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| 1 | Profiling the repertoire of T-cell receptor beta-chain variable genes in peripheral blood lymphocytes from subjects who have recovered from acute hepatitis B virus infection显示文摘T 房间受体贝它链的侧面变量(TRBV ) 基因通常与病毒感染或癌症在题目扭曲。融化的基因光谱模式(GMSP ) 能被用来决定 TRBV 基因家庭的侧面。从从尖锐肝炎 B 病毒感染(AHI ) 恢复了的题目在外部血淋巴细胞探索 TRBV 家庭的肖像,外部血 mononuclear 房间(PBMC ) 被分开并且进一步排序 + 和 CD8 +T 房间子集进 CD4。TRBV 的分子的特征补足的决定区域 3 (CDR3 ) 主题用 GMSP 分析被决定。当 GMSP 侧面显示出一座单个山峰时, monoclonally 扩展的 TRBV 基因被克隆并且定序。多重 TRBV 基因的扭曲的扩大在 CD4 + 和 CD8 +T 房间子集和 PBMC 之中被观察。在 CD8 +T 房间子集的 monoclonally 扩展的 TRBV 基因的频率比 CD4 +T 房间子集和 PBMC 的显著地高。比作 TRBV 基因家庭, TRBV11, BV15 和 BV20 的另外的成员主要在恢复 AHI 题目在外部血淋巴细胞的全部剧目被表示。TRBV5.1 和 BV20 CDR3 的相对保存的氨基酸主题也在 CD4 + 和 CD8 +T 房间子集被检测。这些结果在恢复 AHI 题目表明多重偏导的 TRBV 家庭的存在。特别从 CD8 +T 房间子集, TRBV11, BV15 和 BV20 可能与有 AHI 的题目的致病相关。有相对保存的 CDR3 主题的优先地选择的 TRBV5.1 和 BV20 可以是为长期的 HBV 感染的个性化的处理的潜在的目标。 | Jiezuan Yang | 2014 | Cellular & Molecular Immunology2014，11，4： | 6 |
| 2 | Lignin derived multi-doped(N, S, Cl) carbon materials as excellent electrocatalyst for oxygen reduction reaction in proton exchange membrane fuel cells显示文摘Nowadays,hierarchically macro-/meso-/microporous 3D carbon materials have been paid more attention due to their imaginative application potential in specific electrochemistry.Here,we report a dualtemplate strategy using eutectic NaCl/ZnCl2 melt as airtight and swelling agent to obtain 3D mesoporous skeleton structured carbon from renewable lignin.The prepared lignin-derived biocarbon material(LN-3-1)has a high specific surface area(1289 m^2 g^-1),a large pore volume(2.80 cm^3 g^-1),and a well-connected and stable structure.LN-3-1 exhibits extremely high activity and stability in acidic medium for oxygen reduction reaction(ORR),superior to Pt/C catalyst and most non noble-metal catalysts reported in recent literatures.The prepared carbon material was used as a cathode catalyst to assemble a H2-O2 single fuel cell,and its excellent catalytic performance has been confirmed with the maximum power density of 779 mW cm^-2,which is one of the highest power densities among non-metallic catalysts so far.Density functional theory(DFT)calculations indicate that the synergy of chlorine and nitrogen reconciles the intermediate adsorption energies,leading to an appropriate theoretical ORR onset potential.We develop a cost-effective and highly efficient method to prepare biocarbon catalyst for ORR in proton-exchange membrane fuel cells. | Yixing Shen Yuhang Li Guangxing Yang Qiao Zhang Hong Liang Feng Peng | 2020 | Journal of Energy Chemistry2020，29，5： | 5 |
| 3 | DNA sensing and associated type 1 interferon signaling contributes to progression of radiation-induced liver injury显示文摘Liver damage upon exposure to ionizing radiation(IR),whether accidental or therapeutic,can contribute to liver dysfunction.Currently,radiotherapy(RT)is used for various cancers including hepatocellular carcinoma(HCC);however,the treatment dose is limited by radiation-induced liver disease(RILD)with a high mortality rate.Furthermore,the precise molecular mechanisms of RILD remain poorly understood.Here,we investigated RILD pathogenesis using various knockout mouse strains subjected to whole-liver irradiation.We found that hepatocytes released a large quantity of double-stranded DNA(dsDNA)after irradiation.The cGAS-STING pathway in non-parenchymal cells(NPCs)was promptly activated by this dsDNA,causing interferon(IFN)-I production and release and concomitant hepatocyte damage.Genetic and pharmacological ablation of the IFN-I signaling pathway protected against RILD.Moreover,clinically irradiated human peri-HCC liver tissues exhibited substantially higher STING and IFNβexpression than non-irradiated tissues.Increased serum IFNβconcentrations post-radiation were associated with RILD development in patients.These results delineate cGAS-STING induced type 1 interferon release in NPCs as a key mediator of IR-induced liver damage and described a mechanism of innate-immunity-driven pathology,linking cGAS-STING activation with amplification of initial radiation-induced liver injury. | Shisuo Du Genwen Chen Baoying Yuan Yong Hu Ping Yang Yixing Chen Qianqian Zhao Jian Zhou Jia Fan Zhaochong Zeng | 2021 | Cellular & Molecular Immunology2021，18，7： | 4 |
