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| 1 | Numerical analysis and geophysical monitoring for stability assessment of the Northwest tailings dam at Westwood Mine显示文摘The Westwood Mine aims to reuse the tailings storage facility #1(TSF #1) for solid waste storage, but,downstream of the Northwest dike is considered critical in terms of stability. This paper uses numerical modeling along with geophysical monitoring for assessing the Northwest dike stability during the restoration phase. The impact of waste rock deposition in the upstream TSF #1 is considered. The geophysical monitoring is based on electrical resistivity methods and was used to investigate the internal structure of the dike embankment in different deposition stages. The numerical simulations were performed with SLOPE/W code. The results show a factor of safety well above the minimum recommended value of 1.5. Geophysical monitoring revealed a vertical variation in the electrical resistivity across the dike, which indicates a multilayer structure of the embankment. Without any current in situ data, the geophysical monitoring helped estimating the nature of the materials used and the internal structure of the embankment. These interpretations were validated by geological observation of geotechnical log of the embankment. Based on this study, it is recommended that the water polishing pond be partly filled before waste rock is deposited in TSF #1. In addition, to ensure the stability of the dike, the piezometric head monitoring prior to and during waste rock deposition is recommended. | Coulibaly Yaya Belem Tikou Cheng LiZhen | 2017 | International Journal of Mining Science and Technology2017，27，4： | 11 |
| 2 | High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care显示文摘Managing the dysregulated host response to infection remains a major challenge in sepsis care. Chinese treatment guideline recommends adding Xue Bi Jing, a five-herb medicine, to antibioticbased sepsis care. Although adding Xue Bi Jing further reduced 28-day mortality via modulating the host response, pharmacokinetic herbedrug interaction is a widely recognized issue that needs to be studied.Building on our earlier systematic chemical and human pharmacokinetic investigations of Xue Bi Jing, we evaluated the degree of pharmacokinetic compatibility for Xue Bi Jing/antibiotic combination based on mechanistic evidence of interaction risk. Considering both Xue Bi Jing-antibiotic and antibiotic-Xue Bi Jing interaction potential, we integrated informatics-based approach with experimental approach and developed a compound pair-based method for data processing. To reflect clinical reality, we selected for study Xue Bi Jing compounds bioavailable for drug interactions and 45 antibiotics commonly used in sepsis care in China. Based on the data of interacting with drug metabolizing enzymes and transporters, no Xue Bi Jing compound could pair, as perpetrator, with the antibiotics. Although some antibiotics could,due to their inhibition of uridine 50-diphosphoglucuronosyltransferase 2 B15, organic anion transporters1/2 and/or organic anion-transporting polypeptide 1 B3, pair with senkyunolide I, tanshinol and salvianolic acid B, the potential interactions(resulting in increased exposure) are likely desirable due to these Xue Bi Jing compounds’ low baseline exposure levels. Inhibition of aldehyde dehydrogenase by 7 antibiotics probably results in undesirable reduction of exposure to protocatechuic acid from Xue Bi Jing.Collectively, Xue Bi Jing/antibiotic combination exhibited a high degree of pharmacokinetic compatibility at clinically relevant doses. The methodology developed can be applied to investigate other drug combinations. | Jian Li Olajide E.Olaleye Xuan Yu Weiwei Jia Junling Yang Chuang Lu Songqiao Liu Jingjing Yu Xiaona Duan Yaya Wanga Kai Dong Rongrong He Chen Cheng Chuan Li | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 10 |
