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| 1 | Effects of rare earth elements on inclusions and impact toughness of high-carbon chromium bearing steel显示文摘High-carbon chromium bearing steels with different rare earth (RE) contents were prepared to investigate the effects of RE on inclusions and impact toughness by different techniques. The results showed that RE addition could modify irregular Al2O3 and MnS into regular RE inclusions. With the increase of RE content, the reaction sequence of RE and potential inclusion forming elements should be O, S, As, P and C successively. RE inclusions containing C might precipitate in molten steel and solid state, but the precipitation tem perature was significantly higher than that of carbides in high-carbon chromium bearing steel. For experim ental bearing steels, the volume fraction of inclusions increased steadily with the increase of RE content, but smaller and more dispersed inclusions could be obtained by 0.018% RE content compared with bearing steel without RE, whereas the continuous increase of RE content led to an increasing trend for inclusion size and a gradual deterioration for inclusion distribution. RE addition could improve the transverse impact toughness and isotropy of bearing steel, and for modified highcarbon chrom ium bearing steel by RE alloying, the increase of RE content continuously increased both transverse and longitudinal im pact toughness until excessive RE addition. | Chaoyun Yang Yikun Luan Dianzhong Li Yiyi Li | 2019 | Journal of Materials Science & Technology2019，35，7： | 22 |
| 2 | Effects of overlying water aeration on phosphorus fractions and alkaline phosphatase activity in surface sediment显示文摘Microbial activity may influence phosphorus (P) deposit and release at the water sediment interface.The properties of DO (dissolved oxygen),pH,P fractions (TP,Ca-P,Fe-P,OP,IP),and APA (alkaline phosphatase activity) at the water sediment interface were measured to investigate microbial activity variations in surface sediment under conditions of two-month intermittent aeration in overlying water.Results showed that DO and TP of overlying water increased rapidly in the first week and then decreased gradually after 15 day of intermittent aeration.Microorganism metabolism in surface sediment increased pH and decreased DO and TP in the overlying water.After two-month intermittent aeration,APA and OP from surface sediment (0-2 cm) were both significantly higher than those from bottom sediment (6-8 cm) (p < 0.05),and surface sediment Fe-P was transferred to OP during the course of microorganism reproduction on the surface sediment.These results suggest that microbial activity and microorganism biomass from the surface sediment were higher than those from bottom sediment after two-month intermittent aeration in the overlying water. | Jianjun Chen Shaoyong Lu Yikun Zhao Wei Wang Minsheng Huang | 2011 | Journal of Environmental Sciences2011，23，2： | 20 |
| 3 | NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens显示文摘像点头的受体(NLR ) 是对微生物引起的感染在天生的免疫起关键作用的细胞内部的蛋白质的一个家庭。NLRC5, NLR 家庭的最大的成员,最近吸引了许多注意。然而,在 vitro,研究在主人防卫并且在调整有免疫力的发信号的小径关于 NLRC5 的角色报导了不一致的结果。在里面 NLRC5 的 vivo 功能仍然保持未知。这里,我们报导 NLRC5 是对在 vivo 的细胞内部的病原体的主人防卫的一个批评管理者。NLRC5 明确地为涉及 MHC 一级抗原表示的基因的表示被要求。NLRC5 缺乏的老鼠显示了在 MHC 一级基因和伴随物失败的表示的一个深刻缺点激活 L。monocytogenes 特定的 CD8 + T 房间回答,包括的激活,增长和 cytotoxicity,和变异的老鼠更产生病原体感染。调停 NLRP3 的 inflammasome 激活部分也在 NLRC5 缺乏的老鼠被损害。然而, NLRC5 为 NF-κ 的导致病原体的表示是非必需的; B 依赖的支持 inflammatory 基因以及类型我干扰素基因。因此, NLRC5 极其调整 MHC 一级抗原表示控制细胞内部的病原体感染。 | Yikun Yao Yalong Wang Fuxiang Chen Yin Huang Shu Zhu Qibin Leng Hongyan Wang Yufang Shi Youcun Qian | 2012 | Cell Research2012，22，5： | 13 |