| 4 | Microscopy and Bioinformatic Analyses of Lipid Metabolism Implicate a Sporophytic Signaling Network Supporting Pollen Development in Arabidopsis显示文摘Arabidopsis sporophytic tapetum 经历一个规划退化过程分泌类脂化合物和另外的材料支持花粉开发。然而,调整退化过程的分子的机制是未知的。到进这分子的机制的获得卓见,我们首先决定为到支持花粉开发的 tapetal 分泌物的最批评的时期从有液泡的小孢子阶段到早 binucleate 花粉阶段。我们然后与可得到的 in-silico 数据分析了为类脂化合物生合成和降级负责的酶的表达式。为在雄蕊然而并非在并发的单核的小孢子和 binucleate 花粉被表示的这些酶的基因具有特别兴趣,当他们大概与 gametophytic 织物相比在 sporophytic 纸巾保持线索到唯一的分子的过程。为类脂化合物生合成的没有基因但是为类脂化合物动员多半编码象 patatin 一样蛋白质的单个基因基于选择标准被识别。为基因的搜索与这基因共同表示编码象充满白氨酸的重复受体 kinase,额外大的 G 蛋白质,另外的蛋白质 kinases,和抄写因素那样的典型信号 transduction 部件的识别另外的基因。另外,朊酶,房间墙降级酶,和另外的蛋白质也被识别。这些蛋白质可以因此是导致大量细胞的部件的降级的一个发信号的网络的部件。因为大量降级活动被期望在雄蕊仅仅在 tapetal 退化过程发生在这个阶段,它是进一步的假设发信号的网络在 tapetal 退化过程行动。 | Yixing Wang Hong Wu Ming Yang | 2008 | Molecular Plant2008，1，4： | 4 |
| 5 | Cu/ACF adsorbent modified by non-thermal plasma for simultaneous adsorption–oxidation of H_(2)S and PH_(3)显示文摘Non-thermal plasma(NTP)surface modification technology is a new method to control the surface properties of materials,which has been widely used in the field of environmental protection because of its short action time,simple process and no pollution.In this study,Cu/ACF(activated carbon fiber loaded with copper)adsorbent was modified with NTP to remove H_(2)S and PH_(3) simultaneously under low temperature and micro-oxygen condition.Meanwhile,the effects of different modified atmosphere(air,N_(2) and NH_(3)),specific energy input(0–13 J/mL)and modification time(0–30 min)on the removal of H_(2)S and PH_(3) were investigated.Performance test results indicated that under the same reaction conditions,the adsorbent modified by NH_(3) plasma with 5 J/mL for 10 min had the best removal effect on H_(2)S and PH_(3).CO_(2) temperature-programmed desorption and X-ray photoelectron spectroscopy(XPS)analyzes showed that NH_(3) plasma modification could introduce amino functional groups on the surface of the adsorbent,and increase the types and number of alkaline sites on the surface.Brunauer-Emmett-Teller and scanning electron microscopy showed that NH_(3) plasma modification did not significantly change the pore size structure of the adsorbent,but more active components were evenly exposed to the surface,thus improving the adsorption performance.In addition,X-ray diffraction and XPS analysis indicated that the consumption of active components(Cu and Cu_(2)O)and the accumulation of sulfate and phosphate on the surface and inner pores of the adsorbent are the main reasons for the deactivation of the adsorbent. | Xinyu Yang Kai Li Chi Wang Fei Wang Xin Sun Yixing Ma Yuan Li Lei Shi Ping Ning | 2023 | Journal of Environmental Sciences2023，，5： | 2 |
| 6 | Synthesis and Photocatalytic Activity of Fe-doped TiO_2 Supported on Hollow Glass Microbeads显示文摘In this paper, Fe-doped TiO_2 photocatalyst supported on hollow glass microbeads(Fe-TiO_2 /beads)is prepared by dip-coating method, which uses hollow glass microbeads as the carriers and tetrabutylorthotitanate [Ti(OC_4H_9)_4] as the raw material. The phase structure, ingredient, morphologies, particle size and shell thickness of the products are characterized by X-ray powder diffraction(XRD), energy-dispersive spectroscopy(EDS) and field emission scanning electron microscope(FESEM). The feasibility of photocatylic degradation of Rhodamine B(Rh B) under illumination of UV-vis light is studied. The results show that the core-shell structure catalyst is composed of Fe-doped anatase TiO_2 and hollow glass microbeads, and the catalytic activity of the TiO_2 is markedly enhanced by Fe ion doping. The optimum concentration of Fe ion is 0.1%(molecular fraction) in the precursor and the photocatalytic activity can be increased to 98% compared with that of the undoped one. The presence of ferrum elements neither influences the transformation of anatase to rutile, nor creates new crystal phases. The possible mechanism of photocatalytic oxidation is also discussed. | Wenyan Zhao Wuyou Fu Haibin Yang Chuanjin Tian Minghui Li Juan Ding Wei Zhang Xiaoming Zhou Hui Zhao Yixing Li | 2011 | Nano-Micro Letters2011，3，1： | 1 |
