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| 1 | Breath and string test: A diagnostic package for the identification of treatment failure and antibiotic resistance of Helicobacter pylori without the necessity of upper gastrointestinal endoscopy显示文摘AIM: Helicobacter pylori ( H pylofi) resistance after failed eradication has a major impact on the outcome of a further treatment regimen. The aim of this study was to assess the validity of a non-invasive strategy using the 13C-urea breath test (UBT) and the gastric string test in identifying post-treatment resistance of Hpylori.METHODS: The UBT was routinely performed 4 to 6 wk after H pylorieradication therapy. Forty-two patients (24 females, 18 males, mean age 48 years) with a positive UBT were included in the study. A gastric string test using a capsule containing a 90 cm-long nylon fiber was performed.Before the capsule was swallowed, the free end of the string was taped to the cheek. After one hour in the stomach, the string was withdrawn. The distal 20 cm of the string was inoculated onto an agar plate and processed under microaerophilic conditions. Following the string test, upper gastrointestinal endoscopy was performed to obtain gastric biopsies for conventional culture.RESULTS: H pyloriwas successfully cultured from the gastric string in 34 patients (81%), but not in 5 patients due to contamination with oropharyngeal flora. Hpyloriwas cultured from the gastric biopsies obtained at endoscopy in 39 patients (93%).CONCLUSION: The UBT followed by the gastric string test in the case of treatment failure is a valid diagnostic strategy with the aim of determining the post-therapeutic antibiotic resistance of Hpyloriwith little inconvenience to the patient.Upper GI-endoscopy can be avoided in several cases by applying consequently this diagnostic package. | Andreas Leodolter Kathlen Wolle Ulrike von Arnim Stefan Kahl Gerhard Treiber Matthias P.Ebert Ulrich Peitz Peter Malfertheiner | 2005 | World Journal of Gastroenterology2005，11，4： | 10 |
| 2 | Pretreated Glehnia littoralis Extract Prevents Neuronal Death Following Transient Global Cerebral Ischemia through Increases of Superoxide Dismutase 1 and Brain-derived Neurotrophic Factor Expressions in the Gerbil Hippocampal Cornu Ammonis 1 Area显示文摘 | Joon Ha Park Tae-Kveono Lee Bing-Chun Yan Bich-Na Shin Ji Hyeon Ahn In Hye Kim Jeong Hwi Cho Jae-Chul Lee In Koo Hwang Jong Dai Kim Seongkweon Hong Young Joo Lee Moo-Ho Woll Il Jun Kang | 2017 | Chinese Medical Journal2017，，15： | 10 |
| 3 | Prevalence of H pylori associated 'high risk gastritis' for development of gastric cancer in patients with normal endoscopic findings显示文摘AIM: To investigate the prevalence of H pylori associated corpus-predominant gastritis (CPG) or pangastritis, severe atrophy, and intestinal metaplasia (IM) in patients without any signifi cant abnormal fi ndings during upper- GI endoscopy. METHODS: Gastric biopsies from 3548 patients were obtained during upper GI-endoscopy in a 4-year period. Two biopsies from antrum and corpus were histologically assessed according to the updated Sydney-System. Eight hundred and forty-fi ve patients (mean age 54.8 ± 2.8 years) with H pylori infection and no peptic ulcer or abnormal gross fi ndings in the stomach were identifi ed and analyzed according to gastritis phenotypes using different scoring systems. RESULTS: The prevalence of severe H pylori associated changes like pangastritis, CPG, IM, and severe atrophy increased with age, reaching a level of 20% in patients of the age group over 45 years. No differences in frequencies between genders were observed. The prevalence of IM had the highest increase, being 4-fold higher at the age of 65 years versus in individuals less than 45 years. CONCLUSION: The prevalence of gastritis featuring at risk for cancer development increases with age. These findings reinforce the necessity for the histological assessment, even in subjects with normal endoscopic appearance. The age-dependent increase in prevalence of severe histopathological changes in gastric mucosa, however, does not allow estimating the individual risk forgastric cancer development-only a proper follow-up can provide this information. | Andreas Leodolter Matthias P Ebert Ulrich Peitz Kathlen Wolle Stefan Kahl Michael Vieth Peter Malfertheiner | 2006 | World Journal of Gastroenterology2006，12，34： | 4 |
