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| 1 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 2 | Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020显示文摘African swine fever virus(ASFV)has been circulating in China for more than two years,and it is not clear whether the biological properties of the virus have changed.Here,we report on our surveillance of ASFVs in seven provinces of China,from June to December,2020.A total of 22 viruses were isolated and characterized as genotype II ASFVs,with mutations,deletions,insertions,or short-fragment replacement occurring in all isolates compared with Pig/HLJ/2018(HLJ/18),the earliest isolate in China.Eleven isolates had four different types of natural mutations or deletion in the EP402R gene and displayed a nonhemadsorbing(non-HAD)phenotype.Four isolates were tested for virulence in pigs;two were found to be as highly lethal as HLJ/18.However,two non-HAD isolates showed lower virulence but were highly transmissible;infection with 106 TCID50 dose was partially lethal and caused acute or sub-acute disease,whereas 103 TCID50 dose caused non-lethal,sub-acute or chronic disease,and persistent infection.The emergence of lower virulent natural mutants brings greater difficulty to the early diagnosis of ASF and creates new challenges for ASFV control. | Encheng Sun Zhenjiang Zhang Zilong Wang Xijun He Xianfeng Zhang Lulu Wang Wenqing Wang Lianyu Huang Fei Xi Haoyue Huangfu Ghebremedhin Tsegay Hong Huo Jianhong Sun Zhijun Tian Wei Xia Xuewu Yu Fang Li Renqiang Liu Yuntao Guan Dongming Zhao Zhigao Bu | 2021 | Science China(Life Sciences)2021，64，5： | 46 |
| 3 | Identification of long-range transport pathways and potential sources of PM2.5 and PM10 in Beijing from 2014 to 2015显示文摘Trajectory clustering, potential source contribution function(PSCF) and concentration-weighted trajectory(CWT) methods were applied to investigate the transport pathways and identify potential sources of PM_(2.5)and PM_(10) in different seasons from June 2014 to May 2015 in Beijing.The cluster analyses showed that Beijing was affected by trajectories from the south and southeast in summer and autumn. In winter and spring, Beijing was not only affected by the trajectories from the south and southeast, but was also affected by trajectories from the north and northwest. In addition, the analyses of the pressure profile of backward trajectories showed that backward trajectories, which have important influence on Beijing, were mainly distributed above 970 h Pa in summer and autumn and below 950 h Pa in spring and winter. This indicates that PM_(2.5)and PM_(10) were strongly affected by the near surface air masses in summer and autumn and by high altitude air masses in winter and spring. Results of PSCF and CWT analyses showed that the largest potential source areas were identified in spring, followed by winter and autumn,then summer. In addition, potential source regions of PM_(10) were similar to those of PM_(2.5). There were a clear seasonal and spatial variation of the potential source areas of Beijing and the airflow in the horizontal and vertical directions. Therefore, more effective regional emission reduction measures in Beijing's surrounding provinces should be implemented to reduce emissions of regional sources in different seasons. | Deping Li Jianguo Liu Jiaoshi Zhang Huaqiao Gui Peng Du Tongzhu Yu Jie Wang Yihuai Lu Wenqing Liu Yin Cheng | 2017 | Journal of Environmental Sciences2017，29，6： | 22 |
| 4 | The Reference Genome Sequence of Scutellaria baicalensis Provides Insights into the Evolution of Wogonin Biosynthesis显示文摘Scutellaria baicalensis Georgi is important in Chinese traditional medicine where preparations of dried roots,'Huang Qin,' are used for liver and lung complaints and as complementary cancer treatments. We report a high-quality reference genome sequence for S. baicalensis where 93% of the 408.14-Mb genome has been assembled into nine pseudochromosomes with a super-N50 of 33.2 Mb. Comparison of this sequence with those of closely related species in the order Lamiales, sesamum indicum and Salvia splendens,revealed that a specialized metabolic pathway for the synthesis of 4'-deoxyflavone bioactives evolved in the genus Scu-tellaria. We found that the gene encoding a specific cinnamate coenzyme A ligase likely obtained its newfunc- tion following