| 7 | Effects of Prestressing of the Ring Gear in Interference Fit on Flexural Fatigue Strength of Tooth Root显示文摘When the gearbox body interference is connected to the ring gear, prestressing occurs in the ring gear, which has a significant impact on the strength and life of the gear. Research on the prestressing of the inner ring gear is in the preliminary stage, and the distribution rule of the prestressing and the influence of each parameter on the interference prestressing have not been derived. In this paper, based on the method of calculating the prestressing of the thick cylinder in interference fit, the ring gear is found to be equivalent to a thick cylinder, and the distribution rule of prestressing of the ring gear in the interference fit is inferred. Then, by modeling and analyzing the gearbox body and ring gear in the interference fit using ABAQUS, the distribution rule of prestressing the ring gear in the interference fit is obtained through a numerical simulation. Finally, the prestressing of the ring gear in the interference fit is measured using X-ray di raction, and the distribution rule of prestressing of the ring gear in the interference fit is obtained through analysis. Compared with the distribution rule of prestressing in theory, numerical simulation, and experiment, the theoretical distribution rule of prestressing is amended through a statistical method, and a more accurate formula of prestressing is obtained. Through the calculation of the stress and bending moment in the dangerous section of the ring gear through prestressing, the formula for checking the tooth root flexural fatigue strength in the interference fit prestressing is inferred. This research proposes a tooth root bending strength conditional formula for the inner ring gear of the interference fit, which serves as a guide for the design and production of the actual interference joint inner ring gear. | Shiping Yang Yixing Ji Yulin Mo Tianyu Xia | 2019 | Chinese Journal of Mechanical Engineering2019，32，4： | 1 |
| 8 | Novel SnO 2 hierarchical nanostructures: Synthesis and their gas sensing properties显示文摘 | Xiaoming Zhou Wuyou Fu Haibin Yang Yanyan Zhang Minghui Li Yixing Li | 2013 | Materials Letters2013，，： | 1 |
| 9 | A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis显示文摘 | Li‐Dong Wang Xiuli Bi Xin Song Nicole M. Pohl Yulan Cheng Yixing Zhou Stephen Shears Emmanuel Ansong Mengtao Xing Shaomeng Wang Xiao‐Chun Xu Peng Huang Liyan Xu Liang Wang Zongmin Fan Xueke Zhao Huali Dong Stephen J. Meltzer Ivan Ding Wancai Yang | 2013 | Mol Carcinog2013，，1： | 1 |
| 10 | Surface energy-mediated fibronectin adsorption and osteoblast responses on nanostructured diamond显示文摘Nanostructured diamond have potential applications in many biomedical related fields and demonstrated extraordinary capacity to influence cellular responses. Studying the surface property of nanodiamond and its influence to protein adsorption and subsequent cellular responses along with the mechanism behind such capacity becomes more important. Here the role of surface energy associated with nanostructured diamond in modulating fibronectin and osteoblast(OB, bone forming cells) responses was investigated. Nanocrystalline diamond(NCD) and submicron crystalline diamond(SMCD) films with controllable surface energy were prepared by microwave-enhanced plasma chemical vapor deposition(MPCVD) techniques. Fibronectin adsorption on the diamond films with varied surface energy values was measured via the