| 4 | Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma显示文摘Background:Resistance to ferroptosis,a regulated cell death caused by irondependent excessive accumulation of lipid peroxides,has recently been linked to lung adenocarcinoma(LUAD).Intracellular antioxidant systems are required for protection against ferroptosis.The purpose of the present studywas to investigate whether and how extracellular system desensitizes LUAD cells to ferroptosis.Methods:Established human lung fibroblasts MRC-5,WI38,and human LUAD H1650,PC9,H1975,H358,A549,and H1299 cell lines,tumor and matched normal adjacent tissues of LUAD,and plasma from healthy individuals and LUAD patients were used in this study.Immunohistochemistry and immunoblotting were used to analyze protein expression,and quantitative reverse transcription-PCR was used to analyze mRNA expression.Cell viability,cell death,and the lipid reactive oxygen species generationwere measured to evaluate the responses to ferroptosis.Exosomes were observed using transmission electron microscope.The localization of arachidonic acid(AA)was detected using click chemistry labeling followed by confocal microscopy.Interactions between RNAs and proteins were detected using RNA pull-down,RNA immunoprecipitation and photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation methods.Proteomic analysis was used to investigate RNA-regulated proteins,and metabolomic analysis was performed to analyze metabolites.Cellderived xenograft,patient-derived xenograft,cell-implanted intrapulmonary LUAD mouse models and plasma/tissue specimens from LUAD patients were used to validate the molecular mechanism.Results:Plasma exosome from LUAD patients specifically reduced lipid peroxidation and desensitized LUAD cells to ferroptosis.A potential explanation is that exosomal circRNA_101093(cir93)maintained an elevation in intracellular cir93 in LUAD to modulate AA,a poly-unsaturated fatty acid critical for ferroptosisassociated increased peroxidation in the plasma membrane.Mechanistically,cir93 interacted with and increased fatty acid-binding protein 3(FABP3),which transported AA and facilitated its reaction with taurine.Thus,global AA was reduced,whereas N-arachidonoyl taurine(NAT,the product of AA and taurine)was induced.Notably,the role of NAT in suppressing AA incorporation into the plasma membrane was also revealed.In pre-clinical in vivo models,reducing exosome improved ferroptosis-based treatment.Conclusion:Exosome and cir93 are essential for desensitizing LUAD cells to ferroptosis,and blocking exosome may be helpful for future LUAD treatment. | Xiao Zhang Yunhua Xu Lifang Ma Keke Yu Yongjie Niu Xin Xu Yi Shi Susu Guo Xiangfei Xue Yikun Wang Shiyu Qiu Jiangtao Cui Hong Wang Xiaoting Tian Yayou Miao Fanyu Meng Yongxia Qiao Yongchun Yu Jiayi Wang | 2022 | Cancer Communications2022，42，4： | 10 |
| 5 | The role played by traditional Chinese medicine in preventing and treating COVID-19 in China显示文摘Traditional Chinese medicine(TCM),an ancient system of alternative medicine,played an active role in the prevention and control of COVID-19 in China.It improved the clinical symptoms of patients,reduced the mortality rate,improved the recovery rate,and effectively relieved the operating pressure on the national medical system during critical conditions.In light of the current global pandemic,TCM-related measures might open up a new channel in the control of COVID-19 in other countries and regions.Here,we summarize the TCM-related measures that were widely used in China,including TCM guidelines,the Wuchang pattern,mobile cabin hospitals,integrated treatment of TCM and modern medicine for critical patients,and non-medicine therapy for convalescent patients,and describe how TCM effectively treated patients afflicted with the COVID-19.Effective TCM therapies could,therefore,be recommended and practiced based on the existing medical evidence from increased scientific studies. | Qingwei Li Han Wang Xiuyang Li Yujiao Zheng Yu Wei Pei Zhang Qiyou Ding Jiaran Lin Shuang Tang Yikun Zhao Linhua Zhao Xiaolin Tong | 2020 | Frontiers of Medicine2020，14，5： | 10 |