recent mutations, and that four genes encoding enzymes in the 4'-deoxyflavone pathway are present as tandem repeats in the genome of S. baicalensis. Further analyses revealed that gene duplications, segmental duplication, gene amplification, and point mutations coupled to gene neo- and subfunctionaliza-tions were involved in the evolution of 4'-deoxyflavone synthesis in the genus Scutellaria. Our study not only provides significant insight into the evolution of specific flavone biosynthetic pathways in the mint family, Lamiaceae, but also will facilitate the development of tools for enhancing bioactive productivity by metabolic engineering in microbes or by molecular breeding in plants. The reference genome of S. baicalensis is also useful for improving the genome assemblies for other members of the mint family and offers an important foundation for decoding the synthetic pathways of bioactive compounds in medicinal plants. | Qing Zhao Jun Yang Meng-Ying Cui Jie Liu Yumin Fang Mengxiao Yan Wenqing Qiu Huiwen Shang Zhicheng Xu Reheman Yidiresi Jing-Ke Weng Tomas Pluskal Marielle Vigouroux Burkhard Steuernagel Yukun Wei Lei Yang Yonghong Hu Xiao-Ya Chen Cathie Martin | 2019 | Molecular Plant2019，12，7： | 23 |
| 5 | An overview of the use of plastic-film mulching in China to increase crop yield and water-use efficiency显示文摘Since 1990,crop yields have stagnated in many parts of the world,posing a significant challenge to global food security[1].As such;innovative solutions are needed to increase the resource-use efficiency of cropping systems to produce more grains per unit area. | Dongbao Sun Haigang Li Enli Wang Wenqing He Weiping Hao Changrong Yan Yuzhong Li Xurong Mei Yanqing Zhang Zhanxiang Sun Zhikuan Jia Huaiping Zhou Tinglu Fan Xucheng Zhang Qin Liu Fengju Wang Chaochun Zhang Jianbo Shen Qingsuo Wang Fusuo Zhang | 2020 | National Science Review2020，7，10： | 19 |
| 6 | Utilization of polysaccharides as depressants for the flotation separation of copper/lead concentrate显示文摘The interaction mechanism between dextrin and minerals has been investigated through micro-flotation, adsorption density measurements, Fourier transform infrared ray (FTIR) spectroscopic studies and dissolution tests. Dextrin shows a good depressing action towards galena but not chalcopyrite. FTIR spectroscopic studies indicate that dextrin chemically adsorbed on galena surface in alkaline pH range. Dissolution tests confirm leaching action of metal ions from chalcopyrite and galena surfaces, and dextrin-lead ion interaction. Adsorption measurements present that the higher adsorption density of O-isopropyl-N-ethyl thionocarbamate (IPETC) onto chalcopyrite than that onto galena, and IPETC adsorbed on galena decrease with increasing dextrin concentrations in the presence of dextrin, attesting the flotation results. | Qin Wenqing Wei Qian Jiao Fen Yang Congren Liu Ruizeng Wang Peipei Ke Lifang | 2013 | International Journal of Mining Science and Technology2013，23，2： | 16 |
| 7 | Haze observations by simultaneous lidar and WPS in Beijing before and during APEC, 2014显示文摘We present combined Mie lidar, ozone lidar and wide-range particle spectrometer observations which were carried out in Beijing, north China during two periods—one haze period before the Asia-Pacific Economic Cooperation(APEC) meeting and one moderate pollution period during the meeting in 2014. High extinction coefficient, moderate ozone concentration and variable particle number concentration were obtained throughout the first haze observation period. The mean extinction coefficients in the two pollution periods were 0.52 and 0.23 km?1, respectively, at 532 nm. The ozone concentration during the first haze phase was more various with a higher average value of 49 ppb compared with that in the second pollution observations(32 ppb). Compared with the same metrological condition occurring at the end of October, the sharply decreased aerosol extinction coefficient and ozone concentration show the effectiveness of the emission-cutting measures implemented during APEC in November. The comparison of aerosols and ozone in different heights indicate different pollution sources and the complicated ozone process of generation and disappearance. The correlation between the scattering coefficient and particle number concentrations of various diameter depended on the ambient humidity. Especially the particle number concentration(500 nm–1 ?m) contributed most to PM2.5 concentration. The four-day back trajectories from a Hybrid Single-particle Lagrangian Integrated Trajectory(HYSPLIT) model indicate that the air masses in the lower boundary layer before and during APEC were advected from the densely populated south regions of China and the long pollution transportation passing through northern China. | Zhenyi Chen Jiaoshi Zhang Tianshu Zhang Wenqing Liu Jianguo Liu | 2015 | Science China Chemistry2015，58，9： | 14 |