| 4 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 5 | Hierarchical assemblies of molecular frameworks—MOF-on-MOF epitaxial heterostructures显示文摘Functional,porous metal-organic frameworks(MOFs)have attracted much attention as a very flexible class of crystalline,porous materials.For more advanced applications that exploit photophysical properties,the fabrication of hierarchical assemblies,including the creation of MOF/MOF heterointerfaces,is important.For the manufacturing of superstructures with length scales well beyond that of the MOF pore size,layer-by-layer(Ibl)methods are particularly attractive.These allow the isoreticular approach to be extended to superstructures with micrometer length scales,a range that is not accessible using conventional MOF design.The Ibl approach further substantially extends the compositional diversity in MOFs.At the same time,the favorable elastic properties of MOFs allow for heteroepitaxial growth,even in the case of lattice misfits as large as 20%.While the MOF-on-MOF approach to designing multicomponent superstructures with synergistic multifunctionality can also be realized with sophisticated solvothermal synthesis schemes,the Ibl(or liquid-phase epitaxy)approach carries substantial advantages,in particular when it comes to the integration of such MOF superstructures into optical or electronic devices.While the structure vertical to the substrate can be adjusted using the Ibl method,photolithographic methods can be used for lateral structuring.In this review,we will discuss the Ibl liquid-phase epitaxy approach to growing surface-anchored MOF thins films(SURMOFs)as well as other relevant one-pot synthesis methods for constructing such hierarchically designed structures and their emerging applications. | Ritesh Haidar Christof Woll | 2021 | Nano Research2021，14，2： | 2 |
| 6 | How to Share a Secret with Cheaters显示文摘 | Tompa M Woll H | 1988 | Journal of Cryptography1988，30，： | 2 |
| 7 | 卫星系统测试中的LXI应用显示文摘卫星的应用非常广泛,例如科学研究、天气预报、航海、军事及航空航天。当今地球环绕卫星中最多应用于通信,使得地球上任意地方的人们得以沟通交流。事实上,太空里多一半的卫星都是通信卫星。除此以外,无论人们是否意识到这一点,卫星通信已经与我们日常生活的方方面面都有所关联。也许卫星通信使用最多的形式是传送全世界人们所钟爱的电视节目,此外,机场的控制管理中心也依赖于卫星通信确保旅客得以平安返回。在灾难发生的时候,例如2001年世界贸易中心事件、2005年的印度洋海啸,或者2006年新奥尔良的卡特里娜飓风发生时,卫星通信常常成为人们与世界其他地方联络的唯一手段。一种使用LXI技术的新双频方法应运而生可以让用户用高精度变频器和混频器测量相对组延时,而不需要像通常卫星通信中那样使用本地振荡器。 | Jochen Wolle | 2013 | 国外电子测量技术2013，32，6： | 2 |
| 8 | 定位乡土--青年设计师乡土营建学术论坛显示文摘在全球化的时代,中国的乡村经历了世界上最大规模的城市化进程,广大乡村地区的面貌,都已经完成或正在经历一种自发的“现代化”的转型,乡土自建活动逐步抛弃了传统的流程、技艺、结构、符号,甚至是审美品位。从传统的“农为邦本”里走出的乡民正在自己的有生之年经历着包括物质环境到心理环境的一场巨变,而这种巨变也正以当代乡土住宅和聚落的物质形态呈现在我们眼前, | 钱云 何崴 袁野 郑小东 mika woll 陈忱 高亦陶 段威 | 2017 | 住区2017，，1： | 2 |
| 9 | 神经肽类生长因子与癌症显示文摘过去10年,肿瘤中生长因子及其受体的表达引起了人们的注意。有人推测癌细胞群借助于改变生长因子及其受体表达形式或改变细胞内信号,摆脱正常生长的控制。人们发现很多变化伴有相应癌基因的表达,以此为基础,认为癌症是遗传性伤害积累的结果。虽然有些多肽类生长因子如上皮生长因子、血小板衍化生长因子曾经被广泛讨论,但其致有丝分裂作用最近才被认识。 | Woll P J 顾兴华 | 1992 | 国外医学(肿瘤学分册)1992，19，2： | 2 |
| 10 | Randomized double-blind placebo-controlled trial of thalidomide in combination with gemcitabine and carboplatin in advanced non-small-cell lung cancer 显示文摘 | Lee SM Rudd R Woll PJ | 2009 | J Clin Oncol2009，27，31： | 1 |
| 11 | How to share a secret sharing with cheaters 显示文摘 | TOMPA M WOLL H | 1988 | Journal of Cryptology1988，1，3： | 1 |
| 12 | Na, K-ATPase subunits as markers for epithelial-nmsenchymal transition in cancerand fibrosis 显示文摘 | Rajasekaran SA Huynh TP Wolle DG | 2010 | Mol Cancer Ther2010，9，6： | 1 |
| 13 | Cardiac safety of pegylated liposomal doxorubicin (PLD) in combination with trastuzumab (T) in patients with metastatic breast cancer (MBC) : results from a muhicenter phase Ⅱ study 显示文摘 | Stickeler E Watermann DO Woll J | 2007 | J Clin Oncol 2007 ASCO Meeting Proceedings Part 12007，25，18： | 1 |
| 14 | Osteogenic nodule formation from single embryonic stem cell-derived progenitors显示文摘 | Woll NL Heaney JD Bronson SK | 2006 | Stem Cells2006，24，6： | 1 |
| 15 | Randomized double-blind placebo-controlled trial of thalidomide in combination with gemcitabine and Carboplatin in advanced non-smaU-cell lung cancer 显示文摘 | Lee SM Rudd R Woll PJ | 2009 | J Clin Oncol2009，27，31： | 1 |
| 16 | Spur tered ZnO seed layer enhances photovoltaic behavior in hybrid ZnO/P3HT solar cells显示文摘 | Brooks L W Mativetsky J M Woll A etal | 2013 | Organic Elec- tronics2013，14，12： | 1 |
| 17 | Toward a smart grid: power delivery for the 21st century显示文摘 | AMIN M WOLL ENBERG B F | 2005 | IEEE Power and Energy Magazine2005，3，5： | 1 |
| 18 | 1 W of blue 465 nm radiation Generated by frequency doubling of the out of a high-power diode laser in critically phase matched LBO 显示文摘 | Woll D Bier B | 1999 | Optics Letters1999，24，10： | 1 |
| 19 | How to Share a Secret with the Cheaters显示文摘 | Tompa M Woll H | 1988 | Journal of Cryptology1988，1，2： | 1 |
| 20 | Der Fragebogen zur Erfas- sung des motorischen Funktionsstatus(FFB-Mot)显示文摘 | BOS K ABEL T WOLL A | 2002 | Diagnostica2002，48，2： | 1 |
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