| 6 | Mass production of 2D materials by intermediate-assisted grinding exfoliation显示文摘The scalable and high-efficiency production of 2D materials is a prerequisite to their commercial use.Currently,only graphene and graphene oxide can be produced on a ton scale,and the inability to produce other 2D materials on such a large scale hinders their technological applications.Here we report a grinding exfoliation method that uses micro-particles as force intermediates to resolve applied compressive forces into a multitude of small shear forces,inducing the highly efficient exfoliation of layer materials.The method;referred to as intermediate-assisted grinding exfoliation(iMAGE);can be used for the large-scale production of many 2D materials.As an example;we have exfoliated bulk h-BN into 2D h-BN with large flake sizes;high quality and structural integrity,with a high exfoliation yield of 67%,a high production rate of 0.3 g h^-1 and a low energy consumption of 3.01 x 106 J g^-1.The production rate and energy consumption are one to two orders of magnitude better than previous results.Besides h-BN,this iMAGE technology has been used to exfoliate various layer materials such as graphite,black phosphorus,transition metal dichalcogenides;and metal oxides;provings universality.Molybdenite concentrate,a natural low-cost and abundant mineral;was used as a demo for the large-scale exfoliation production of 2D M0S2 flakes.Our work indicates the huge potential of the iMAGE method to produce large amounts of various 2D materials;which paves the way for their commercial application. | Chi Zhang Junyang Tan Yikun Pan Xingke Cai Xiaolong Zou Hui-Ming Cheng Bilu Liu | 2020 | National Science Review2020，7，2： | 10 |
| 7 | Experimental evaluation of thermolysis-driven gas emissions from LiPF6-carbonate electrolyte used in lithium-ion batteries显示文摘This paper performs an experimental evaluation of thermolysis-driven gases generated by the thermal decomposition of 1 M LiPF6+EC/DMC=1/1 v/v electrolytes at various decomposition temperatures,pyrolysis durations,and oxygen concentrations.Carried out in a home-built autoclave filled with pure helium,the experiment reveals that as the decomposition temperature increases,more types and larger quantities of gases will be released.Specifically,the experimental results demonstrate trends of logistic growth in the volume concentration of CO2,C2H6O,C2H4,CO,and C2H4O2 with the increase of decomposition temperature.With a prolonged pyrolysis duration,while volume concentrations of certain gases,such as CO2,C2H6O,C2H5F,and CO would increase,the concentration of C2H4O2 actually decreases.Moreover,concentrations of both C2H4 and C2H5F will first decrease and reach their minimum values at 1%v/v oxygen concentration,and then they would quickly climb back at higher oxygen concentrations,while the concentrations of C2H6 and C2H3F would decrease monotonically.It is envisioned that the detailed experimental results and findings on the gas generation pattern of 1 M LiPF6+EC/DMC=1/1 v/v electrolytes can facilitate the development of an early warning mechanism of thermal runaway based on gas sensing technology,which can be effectively applied to monitor the potential thermal failures of lithium-ion batteries with the same type of electrolyte and thus promote the thermal safety of battery packs in safety-critical applications. | Zhenghai Liao Shen Zhang Yikun Zhao Zongjia Qiu Kang Li Dong Han Guoqiang Zhang Thomas G.Habetler | 2020 | Journal of Energy Chemistry2020，29，10： | 7 |
| 8 | Magnetic microstructure and coercivity mechanism of high performance Nd-Fe-B magnets显示文摘Magnetic microstructure of high performance Nd-Fe-B magnets was investigated by using magnetic force microscopy. The correlation between magnetic microstructure and coercivity for high performance Nd-Fe-B magnets was studied. It is found that the magnets with different coercivity mechanism take on different microstructures and magnetism. Moreover, the magnetic microstructures of high performance permanent magnets can be explained by the starting field theory model. | ZHU Minggang LIU Xingmin FANG Yikun LI Zhengbang LI Wei | 2006 | Rare Metals2006，25，z1： | 7 |