| 8 | Different properties of GaN-based LED grown on Si(111) and transferred onto new substrate显示文摘InGaN MQW LEDs, grown by metal-organic chemical vapor deposition (MOCVD) on Si(111) substrates, were successfully bonded and transferred onto new Si substrate. After chemical etching Si(111) substrate and inductively coupled plasma (ICP) etching the transferred LED film to Si-doped layer, a vertical structure GaN blue LEDs were then fabricated. The characteristics of the lateral structure LED (grown on Si) and the vertical structure LED (bonded on Si) were investigated. It shows the performance of ver- tical structure LEDs had obviously been improved compared to the lateral structure LEDs and the tensile stress in GaN layer of vertical structure LEDs is smaller than that in lateral structure LEDs. | XIONG Chuanbing JIANG Fengyi FANG Wenqing WANG Li LIU Hechu MO Chunnan | 2006 | Science China(Technological Sciences)2006，49，3： | 12 |
| 9 | Dynamics for multistage pool formation of Lunnan low uplift in Tarim Basin显示文摘Lunnan area in the Tarim Basin has become animportant onshore oil production base in China. Formationof the oil and gas pools in the low uplift of Lunnan has ex-perienced a comparatively complex process of dynamics.Based on the hydrocarbon generation period of source rocks,the formation period of cap rocks and traps, the analysis oforganic inclusion and the analysis of bitumen in the reservoir,this paper draws the conclusion that the low uplift area ofLunnan has experienced three pool formation periods: thePermian period, the Cretaceous-Early Tertiary period andthe Late Tertiary-Quaternary period and two oil and gasreservoir adjustment periods: the Late Permian period andthe Late Tertiary-Quaternary period. The comprehensivestudy indicates that the large-scale Ordovician buried hill,formed in Early Hercynian, became the reservoir during thePermian period, because the Cambrian-Lower Ordovicianoil was discharged laterally into the reservoir along the topof the Ordovician weathering crust from south to north. Thereservoir experienced a complicated process-reconstruc-tion in the end of Permian, adjustment in Cretaceous-EarlyTertiary and re-discharging process in Late Tertiary-Qua-ternary, leading to the early original heavy oil reservoir ofmarine facies and the late original light oil reservoir and gaspool. Carboniferous, Triassic and Jurassic oil and gas reser-voirs result from upward adjustment and re-distribution ofOrdovician oil and gas reservoirs. Of those results, the for-mation of Triassic-Jurassic oil and gas pools came under theinfluence of the northward-tilting structure. The oil and gassourcing from the different hydrocarbon source rock inter-vals vertically migrated into the base unconformity of Trias-sic system. Then the oil and gas migrated laterally fromnorth to south and accumulated into the reservoir. | HE Dengfa JIA Chengzao LIU Shaobo PAN Wenqing WANG Shejiao | 2002 | Chinese Science Bulletin2002，47，S1： | 11 |
| 10 | Structural basis for the impact of phosphorylation on the activation of plant receptor-like kinase BAK1显示文摘 | Liming Yan Yuanyuan Ma Dan Liu Xiaochao Wei Yuna Sun Xiaoyue Chen Huadong Zhao Jingwen Zhou Zhiyong Wang Wenqing Shui Zhiyong Lou | 2012 | Cell Research2012，22，8： | 10 |
| 11 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 12 | Ethylene oligomerization by novel iron(Ⅱ) diimine complexes/MAO显示文摘Two novel Fe(Ⅱ) diimine complexes have been synthesized. In combination with MAO, they generate active catalytic systems that oligomerize ethylene with both high catalytic activity and high selectivity for a-olefins. The effects of substituents on the aryl ring, reaction temperatures and molar ratios of Al/Fe on catalytic activity and product distribution are studied. | WANG Hang, YAN Weidong, JIANG Tao, LIU Binbin, XU Wenqing, MA Jianjiang & HU YouliangState Key Laboratory of Engineering Plastics, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Graduate Student of | 2002 | Chinese Science Bulletin2002，47，19： | 8 |
