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| 1 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 2 | 具有低动脉粥样硬化风险特征的专业耐力运动员的亚临床冠状动脉疾病发病率显示文摘研究表明,具有冠状动脉疾病(coronary artery disease,CAD)危险因素的中老年(健将)运动员比久坐个体冠状动脉钙化(coronary artery calcium,CAC)评分更高。尚没有研究评估具有低动脉粥样硬化风险特征的专业运动员的CAD患病率。 | 刘莉 叶鹏 Merghani A Maestrini V Rosmini S Cox AT Dhutia H Bastiaenen R David S Yeo TJ Narain R Malhotra A Papadakis M Wilson MG Tome M AlFakih K Moon JC Sharma S | 2017 | 中华高血压杂志2017，25，6： | 8 |
| 3 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 4 | Gas/particle concentrations and partitioning of PCBs in the atmosphere of Korea 显示文摘 | Yeo H-G Choi M Chun M-Y | 2003 | Atmospheric Environment2003，37，25： | 2 |
| 5 | Pancreatic cancer显示文摘 | Theresa Pluth Yeo Ralph H Hruban Steven D Leach Robb E Wilentz Taylor A Sohn Scott E Kern Christine A Iacobuzio-Donahue Anirban Maitra Michael Goggins Marcia I Canto Ross A Abrams Daniel Laheru Elizabeth M Jaffee Manuel Hidalgo Charles J Yeo | 2002 | Current Problems in Cancer2002，，4： | 2 |
| 6 | Video visualization for compact presentation and fast browsing of pictorial content显示文摘 | Yeung M M Yeo B L | 1997 | IEEE Transactions on Circuits and Systems for Video Technology1997，7，5： | 1 |
| 7 | A fast procedure for computing incremental growth distances显示文摘 | Hong S M Yeo J H Park H W | 2000 | Robotics2000，18，4： | 1 |
| 8 | Time-frequency imaging algorithm for high speed spinning targets in two dis- mensions 显示文摘 | Li J Qiu C W Xing M D Bao Z Yeo T S | 2010 | lET2010，4，6： | 1 |
| 9 | Non-puerperal uterine inver-siona case report显示文摘 | LaiF M Tseng P Yeo S H | 1993 | Singpore Med J1993，34，5： | 1 |
| 10 | High Temperature Deformation Behavior of Carbon Steel in the Austenite and δ-Ferrite Regions显示文摘 | Seol D J Won Y M Yeo T J | 1999 | ISIJ International1999，39，1： | 1 |
| 11 | Apoptosis in rheumatoid arthritis synovium 显示文摘 | Firestein G S Yeo M Zvaifler N J | 1995 | J Clin Invest1995，96，3： | 1 |
| 12 | Dual-polarized slotcoupled planar antenna with wide bandwidth显示文摘 | GAO S LI L LEONG M YEO T | 2003 | IEEE Transactions on Antennas Propagat2003，51，： | 1 |
| 13 | Apoptosis in rheumatoid arthritis symofium 显示文摘 | Fireein GS Yeo M Zrairrler NT | 1995 | J Clin Lmrdsl1995，96，： | 1 |
| 14 | Evaluation of imprecision for cardiac troponin assays at low-range concentrations 显示文摘 | Panteghini M Pagani F Yeo KT | 2004 | Clin Chem2004，50，2： | 1 |
| 15 | Chronic illness and disability 显示文摘 | Yeo M Sawyer S | 2005 | BMJ2005，330，7493： | 1 |
| 16 | Loss of transgelin in repeated bouts of ulcerative colitis induced colon carcinogenesis显示文摘 | Yeo M Kim D K Park H J et aI | 2006 | Proteomics2006，6，4： | 1 |
| 17 | Neoadjuvant paclitaxel and cisplatin in uterine cervical cancer: long-term results显示文摘 | Park D C Sub M J Yeo S G | 2009 | Int J Gynecol Cancer2009，19，5： | 1 |
| 18 | A study on the control of water flow and temperature in the radiant cooling system through simulations 显示文摘 | Kim Y Y Lim J H Yeo M S | 2001 | Korean Journal of Air-Conditioning and Refrigeration Engineering2001，13，6： | 1 |
| 19 | Membrane blebbing dunig apoptosis resuits from caspase mediated activation of Rock Ⅰ显示文摘 | Colernan ML Sahai EA Yeo M | 2001 | Nat Cell Biol2001，3，4： | 1 |
| 20 | Three-dimensional hierarchical composite scaffolds consisting of polycaprolactone, 13-tricalcium phosphate, and collagen nanofibers : fabrication, physical properties, and in vitro cell activity for bone tissue regeneration 显示文摘 | Yeo M Lee H Kim G | 2011 | Biomacromolecules2011，12，2： | 1 |
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