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| 1 | Regulation of glucose and lipid metabolism in health and disease显示文摘Glucose and fatty acids are the major sources of energy for human body. Cholesterol, the most abundant sterol in mammals, is a key component of cell membranes although it does not generate ATP. The metabolisms of glucose, fatty acids and cholesterol are often intertwined and regulated. For example, glucose can be converted to fatty acids and cholesterol through de novo lipid biosynthesis pathways. Excessive lipids are secreted in lipoproteins or stored in lipid droplets. The metabolites of glucose and lipids are dynamically transported intercellularly and intracellularly, and then converted to other molecules in specific compartments. The disorders of glucose and lipid metabolism result in severe diseases including cardiovascular disease, diabetes and fatty liver. This review summarizes the major metabolic aspects of glucose and lipid, and their regulations in the context of physiology and diseases. | Ligong Chen Xiao-Wei Chen Xun Huang Bao-Liang Song Yan Wang Yiguo Wang | 2019 | Science China(Life Sciences)2019，62，11： | 40 |
| 2 | Predicting geological hazards during tunnel construction显示文摘The complicated geological conditions and geological hazards are challenging problems during tunnel construction,which will cause great losses of life and property.Therefore,reliable prediction of geological defective features,such as faults,karst caves and groundwater,has important practical significances and theoretical values.In this paper,we presented the criteria for detecting typical geological anomalies using the tunnel seismic prediction(TSP) method.The ground penetrating radar(GPR) signal response to water-bearing structures was used for theoretical derivations.And the 3D tomography of the transient electromagnetic method(TEM) was used to develop an equivalent conductance method.Based on the improvement of a single prediction technique,we developed a technical system for reliable prediction of geological defective features by analyzing the advantages and disadvantages of all prediction methods.The procedure of the application of this system was introduced in detail.For prediction,the selection of prediction methods is an important and challenging work.The analytic hierarchy process(AHP) was developed for prediction optimization.We applied the newly developed prediction system to several important projects in China,including Hurongxi highway,Jinping II hydropower station,and Kiaochow Bay subsea tunnel.The case studies show that the geological defective features can be successfully detected with good precision and efficiency,and the prediction system is proved to be an effective means to minimize the risks of geological hazards during tunnel construction. | Shucai Li Shuchen Li Qingsong Zhang Yiguo Xue Bin Liu Maoxin Su Zhechao Wang Shugang Wang | 2010 | Journal of Rock Mechanics and Geotechnical Engineering2010，2，3： | 25 |
| 3 | Tumor necrosis factor-a: a key contributor to intervertebral disc degeneration显示文摘Intervertebral 圆盘(IVD ) 退化(国际直拨长途电话) 是导致腰骶部疼痛(LBP ) 的最普通的原因,它是一高度流行,昂贵,并且削弱世界范围的状况。为国际直拨长途电话的当前的治疗被限制对待症状并且不指向 pathophysiology。肿瘤坏死因素 --(TNF-) 通过它的受体 TNFR1 和 TNFR2 是大多数有势力支持 inflammatory cytokines 和信号之一。TNF- 高度在退化 IVD 纸巾被表示,并且它深深地涉及圆盘退化的多重病理学的过程,包括矩阵破坏,煽动性的回答, apoptosis, autophagy,和房间增长。重要地, anti-TNF- 治疗为减轻圆盘退化并且减轻 LBP 显示出诺言。在这考察,跟随对 TNF- 信号 transduction 的简短描述,我们主要在国际直拨长途电话集中于表达式模式和 TNF- 的角色,并且总结关于它象磁盘退化和联系 LBP 的一条有希望的生物治疗学的途径的抑制的新兴的进步。更好的理解将帮助开发新奇 TNF -- 为退化圆盘疾病的集中的治疗学的干预。 | Cheng Wang Xiaohua Yu Yiguo Yan Wei Yang Shujun Zhang Yongxiao Xiang Jian Zhang Wenjun Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，1： | 26 |
| 4 | Prognostic significance of cell infiltrations of immunosurveillance in colorectal cancer显示文摘AIM: To determine whether the mast cell (MCs) and tumor-associated macrophage (TAMs) counts have any correlation with clinical outcome in colorectal cancer, and to investigate whether MCs undergo phenotypic changes in colorectal cancer.METHODS: The MC and TAM counts were determined immunohistochemically in 60 patients with colorectal cancer and the depth of invasion, lymph node metastasis rate, distant metastasis rates, and survival rates were compared between patients with low (less than the mean number of positive cells) and high (more than the mean number of positive cells) cell counts.RESULTS: