and combinatorial biosynthesis as it facilitates rational design and modification of natural products to increase their value and productivity.In this study,we developed a method for scarless and precise modification of large gene clusters by using RecET/RED-mediated polymerase chain reaction(PCR) targeting combined with Gibson assembly.In this strategy,the biosynthetic genes for peptidyl moieties(HPHT) in the nikkomycin biosynthetic gene cluster were replaced with those for carbamoylpolyoxamic acid(CPOAA)from the polyoxin biosynthetic gene cluster to generate a^40 kb hybrid gene cluster in Escherichia coli with a reusable targeting cassette.The reconstructed cluster was introduced into Streptomyces lividans TK23 for heterologous expression and the expected hybrid antibiotic,polynik A,was obtained and verified.This study provides an efficient strategy for gene cluster reconstruction and modification that could be applied in synthetic biology and combinatory biosynthesis to synthesize novel bioactive metabolites or to improve antibiotic production. | Jiming Zhuo Binbin Ma Jingjing Xu Weihong Hu Jihui Zhang Huarong Tan Yuqing Tian | 2017 | Science China(Life Sciences)2017，60，9： | 6 |
| 3 | Photoinduced large polaron transport and dynamics in organic-inorganic hybrid lead halide perovskite with terahertz probes显示文摘Organic-inorganic hybrid metal halide perovskites(MHPs)have attracted tremendous attention for optoelectronic applications.The long photocarrier lifetime and moderate carrier mobility have been proposed as results of the large polaron formation in MHPs.However,it is challenging to measure the effective mass and carrier scattering parameters of the photogenerated large polarons in the ultrafast carrier recombination dynamics.Here,we show,in a one-step spectroscopic method,that the optical-pump and terahertz-electromagnetic probe(OPTP)technique allows us to access the nature of interplay of photoexcited unbound charge carriers and optical phonons in polycrystalline CH_(3)NH_(3)PbI_(3)(MAPbI_(3))of about 10μm grain size.Firstly,we demonstrate a direct spectral evidence of the large polarons in polycrystalline MAPbI_(3).Using the Drude-Smith-Lorentz model along with the Frӧhlich-type electron-phonon(e-ph)coupling,we determine the effective mass and scattering parameters of photogenerated polaronic carriers.We discover that the resulting moderate polaronic carrier mobility is mainly influenced by the enhanced carrier scattering,rather than the polaron mass enhancement.While,the formation of large polarons in MAPbI_(3)polycrystalline grains results in a long charge carrier lifetime at room temperature.Our results provide crucial information about the photo-physics of MAPbI3 and are indispensable for optoelectronic device development with better performance. | Zuanming Jin Yan Peng Yuqing Fang Zhijiang Ye Zhiyuan Fan Zhilin Liu Xichang Bao Heng Gao Wei Ren Jing Wu Guohong Ma Qianli Chen Chao Zhang Alexey VBalakin Alexander PShkurinov Yiming Zhu Songlin Zhuang | 2022 | Light(Science & Applications)2022，11，8： | 4 |
| 4 | Black-Box and Public Traceability in Multi-authority Attribute Based Encryption显示文摘Cipher text-policy Att ribu te・based encryption(CP-ABE)is a promising tool for implementing finegrained cryptographic access control.While the uniqueness of generating private keys brings extra security issues.The key escrow is inherent in CP-ABE systems because the trusted authority has the power to decrypt every cipher text.The priva te keys are only associa ted with the attributes nor the user's identity.Some malicious users might be tempted to leak their decryption privileges for financial gain without the risk of being caught as the decryption privilege could be shared by multiple users who own the same set of attributes.We propose a new multiauthority CP-ABE with blackbox and public traceability,where the private keys are assigned by the cooperation bet ween one cen tral authority and multi-au thorities.The performance and securi ty analyses indicate that the proposed scheme is highly efficient and provably secure under the security model. | ZHAO Qianqian WU Gaofei MA Hua ZHANG Yuqing WANG He | 2020 | Chinese Journal of Electronics2020，29，1： | 4 |