| 3 | Ultrabroad band microwave absorption from hierarchical MoO_(3)/TiO_(2)/Mo_(2)TiC_(2)Tx hybrids via annealing treatment显示文摘Two-dimensional(2D)transition metal carbide MXene-based materials hold great potentials applied for new electromagnetic wave(EMW)absorbers.However,the application of MXenes in the field of electromagnetic wave absorption(EMA)is limited by the disadvantages of poor impedance matching,single loss mechanism,and easy oxidation.In this work,MoO_(3)/TiO_(2)/Mo_(2)TiC_(2)T_(x)hybrids were prepared by the annealing-treated Mo_(2)TiC_(2)T_(x)MXene and uniform MoO_(3)and TiO_(2)oxides in-situ grew on Mo_(2)TiC_(2)T_(x)layers.At the annealing temperature of 300℃,the minimum reflection loss(RLmin)value of MoO_(3)/TiO_(2)/Mo_(2)TiC_(2)T_(x)reaches-30.76 dB(2.3 mm)at 10.18 GHz with a significantly broadening effective absorption bandwidth(EAB)of 8.6 GHz(1.8 mm).The in-situ generated oxides creating numerous defects and heterogeneous interfaces enhance dipolar and interfacial polarizations and optimize the impedance matching of Mo_(2)TiC_(2)T_(x).Considering the excellent overall performance,the MoO_(3)/TiO_(2)/Mo_(2)TiC_(2)T_(x)hybrids can be a promising candidate for EMA. | Feiyue HU Fan ZHANG Xiaohan WANG Yaya LI Hailong WANG Rui ZHANG Hongxia LI Bingbing FAN | 2022 | Journal of Advanced Ceramics2022，11，9： | 5 |
| 4 | 胡萝卜软腐欧文氏菌CSSY002菌株hrpN基因的克隆、鉴定及其表达产物Harpin蛋白的活性分析显示文摘从感染软腐病的胡萝b组织中分离出胡萝卜软腐欧文氏菌胡萝b亚种( Erwinia carotovora subsp, carotovora)CSSY002菌株.用该菌株接种非寄主植物烟草不能引起过敏反应.构建CSSY002菌株的基因组文库,应用α-P^32标记的hrpN基因作探针,通过菌落原位杂交技术从该文库中筛选到1.5~2.0 kb的hrpN-like阳性克隆,进一步将该片段亚克隆到pBluescript—II SK(+)载体中,进行核苷酸序列测定.结果表明,hrpN-like基因(即hrpNCSSY002基因)的开放阅读框(ORF)为1071bp,其核苷酸序列已在Genbank注册,登录号为bankit AY999002.hrpN-like基因的编码产物Harpin—like蛋白(即HarpinCSSY002蛋白)由356个氨基酸残基组成,分子量为36.64×10^3,等电点pI5.9.将hrpN—like基因构建到表达质粒pET-28a(+)的17强启动子下,并转化到大肠杆菌工程菌JM109(DE3)细胞中,经WTG(异丙基硫代-β-D半乳糖苷)诱导获得Harpin-like蛋白的高效表达,并通过接种烟草叶片的过敏反应检测Harpin—like蛋白的生物学活性. | 曹茂林 张珏 汤承 CUI Yaya 吴伯骥 | 2007 | 应用与环境生物学报2007，13，2： | 4 |
| 5 | Mars Ion and Neutral Particle Analyzer (MINPA) for Chinese Mars Exploration Mission (Tianwen-1): Design and ground calibration显示文摘The main objective of the Mars Ion and Neutral Particle Analyzer(MINPA)aboard the Chinese Mars Exploration Mission(Tianwen-1)is to study the solar wind-Mars interaction by measuring the ions and energetic neutral atoms(ENAs)near Mars.The MINPA integrates ion and ENA measurements into one sensor head,sharing the same electronics box.The MINPA utilizes a standard toroidal top-hat electrostatic analyzer(ESA)followed by a time of flight(TOF)unit to provide measurement of ions with energies from 2.8 eV to 25.9 keV and ENAs from 50 eV to 3 keV with a base time resolution of 4 seconds.Highly polished silicon single crystal substrates with an Al2O3 film coating are used to ionize the ENAs into positive ions.These ions can then be analyzed by the ESA and TOF,to determine the energy and masses of the ENAs.The MINPA provides a 360°×90°field of view(FOV)with 22.5°×5.4°angular resolution for ion measurement,and a 360°×9.7°FOV with 22.5°×9.7°angular resolution for ENA measurement.The TOF unit combines a-15 kV acceleration high voltage with ultra-thin carbon foils to resolve H+,He2+,He+,O+,O2+and CO2+for ion measurement and to resolve H and O(≥16 amu group)for ENA measurement.Here we present the design principle and describe our ground calibration of the MINPA. | LingGao Kong AiBing Zhang Zhen Tian XiangZhi Zheng WenJing Wang Bin Liu Peter Wurz Daniele Piazza Adrian Etter Bin Su YaYa An JianJing Ding WenYa Li Yong Liu Lei Li YiRen Li Xu Tan YueQiang Sun | 2020 | Earth and Planetary Physics2020，4，4： | 4 |
| 6 | A Satellite-borne Miniature Ion Mass Spectrometer for Space Plasma显示文摘The miniature design technology is an important trend in space exploration.Mass spectrometer is used extensively in the space environment detection.The miniature ion mass spectrometer utilizes a 127° cylindrical electrostatic analyzer accompanied with a Time of Flight(TOF)unit based on ultrathin carbon foil to measure the energy spectra and composition of space plasma.The Time of Flight technique has been used broadly in space plasma measurement.A new type of miniature method for the ion mass spectrometer is introduced.The total mass of the instrument is1.8 kg and the total power consumption is 2.0 W.The calibration results show that the energy measurement range is 8.71~43550eV,the energy resolution is 1.86%and the ion mass from 1 amu(1 amu= 1.67 × 10^(-27)kg) to 58 amu can be resolved by the miniature mass spectrometer.The miniature ion mass spectrometer also has a potential to be increased in the field of view by an electrostatic deflecting system to extend its application in space plasma detection.The miniature ion mass spectrometer has been selected for pre-study of Chinese Strategic Priority Research Program on Space Science. | KONG Linggao ZHANG Aibing ZHENG Xiangzhi AN Yaya WANG Wenjing TIAN Zhen GUAN Yibing LIU Chao DING Jianjing SUN Yueqiang | 2015 | 空间科学学报2015，35，6： | 2 |