Both patients with a low MC count and patients with a low TAM count had significantly deeper depth of invasion than those with a high MC count and those with a high TAM count (P<0.01 and P<0.01 respectively).Patients with a high MC count and patients with a high TAM count were significantly higher showing significantly lower rates of lymph node metastasis, distant metastasis than those with a low MC count and those with a low TAM count. There were significant positive correlation between MC counts and TAM counts (r = 0.852, P<0.01).In both cancerous tissue and normal colorectal tissue,the predominant MC phenotype was MCTC. The 5-year survival rate estimated was significantly lower in both patients with a low MC count and patients with a low TAM count than in those with a high MC count and those with a high TAM count (P<0.05 and P<0.01 respectively).CONCLUSION: There appears to be a direct relationship between the number of MCs and clinical outcome in patients with colorectal cancer, even though MCs exhibited no significant phenotypic changes. TAM count is of value to predict the clinical outcome or prognosis. It is more beneficial for estimating biological character of colorectal carcinoma to combine MC and TAM counts. | Shi-YunTan YanFan He-ShengLuo Zhi-XiangShen YiGuo Liang-JiaZhao | 2005 | World Journal of Gastroenterology2005，11，8： | 19 |
| 5 | Effect of acupuncture at Neiguan (PC 6) on cardiac function using echocardiography in myocardial ischemia rats induced by isoproterenol显示文摘OBJECTIVE: To investigate the effect of acupuncture at Neiguan(PC 6) on cardiac function using echocardiography in rat models of myocardial ischemia(MI) induced by isoproterenol(ISO).METHODS: Twenty-seven Sprague-Dawley rats were randomly assigned to normal, model, and acupuncture groups. The model and acupuncture groups were given injections of ISO(85 mg/kg) to establish the MI model. After model establishment,the acupuncture group was treated with acupuncture at Neiguan(PC 6) for 30 min. Echocardiography was used to monitor diastolic and systolic function for 30 min starting from the time after the acupuncture needles were removed. Changes in the length of left ventricular internal diameter at end-diastole(LVIDd), length of left ventricular internal diameter at end-systole(LVIDs), the ratio of mitral peak velocity at early diastole and atrial contraction(E/A), ejection fraction(EF), fractional shortening(FS), and stroke volume(SV) were measured.RESULTS: Compared with the model group at 0and 15 min after needles were removed, the means of LVIDd and LVIDs were significantly lower(P <0.01) and E/A, EF, FS, and SV significantly higher(P < 0.01) in the acupuncture group. In the acupuncture group, the means of LVIDd and LVIDs15 min after the needles were removed were significantly higher(P < 0.01) than those at 0 min. The means of E/A, EF, FS, and SV significantly decreased(P < 0.01) from 0 to 15 min in the acupuncture group.CONCLUSION: These findings indicate that acupuncture at Neiguan(PC 6) can affect cardiac function by increasing left ventricular diastolic and systolic function in MI rat models, but the effect only lasts for 15 min. | Wang Songzi Ren Lu Jia Lianqun Gu Zhongyue Fan Xu Chen Wenna Hou Ping Liang Fanrong Rong Peijing Ma Tieming Liu Xulai Chen Yiguo | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 12 |
| 6 | PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation显示文摘A change in the metabolic flux of glucose from mitochondrial oxidative phosphorylation (OXPHOS) to aerobic glycolysis is regarded as one hallmark of cancer. However, the mechanisms underlying the metabolic switch between aerobic glycolysis and OXPHOS are unclear. Here we show that the M2 isoform of pyruvate kinase (PKM2), one of the rate-limiting enzymes in glycolysis, interacts with mitofusin 2 (MFN2), a key regulator of mitochondrial fusion, to promote mitochondrial fusion and OXPHOS, and attenuate glycolysis. mTOR increases the PKM2:MFN2 interaction by phosphorylating MFN2 and thereby modulates the effect of PKM2: MFN2 on glycolysis, mitochondrial fusion and OXPHOS. Thus, an mTOR-MFN2-PKM2 signaling axis couples glycolysis and OXPHOS to modulate cancer cell growth. | Tong Li Jinbo Han Liangjie Jia Xiao Hu Liqun Chen Yiguo Wang | 2019 | Protein & Cell2019，10，8： | 10 |