| 5 | Corrosion resistance and anti-soiling performance of micro-arc oxidation/graphene oxide/stearic acid superhydrophobic composite coating on magnesium alloys显示文摘Magnesium(Mg)alloys,the lightest metal construction material used in industry,play a vital role in future development.However,the poor corrosion resistance of Mg alloys in corrosion environments largely limits their potential wide applications.Therefore,a micro-arc oxidation/graphene oxide/stearic acid(MAO/GO/SA)superhydrophobic composite coating with superior corrosion resistance was fabricated on a Mg alloy AZ91D through micro-arc oxidation(MAO)technology,electrodeposition technique,and self-assembly technology.The composition and microstructure of the coating were characterized by scanning electron microscopy,X-ray diffraction,energy dispersive spectroscopy,and Raman spectroscopy.The effective protection of the MAO/GO/SA composite coating applied to a substrate was evaluated using potentiodynamic polarization,electrochemical impedance spectroscopy tests,and salt spray tests.The results showed that the MAO/GO/SA composite coating with a petal spherical structure had the best superhydrophobicity,and it attained a contact angle of 159.53°±2°.The MAO/GO/SA composite coating exhibited high resistance to corrosion,according to electrochemical and salt spray tests. | Dong Wang Chen Ma Jinyu Liu Weidong Li Wei Shang Ning Peng Yuqing Wen | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，6： | 3 |
| 6 | Recent understanding of solid-liquid friction in ionic liquids显示文摘Ionic liquids(ILs)-solid interfacial phenomenon is undoubtedly one of the topic issues in energy related fields,especially bringing great challenges in the development of chemical engineering.Solid-ILs friction under microscale shows outstanding properties such as widely studied electro-controllability by surface potential or electric field,and promising performance of superlubricity.Vast applications,such as boundary lubrication and supercapacitors,have been benefiting from these studies.In this review,we summarized the recent advances of the measurements of solid-ILs friction,and focused on the microscale and fascinating findings.A brief tutorial for this topic,containing both experimental and theoretical methods,was also provided.It was anticipated that this review would help researchers grasp the emerging field and stimulate the advance of new ideas and methods in ILs on solids. | Yuqing He Han Li Cangyu Qu Wei Cao Ming Ma | 2021 | Green Chemical Engineering2021，2，2： | 2 |
| 7 | Improvement of cardiac function by hepatocyte growth factor via intracoronary transfection in the swine myocardial infarction model显示文摘Objective:To study the amelioration effect of Adenovirus5-mediated human hepatocyte growth factor(Ad5-HGF)on postinfarction heart failure in the swine myocardial infarction model.Methods:Twelve SuZhong young swine were randomly divided into 2 groups with 6 swine in each group:Ad5-HGF-treated group and null-Ad5 group.Four weeks after ligation at left anterior descending coronary artery in swine hearts,Ad5-HGF was transferred to the swine myocardium.Simultaneously,Gated myocardial perfusion imaging was performed to evaluate cardiac perfusion and heart function.After three weeks,Gated myocardial perfusion imaging was performed again,then the hearts were harvested and sectioned to examine the expression of HGF through ELISA.Results:High expression of human HGF was observed in the myocardium of Ad5-HGF-treated group.From 4 weeks to 7 weeks after operation,Left ventricular ejection fraction was increased in Ad5-HGF-treated group.The improvement in LVEF was greater in Ad5-HGF-treated group than that in null-Ad5 group at 7 weeks after operation.Cardiac perfusion was significantly improved in the Ad5-HGF-treated group.Conclusion:High expression of human HGF was observed in the myocardium through intracoronary transfection,which suggests that HGF can ameliorate heart function in swine with postinfarction heart failure. | Wei Wang Zhijian Yang Dongchao Ma Shunlin Xu Yourong Zhang Yuqing Zhang Liansheng Wang Bo Chen Kejiang Cao Wenzhu Ma | 2006 | Journal of Nanjing Medical University2006，20，4： | 2 |
| 8 | Experimental study and numerical analysis of a composite truss joint显示文摘 | Dongyan Xue Yuqing Liu Jun He Biao Ma | 2011 | Journal of Constructional Steel Research2011，，6： | 2 |
