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| 1 | Dissecting the molecular pathophysiology of drug-induced liver injury显示文摘Drug-induced liver injury(DILI) has become a major topic in the field of Hepatology and Gastroenterology. DILI can be clinically divided into three phenotypes: hepatocytic, cholestatic and mixed. Although the clinical manifestations of DILI are variable and the pathogenesis complicated, recent insights using improved preclinical models, have allowed a better understanding of the mechanisms that trigger liver damage. In this review, we will discuss the pathophysiological mechanisms underlying DILI. The toxicity of the drug eventually induces hepatocellular damage through multiple molecular pathways, including direct hepatic toxicity and innate and adaptive immune responses. Drugs or their metabolites, such as the common analgesic, acetaminophen, can cause direct hepatic toxicity through accumulation of reactive oxygen species and mitochondrial dysfunction. The innate and adaptive immune responses play also a very important role in the occurrence of idiosyncratic DILI. Furthermore, we examine common forms of hepatocyte death and their association with the activation of specific signaling pathways. | Hui Ye Leonard J Nelson Manuel Gómez del Moral Eduardo Martínez-Naves Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，13： | 19 |
| 2 | Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models显示文摘表示为基于 radiopharmaceutical 的成像为生物体之发光成像或 HSV1 thymidine kinase (HSV1-TK ) 编码任何一个萤火虫酶(fLuc ) 的记者 transgene 的 lentiviral 向量的二种新类型被构造监视人的胚胎的干细胞(hESC ) 在在移植以后的活老鼠的嫁接和增长。任何一个 transgene 的组成的表示没在文化改变 hESCs 的性质。我们下次在 SCID 鼠标监视了 teratomas 的形成到测试(1 ) 是否修改基因的 hESCs 维持他们的发展 pluripotency,并且(2 ) 是否支撑了记者基因表示,允许 noninvasive,在一个活鼠标模型的 hESC 衍生物的整个身体的成像。我们在接种以后从修改基因的房间以及野类型的 hESCs 2-4 月的两种类型观察了 teratoma 形成。用一个光成像系统,从 fLuc-transduced hESCs 的生物体之发光容易在在摸得出的肿瘤能被检测以前,长忍受 teratomas 的老鼠被检测。开发一个 noninvasive 成像方法对诊所更容易地可译,我们也利用了 HSV1-TK 和它的特定的底层, 1-(2 鈥 ? deoxy-2 鈥 ?fluoro- 尾 - D-arabinofuranosyl )-5-[125I]iodouracil ([125I ] FIAU ) ,记者 / 探查对。在全身的管理以后,[125I ] FIAU 是仅仅由编码 transgene 的 HSV1-TK 酶的 phosphorylated 并且在 transduced 以内保留(并且移植) 房间,由单个光子的排放允许敏感、量的成像计算了断层摄影术。象这些那样的 Noninvasive 成像方法可以使我们能在实时接受者以内重复地监视移植人的干细胞的存在和分发在上一通过记者基因的表达式长期。 | Martin G Pomper Holly Hammond Xiaobing Yu Zhaohui Ye Catherine A Foss Doris D Lin James J Fox Linzhao Cheng | 2009 | Cell Research2009，19，3： | 9 |
| 3 | 桑叶多糖对早期断奶仔猪生长性能、腹泻、血液指标和肠道菌群的影响显示文摘研究旨在探讨日粮补充桑叶多糖(MLPs)对早期断奶仔猪生长性能、腹泻、血液生化指标和肠道菌群的影响。共选取(28±2)日龄、体重为(9.18±0.46)kg的'杜洛克×长白×约克夏'杂交断奶仔猪150头,随机分成5个处理组,每组6个重复,每个重复5头猪。饮食处理如下:对照组(CT):基础日粮(BD);低剂量桑叶多糖组(LT):0.3 g·kg-1MLPs+BD;中剂量桑叶多糖组(MT):0.6 g·kg-1MLPs+BD;高剂量桑叶多糖组(HT):0.9 g·kg-1MLPs+BD;抗生素处理组(AT):0.15 g·kg-1金霉素+BD。分别在第0、10、21天的早晨,每头猪空腹测量体重并记录采食量,这些数据用来计算平均日增重(ADG)、平均日采食量(ADFI)和料重比(F/G)。每天两次(上午和下午)对每头仔猪的腹泻状况进行检查并记录。在试验结束时,收集血液样本用于生化分析,并收集盲肠、结肠和直肠内容物进行识别和量化相关的肠道菌群。研究结果表明,MLPs处理组间的日增重、平均日采食量和料重比无显著差异(P>0.05),但低剂量组(LT)、中剂量组(MT)、高剂量组(HT)的平均日采食量高于对照组(CT)和抗生素组(AT)。并且,LT、MT和HT组的料重比低于CT和AT组。与CT和AT组相比,LT、MT和HT组仔猪的腹泻发病率也显著降低(P<0.05)。生化分析表明,MLPs各处理组仔猪的血糖(GLU)水平均显著低于CT或AT组(P<0.05)。MT和HT组血液尿素氮(BUN)水平与CT和AT组存在显著差异(P<0.05),HT组T3水平显著高于CT和AT组(P<0.05)。虽然MLPs各处理组的T4水平与AT组并没有显著差异(P>0.05),但MT组的胰岛素样生长因子Ⅰ(IGF-Ⅰ)和生长激素(GH)水平较CT或AT组均显著升高(P<0.05)。LT、MT和HT 3组在抑制肠道大肠杆菌生长和促进肠道乳酸杆菌和双歧杆菌生长的整体效果上均优于CT和AT组。值得注意的是,与CT和AT组相比,HT组(0.9 g·kg-1MLPs)对抑制肠道大肠杆菌以及促进肠道有益菌群具有更显著效果(P<0.05)。结果表明,日粮添加桑叶多糖可以改善早期断奶仔猪肠道菌群的生态环境,降低腹泻率,提高整体生长性能。 | Zhao X J Lin L Luo Q L Ye M Q Luo G Q Kuang Z S | 2015 | 饲料博览2015，0，7： | 7 |