| 7 | Multigene editing via CRISPR/Cas9 guided by a single-sgRNA seed in Arabidopsis显示文摘We report that a solo single-guide RNA(sg RNA) seed is capable of guiding Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)/CRISPRàassociated 9(CRISRP/Cas_9) to simultaneously edit multiple genes At RPL_(10)A, At RPL_(10)B and At RPL_(10)C in Arabidopsis. Our results also demonstrate that it is possible to use CRISPR/Cas_9 technology to create At RPL_(10) triple mutants which otherwise cannot be generated by conventional genetic crossing. Compared to other conventional multiplex CRISPR/Cas systems, a single sg RNA seed has the advantage of reducing off-target gene-editing. Such a gene editing system might be also applicable to modify other homologous genes, or even less-homologous sequences for multiple gene-editing in plants and other organisms. | Zhiming Yu Qiyuan Chen Weiwei Chen Xian Zhang Fengling Mei Pengcheng Zhang Mei Zhao Xiaohong Wang Nongnong Shi Stephen Jackson Yiguo Hong | 2018 | Journal of Integrative Plant Biology2018，60，5： | 10 |
| 8 | Air-sea heat flux exchange over the South China Sea under different weather conditions before and after southwest monsoon onset in 2000显示文摘With the data observed from the Second SCS Air-Sea Flux Experiment on the Xisha air-sea flux research tower, the radiation budget, latent, sensible heat fluxes and net oceanic heat budgetswere caculated before and after summer monsoon onset. It is discovered that, after summer monsoononset, there are considerable changes in air-sea fluxes, especially in latent heat fluxes and net oceanicheat budget. Furthermre, the analyzed results of five synoptic stages are compared. And the character-istics of the flux transfer during different stages around onset of South China Sea monsoon are discussed.The flux change shows that there is an oceanic heat accumulating process during the pre-onset and thebreak period, as same as oceanic heat losing process during the onset period. Moreover, latent fluxes,the water vapor moving to the continent, even the rainfall appearance in Chinese Mainland also can beinfluenced by southwester. Comparing Xisha fluxes with those obtained from the Indian Ocean and thewestern Pacific Ocean, their differences may be obeerved. It is the reason why SSTs can keep stableover the South China Sea while they decrease quickly over the Arabian Sea and the Bay of Bengal aftermonsoon onset. | Junyue Yan, Huadong Yao, Jianglong Li, Zhiyi Tang, Guorong Jiang, Wenyu Sha, Xunqiang Li, Yiguo Xiao National Climate Center, Beijing 100081, China. E-mail: yanjy@cma.gov.cnPLA University of Science Technology, Nanjing 211101, China | 2003 | Acta Oceanologica Sinica2003，22，3： | 8 |
| 9 | mTORC1 signaling in hepatic lipid metabolism显示文摘表明小径的 rapamycin (mTOR ) 的机械学的目标在不同机关或纸巾调整许多新陈代谢、生理的过程。mTOR 发信号的 Dysregulation 包括肥胖,糖尿病,癌症,脂肪肝疾病,和 neuronal 在许多人的疾病被含有混乱。这里,我们在理解发信号的 mTORC1 (mTOR 建筑群 1 ) 怎么在肝调整类脂化合物新陈代谢考察最近的进步。 | Jinbo Han Yiguo Wang | 2018 | Protein & Cell2018，9，2： | 6 |
| 10 | Application of GA-SVM in classification of surrounding rock based on model reliability examination显示文摘In order to improve the discrimination precision of support vector machine(SVM) in classification of surrounding rock, a Genetic Algorithm(GA) was used to optimize SVM parameters in the solution space.The idea of examination of model reliability was introduced to check the reliability of the SVM parameters,obtained by genetic algorithms.In the process of model reliability,a trend examination method is presented,which checks the reliability of the model via the influence trend of impact factors on the object of evaluation and their evaluation level.Trend examination methods are universal,showing new ideas in model reliability examination and can be used in any problems of examination of reliability of models,based on previous experience.We established a GA-SVM based reliability model of a classification the surrounding rock and applied it to a practical engineering situation.The result shows that the improved SVM has a high capability for generalization and prediction accuracy in classification of surrounding rock. | QIU Daohong LI Shucai ZHANG Lewen XUE Yiguo | 2010 | Mining Science and Technology2010，20，3： | 6 |