| 9 | Recent Advancements in Ultrasound Transducer:From Material Strategies to Biomedical Applications显示文摘Ultrasound is extensively studied for biomedical engineering applications.As the core part of the ultrasonic system,the ultrasound transducer plays a significant role.For the purpose of meeting the requirement of precision medicine,the main challenge for the development of ultrasound transducer is to further enhance its performance.In this article,an overview of recent developments in ultrasound transducer technologies that use a variety of material strategies and device designs based on both the piezoelectric and photoacoustic mechanisms is provided.Practical applications are also presented,including ultrasound imaging,ultrasound therapy,particle/cell manipulation,drug delivery,and nerve stimulation.Finally,perspectives and opportunities are also highlighted. | Jiapu Li Yuqing Ma Tao Zhang KKirk Shung Benpeng Zhu | 2022 | Biomedical Engineering Frontiers2022，3，1： | 2 |
| 10 | Testing universality of Feynman-Tan relation in interacting Bose gases using high-order Bragg spectra显示文摘The Feynman-Tan relation,obtained by combining the Feynman energy relation with the Tan’s two-body contact,can explain the excitation spectra of strongly interacting 39K Bose-Einstein condensate(BEC).Since the shift of excitation resonance in the Feynman-Tan relation is inversely proportional to atomic mass,the test of whether this relation is universal for other atomic systems is significant for describing the effect of interaction in strongly correlated Bose gases.Here we measure the high-momentum excitation spectra of 133Cs BEC with widely tunable interactions by using the second-and third-order Bragg spectra.We observe the backbending of frequency shift of excitation resonance with increasing interaction,and even the shift changes its sign under the strong interactions in the high-order Bragg spectra.Our finding shows good agreement with the prediction based on the Feynman-Tan relation.Our results provide significant insights for understanding the profound properties of strongly interacting Bose gases. | Yunfei Wang Huiying Du Yuqing Li Feng Mei Ying Hu Liantuan Xiao Jie Ma Suotang Jia | 2023 | Light(Science & Applications)2023，12，3： | 2 |
| 11 | Enrichment of anammox biomass during mainstream wastewater treatment driven by achievement of partial denitrification through the addition of bio-carriers显示文摘Anammox is widely considered as the most cost-effective and sustainable process for nitrogen removal.However,how to achieve the enrichment of anammox biomass remains a challenge for its large-scale application,especially in mainstream wastewater treatment.In this study,the feasibility of enrichment of anammox biomass was explored through the realization of partial denitrification and the addition of bio-carriers.By using ordinary activated sludge,a sequencing batch reactor(SBR)followed by an up-fow anaerobic sludge bed(UASB)was operated at 25±2℃ for 214 days.The long-term operation was divided into five phases,in which SBR and UASB were started-up in Phases I and II,respectively.By eliminating oxygen and adjusting the infow ratios in Phases III-V,advanced nitrogen removal was achieved with the effuent total nitrogen being 4.7 mg/L and the nitrogen removal efficiency being 90.5%in Phase V.Both in-situ and ex-situ activity tests demonstrated the occurrence of partial denitrification and anammox.Moreover,16S rRNA high-throughput sequencing analysis revealed that Candidatus Brocadia was enriched from below the detection limit to in biofilms(0.4%in SBR,2.2%in UASB)and the foc sludge(0.2%in SBR,1.3%in UASB),while Thauera was mainly detected in the foc sludge(8.1%in SBR,8.8%in UASB),which might play a key role in partial denitrification.Overall,this study provides a novel strategy to enrich anammox biomass driven by rapid achievement of partial denitrification through the addition of bio-carriers,which will improve large-scale application of anammox processes in mainstream wastewater treatment. | Yuqing Ma Bo Wang Xiaodi Li Shuo Wang Wen Wang Yongzhen Peng | 2024 | Journal of Environmental Sciences2024，，3： | 1 |
| 12 | Combination of amlodipine plus angiotensin receptor blocker or diuretics in high-risk hypertensive patients:a 96-week efficacy and safety study显示文摘 | Liyuan Ma Wen Wang Yong Zhao Yuqing | 2012 | American journal of cardiovascular drugs:drugs devices and other interventions2012，12，2： | 1 |
