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| 1 | Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study显示文摘 | Patrick Marcellin Edward Gane Maria Buti Nezam Afdhal William Sievert Ira M Jacobson Mary Kay Washington George Germanidis John F Flaherty Raul Aguilar Schall Jeffrey D Bornstein Kathryn M Kitrinos G Mani Subramanian John G McHutchison E Jenny Heathcote | 2012 | The Lancet2012，，： | 14 |
| 2 | Identification of pathologic features associated with “ulcerative colitis-like” Crohn's disease显示文摘AIM: To identify pathologic features associated with this 'ulcerative colitis(UC)-like' subgroup of Crohn's disease(CD).METHODS: Seventeen subjects diagnosed as having UC who underwent proctocolectomy(RPC) from 2003-2007 and subsequently developed CD of the ileal pouch were identified. UC was diagnosed based on preoperative clinical, endoscopic, and pathologic studies. Eighteen patients who underwent RPC for UC within the same time period without subsequently developing CD were randomly selected and used as controls. Pathology reports and histological slides were reviewed for a wide range of gross and microscopic pathological features, as well as extent of disease. The demographics, gross description and histopathology of the resection specimens were reviewed and compared between the two groups. RESULTS: Patients with 'UC-like' CD were on average 13 years younger than those with 'true' UC(P < 0.01). More severe disease in the proximal involved region and active ileitis with/without architectural distortion were observed in 6 of 17(35%) and 7 of 17(41%) 'UC-like' CD cases, respectively, but in none of the 'true' UC cases(P < 0.05). Active appendicitis occurred in 8 of 16(50%) 'UC-like' CD cases but in only two(11%) 'true' UC cases(P < 0.05). Conspicuous lamina propria neutrophils were more specific for 'UClike' CD(76% vs 22%, P < 0.05). In addition, prominent lymphoid aggregates tended to be more common in 'UC-like' CD(P = 0.07). The 'true' UC group contained a greater number of cases with severe activity(78% vs 47%). Therefore, the features more commonly seen in 'UC-like' CD were not due to a more severe disease process. Crohn's granulomas and transmural inflammation in non-ulcerated areas were absent in both groups.CONCLUSION: More severe disease in the proximal involved region, terminal ileum involvement, active appendicitis, and prominent lamina propria neutrophils may be morphological factors associated with 'UC-like' CD. | Samuel D James Paul E Wise Tania Zuluaga-Toro David A Schwartz M Kay Washington Chanjuan Shi | 2014 | World Journal of Gastroenterology2014，20，36： | 4 |
| 3 | BATE curve in assessment of clinical utility of predictive biomarkers显示文摘In this paper,for time-to-event data,we propose a new statistical framework for casual inference in evaluating clinical utility of predictive biomarkers and in selecting an optimal treatment for a particular patient.This new casual framework is based on a new concept,called Biomarker Adjusted Treatment Effect (BATE) curve.The BATE curve can be used for assessing clinical utility of a predictive biomarker,for designing a subsequent confirmation trial,and for guiding clinical practice.We then propose semi-parametric methods for estimating the BATE curves of biomarkers and establish asymptotic results of the proposed estimators for the BATE curves.We also conduct extensive simulation studies to evaluate finite-sample properties of the proposed estimation methods.Finally,we illustrate the application of the proposed method in a real-world data set. | ZHOU XiaoHua 1,2,3,& MA YunBei 4,5 1 Northwest HSR&D Center of Excellence,VA Puget Sound Health Care System,Seattle,WA 98198,USA 2 Department of Biostatistics,University of Washington,Seattle,WA 98198,USA 3 Beijing International Center for Mathematical Research,Peking University,Beijing 100871,China 4 Department of Operations Research and Financial Engineering,Princeton University,Princeton,NJ 08540,USA 5 School of Statisitcs,Southwest University of Finance and Economics,Chengdu 611130,China | 2012 | Science China Mathematics2012，55，8： | 2 |