| 11 | Tunable near-infrared plasmonic perfect absorber based on phase-change materials显示文摘A tunable plasmonic perfect absorber with a tuning range of 650 nm is realized by introducing a 20 nm thick phase-change material Ge2Sb2Te5 layer into the metal–dielectric–metal configuration.The absorption at the plasmonic resonance is kept above 0.96 across the whole tuning range.In this work we study this extraordinary optical response numerically and reveal the geometric conditions which support this phenomenon.This work shows a promising route to achieve tunable plasmonic devices for multi-band optical modulation,communication,and thermal imaging. | Yiguo Chen Xiong Li Xiangang Luo Stefan AMaier Minghui Hong | 2015 | Photonics Research2015，3，3： | 5 |
| 12 | Stability analysis and optimization of excavation method of double-arch tunnel with an extra-large span based on numerical investigation显示文摘The Xiamen Haicang double-arch tunnel has a maximum span of 45.73 m and a minimum burial depth of 5.8 m.A larger deformation or collapse of the tunnel is readily encountered during tunnel excavation.It is therefore necessary to select a construction approach that is suitable for double-arch tunnel projects with an extra-large span.In this study,three construction methods for double-arch tunnels with extra-large spans were numerically simulated.Subsequently,the deformation behavior and stress characteristics of the surrounding rock were obtained and compared.The results showed that the double-side-drift method with temporary vertical support achieves better adaptability in the construction of such tunnels,which can be observed from both the numerical results and in situ monitoring data.In addition,the improved temporary support plays a critical role in controlling the surrounding rock deformation.In addition,the disturbance resulting from the excavation of adjacent drifts was obvious,particularly the disturbance of the surrounding rock caused by the excavation of the middle drift.The present findings can serve as the initial guidelines for the construction of ultra-shallowly buried double-arch tunnels with extra-large spans. | Yiguo XUE Huimin GONG Fanmeng KONG Weimin YANG Daohong QIU Binghua ZHOU | 2021 | Frontiers of Structural and Civil Engineering2021，15，1： | 4 |
| 13 | Effect of electronic stimulation at Neiguan(PC 6) acupoint on gene expression of adenosine triphosphate-sensitive potassium channel and protein kinases in rats with myocardial ischemia显示文摘OBJECTIVE:To investigate the effects of electronic stimulation at acupoints Neiguan(PC 6) and Lieque(LU 7) on the gene expression of the adenosine triphosphate(ATP)-Sensitive potassium channel(KATP:Kir6.1,Kir6.2,SUR2 A,and SUR2B) and protein kinases(PKA,PKG,and PKCβ2) in myocardial cells of rats with myocardial ischemia(Ml) induced by isoproterenol(ISO).METHODS:Rats were randomly divided into a control,model,Neiguan(PC 6),Lieque(LU 7),and non-acupoint groups.The Ml model was established by injecting rats with ISO.Electro-acupuncture treatment was given to the acupuncture groups,once a day for 7 days.Gene expression was analyzed with real-time PCR.RESULTS:The gene expression of KATP and protein kinases in the model group was higher than those in the control group(P < 0.05).After acupuncture treatment,the KATP and protein kinase expression levels were significantly lower in the Neiguan(PC 6)and Lieque(LU 7) groups compared with the model group[P < 0.05).The Neiguan(PC 6) group lowered these levels significantly more than that of the Lieque(LU 7) group(P < 0.05).No significant differences were observed between the model and non-acupoint groups(P > 0.05).CONCLUSION:Our findings suggest that electronic needling of Neiguan(PC 6) can both reduce the gene expression of KATP and protein kinases in rats with ISO-induced Ml. | Wang Wei Li Jiquan Meng Xiangyu Chen Yiguo | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 4 |
| 14 | An Optimal Control Strategy for Multi-UAVs Target Tracking and Cooperative Competition显示文摘An optimal control strategy of winner-take-all(WTA)model is proposed for target tracking and cooperative competition of multi-UAVs(unmanned aerial vehicles).In this model,firstly,based on the artificial potential field method,the artificial potential field function is improved and the fuzzy control decision is designed to realize the trajectory tracking of dynamic targets.Secondly,according to the finite-time convergence high-order differentiator,a double closed-loop UAV speed tracking the controller is designed to realize the speed control and tracking of the target tracking trajectory.Numerical simulation results show that the designed speed tracking controller has the advantages of fast tracking,high precision,strong stability and avoiding chattering.Finally,a cooperative competition scheme of multiple UAVs based on WTA is designed to find the minimum control energy from multiple UAVs and realize the optimal control strategy.Theoretical analysis and numerical simulation results show that the model has the fast convergence,high control accuracy,strong stability and good robustness. | Yiguo Yang Liefa Liao Hong Yang Shuai Li | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，12： | 4 |