enzyme-linked immunosorbent assay(ELISA) and the relationship between the surface energy and fibronectin adsorption was studied. The result indicated that fibronectin adsorption on nanostructured surfaces was closely related to both surface energy and material microstructures. The spreading and migration of OB aggregates(each containing 30–50 cells) on the NCD with varied surface energy values were also studied. The result indicates a correlation between the cell spreading and migration on nanodiamond and the surface energy of nanostructured surface. | Yixing Tian Huiling Liu Brian W.Sheldon Thomas J.Webster Sichen Yang Huilin Yang Lei Yang | 2019 | Journal of Materials Science & Technology2019，35，5： | 1 |
| 11 | Composite Converter Combined APFC with Switched-capacitor Converter显示文摘To reduce switch numbers and voltage stress in semiconductor devices,this paper proposes a novel single-phase converter combined Active Power Factor Correction(APFC)with switched-capacitor converter.In addition,dynamic voltage regulation and voltage gain are improved by integrating the boost converter and switching capacitor cells.The interstage bulk capacitor is no longer needed.An average current control with redistribution of voltage in cells is proposed to obtain voltage lift ability of the switching capacitor cells and maintain a high-power factor.To study and verify the proposed converter preliminarily,theoretical analysis and simulation are presented in the paper.Furthermore,a 50o W prototype with two different configurations is built for experimental verification.The proposed converter can reach 95.62%of maximum efficiency,0.99 of power factor,and 3.55%of THD with 600 V output voltage,simultaneously. | Qing Fu Yishan Chen Yixing Su Yang Hang | 2024 | CSEE Journal of Power and Energy Systems2024，10，1： | 0 |
| 12 | On the monolayer dispersion behavior of Co_(3)O_(4)on HZSM-5 support:designing applicable catalysts for selective catalytic reduction of nitrogen oxides by ammonia显示文摘Based on monolayer dispersion theory,Co_(3)O_(4)/ZSM-5 catalysts with different loadings have been prepared for selective catalytic reduction of nitrogen oxides by ammonia.Co_(3)O_(4)can spontaneously disperse on HZSM-5 support with a monolayer dispersion threshold of 0.061 mmol 100 m^(-2),equaling to a weight percentage around 4.5%.It has been revealed that the quantities of surface active oxygen(O_(2)^(-))and acid sites are crucial for the reaction,which can adsorb and activate NO_(x)and NH_(3)reactants effectively.Below the monolayer dispersion threshold,Co_(3)O_(4)is finely dispersed as sub-monolayers or monolayers and in an amorphous state,which is favorable to generate the two kinds of active sites,hence promoting the performance of ammonia selective catalytic reduction of nitrogen oxide.However,the formation of crystalline Co_(3)O_(4)above the capacity is harmful to the reaction performance.4%Co_(3)O_(4)/ZSM-5,the catalyst close to the monolayer dispersion capacity,possesses the most abundant active O_(2)^(-)species and acidic sites,thereby demonstrating the best reaction performance in all the samples.It is proposed the optimal Co_(3)O_(4)/ZSM-5 catalyst can be prepared by loading the capacity amount of Co_(3)O_(4)onto HZSM-5 support. | Yufeng Yang Lihong Zhang Tao Song Yixing Huang Xianglan Xu Junwei Xu Xiuzhong Fang Qing Wang Haiming Liu Xiang Wang | 2023 | Frontiers of Chemical Science and Engineering2023，17，11： | 0 |