| 7 | Lensless Fourier-transform terahertz digital holography for real-time full-field phase imaging显示文摘With the development of continuous-wave terahertz(THz) sources and array detectors, the pursuit of highfidelity real-time imaging is receiving significant attention within the THz community. Here, we report a real-time full-field THz phase imaging approach based on lensless Fourier-transform THz digital holography.A triangular interferometric layout is proposed based on an oblique illumination of 2.52 THz radiation, which is different from other lensless holographic configurations at other frequencies. A spherical reference beam is generated by a reflective parabolic mirror with minor propagation loss. The complex-valued images are reconstructed using a single inverse Fourier transform of the hologram without complex calculation of the diffraction propagation. The experimental result for a Siemens star validates the lateral resolution of-46 μm in the diagonal direction. Sub-pixel image registration and image stitching algorithms are applied to enlarge the area of the reconstructed images. The dehydration process of an aquatic plant leaf(Hottonia inflata) is monitored for the first time, to the best of our knowledge, at the THz band. Rapid variations in water content and morphology are measured with a time interval of 0.6 s and a total time of 5 min from a series of reconstructed amplitude and phase images, respectively. The proposed method has the potential to become a powerful tool to investigate spontaneous phenomena at the THz band. | Yaya Zhang Jie Zhao Dayong WANG Yunxin Wang Lu Rong | 2022 | Photonics Research2022，10，2： | 2 |
| 8 | IFN-γ-mediated IRF1/miR-29b feedback loop suppresses colorectal cancer cell growth and metastasis by repressing IGF1显示文摘 | Li Yuan Chang Zhou Yanxia Lu Min Hong Zuoyang Zhang Zheying Zhang Yaya Chang Chao Zhang Xuenong Li | 2015 | Cancer Letters2015，，： | 1 |
| 9 | The Tsallis statisticaldistribution in completely open system显示文摘 | Li Heling Xiong Ying Li Yaya | 2011 | Physica A2011，390，15： | 1 |
| 10 | Customer chum pre-diction using improved balanced random forests 显示文摘 | XIE Yaya LI Xiu NGAI E W T | 2009 | ExpertSystems with Applications2009，36，3： | 1 |
| 11 | Mitochondrial protein IF1 is a potential regulator of glucagon-like peptide(GLP-1) secretion function of the mouse intestine显示文摘IF1(ATPIF1) is a nuclear DNA-encoded mitochondrial protein whose activity is inhibition of the F1Fo-ATP synthase to control ATP production.IF1 activity remains unknown in the regulation of GLP-1 activity.In this study,IF1 was examined in the diet-induced obese mice using the gene knockout(If1-KO) mice.The mice gained more body weight on a high fat diet without a change in food intake.Insulin tolerance was impaired,but the oral glucose tolerance was improved through an increase in GLP-1 secretion.The KO mice exhibited an improved intestine structure,mitochondrial superstructure,enhanced mitophagy,reduced apoptosis and decreased adenine nucleotide translocase 2(ANT2) protein in the intestinal epithelial cells together with preserved gut microbiota.The data suggest that GLP-1 secretion was enhanced in the obese If1-KO mice to preserve glucose tolerance through a signaling pathway of ANT2/mitochondria/L-cells/GLP-1/insulin.IF1 is a potential mitochondrial target for induction of GLP-1 secretion in L-cells. | Ying Wang Jiaojiao Zhang Xinyu Cao Yaya Guan Shuang Shen Genshen Zhong Xiwen Xiong Yanhong Xu Xiaoying Zhang Hui Wang Jianping Ye | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 1 |
| 12 | Temozolomide and concomitant whole brain radiotherapy in patients with brain metastases:a phase II randomized trial显示文摘 | Verger E Gil M Yaya R | 2005 | Radiat Oncol Biol Phys2005，61，1： | 1 |
| 13 | Glio- blastoma: changing expectations? 显示文摘 | Arribas Alpuente L Menendez Lopez A Yaya Tur R | 2011 | Clin Transl Oncol2011，13，4： | 1 |
| 14 | Effect of redox mediator, AQDS, on the decolourisation of a reactive azo dye containing triazine group in a thermophi- lic anaerobic EGSB reactor显示文摘 | DOS SANTOS A B CERVANTES F J YAYA BEAS R E | 2003 | Enzyme and Microbial Tech- nology2003，33，3： | 1 |
