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| 1 | Hydrogen sulfide suppresses transforming growth factor-β1-induced differentiation of human cardiac fibroblasts into myofibroblasts显示文摘In heart disease, transforming growth factor-β1(TGF-β1) converts fibroblasts into myofibroblasts, which synthesize and secrete fibrillar type I and III collagens. The purpose of the present study was to investigate how hydrogen sulfide(H2S) suppresses TGF-β1-induced differentiation of human cardiac fibroblasts to myofibroblasts. Human cardiac fibroblasts were serum-starved in fibroblast medium for 16 h before exposure to TGF-β1(10 ng m L-1) for 24 h with or without sodium hydrosulfide(Na HS, 100 μmol L-1, 30 min pretreatment) treatment. Na HS, an exogenous H2 S donor, potently inhibited the proliferation and migration of TGF-β1-induced human cardiac fibroblasts and regulated their cell cycle progression. Furthermore, Na HS treatment led to suppression of fibroblast differentiation into myofibroblasts, and reduced the levels of collagen, TGF-β1, and activated Smad3 in TGF-β1-induced human cardiac fibroblasts in vitro. We therefore conclude that H2 S suppresses TGF-β1-stimulated conversion of fibroblasts to myofibroblasts by inhibiting the TGF-β1/Smad3 signaling pathway, as well as by inhibiting the proliferation, migration, and cell cycle progression of human cardiac myofibroblasts. These effects of H2 S may play significant roles in cardiac remodeling associated with heart failure. | ZHANG YouEn WANG JiaNing LI Hua YUAN LiangJun WANG Lei WU Bing GE JunBo | 2015 | Science China(Life Sciences)2015，58，11： | 11 |
| 2 | Progress of the injection laser system of SG-Ⅱ显示文摘A high power laser system was used to drive the ignition of inertial confinement fusion(ICF), of which the high energy,the uniform focal spot, the accurate laser waveform, and the synchronization between the laser beams are key parameters.To accomplish this, global laser characteristics control should be assured, which was the main purpose of the injection laser system. In this paper, the key technological progress involved in the improvement of the performance of the injection laser of SG-II is reported, including frequency domain control, time domain control, near-field spatial shaping, preamplifier technology, and the optical parametric chirped pulse amplification pump source. | Wei Fan Youen Jiang Jiangfeng Wang Xiaochao Wang Dajie Huang Xinghua Lu Hui Wei Guoyang Li Xue Pan Zhi Qiao Chao Wang He Cheng Peng Zhang Wenfa Huang Zhuli Xiao Shengjia Zhang Xuechun Li Jianqiang Zhu Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，2： | 3 |
| 3 | Identification of two novel B cell epitopes on porcine epidemic diarrhea virus spike protein显示文摘 | Dongbo Sun Li Feng Hongyan Shi Jianfei Chen Xiaochen Cui Hongyan Chen Shengwang Liu Youen Tong Yunfeng Wang Guangzhi Tong | 2008 | Veterinary Microbiology2008，，1： | 2 |
| 4 | Development of contrast agents targeted to macrophage cavenger receptors for MRI of vascular inflammation显示文摘 | Gustafsson B Youens S Louie AY | 2006 | Bioconjug Chem2006，17，2： | 1 |
| 5 | Measurement correlation for multiple sensor tracking in a dense target enviroment显示文摘 | Chang C B Youens L C | 1982 | IEEE Trans1982，27，6： | 1 |
| 6 | Clinical experience with the Cervista HPV HP Assay correlation of cytology and HPV status from 56501 specimens显示文摘 | Youens K Hosler G Washinqton P | 2011 | J Mol Diaqn2011，13，2： | 1 |
| 7 | Subsequent develop- ment of thrombocytopenia and coagulopathy in moderate and severe head injury: support for serial laboratory examination 显示文摘 | Carrick M M Tyroch A H Youens C A | 2005 | J Trauma2005，58，4： | 1 |
| 8 | Measurement correlation for multiple sensor trackong in a dense target environment显示文摘 | CHANG C B YOUENS L C | 1982 | IEEE Transac- tions on Automatic Control1982，27，6： | 1 |
| 9 | Identification of two novel B cell epitopes on porcine epidemic diarrhea virus spike protein显示文摘 | Dongbo Sun Li Feng Hongyan Shi Jianfei Chen Xiaochen Cui Hongyan Chen Shengwang Liu Youen Tong Yunfeng Wang Guangzhi Tong | 2008 | Veterinary Microbiology2008，，1： | 1 |
| 10 | Subsequent development of thrombocytopenia and coagulopathy in moderate and severe head injury:support for serial laboratory examination显示文摘 | Tyroch AH Youens CA | 2005 | J Trauma2005，58，4： | 1 |
| 11 | Measurement Correlation for Multiple Sensor Tracking in a Dense Target Enviroment显示文摘 | CHANG C B YOUENS L C | | IEEE Trans0，27，6： | 1 |
| 12 | Extralnodal follicular dendritic cell sarcoma显示文摘 | Youens K E Waugh M S | 2008 | Arch Pathol Lab Med2008，132，10： | 1 |
| 13 | Clinical experience with the Cervista HPV HR assay:correlation of cytology and HPV status from 56,501 specimens显示文摘 | Youens KE Hosler GA Washington PJ | 2011 | J Mol Diagn2011，13，2： | 1 |
| 14 | Clinical Experiencewith the Cervista HPV HR Assay Correlation of Cytology and HPV Status from 56, 501Specimens显示文摘 | Youens KE Hosler GA Washington PJ | 2011 | J Mol Diagn2011，13，： | 1 |
| 15 | Subsequent De- velopment of Thrombocytopenia and Coagulopathy in Moder- ate and Severe Head Injury: Support for Serial Laboratory Examination显示文摘 | Carriek MM Tyroch AH Youens CA | 2005 | Trauma2005，58，4： | 1 |
| 16 | Extranodal follicular dendritic cell sarco- ma显示文摘 | Youens KE Waugh MS | 2008 | Arch Pathol Lab Med2008，132，10： | 1 |
| 17 | Subsequent development of thrombocytopenia and coagulopathy in moderate and severe head injury:support for serial laboratory examination显示文摘 | Tyroch AH Youens CA | 2005 | J Trauma2005，58，4： | 1 |
| 18 | Donor cell leukemia in- umbilical cord blood transplant patients: a case study and litera- ture review highlighting the importance of molecular engraftment analysis显示文摘 | Crow J Youens K Miehalowski S | 2010 | J Mol Diagn2010，12，4： | 1 |
| 19 | Measurement correlation for multiple sensors tracking in a dense target environment显示文摘 | CHANG C B YOUENS L C | 1982 | IEEE Trans AC1982，27，6： | 1 |
| 20 | Development of contrast agents targeted to macrophage scavenger receptors for MRI of vascular inflammation显示文摘 | Gustafsson B Youens S Louie AY | 2006 | Bioconjug Chem2006，17，2： | 1 |
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