| 13 | Effect of N fertilization rate on soil alkalihydrolyzable N, subtending leaf N concentration,fiber yield, and quality of cotton显示文摘Soil alkali-hydrolyzable nitrogen, which is sensitive to N fertilization rate, is one of the indicators of soil nitrogen supplying capacity. Two field experiments were conducted in Dongtai(120°19″ E, 32°52″ N), Jiangsu, China in 2009 and Dafeng(120°28″ E, 33°12″ N), Jiangsu province, China in 2010. Six nitrogen rates(0, 150, 300, 375, 450, and 600 kg ha^(-1)) were used to study the effect of N fertilization rate on soil alkali-hydrolyzable nitrogen content(SAHNC), subtending leaf nitrogen concentration(SLNC), yield, and fiber quality. In both Dongtai and Dafeng experiment station, the highest yield(1709 kg ha^(-1)), best quality(fiber length 30.6 mm, fiber strength 31.6 c N tex^(-1), micronaire 4.82), and highest N agronomic efficiency(2.03 kg kg^(-1)) were achieved at the nitrogen fertilization rate of 375 kg ha^(-1). The dynamics of SAHNC and SLNC could be simulated with a cubic and an exponential function,respectively. The changes in SAHNC were consistent with the changes in SLNC. Optimal average rate(0.276 mg day^(-1)) and duration(51.8 days) of SAHNC rapid decline were similar to the values obtained at the nitrogen rate of 375 kg ha^(-1)at which cotton showed highest fiber yield, quality, and N agronomic efficiency. Thus, the levels and strategies of nitrogen fertilization can affect SAHNC dynamics. The N fertilization rate that optimizes soil alkali-hydrolyzable nitrogen content would optimize the subtending leaf nitrogen concentration and thereby increase the yield and quality of the cotton fiber. | Binglin Chen Hongkun Yang Weichao Song Chunyu Liu Jiao Xu Wenqing Zhao Zhiguo Zhou | 2016 | The Crop Journal2016，4，4： | 8 |
| 14 | Adsorption-energy-based activity descriptors for electrocatalysts in energy storage applications显示文摘Energy storage technologies, such as fuel cells, ammonia production and lithium–air batteries, are important strategies for addressing the global challenge of energy crisis and environmental pollution.Taking overpotential as a direct criterion, we illustrate in theory and experiment that the adsorption energies of charged species such as Li^++e^-and H^++e^-are a central parameter to describe catalytic activities related to electricity-in/electricity-out efficiencies. The essence of catalytic activity is revealed to relate with electronic coupling between catalysts and charged species. Based on adsorption energy, some activity descriptors such as d-band center, e_g-electron number and charge-transfer capacity are further defined by electronic properties of catalysts that directly affect interaction between catalysts and charged species. The present review is helpful for understanding the catalytic mechanisms of these electrocatalytic reactions and developing accurate catalytic descriptors, which can be employed to screen high-activity catalysts in future high-throughput calculations and experiments. | Youwei Wang Wujie Qiu Erhong Song Feng Gu Zhihui Zheng Xiaolin Zhao Yingqin Zhao Jianjun Liu Wenqing Zhang | 2018 | National Science Review2018，5，3： | 8 |
| 15 | Detrital-zircon geochronology of the Jurassic coal-bearing strata in the western Ordos Basin, North China: Evidences for multi-cycle sedimentation显示文摘The western Ordos Basin(WOB), situated in a tectonic transition zone in the North China Craton, acts as an excellent example for studying the Mesozoic intraplate sedimentation and deformation in Asia. In this study, U-Pb ages for 1203 detrital zircons of 14 sandstone samples collected from 11 sections are presented to unravel the sediment source locations and paleogeographic environments of the Early-Middle Jurassic coal-bearing Yan'an Formation in the WOB. Data show that there are five prominent age groups in the detrital zircons of the Yan'an Formation, peaking at ca. 282 Ma, 426 Ma, 924 Ma, 1847 Ma, and2468 Ma. Samples from the northern, middle, and southern parts of the WOB contain these five age categories in various proportions. In the northern region, the Yan'an Formation exclusively contains Early Permian detrital zircons