| 9 | Aerosol characteristics and impacts on weather and climate over the Tibetan Plateau显示文摘With themostmassive snow and ice globally between 60°S and 60°S ,the Tibetan Plateau(TP),also called the third pole of the world,plays significant roles in the weather,climate and lives in South Asia and East Asia and even the world[1–3].Investigating the variation of weather and the climate system over the TP has long been carried out,which is significant for fresh water supplies for over 1.4 billion people in Asia.Actually,the‘Third Pole Environment’program was initiated to call international efforts to understand both climate and environment changes on the plateau[1],which has already shown rapid warming and intensified cryospheric melt and water cycle. | Chuanfeng Zhao Yikun Yang Hao Fan Jianping Huang Yunfei Fu Xiaoye Zhang Shichang Kang Zhiyuan Cong Husi Letu Massimo Menenti | 2020 | National Science Review2020，7，3： | 7 |
| 10 | Optimization of microstructures and magnetic properties of Sm(Co_(bal)Fe_(0.227)Cu_(0.07)Zr_(0.023))_(7.6) magnets by sintering treatment显示文摘Magnetic properties and microstructures of Sm(Co_(bal)Fe_(0.227)Cu_(0.07)Zr_(0.023_)_(7.6) sintered magnets were optimized by sintering treatment. Results show that the knee-point magnetic field, Hknee, is twofold up and the intrinsic coercivity Hcjincreases by 40%, ranging from 21.64 to 30.39 kOe at the cost of a little decrease of Brfrom 10.84 to 10.31 kGs with sintering temperature decreasing from 1488 to 1473 K. And the average domain width is narrower and more uniform for the specimen sintered at 1473 K than that of the specimen sintered at 1488 K. It is impressive that the density of lamellar phase increases from ~0.050 to ~0.058 nm^(-1) with the sintering temperature decreasing from 1488 to 1473 K. Moreover, the average cellular size is about ~84 nm for the magnets sintered at 1473 K, which is 80% of that of the magnets sintered at 1488 K(~97 nm). And the cell boundary width of the magnets sintered at 1473 K(~7 nm) is only half average width of the magnets sintered at 1488 K(~14 nm). It is found that the Cu content in the cell boundaries is much higher(~17 at%) in the magnets sintered at 1473 K compared to that of the magnets sintered at 1488 K(~10 at%). It can be concluded that smaller cells and narrower cell boundaries together with higher gradient of Cu content are key points for obtaining the optimum Hkneeand Hcj. | Kuikui Songa Wei Suna Yikun Fang Shuai Wang Nengjun Yu Meiling Zhang Minggang Zhu Wei Li | 2019 | Journal of Rare Earths2019，37，2： | 6 |
| 11 | CDP1, a novel component of chloroplast division site positioning system in Arabidopsis显示文摘叶绿体是从 endosymbiotic cyanobacteria 演变的植物特定的细胞器。他们通过二进制分裂划分。叶绿体部门地点的选择为对称的叶绿体部门是枢轴的。在 E。coli,在房间的中点部门地点放被 Min 系统的动态摆动调整,它包括 MinC,头脑和矿。在植物的头脑和矿的相当或相同的事物涉及叶绿体分割。MinC 的相当或相同的事物仍然没在更高的植物被识别。然而,象 FtsZ 一样蛋白质, ARC3,被发现地点放涉及叶绿体分割。这里,我们报导放 1 的那个叶绿体部门地点(AtCDP1 ) 是在 Arabidopsis 涉及叶绿体部门地点放置的新奇叶绿体部门蛋白质。AtCDP1 被与房间部门显型为殖民地在细菌屏蔽一个 Arabidopsis cDNA 表示图书馆发现。AtCDP1 只在 Arabidopsis 在年轻绿纸巾被表示。有多重部门地点的伸长的叶绿体在 loss-of-function cdp1 异种被观察。AtCDP1 的 Overexpression 也引起了一个叶绿体部门显型。蛋白质相互作用试金建议 AtCDP1 可以调停通过和 ARC3 的相互作用放的叶绿体部门地点。总的来说,我们的结果显示 AtCDP1 是放系统,和这个系统的工作机制的叶绿体部门地点的一个新奇部件与在原核生物的房间的传统的 MinCDE 系统的不同。 | Min Zhang Yong Hu Jingjing Jia Dapeng Li Runjie Zhang Hongbo Gao Yikun He | 2009 | Cell Research2009，19，7： | 5 |