| 4 | Epidermal growth factor receptor inhibits colitis-associated cancer in mice显示文摘 | Dubé Philip E Yan Fang Punit Shivesh Girish Nandini McElroy Steven J Washington M Kay Polk D Brent | 2012 | EN2012，，8： | 2 |
| 5 | Secondary tumors of the gastro- intestinal tract: surgical pathologic {indings and comparison with autopsy survey显示文摘 | Washington K Mcdonagh D | 1995 | Mod Patbol1995，8，： | 1 |
| 6 | Individual differences in servant leadership: The roles of values and personality 显示文摘 | Washington R R Sutton C D Field H S | 2006 | Leadership &Organization Development Journal2006，27，8： | 1 |
| 7 | Clinical practice:current approaches to cervical cancer screening显示文摘 | Sawaya G F Brown A D Washington A E | 2001 | N Engl J Med2001，344，21： | 1 |
| 8 | Myofibrosarcoma treated with Mobs micrographic surgery显示文摘 | Chiller K Parker D Washington C | 2004 | Dermatol Surg2004，30，122： | 1 |
| 9 | Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study显示文摘 | Patrick Marcellin Edward Gane Maria Buti Nezam Afdhal William Sievert Ira M Jacobson Mary Kay Washington George Germanidis John F Flaherty Raul Aguilar Schall Jeffrey D Bornstein Kathryn M Kitrinos G Mani Subramanian John G McHutchison E Jenny Heathcote | 2012 | The Lancet2012，，： | 1 |
| 10 | Imaging of bacterial pulmonary infection in the immunocometent patient显示文摘 | Washington L Palacio D | 2007 | Semin Roentgenol2007，42，2： | 1 |
| 11 | Evidence for simultaneous abiotic-biotic oxidations in a microbial -Fenton's system显示文摘 | HOWSAKENG J WATTS R J WASHINGTON D L | 2001 | Environmental Science and Technology2001，35，： | 1 |
| 12 | Hydrogen sulfide - producing variants of Escherichia coli 显示文摘 | Maker M D Washington J A | 1974 | Applied Microbiology1974，28，2： | 1 |
| 13 | Immunophenotypic analysis of hematogones(B-lymphocyte precursors) in 662 consecutive bone marrow specimens by 4-color flow cytometry显示文摘 | McKenna RW Washington LT Aquino D | 2001 | Blood2001，98，8： | 1 |
| 14 | Light- scattering investigation of the temperature-driven conformationchange in xanthan显示文摘 | HACCHE L S WASHINGTON G E BRANT D A | 1987 | Macromolecules1987，20，9： | 1 |
| 15 | Clinical practice: current approaches to cervical cancer screening显示文摘 | SAWAYA G F BROWN A D WASHINGTON A E | 2001 | N Engl J Med2001，344，21： | 1 |
| 16 | Polarization insensitive fibre optic michelson interferometer显示文摘 | KERSEY A D MARRONE M J WASHINGTON D C | | 0，，06： | 1 |
| 17 | How much more global warming and Sea Level Rise? 显示文摘 | Meehl G A Washington W M Collins W D | 2005 | Science2005，307，5716： | 1 |
| 18 | Dry granulation of slag turned waste into valuable cement binder 显示文摘 | Xie D Washington B Norgate T | 2005 | CAMP-ISIJ2005，，18： | 1 |
| 19 | Evidence for the formation of amphotericin β-phospholipid complexes in Langmuir monolayers显示文摘 | Martin R L Clive Washington Stanley S D | 1996 | Pharmaceutical Research1996，13，7： | 1 |
| 20 | Superovulation of ewes immunized against the human recombinant inhibin a-subunit associated with increased pre and postovulatory follicle-stimulating hormone levels显示文摘 | Mizumachi M Voglmayer J K Washington D W | 1990 | Endocrinology1990，126，： | 1 |
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