with a single age group peaking at 282 Ma, matching well with the crystallizing ages of the widespread Early Permian granites in the Yinshan Belt to the north and the Alxa Block to the northwest. While in the southern region, the Yan'an Formation mainly contains three groups of detrital zircons, with age peaks at 213 Ma, 426 Ma, and 924 Ma. These zircon ages resemble those of the igneous rocks in the Qilian-Qinling Orogenic Belt to the south-southwest. Samples in the middle region, characterized by a mixture age spectrum with peaks at 282 Ma, 426 Ma, 924 Ma, 1847 Ma and 2468 Ma, are previously thought to have mixed derivations from surrounding ranges. However, by referring to the detrital-zircon age compositions of the pre-Jurassic sedimentary successions and combining with paleontological and petrographic analysis, we firstly propose that the sediments of the Yan'an Formation in the middle region were partly recycled from the Triassic and Paleozoic sedimentary strata in the WOB.The occurrence of recycled sedimentation suggests that the Late Triassic-Early Jurassic intraplate compressional deformation was very intense in the WOB, especially for regions in front of the Qilian Orogenic Belt. | Pei Guo Chiyang Liu Jianqiang Wang Yu Deng Guangzhou Mao Wenqing Wang | 2018 | Geoscience Frontiers2018，9，6： | 8 |
| 16 | An Epidemic of Hepatitis A--Liaoning Province,2020显示文摘What is already known about this topic?Hepatitis A(HA)is caused by acute hepatitis A virus(HAV)infection and was once very common in China.Following the 2008 introduction of the HA vaccine into the national Expanded Program on Immunization(EPI),the incidence of reported HA in China decreased markedly.However,HA epidemics still occur in Liaoning Province every 3–5 years,although with far fewer cases than in the pre-HA-vaccination era.What is added by this report?Between January 1,2020 and March 18,2020,the number of reported cases of HA in Dalian and Dandong cities of Liaoning Province increased significantly compared with the same period in previous years.All cases were sporadic,and cases were seen in nearly every township.The increase in HA occurred one month after local fresh seafood became available with most cases being among adults.A casecontrol study showed that consuming raw or undercooked seafood,clams,snapping shrimp,and oysters were significantly associated with the increase in HA.What are the implications for public health practices?Strengthening health education for residents to avoid consumption of raw seafood and encouraging HAV vaccination of adults aged 20 to 54 years are important to prevent periodic HAV endemic outbreaks.Further multisectoral cooperation must be emphasized on HA surveillance in areas with a high prevalence of HA. | Jing Sun Yuanqiu Li Xing Fang Yan Wang Yinan Han Yang Liu Jingyuan Cao Wenting Zhou Hui Zheng Wenqing Yao | 2020 | China CDC weekly2020，2，30： | 7 |
| 17 | Recent Progress of Marine Geographic Information System in China:A Review for 2006-2010显示文摘In this article,the progress of marine geographic information system(MGIS) in China during 2006?2010 is reviewed with emphases on generic MGIS,advanced MGIS and MGIS-based applications.Generic MGIS can be divided into two categories:data-oriented MGIS and user-oriented MGIS,recent achievements of which by Chinese researchers are summarized respectively.Advanced MGIS mainly involves the establishment of 3D virtual marine environment and 'Digital Ocean'.An overview of the 3D MGIS based simulations in the context of ocean phenomena,ocean engineering and ocean battlefield is also presented.Several sug-gestions for future development of MGIS in China are proposed,and trends of development are addressed. | CHEN Ge LI Wenqing KONG Qianqian LIU Shouxin LV Chongjing TIAN Fenglin | 2012 | Journal of Ocean University of China2012，11，1： | 7 |