| 15 | NUMERICAL SIMULATION OF DEFORMATION BEHAVIOR OF 22MnB5 BORON STEEL AT ELEVATED TEMPERATURES AND EXPERIMENTAL VERIFICATION显示文摘The effects of strain, strain rate and temperature on the mechanical behavior of22 Mn B5 boron steel deformed isothermally under uniaxial tension tests and the experimental characterization of 22 Mn B5 boron steel in the austenitic region have been investigated. Based on the crystal plasticity theory and thermal kinematics, an improved integration model is presented.In this model, the elastic deformation gradient is the integration variable of the governing equation,which contains not only the elastic deformation but also the thermal effects. In the coupled thermomechanical process, this model can reveal the evolution of microstructures such as the rotation of a single crystal and the slip systems in each of them. The plastic behavior of the boron steel can be well described by the presented model. | Dan Zhao Yiguo Zhu Liang Ying Ping Hu Ying Chang Wanxi Zhang | 2014 | Acta Mechanica Solida Sinica2014，27，6： | 3 |
| 16 | Fasting-induced hormonal regulation of lysosomal function显示文摘 | Chen, Liqun Wang, Ke Long, Aijun Jia, Liangjie Zhang, Yuanyuan Deng, Haiteng Li, Yu Han, Jinbo Wang, Yiguo | 2017 | Cell Research2017，27，6： | 3 |
| 17 | sEMG based quantitative assessment of acupuncture on Bell's palsy:an experimental study显示文摘Acupuncture is a traditional Chinese therapeutic method, recognized by western medicine as an important complementary therapy. However, the efficacy assessment of this traditional intervention has been mainly empirical rather than scientific. In this paper, we propose a surface electromyography(s EMG) based approach for quantitative assessment of acupuncture on Bell's palsy. The assessment is made by comparing the muscle activities of healthy with diseased ones. A feature-vector of four individual s EMG features is introduced for more comprehensive representation of muscle activity. A clustering technique is then proposed to calculate quantitative differences between the muscle activities of the healthy and diseased sides. A regressive model is also proposed to predict the recovery trend of a patient based on the quantitative assessments during his/her clinical acupuncture history. As reported in the paper, a total of 20 selected Bell's palsy patients have participated in the extensive experiments that were conducted to verify the performance of the proposed method. | HAN JianDa XIONG AnBin ZHAO XinGang DING QiChuan CHEN YiGuo LIU GuangJun | 2015 | Science China(Information Sciences)2015，58，8： | 3 |
| 18 | Comparative WGBS identifies genes that influence non-ripe phenotype in tomato epimutant Colourless non-ripening显示文摘Whole-genome bisulfite sequencing(WGBS)allows single-base resolution and genome-wide profiling of DNA methylation in plants and animals.This technology provides a powerful tool to identify genes that are potentially controlled by dynamic changes of DNA methylation and demethylation.However,naturally occurring epimutants are rare and genes under epigenetic regulation as well as their biological relevances are often difficult to define.In tomato,fruit development and ripening are a complex process that involves epigenetic control.We have taken the advantage of the tomato epimutant Colourless non-ripening(Cnr)and performed comparative mining of the WGBS datasets for the Cnr and Sl CMT3-silenced Cnr fruits.We compared DNA methylation profiles for the promoter sequences of approximately 5,000 bp immediately upstream of the coding region of a list of20 genes.Differentially methylated regions were found for some of these genes.Virus-induced gene silencing(VIGS)of differentially methylated gene Sl DET1 or Sl PDS resulted in unusual brown pigmentation in Cnr fruits.These results suggest that comparative WGBS coupled with VIGS can be used to identify genes that may contribute to the colourless unripe phenotype of fruit in the Cnr epimutant. | Weiwei Chen Zhiming Yu Junhua Kong Hui Wang Yichen Li Mei Zhao Xiaohong Wang Qianqian Zheng Nongnong Shi Pengcheng Zhang Silin Zhong Paul Hunter Mahmut Tor Yiguo Hong | 2018 | Science China(Life Sciences)2018，61，2： | 3 |