| 13 | Bioinformatics analysis of SARS-CoV-2 infectionassociated immune injury and therapeutic prediction for COVID-19显示文摘Background:Severe acute respiratory syndrome coronavirus 2 is a highly contagious viral infection,without any available targeted therapies.The high mortality rate of COVID-19 is speculated to be related to immune damage.Methods:In this study,clinical bioinformatics analysis was conducted on transcriptome data of coronavirus infection.Results:Bioinformatics analysis revealed that the complex immune injury induced by coronavirus infection provoked dysfunction of numerous immune-related molecules and signaling pathways,including immune cells and toll-like receptor cascades.Production of numerous cytokines through the Th17 signaling pathway led to elevation in plasma levels of cytokines(including IL6,NF-kB,and TNF-a)followed by concurrent inflammatory storm,which mediates the autoimmune response.Several novel medications seemed to display therapeutic effects on immune damage associated with coronavirus infection.Conclusions:This study provided insights for further large-scale studies on the target therapy on reconciliation of immunological damage associated with COVID-19. | Haomin Zhang Haoran Chen Jundong Zhang Ximeng Chen Bin Guo Peng Zhi Zhuoyang Li Geliang Liu Bo Yang Xiaohua Chi Yixing Wang Feng Cao Jun Ren Xuechun Lu | 2021 | Emergency and Critical Care Medicine2021，1，1： | 0 |
| 14 | Modern Radiotherapy in the Multidisciplinary Management of Common Cancers显示文摘Radiotherapy(RT)is an indispensable treatment for nearly all cancer types.Rapid evolution of technology has progressively increased the safely deliverable radiation dose,minimizing the exposure of uninvolved normal tissue and thus improving the efficacy,safety,and accessibility of radiation therapy.Meanwhile,multidisciplinary team management that aims to define personalized,optimal treatment strategies through shared decision-making between healthcare professionals and patients is a fundamental aspect of high-quality cancer diagnosis and treatment and often includes radiation oncology.How to combine this with other anti-tumor modalities,especially immunotherapy,in the era of modern RT has been increasingly emphasized.Here,in this review,we introduce the innovations in RT technology,and aim to provide an outline of the role of contemporary RT in the multidisciplinary treatment of most common cancers,including non-small cell lung cancer,esophageal cancer,breast cancer,hepatocellular carcinoma,gastric/esophageal-gastric junction cancer,and colorectal cancer,focusing on the main areas of innovation that are conducive to a change toward the personalized application of RT.We also discuss the future research directions for combination with modern RT. | Shisuo DU Yixing CHEN Qian ZHANG Jing SUN Guifen MA Jian WANG Xian ZHANG Taiwei SUN Yang ZHANG Jianying ZHANG Qiqiao WU Zhaochong ZENG | 2022 | Clinical Cancer Bulletin2022，1，2： | 0 |
| 15 | Synthesis Optimization of SSZ-13 Zeolite Membranes by Dual Templates for N_(2)/NO_(2) Separation显示文摘High-silica SSZ-13 zeolite membranes are promising in industrial separations of light gases and continuous membranes are highly demanded for better separation performances. Herein, pure-phase, continuous and thin SSZ-13 zeolite membranes were synthesized using dual templates of N,N,N-trimethtyl-1-adamantammonium hydroxide(TMAdaOH) and tetraethylammonium hydroxide(TEAOH). Systematical investigations of TMAdaOH/TEAOH ratios and their concentrations show that TMAdaOH acts as the main structure-directing agent in the formation of the SSZ-13 zeolite. TMAdaOH cooperatively plays with TEAOH in promoting the SSZ-13 crystal intergrowth to form a continuous polycrystalline membrane. Additionally, appropriate introduction of TEAOH is able to adjust the membrane thickness to the crystal-comparable size of ca. 2.0 μm. The SSZ-13 membranes are further applied for N2/NO2separation, which is firstly reported on zeolite membranes. The gas permeation results show that the SSZ-13 membrane synthesized by the dual-template approach exhibits selective separation of N2 over NO2 with N2/NO2 separation factor of 7.6 and N2 permeance of 1.66×10-8 mol·m-2·s-1·Pa-1. | LI Jun RONG Huazhen CHEN Cong LI Ziyi ZUO Jiayu WANG Wenjian LIU Xinjian GUAN Yixing YANG Xiong LIU Yingshu ZOU Xiaoqin ZHU Guangshan | 2022 | Chemical Research in Chinese Universities2022，38，1： | 0 |