| 12 | Characterization of Distinct T Cell Receptor Repertoires in Tumor and Distant Non-tumor Tissues from Lung Cancer Patients显示文摘T cells and T cell receptors(TCRs)play pivotal roles in adaptive immune responses against tumors.The development of next-generation sequencing technologies has enabled the analysis of the TCRb repertoire usage.Given the scarce investigations on the TCR repertoire in lung cancer tissues,in this study,we analyzed TCRb repertoires in lung cancer tissues and the matched distant non-tumor lung tissues(normal lung tissues)from 15 lung cancer patients.Based on our results,the general distribution of T cell clones was similar between cancer tissues and normal lung tissues;however,the proportion of highly expanded clones was significantly higher in normal lung tissues than in cancer tissues(0.021%±0.002%vs.0.016%±0.001%,P=0.0054,Wilcoxon signed rank test).In addition,a significantly higher TCR diversity was observed in cancer tissues than in normal lung tissues(431.37±305.96 vs.166.20±101.58,P=0.0075,Mann-Whitney U test).Moreover,younger patients had a significantly higher TCR diversity than older patients(640.7±295.3 vs.291.8±233.6,P=0.036,Mann-Whitney U test),and the higher TCR diversity in tumors was significantly associated with worse cancer outcomes.Thus,we provided a comprehensive comparison of the TCR repertoires between cancer tissues and matched normal lung tissues and demonstrated the presence of distinct T cell immune microenvironments in lung cancer patients. | Xiang Wang Botao Zhang Yikun Yang Jiawei Zhu Shujun Cheng Yousheng Mao Lin Feng Ting Xiao | 2019 | Genomics, Proteomics & Bioinformatics2019，17，3： | 5 |
| 13 | A transceptor-channel complex couples nitrate sensing to calcium signaling in Ambidopsis显示文摘Nitrate-induced Ca^(2+) signaling is crucial for the primary nitrate response in plants.However,the molecular mechanism underlying the generation of the nitrate-specific calcium signature remains unknown.We report here that a cyclic nucleotide-gated channel(CNGC)protein,CNGC15,and the nitrate transceptor(NRT1.1)constitute a molecular switch that controls calcium influx depending on nitrate levels.The expression of CNGC15 is induced by nitrate,and its protein is localized at the plasma membrane after establishment of young seedlings.We found that disruption of CNGC15 results in the loss of the nitrate-induced Ca^(2+) signature(primary nitrate response)and retards root growth,reminiscent of the phenotype observed in the nrt1.1 mutant.We further showed that CNGC15 is an active Ca^(2+)-permeable channel that physically interacts with the NRT1.1 protein in the plasma membrane.Importantly,we discovered that CNGC15-NRT1.1 interaction silences the channel activity of the heterocomplex,which dissociates upon a rise in nitrate levels,leading to reactivation of the CNGC15 channel.The dynamic interactions between CNGC15 and NRT1.1 therefore control the channel activity and Ca^(2+) influx in a nitrate-dependent manner.Our study reveals a new nutrient-sensing mechanism that utilizes a nutrient transceptor-channel complex assembly to couple nutrient status to a specific Ca^(2+) signature. | Xiaohan Wang Changxin Feng LiLi Tian Congcong Hou Wang Tian Bin Hu Qian Zhang Zhijie Ren Qi Niu Jiali Song Dongdong Kong Liangyu Liu Yikun He Ligeng Ma Chengcai Chu Sheng Luan Legong Li | 2021 | Molecular Plant2021，14，5： | 5 |
| 14 | MoS2 nanorods with inner caves through synchronous encapsulation of sulfur for high performance Li–S cathodes显示文摘Lithium–sulfur(Li–S)batteries have become one of the most promising candidates for next-generation batteries owing to their high specific capacity,low cost,and environment-friendliness.Many efforts have been made to mitigate the'shuttle effect'through physical adsorption and chemical bonding.MoS2 has been proposed as a cathode material to provide effective anchoring sites for lithium polysulfides(Li PSs),but is still limited by its layer structure.Herein,we designed novel MoS2 nanorods with inner caves based on our previous work,and performed synchronous encapsulation of sulfur during the synthesis process.The outer MoS2 tubular shells physically inhibit the outward diffusion of polysulfide species while the inner particles chemically anchor the polysulfides to prevent shuttling.As the cathode matrix in Li–S batteries,the electrochemical results deliver a high initial discharge capacity of 1213 mAhg^-1 for sulfur at 0.1 C.After cycling at 1 C for 300 cycles,the cells exhibit a capacity decay of only 0.076%per cycle and high average coulombic efficiency over 95%.The tubular MoS2 structure is an innovative and appealing design,which could be regarded as a prospective substrate for the improved performance of Li–S batteries. | Yikun Yi Zechen Liu Pu Yang Tao Wang Xuewen Zhao Hongyang Huang Yonghong Cheng Jinying Zhang Mingtao Li | 2020 | Journal of Energy Chemistry2020，29，6： | 5 |