| 13 | Authenticated Quantum Dialogue Without Information Leakage显示文摘A lot of authenticated quantum dialogue protocols are springing up. Many of them have the problem of information leakage, or suffer from Man-In-TheMiddle attack. Some protocols can guarantee security, but have relatively low efficiency. Based on the above situation, we present a novel authenticated quantum dialogue protocol by using Bell states and entanglement swapping.In this protocol, we adopt Einstein-Podolsky-Rosen(EPR)pairs to detect eavesdropping and transmit secret messages. We employ polarized photons to achieve authentication of users' identity information. Compared with other quantum dialogue schemes with authentication, our protocol has several advantages. The transmitted particles are passed once and do not carry any secret messages. The proposed protocol can overcome the drawback of information leakage and resist against typical attacks. The efficiency is acceptable. | WANG He ZHANG Yuqing WU Gaofei MA Hua | 2018 | Chinese Journal of Electronics2018，27，2： | 1 |
| 14 | Cryptotanshinone induces cell cycle arrest and apoptosis of multidrug resistant human chronic myeloid leukemia cells by inhibiting the activity of eukaryotic initiation factor 4E显示文摘 | Yuqing Ge Rubin Cheng Yuhong Zhou Jianping Shen Laijun Peng Xiaofeng Xu Qun Dai Pei Liu Haibing Wang Xiaoqiong Ma Jia Jia Zhe Chen | 2012 | Molecular and Cellular Biochemistry2012，，1： | 1 |
| 15 | Simultaneous Quantification of Seven Main Triterpenoid Saponins in Radix et Rhizoma Clematidis by LC–ELSD显示文摘 | Xiaoli Ma Le Xie Lifang Liu Qiuling Tang Zhuqing Wan Yuqing Li | 2009 | Chromatographia (-)2009，，5： | 1 |
| 16 | Comparative study of effects of bone marrow cell vs. Ad_5-HGF administration via non-infarct-related artery injection in myocardial infarction in swine显示文摘Objective: To evaluate the effect of transplanting bone marrow-derived mesenchymal stem cells(BM-MSCs) or adenovirus5-hepatocyte growth factor(Ad5-HGF) via non-infarct-related artery injection in swine myocardial infarction models. Methods:BM-MSCs were obtained from swine bone marrow and expanded in vitro to a purity of >50%. A myocardial infarction(MI) was created by ligating the distal left anterior descending artery in swine. Either BM-MSCs(5 × 106/ml) or Ad5-HGF(4 × 109 pfu) were transfused via the right coronary artery(non-infarcted artery) four weeks after MI. Gate-controled cardiac perfusion imaging was performed at the end of four and seven weeks after LAD ligation, to evaluate heart function and cardiac perfusion. Morphologic and histologic characteristics of the hearts were also studied. Results:(1)The gate-controlled cardiac perfusion imaging showed that the improvement in LVEF was greater in both treatment groups than in control group at the 4th weeks. (2)In both treatment groups, capillary density was significantly higher than that of control group(P < 0.05). Conclusion:BM-MSCs or Ad5-HGF transplantation via non-infarcted artery administration can stimulate angiogenesis and improve heart function, but there was no difference in therapeutic efficacy between BM-MSCs and Ad5-HGF. | Liansheng Wang Zhijian Yang Wei Wang Dongchao Ma Shunlin Xu Yuqing Zhang Fang Zhou Bo Chen Kejiang Cao Jun Huang | 2007 | Journal of Nanjing Medical University2007，21，2： | 1 |
| 17 | Laser intensity induced transparency in atom-molecular transition process显示文摘We propose a new transparency mechanism,which is based on photoassociation(PA)laser intensity induced transitional frequency shift for ultracold cesium molecules formed in PA scheme.The PA laser intensity is supposed to change before the atom-molecule resonance.Thus,a remarkable transparent effect for PA laser is expected to appear in the vicinity of original resonant transitional line,where the variation of PA laser intensity induces the shift of the excited molecular levels.The mechanism is different from electromagnetically induced transparency effect and interesting for further research on the scattering length for cesium atomic condensate. | Jie Ma Yuqing Li Jizhou Wu Liantuan Xiao Suotang Jia | 2014 | Chinese Science Bulletin2014，59，22： | 1 |
| 18 | Disturbed gut virome with potent interferonogenic property in systemic lupus erythematosus显示文摘Accumulating evidence suggests an essential role of disturbed gut microbiota in the etiopathogenesis of systemic lupus erythematosus(SLE),but it remains unclear as to gut virome.In this study,fecal virus-like particles(VLPs)isolated from 76 non-treated SLE patients and 75 healthy controls were subjected to gut virome profiling.The proportion of bacteriophages was significantly elevated in the SLE gut,and the altered viral taxa were correlated with clinical parameters.Gut virome and bacteriome were closely associated with each other in SLE patients.The combination of gut viral and bacterial markers displayed better performance in distinguishing SLE patients from healthy controls.Further,VLPs from non-treated SLE patients promoted interferon-a production in an epithelial cell line and human immune cells.Intriguingly,the interferon-stimulatory capacity diminished in VLPs from post-treated SLE patients.Our findings may shed novel insights into SLE pathogenesis.Further in-depth understanding of gut virome might help develop future biomarkers and therapeutics for SLE patients. | Beidi Chen Jiabao Cao Wei Liu Yuqing Zhang Yudong Liu Min Wang Fei Xiao Jie Ma Jun Wang Xuan Zhang | 2023 | Science Bulletin2023，，3： | 1 |