| 16 | Prediction of lute acoustic quality based on soundboard vibration performance using multiple choice model显示文摘The vibrational performance of wood materials critical affects the acoustic quality of a lute. The purpose of this research was to apply a multiple choice model to predict the quality of musical instruments based on data on lute soundboard vibrational properties of Paulownia wood.In the lute production, lute material selection mainly depends on the subjective evaluation of technicians, which is not only inefficient, but inaccurate. In this study, nine lutes were fabricated. Using the multiple selection model,the lute tone quality was predicted by the soundboard wood vibration data. Compared with the actual value, the dependent value predicted by the count of observations with the maximum probability had 22 erroneous judgments. The model precision is 87.78%. The results confirmed that the prediction model can be used as a guideline for the selection of the soundboard wood in musical instrument plants. | Yang Yang Zhenbo Liu Yixing Liu | 2017 | Journal of Forestry Research2017，28，4： | 0 |
| 17 | Novel Ag-AgBr decorated composite membrane for dye rejection and photodegradation under visible light显示文摘Photocatalytic membranes have received increasing attention due to their excellent separation and photodegradation of organic contaminants in wastewater.Herein,we bound Ag-AgBr nanoparticles onto a synthesized polyacrylonitrile-ethanolamine(PAN-ETA)membrane with the aid of a chitosan(CS)-TiO_(2) layer via vacuum filtration and in-situ partial reduction.The introduction of the CS-TiO_(2) layer improved surface hydrophilicity and provided attachment sites for the Ag-AgBr nanoparticles.The PAN-ETA/CS-Ti0_(2)/Ag-AgBr photocatalytic membranes showed a relatively high water permeation flux(〜47 L·m^(-2)·h^(-1)·bar^(-1))and dyes rejection(methyl orange:88.22%;congo red:95%;methyl blue:97.41%;rose bengal:99.98%).Additionally,the composite membranes exhibited potential long-term stability for dye/salt separation(dye rejection:-97%;salt rejection:-6.5%).Moreover,the methylene blue and rhodamine B solutions(20 mL,10 mg·L^(-1))were degraded approximately 90.75% and 96.81% in batch mode via the synthesized photocatalytic membranes under visible light irradiation for 30 min.This study provides a feasible method for the combination of polymeric membranes and inorganic catalytic materials. | Yixing Wang Liheng Dai Kai Qu Lu Qin Linzhou Zhuang Hu Yang Zhi Xu | 2021 | Frontiers of Chemical Science and Engineering2021，15，4： | 0 |
| 18 | Archetype identification and urban building energy modeling for city-scale buildings based on GIS datasets显示文摘Urban building energy modeling has become an efficient way to understand urban building energy use and explore energy conservation and emission reduction potential.This paper introduced a method to identify archetype buildings and generate urban building energy models for city-scale buildings where public building information was unavailable.A case study was conducted for 68,966 buildings in Changsha city,China.First,clustering and random forest methods were used to determine the building type of each building footprint based on different GIS datasets.Then,the convolutional neural network was employed to infer the year built of commercial buildings based on historical satellite images from multiple years.The year built of residential buildings was collected from the housing website.Moreover,twenty-two building types and three vintages were selected as archetype buildings to represent 59,332 buildings,covering 87.4%of the total floor area.Ruby scripts leveraging on OpenStudio-Standards were developed to generate building energy models for the archetype buildings.Finally,monthly and annual electricity and natural gas energy use were simulated for the blocks and the entire city by EnergyPlus.The total electricity and natural gas use for the 59,332 buildings was 13,864 GWh and 23.6×10^(6) GJ.Three energy conservation measures were evaluated to demonstrate urban energy saving potential.The proposed methods can be easily applied to other cities in China. | Zhang Deng Yixing Chen Jingjing Yang Zhihua Chen | 2022 | Building Simulation2022，15，9： | 0 |