| 15 | The invisible addiction: Cell-phone activities and addiction among male and female college students显示文摘 | Roberts JA Yaya LH Manolis C | 2014 | J Behav Addict2014，3，4： | 1 |
| 16 | Temozolomide and concomitant whole brain radiotherapy in patients with brain metastases: a phase II randomized trial 显示文摘 | Verger E Gil M Yaya R | 2005 | Int J Radiat Oneol Biol Phys2005，61，1： | 1 |
| 17 | CpG island hy-permethylation of the DNA repair enzyme methyllransferase predicts response to temozolomide in primary gliomas显示文摘 | Paz M F Yaya Tur R Rojas Marcos I | 2004 | Clin Cancer Res2004，10，15： | 1 |
| 18 | Hierarchically Micro/Nanostructured Current Collectors Induced by Ultrafast Femtosecond Laser Strategy for High-Performance Lithium-ion Batteries显示文摘Commercial Cu and Al current collectors for lithium-ion batteries(LIBs)possess high electrical conductivity,suitable chemical and electrochemical stability.However,the relatively flat surface of traditional current collectors causes weak bonding strength and poor electrochemical contact between current collectors and electrode materials,resulting in potential detachment of active materials and rapid capacity degradation during extended cycling.Here,we report an ultrafast femtosecond laser strategy to manufacture hierarchical micro/nanostructures on commercial Al and Cu foils as current collectors for high-performance LIBs.The hierarchically micro/nanostructured current collectors(HMNCCs)with high surface area and roughness offer strong adhesion to active materials,fast electronic delivery of entire electrodes,significantly improving reversible capacities and cyclic stability of HMNCCs based LIBs.Consequently,LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2)(NCM523)cathode with Al HMNCC generated a high reversible capacity after 200 cycles(25%higher than that of cathode with Al CC).Besides,graphite anode with Cu HMNCC also maintained prominent reversible capacity even after 600 cycles.Moreover,the full cell assembled by graphite anode with Cu HMNCC and NCM523 cathode with Al HMNCC achieved high reversible capacity and remarkable cycling stability under industrial-grade mass loading.This study provides promising candidate for achieving high-performance LIBs current collectors. | Yaya Wang Zexu Zhao Jiang Zhong Tao Wang Lei Wang Hanjiao Xu Jinhui Cao Jinhao Li Guanhua Zhang Huilong Fei Jian Zhu | 2022 | Energy & Environmental Materials2022，5，3： | 1 |
| 19 | Ultrastretchable and wearable conductive multifilament enabled by buckled polypyrrole structure in parallel显示文摘Stretchable conductive fibers have attracted much attention due to their potential use in wearable electronics.However,the ultrahigh strain insensitive conductivity is hindered by mechanical mismatch in Young’s modulus and failure of stretchable structures under large deformation.This challenge is addressed with a conductive and elastic multifilament made of the polyurethane monofilaments that are surface-coated with buckled polypyrrole(PPy)of which flexibility is improved by sodium sulfosalicylate.Such parallel conductive monofilaments with PPy buckling on surface reduce the influence of cracks in the conductive coating on the overall conductivity,displaying an ultra-high strain insensitive behavior(quality factor Q=10.9).Remarkably,various complex forms of wearable electronic textiles made by this conductive multifilament maintain the strain-insensitive behavior of the original multifilament,even upon the large deformation of human joint.This multifilament with wrinkled PPy has attractive advantages in the application of super-stretched wearable electronic devices. | Yimeng Li Yaya Gao Lizhen Lan Qian Zhang Leqian Wei Mengqi Shan Lamei Guo Fujun Wang Jifu Mao Ze Zhang Lu Wang | 2022 | npj Flexible Electronics2022，6，1： | 1 |
| 20 | Improved photoconductive properties of composite nanofibers based on aligned conjugated polymer and single-walled carbon nanotubes显示文摘 | Florian Massuyeau Yuanchun Zhao Abdel Aziz El Mel Abu Yaya Frederic Geschier Eric Gautron Serge Lefrant Jean Yves Mevellec Chris Ewels Chain-Shu Hsu Eric Faulques Jany Wery Jean Luc Duvail | 2013 | Nano Research2013，6，2： | 1 |
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