| 15 | Optimization of both coercivity and knee-point magnetic field of Sm2Co17-type magnets via solid solution process显示文摘It is confirmed that phase homogenization is very important for improving the magnetic properties of 2:17-type Sm-Co sintered magnets,In this work,the influence of solid solution process on microstructure and magnetic properties of the Sm(CobalFe0.233Cu0.073Zr0.024)7.6 sintered magnets was systematically studied.With the solid-solution treating duration(tS)increasing from 0 to 4 h,intrinsic coercivity(Hcj)increases from 12.83 to 36.54 kOe,magnetic field at knee-point(Hknee)increases from2.76 to 19.14 kOe,and the maximum energy product increases from 19.79 to 29.48 MGOe.The electron probe microanalyzer results reveal that there mainly exist gray and dark regions besides'white'rare earth-rich phase,and the conte nt of Sm,Fe and Cu elements for the two kinds of regions changes a lot for the specimens,Furthermore,with tS increasing up to 4 h,the elements content deviation between the gray and dark regions becomes small gradually from 3.94 at%to 0.27 at%,7.66 at%to 0.21 at%and 7.27 at%to 0.16 at%for Sm,Fe and Cu elements,respectively.Moreover,transmission electron microscopy results show that the distribution of cell size is much more concentrated for aged specimens when tS is 4 h.It is also found that the Cu concentration at cell boundaries for the 4 h solid-solution treatment case shows relatively higher values and greater concentration gradient(1.94 at%/nm).It is verified that sufficient solution treatment duration is prerequisite to form these homogeneous microstructural features,which are the key points for obtaining both high Hcj and Hknee. | Shuai Wang Yikun Fang Kuikui Song Xiaoyu Zhu Lei Wang Wei Sun Wei Pan Minggang Zhu Wei Li | 2020 | Journal of Rare Earths2020，38，11： | 5 |
| 16 | Nonlinear Vibration of A Loosely Supported Curved Pipe Conveying Pulsating Fluid under Principal Parametric Resonance显示文摘In this paper,the nonlinear dynamics of a curved pipe is investigated in the case of principal parametric resonance due to pulsating flow and impact with loose supports.The coupled in-plane and out-of-plane governing equations with the consideration of von Karman geometric nonUnearity are presented and discretized via the differential quadrature method(DQM).The nonlinear dynamic responses are calculated numerically to demonstrate the influence of pulsating frequency.Finally,the impact is taken into consideration.The influence of clearance on frettingwear damage,such as normal work rate,contact ratio and impact force level,is demonstrated. | Yangyang Luo Min Tang Qiao Ni Yikun Wang Lin Wang | 2016 | Acta Mechanica Solida Sinica2016，29，5： | 5 |
| 17 | Cloning of plastid division gene GlFtsZ from Gentiana lutea and its expression during petal development显示文摘A full-length cDNA of GlFtsZ was isolated by screening the cDNA library of Gentiana lutea. Analysis of the deduced amino acid sequence encoded by GlFtsZ indicated that GlFtsZ protein possesses the typical conservative motifs existed in all FtsZ proteins. The existence of putative plastid transit peptide in its N-terminus suggested that GlFtsZ might function inside of plastids. With the deve- lopmental process of petals of Gentiana lutea, the expression of plastid division gene GlFtsZ declined gradually, whereas the expression of carotenoids biosynthesis gene Zds increased obviously; meanwhile, in contrast to the increment of carotenoids, the content of chlorophyll in petals decreased sharply. The chloroplasts turned into chromoplasts, and the color of petals also turned from green to golden. All of these results suggested that the expression of GlFtsZ is accompanied with the development and differentiation of plastids. | HE Yikun , ZHU Changfu , WANG Dong, KONG Dongdong and SUN Jingsan(1. Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China 2. Department of Biology, Capital Normal University, Beijing 100037, China 3. College of Life Science, Northeast Normal University, Changchun 130024, China) | 2002 | Progress in Natural Science:Materials International2002，12，8： | 5 |
