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| 1 | Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine显示文摘With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies.Despite numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases.It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies.There has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two decades.Among all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.In fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral vectors.This review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative medicine.Current challenges and future directions regarding the use of adenoviral vectors are also discussed.It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine. | Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He | 2017 | Genes & Diseases2017，4，2： | 19 |
| 2 | 后循环大血管闭塞性卒中的血管内治疗策略:美国神经介入外科学会(SNIS)标准和指南委员会共识显示文摘后循环卒中大约占所有卒中的20%,但后循环急性大血管闭塞(pc-ELVO)仅占所有急性大血管闭塞性卒中的5%。尽管少见,但pc-ELVO患者往往病情严重,症状也不典型,良好预后率低。如何更好地对这些患者进行管理,是目前临床治疗的难点。近期,美国神经介入外科学会(SNIS)发布了一项关于后循环大血管闭塞性卒中的血管内治疗指南,旨在为pc-ELVO的影像学检查、诊断和血管内治疗技术提供详细的最新指导。 | Yasha Kayan Philip M Meyers Charles J Prestigiacomo Peter Kan Justin F Fraser 王丽娜(翻译) 刘焕(翻译) 贺迎坤(翻译) 邢莹(翻译) 何艳艳(翻译) 李天晓(翻译) 朱良付(翻译) 李钊硕(翻译) | 2019 | 中华介入放射学电子杂志2019，7，4： | 11 |
| 3 | ScenicPlanner: planning scenic travel routes leveraging heterogeneous user-generated digital footprints显示文摘 | Chao CHEN Xia CHEN Zhu WANG Yasha WANG Daqing ZHANG | 2017 | Frontiers of Computer Science2017，11，1： | 10 |
| 4 | Real-time and generic queue time estimation based on mobile crowdsensing显示文摘 | Jiangtao WANG Yasha WANG Daqing ZHANG Leye WANG Chao CHEN Jae Woong LEE Yuanduo HE | 2017 | Frontiers of Computer Science2017，11，1： | 4 |
| 5 | Controllable Biosynthesis and Properties of Gold Nanoplates Using Yeast Extract显示文摘Biosynthesis of gold nanostructures has drawn increasing concerns because of its green and sustainable synthetic process. However, biosynthesis of gold nanoplates is still a challenge because of the expensive source and difficulties of controllable formation of morphology and size. Herein, one-pot biosynthesis of gold nanoplates is proposed, in which cheap yeast was extracted as a green precursor. The morphologies and sizes of the gold nanostructures can be controlled via varying the pH value of the biomedium. In acid condition, gold nanoplates with side length from 1300 ± 200 to 300 ± 100 nm and height from 18 to 15 nm were obtained by increasing the pH value. Whereas, in neutral or basic condition, only gold nanoflowers and nanoparticles were obtained. It was determined that organic molecules, such as succinic acid, lactic acid, malic acid, and glutathione, which are generated in metabolism process, played important role in the reduction of gold ions. Besides, it was found that the gold nanoplates exhibited plasmonic property with prominent dipole infrared resonance in near-infrared region, indicating their potential in surface plasmon-enhanced applications, such as bioimaging and photothermal therapy. | Zhi Yang Zhaohui Li Xuxing Lu Fengjiao He Xingzhong Zhu Yujie Ma Rong He Feng Gao Weihai Ni Yasha Yi | 2017 | Nano-Micro Letters2017，9，1： | 2 |
| 6 | Primary angiitis of CNS neuropathological study of three autopsied cases witll brief review of literature显示文摘 | Panda KM Santosh V Yasha TC | 2000 | Neurol India2000，48，： | 1 |
| 7 | Clival tumor presenting with acromegaly显示文摘 | Konar S Devi BI Yasha TC | 2013 | Neurol India2013，61，： | 1 |
| 8 | Primary angiitis of CNS : neuropathological study of three autopsied cases with brief review of literature显示文摘 | Panda K M Santosh V Yasha T C | 2000 | Neurol India2000，48，2： | 1 |
| 9 | Primary angiitisofCNS:neuropathological study of three autopsied caseswith brief review of literature显示文摘 | Panda KM Santosh V Yasha TC | 2000 | Neurol India2000，48，： | 1 |
| 10 | Angioplasty and stenting in carotid dissection with or without associated pseudoaneurysm 显示文摘 | Yasha K David TJ Christopher JM | 2005 | AJNR2005，26，： | 1 |
| 11 | Primmp angiitis of CNS: neuro -pathological study of three autopsied cases with brief review of literature显示文摘 | Panda KM Santash V Yasha TC | 2000 | Neurol India2000，48，： | 1 |
| 12 | Progressive myoclonic epilepsy: A clinical, electrophysiological and pathological study from south India显示文摘 | Sinha S Satishchandra P Yasha T | 2004 | Neurol Asia2004，9，1： | 1 |
| 13 | Primary angiitis of CNS:neuropathological study of three autopsied cases with brief review of literature显示文摘 | Panda KM Santosh V Yasha TC | 2000 | eurol India2000，48，： | 1 |
| 14 | Increased expression of Aquaporin-4and its correlation with contrast enhancement and perilesional edema in brain tumors显示文摘 | Dua RK Devi BI Yasha TC | 2010 | Br J Neurosurg2010，24，4： | 1 |
| 15 | Progressive myoclonic epilepsy:A clinical,electrophysiological and pathological study from south India显示文摘 | Sinha S Satishchandra P Yasha T et a1 | 2004 | Neurol Asia2004，9，1： | 1 |
| 16 | Research on the privilege control mechanism and modeling of a high level information system 显示文摘 | CHEN Yasha ZHAO Yong LIU Yan | 2011 | Journal of Shandong University : Natural Science2011，，9： | 1 |
| 17 | Primary angiitis of CNS: neuropathological study of three autopsied cases with brief re- view of literature显示文摘 | Panda KM Santosh V Yasha TC | 2000 | Neurology india2000，48，2： | 1 |
| 18 | RSMC:A Safety Model Checker for Concurrency and Memory Safety of Rust显示文摘Rust is a system-level programming language that provides thread and memory safety guarantee through a suite of static compiler checking rules and prevents segmentation errors.However,since compiler checking is too strict to confine Rust's programmability,the developers prefer to use the keyword'unsafe'to bypass compiler checking,through which the caller could interact with OS directly.Unfortunately,the code block with'unsafe'would easily lead to some serious bugs such as memory safety violation,race condition and so on.In this paper,to verify memory and concurrency safety of Rust programs,we present RSMC(Safety Model Checker for Rust),a tool based on Smack to detect concurrency bugs and memory safety errors in Rust programs,in which we combine concurrency primitives model checking and memory boundary model checking.RSMC,with an assertion generator,can automatically insert assertions and requires no programmer annotations to verify Rust programs.We evaluate RSMC on two categories of Rust programs,and the result shows that RSMC can effectively find concurrency bugs and memory safety errors in vulnerable Rust programs,which include unsafe code. | YAN Fei WANG Qizhong ZHANG Liqiang CHEN Yasha | 2020 | Wuhan University Journal of Natural Sciences2020，25，2： | 1 |
| 19 | Infratentorial dysembryoplastic neuroepithelial tumor(DNT)associated with Amold-Chiari malformation显示文摘 | Yasha TC Mohanty A Radhesh S | 1998 | Clin Neuropathol1998，17，6： | 1 |
| 20 | Medulloblastoma with extensive nodularity: a variant occurring in the very young-clinicopathological and immunohistochemical study of four cases 显示文摘 | Suresh T N Santosh V Yasha T C | 2004 | Childs Nerv Syst2004，20，： | 1 |
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