| 19 | Mild hyperthermia synergized chemotherapy by Bi_(2)Se_(3)/MoSe_(2)nanosaucers for cancer treatment with negligible thermal resistance显示文摘Harsh photothermal temperatures(>50℃)caused heating damage to the normal tissues and induced thermal resistance in cancer cells,which significantly limited the safety and efficacy of photothermal therapy(PTT)in cancer treatment.Mild hyperthermia(<42℃)combined with chemotherapy might solve this issue.Herein,a novel transition metal dichalcogenides nanostructure,namely,Bi_(2)Se_(3)/MoSe_(2)nanosaucers(BMNSs),was designed to produce mild photo-hyperthermia(mPTT)and combined with chemotherapy to improve the overall antitumor efficacy.The BMNSs were constituted by Bi_(2)Se_(3)hexagonal nanoplates and enclosed with MoSe_(2)nanosheets evenly.While the MoSe_(2)moiety endowed the nanoplatform with excellent photothermal efficacy,the Bi_(2)Se_(3)substrates provided large specific surface area to anchor more doxorubicin(DOX)molecules as chemotherapeutic agent.Under the stimuli of mPTT/tumor acidic microenvironment,the tumor-specific drug release and the enhanced chemotherapy could be realized,showing impressive therapeutic outcomes against 4T1 cells.The synergetic therapeutic mechanism might be attributed to the mPTT induced cell membrane permeability,and interestingly,the expression of heat shock proteins 70 was not elevated obviously after the synergetic therapy,thus to avoid the tumor thermal resistance and further improve the therapeutic effect.The in vivo anti-tumoral performance of the BMNSs was further studied and complete tumor eradication was achieved without any recurrence and biotoxicity.Not only demonstrating a paradigm of high therapeutic efficacy of mild hyperthermia and synergistic chemotherapy for precise cancer therapy,our findings proved that the cancer therapeutic effect can be improved with minimal side effects through exquisite designing of the microstructures and the physiochemical properties of the nanoplatform. | Fei Gao Tingbin Zhang Yuqing Miao Huijun Ma Hui Guo Ruyi Jin Zhi Li Haifang Wang Haiming Fan Lingyun Zhao | 2022 | Nano Research2022，15，9： | 1 |
| 20 | Identification of a phage-derived depolymerase specific for KL47 capsule of Klebsiella pneumoniae and its therapeutic potential in mice显示文摘Klebsiella pneumoniae is one of the major pathogens causing global multidrug-resistant infections.Therefore,strategies for preventing and controlling the infections are urgently needed.Phage depolymerase,often found in the tail fiber protein or the tail spike protein,is reported to have antibiofilm activity.In this study,phage P560isolated from sewage showed specific for capsule locus type KL47 K.pneumoniae,and the enlarged haloes around plaques indicated that P560 encoded a depolymerase.The capsule depolymerase,ORF43,named P560dep,derived from phage P560 was expressed,purified,characterized and evaluated for enzymatic activity as well as specificity.We reported that the capsule depolymerase P560dep,can digest the capsule polysaccharides on the surface of KL47 type K.pneumoniae,and the depolymerization spectrum of P560dep matched to the host range of phage P560,KL47 K.pneumoniae.Crystal violet staining assay showed that P560dep was able to significantly inhibit biofilm formation.Further,a single dose(50μg/mouse)of depolymerase intraperitoneal injection protected 90%–100%of mice from lethal challenge before or after infection by KL47 carbapenem-resistant K.pneumoniae.And pathological changes were alleviated in lung and liver of mice infected by KL47 type K.pneumoniae.It is demonstrated that depolymerase P560dep as an attractive antivirulence agent represents a promising tool for antimicrobial therapy. | Min Li Hui Wang Long Chen Genglin Guo Pei Li Jiale Ma Rong Chen Hong Du Yuqing Liu Wei Zhang | 2022 | Virologica Sinica2022，37，4： | 1 |
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