| 18 | Mechanism of Hg^0 oxidation in the presence of HCl over a commercial V_2O_5–WO_3/TiO_2 SCR catalyst显示文摘Experiments were conducted in a fixed-bed reactor containing a commercial V2O5/WO3/TiO2 catalyst to investigate mercury oxidation in the presence of HCl and O2. Mercury oxidation was improved significantly in the presence of HCl and O2, and the Hg0 oxidation efficiencies decreased slowly as the temperature increased from 200 to 400°C. Upon pretreatment with HCl and O2 at 350°C, the catalyst demonstrated higher catalytic activity for Hg0 oxidation. Notably,the effect of pretreatment with HCl alone was not obvious. For the catalyst treated with HCl and O2, better performance was observed with lower reaction temperatures. The results showed that both HCl and Hg0 were first adsorbed onto the catalyst and then reacted with O2 following its adsorption, which indicates that the oxidation of Hg0 over the commercial catalyst followed the Langmuir–Hinshelwood mechanism. Several characterization techniques, including Hg0temperature-programmed desorption(Hg-TPD) and X-ray photoelectron spectroscopy(XPS), were employed in this work. Hg-TPD profiles showed that weakly adsorbed mercury species were converted to strongly bound species in the presence of HCl and O2. XPS patterns indicated that new chemisorbed oxygen species were formed by the adsorption of HCl, which consequently facilitated the oxidation of mercury. | Ruihui Liu Wenqing Xu Li Tong Tingyu Zhu | 2015 | Journal of Environmental Sciences2015，27，10： | 7 |
| 19 | Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging显示文摘Detailed knowledge on tissue-specific metabolic reprogramming in diabetic nephropathy(DN)is vital for more accurate understanding the molecular pathological signature and developing novel therapeutic strategies.In the present study,a spatial-resolved metabolomics approach based on air flowassisted desorption electrospray ionization(AFADESI)and matrix-assisted laser desorption ionization(MALDI)integrated mass spectrometry imaging(MSI)was proposed to investigate tissue-specific metabolic alterations in the kidneys of high-fat diet-fed and streptozotocin(STZ)-treated DN rats and the therapeutic effect of astragalosideⅣ,a potential anti-diabetic drug,against DN.As a result,a wide range of functional metabolites including sugars,amino acids,nucleotides and their derivatives,fatty acids,phospholipids,sphingolipids,glycerides,carnitine and its derivatives,vitamins,peptides,and metal ions associated with DN were identified and their unique distribution patterns in the rat kidney were visualized with high chemical specificity and high spatial resolution.These region-specific metabolic disturbances were ameliorated by repeated oral administration of astragaloside Ⅳ(100 mg/kg)for 12 weeks.This study provided more comprehensive and detailed information about the tissue-specific metabolic reprogramming and molecular pathological signature in the kidney of diabetic rats.These findings highlighted the promising potential of AFADESI and MALDI integrated MSI based metabolomics approach for application in metabolic kidney diseases. | Zhonghua Wang Wenqing Fu Meiling Huo Bingshu He Yaqi Liu Lu Tian Wanfang Li Zhi Zhou Baili Wang Jianzhen Xia Yanhua Chen Jinfeng Wei Zeper Abliz | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 7 |
| 20 | FoxO directly regulates the expression of TOR/S6K and vitellogenin to modulate the fecundity of the brown planthopper显示文摘As a conserved transcription factor,FoxO plays a crucial role in multiple physiological processes in vivo,including stress resistance,longevity,growth and reproduction.Previous studies on FoxO have focused on human,mouse,Drosophila melanogaster and Caenorhabditis elegans,while there are few reports on agricultural pests and little is known about how FoxO modulates insect fecundity.In Asia,the brown planthopper(BPH)Nilaparvata lugens(St?l)is one of the most serious pests in rice production and high fecundity is the basis of the outbreak of BPH.Here,using the genome-wide ChIP-seq of NlFoxO in BPH,we found that NlFoxO binds to the promoters of ribosomal protein S6 kinase(NlS6K)and serine/threonine-protein kinase mTOR(NlTOR)and increases their expression levels.We also found that NlFoxO directly binds to the exon of vitellogenin(NlVg)and has a specific inhibitory effect on its expression.In addition,the number of eggs laid and their hatching rate decreased significantly after injection of NlFoxO double-stranded RNA into BPH adults.Our findings provide direct evidence that FoxO modulates insect fecundity through binding to the promoters of NlS6K,NlTOR and the exon of NlVg and affecting their gene expression in the Vg network. | Yi Dong Weiwen Chen Kui Kang Rui Pang Yipei Dong Kai Liu Wenqing Zhang | 2021 | Science China(Life Sciences)2021，64，1： | 6 |
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