| 18 | Direct generation of watt-level yellow Dy^(3+)-doped fiber laser显示文摘Yellow lasers(∼565–590 nm)are of tremendous interest in biomedicine,astronomy,spectroscopy,and display technology.So far,yellow lasers still have relied heavily on nonlinear frequency conversion of near-infrared lasers,precluding compact and low-cost yellow laser systems.Here,we address the challenge through demonstrating,for the first time,to the best of our knowledge,watt-level high-power yellow laser generation directly from a compact fiber laser.The yellow fiber laser simply consists of a Dy^(3+)-doped ZBLAN fiber as gain medium,a fiber end-facet mirror with high reflectivity at yellow and a 450-nm diode laser as the pump source.We comprehensively investigated the dependence of the yellow laser performance on the output coupler reflectivity and the gain fiber length and demonstrated that the yellow fiber laser with an output coupler reflectivity of 4% and a gain fiber length of∼1.8 m yields a maximum efficiency of 33.6%.A maximum output power of 1.12 W at 575 nm was achieved at a pump power of 4.20 W.This work demonstrated the power scaling of yellow Dy^(3+)-doped ZBLAN fiber lasers,showing their promise for applications in ophthalmology,astronomical exploration,and high-resolution spectroscopy. | Jinhai Zou Tianran Li Yanbo Dou Jin Li Nan Chen Yikun Bu Zhengqian Luo | 2021 | Photonics Research2021，9，4： | 5 |
| 19 | Expression regulation and function of NLRC5显示文摘The NOD like receptors(NLRs),a class of intracellular receptors that respond to pathogen attack or cellular stress,have gained increasing attention.NLRC5,the largest member of the NLR protein family,has recently been identified as a critical regulator of immune responses.While NLRC5 is constitutively and widely expressed,it can be dramatically induced by interferons during pathogen infections.Both in vitro and in vivo studies have demonstrated that NLRC5 is a specifi c and master regulator of major mistocompatibility complex(MHC)class I genes as well as related genes involved in MHC class I antigen presentation.The expression of MHC class I genes is regulated by NLRC5 in coordination with the RFX components through an enhanceosome-dependent manner.And the involvement of NLRC5 in MHC class I mediated CD8^(+)T cell activation,proliferation and cytotoxicity is proved to be critical for host defense against intracellular bacterial infections.Nevertheless,the role of NLRC5 in innate immunity remains to be further explored.Here,we review the research advances on the structure,expression regulation and function of NLRC5. | Yikun Yao Youcun Qian | 2013 | Protein & Cell2013，4，3： | 5 |
| 20 | Computer simulation of core filling process of cast high speed steel roll显示文摘Core filling process of cast high speed steel roll was simulated.Ductile iron was used as core material.The influences of filling parameters,such as core filling time and core filling temperature,on the filling process were investigated.Based on the simulated results,optimal core filling parameters were determined.The predicted temperature fields show that the temperature at the roll shoulder is the lowest during the core filling process and usually causes binding defects there.Method for solving this problem was presented. | Song Nannan Luan Yikun Bai Yunlong Kang Xiuhong Xia Lijun Li Dianzhong | 2009 | China Foundry2009，6，4： | 4 |
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