| 4 | An energy efficient clustering scheme in wireless sensor networks显示文摘 | M Ye C F Li G H Chen J Wu | 2007 | International Journal of Ad Hoc & Sensor Wireless Networks2007，3，2： | 1 |
| 5 | 显示文摘 | Lu J G Ye Z Z Huang J Y | 2002 | Mater Sci SemiconProcess2002，5，： | 1 |
| 6 | Synthese and characterization of oligomers containing the α-aminoalkylphenone chromophore as oligomeric photoinitiator 显示文摘 | Ye G D Zhou H Z Yang J W | 2006 | J Appl Polym Sci2006，99，： | 1 |
| 7 | Sodium buty- rate induces differentiation of gastric cancer cells to in- testinal cells via the PTEN/phosphoinositide 3-kinase pathway 显示文摘 | BAI Z G ZHANG Z T YE Y J | 2010 | Cell Biology International2010，34，12： | 1 |
| 8 | Photocatalytic decomposition of organic contaminants by Bi2WO6 under visible light ir- radiation 显示文摘 | Tang J W Zou Z G Ye J H | 2004 | Catal Lett2004，92，12： | 1 |
| 9 | Immunosuppressive treatment for ne-phrotic idiopathic membranous nephropathy : a meta - analysisbased on Chinese adults显示文摘 | Xie G Xu J Ye C | 2012 | PLoS One2012，7，44： | 1 |
| 10 | Photophysical and photocatalytic properties of AgInW2O8 显示文摘 | Tang J W Zou Z G Ye J H | 2003 | J Phys Chem B2003，107，51： | 1 |
| 11 | Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study显示文摘 | Zheng Ye Stephen J Sharp Stephen Burgess Robert A Scott Fumiaki Imamura Claudia Langenberg Nicholas J Wareham Nita G Forouhi | 2015 | The Lancet Diabetes & Endocrinology2015，，1： | 1 |
| 12 | The Role and Regulation of Human Thl7 Cells in tumor Immunity显示文摘 | Ye J Livergood RS Peng G | 2013 | Am J Pathol2013，182，1： | 1 |
| 13 | Imaging study of the long ex- tracranial extension of the inferior petrosal sinus with MSCT显示文摘 | Zhang W G Ye Y Y Chen J H | 2010 | Clin Anat2010，23，2： | 1 |
| 14 | Photocatalytic decomposition of organic contaminants by Bi2WO6under visible light irradiation显示文摘 | Tang J W Zou Z G Ye J H | 2004 | Catalysis Letters2004，92，12： | 1 |
| 15 | Dependence of Properties of N-Al Codoped p-Type ZnO Thin Films on Hrowth Temperature显示文摘 | Lu J G Zhu L P Ye Z Z | 2005 | Applied Surface Science2005，245，： | 1 |
| 16 | Structural damage detection using digital video imaging technique and wavelet transformation显示文摘 | Poudel U P Fu G Ye J | 2005 | Journal of Sound and Vibration2005，286，45： | 1 |
| 17 | fl-phase tungsten nanorod formation by oblique-angle sputter deposition显示文摘 | KARABACAK T MALLIKARJUNAN A SINGH J P YE D WANG G C LU T M | 2003 | Applied Physics Letters2003，83，15： | 1 |
| 18 | Large-span woven web structure made of fiber-reinforced polymer 显示文摘 | Feng Peng Ye Lie-ping Teng J G | 2007 | Journal of Composites for Construction2007，11，2： | 1 |
| 19 | Online learning for PLSA- based visual recognition 显示文摘 | Xu J Ye G T Wang Y | 2011 | Lecture Notes in Computer Science2011，6493，： | 1 |
| 20 | Effect of heat treatment on the phenolic compounds and antioxidant capacity of citrus peel extract显示文摘 | Xu G H Ye X Q Chen J C | 2007 | Journal of Agricultural and Food Chemistry2007，55，2： | 1 |
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