| 19 | Safety of SARS-CoV-2 vaccines:a systematic review and meta-analysis of randomized controlled trials显示文摘Background Various modalities of vaccines against coronavirus disease 2019(COVID-19),based on different platforms and immunization procedures,have been successively approved for marketing worldwide.A comprehensive review for clinical trials assessing the safety of COVID-19 vaccines is urgently needed to make an accurate judgment for mass vaccination.Main text A systematic review and meta-analysis was conducted to determine the safety of COVID-19 vaccine candidates in randomized controlled trials(RCTs).Data search was performed in PubMed,Embase,Cochrane library,Scopus,Web of Science,and MedRxiv.Included articles were limited to RCTs on COVID-19 vaccines.A total of 73,633 subjects from 14 articles were included to compare the risks of adverse events following immunization(AEFI)after vaccinating different COVID-19 vaccines.Pooled risk ratios(RR)of total AEFI for inactivated vaccine,viral-vectored vaccine,and mRNA vaccine were 1.34[95%confidence interval(CI)1.11–1.61,P<0.001],1.65(95%CI 1.31–2.07,P<0.001),and 2.01(95%CI 1.78–2.26,P<0.001),respectively.No significant differences on local and systemic AEFI were found between the first dose and second dose.In addition,people aged≤55 years were at significantly higher risk of AEFI than people aged≥56 years,with a pooled RR of 1.25(95%CI 1.15–1.35,P<0.001).Conclusions The safety and tolerance of current COVID-19 vaccine candidates are acceptable for mass vaccination,with inactivated COVID-19 vaccines candidates having the lowest reported AEFI.Long-term surveillance of vaccine safety is required,especially among elderly people with underlying medical conditions. | Musha Chen Yue Yuan Yiguo Zhou Zhaomin Deng Jin Zhao Fengling Feng Huachun Zou Caijun Sun | 2021 | Infectious Diseases of Poverty2021，10，4： | 2 |
| 20 | Spatiotemporal changes in water,land use,and ecosystem services in Central Asia considering climate changes and human activities显示文摘Central Asia is located in the hinterland of Eurasia,comprising Kazakhstan,Uzbekistan,Kyrgyzstan,Turkmenistan,and Tajikistan;over 93.00%of the total area is dryland.Temperature rise and human activities have severe impacts on the fragile ecosystems.Since the 1970s,nearly half the great lakes in Central Asia have shrunk and rivers are drying rapidly owing to climate changes and human activities.Water shortage and ecological crisis have attracted extensive international attention.In general,ecosystem services in Central Asia are declining,particularly with respect to biodiversity,water,and soil conservation.Furthermore,the annual average temperature and annual precipitation in Central Asia increased by 0.30℃/decade and 6.9 mm/decade in recent decades,respectively.Temperature rise significantly affected glacier retreat in the Tianshan Mountains and Pamir Mountains,which may intensify water shortage in the 21st century.The increase in precipitation cannot counterbalance the aggravation of water shortage caused by the temperature rise and human activities in Central Asia.The population of Central Asia is growing gradually,and its economy is increasing steadily.Moreover,the agricultural land has not been expended in the last two decades.Thus,water and ecological crises,such as the Aral Sea shrinkage in the 21st century,cannot be attributed to agriculture extension any longer.Unbalanced regional development and water interception/transfer have led to the irrational exploitation of water resources in some watersheds,inducing downstream water shortage and ecological degradation.In addition,accelerated industrialization and urbanization have intensified this process.Therefore,all Central Asian countries must urgently reach a consensus and adopt common measures for water and ecological protection. | YU Yang CHEN Xi Ireneusz MALIK Malgorzata WISTUBA CAO Yiguo HOU Dongde TA Zhijie HE Jing ZHANG Lingyun YU Ruide ZHANG Haiyan SUN Lingxiao | 2021 | Journal of Arid Land2021，13，9： | 2 |
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