| 19 | An incremental elastic-plastic cohesive constitutive model with considering damage显示文摘The interface has a significant influence on the macroscopic mechanical behaviors of composite materials,with interface cracking being a typical failure event.The ability to precisely describe the mechanical behavior of the interface is critical for analyzing the failure of composite materials.Based on plasticity theory and damage mechanics,an elastic-plastic interface constitutive model is developed to simulate the irreversible plastic deformation at the interface under the cyclic loading condition.Furthermore,by incorporating a damage factor in scalar form,the model is able to simulate mixed loading forms(Modes I and II).The influence of interfacial strength and toughness on the overall mechanical properties of unidirectional fiber reinforced composites under transverse loading is studied with this model.The simulation results are consistent with the experimental data in the literature,demonstrating the model's effectiveness.The model can be used to simulate the mechanical behavior of composites with interfaces under cyclic loading,and it is helpful for understanding the plastic behavior and damage accumulation at the interfaces in the composites. | XIA Tong QIAN YiXing XU ShengYao YANG ZhenYu LU ZiXing | 2023 | Science China(Technological Sciences)2023，66，12： | 0 |
| 20 | Improved diagnosis of thyroid cancer aided with deep learning applied to sonographic text reports:a retrospective,multi-cohort,diagnostic study显示文摘Objective:Large volume radiological text data have been accumulated since the incorporation of electronic health record(EHR)systems in clinical practice.We aimed to determine whether deep natural language processing algorithms could aid radiologists in improving thyroid cancer diagnosis.Methods:Sonographic EHR data were obtained from the EHR database.Pathological reports were used as the gold standard for diagnosing thyroid cancer.We developed thyroid cancer diagnosis based on natural language processing(THCaDxNLP)to interpret unstructured sonographic text reports for thyroid cancer diagnosis.We used the area under the receiver operating characteristic curve(AUROC)as the primary metric to measure the performance of the THCaDxNLP.We compared the performance of thyroid ultrasound radiologists aided with THCaDxNLP vs.those without THCaDxNLP using 5 independent test sets.Results:We obtained a total number of 788,129 sonographic radiological reports.The number of thyroid sonographic data points was 132,277,18,400 of which were thyroid cancer patients.Among the 5 test sets,the numbers of patients per set were 439,186,82,343,and 171.THCaDxNLP achieved high performance in identifying thyroid cancer patients(the AUROC ranged from 0.857–0.932).Thyroid ultrasound radiologists aided with THCaDxNLP achieved significantly higher performances than those without THCaDxNLP in terms of accuracy(93.8%vs.87.2%;one-sided t-test,adjusted P=0.003),precision(92.5%vs.86.0%;P=0.018),and F1 metric(94.2%vs.86.4%;P=0.007).Conclusions:THCaDxNLP achieved a high AUROC for the identification of thyroid cancer,and improved the accuracy,sensitivity,and precision of thyroid ultrasound radiologists.This warrants further investigation of THCaDxNLP in prospective clinical trials. | Qiang Zhang Sheng Zhang Jianxin Li Yi Pan Jing Zhao Yixing Feng Yanhui Zhao Xiaoqing Wang Zhiming Zheng Xiangming Yang Lixia Liu Chunxin Qin Ke Zhao Xiaonan Liu Caixia Li Liuyang Zhang Chunrui Yang Na Zhuo Hong Zhang Jie Liu Jinglei Gao Xiaoling Di Fanbo Meng Wei Ji Meng Yang Xiaojie Xin Xi Wei Rui Jin Lun Zhang Xudong Wang Fengju Song Xiangqian Zheng Ming Gao Kexin Chen Xiangchun Li | 2022 | Cancer Biology & Medicine2022，19，5： | 0 |
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