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| 1 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 2 | Grassland degradation in Northern Tibet based on remote sensing data显示文摘This study selected vegetation cover as the main evaluation index, calculated the grassland degradation index (GDI) and established the remote sensing monitoring and evaluation system for grassland degradation in Northern Tibet, according to the National Standard (GB19377-2003), based on the remote sensing data such as NDVI data derived from NOAA/AVHRR with a spatial resolution of 8 km of 1981-2000, from SPOT/VGT with a spatial resolution of 1 km of 2001 and from MODIS with a spatial resolution of 0.25 km of 2002-2004 respectively in this area, in combination with the actual condition of grassland degradation. The grassland degradation processes and their responses to climate change during 1981-2004 were discussed and analyzed in this paper. The result indicated that grassland degradation in Northern Tibet is very serious, and the mean value of GDI in recent 20 years is 2.54 which belongs to the serious degradation grade. From 1981 to 2004, the GDI fluctuated distinctly with great interannual variations in the proportion of degradation degree and GDI but the general tendency turned to severe-grade during this period with the grassland degradation grade changed from light degraded to serious degraded in Northern Tibet. The extremely serious degraded and serious degraded grassland occupied 1.7% and 8.0% of the study area, the moderate and light degraded grassland accounted for 13.2% and 27.9% respectively, and un-degraded grassland occupied 49.2% of the total grassland area in 2004. The grassland degradation was serious, especially in the conjunctive area of Naqu, Biru and Jiali counties, the headstream of the Yangtze River lying in the Galadandong snow mountain and glaciers, the area along the Qinghai-Tibet highway and railway, and areas around the Tanggula and Nianqingtanggula snow mountains and glaciers. So the snow mountains and glaciers as well as their adjacent areas in Northern Tibet were sensitive to climate change and the areas along the vital communication line with frequent human activities experienced relatively serious grassland degradation. | GAO Qingzhu LI Yu'e WAN Yunfan LIN Erda XIONG Wei JIANGCUN Wangzha WANG Baoshan LI Wenfu | 2006 | Journal of Geographical Sciences2006，16，2： | 10 |
| 3 | 牧草如何生长——植物生长与放牧管理之关联(英文)显示文摘适当管理饲料饲草资源的基本原则是理解多年生牧草如何生长。长期以来 ,对根系生长有了基本的了解 ,对去叶和环境对根系生长的影响也知之甚多。然而 ,对去叶、干旱及其他环境因素对多年生牧草的影响以及这些牧草对去叶的反应缺乏应有的理解。从牧草返青到开花 ,植物处于短枝阶段 ,适度放牧并不对多年生牧草的健康和活力造成危害 ,因为植物会弥补其失去的叶片。然而 ,当牧草从短枝向长枝阶段 (节间伸长和开花期 )转移时 ,碳水化合物主要用于节间伸长和开花过程。在开花后和休眠前期 ,碳水化合物主要向茎基和植物基部转移 ,以供来年新枝条的发育。因此 ,在花后和休眠前期 ,放牧系统必须被调节到“无放牧”状态。“无放牧”状态 ,如休息、轮牧、延迟轮牧和快速轮牧制 ,其价值在于这种定期的禁牧可提高多年生牧草的活力 ,改善草地的健康状况 ,并且在不利的环境条件下 。 | Ronald E Sosebee David B Wester J Carlos Villalobos Carlton M Britton Changgui Wan Hisham Nofal | 2005 | 草业学报2005，14，1： | 8 |
| 4 | Genome-wide association mapping of vitamins B1 and B2 in common wheat显示文摘Vitamin B is essential for maintaining normal life activities in humans and animals who have to intake the microelement from the outside, especially from cereal products. In the present study 166 Chinese and foreign wheat cultivars planted in two environments were characterized for variation in vitamin B1 and B2 contents. A genome-wide association study(GWAS) using the wheat 90 K SNP assay identified 17 loci for vitamin B1 and 7 for vitamin B2 contents. Linear regression analysis showed a significantly positive correlation of the number of favorable alleles with vitamin B1 and B2 contents. Marker-trait associations(MTAs) at IWB43809(6AS, 0cM) and IWB69903(6AS, 13cM) were new and stable, and significantly associated with vitamin B1 content across two environments. The loci identified in this study and associated SNP markers could be used for improvement of vitamin B1 and B2 contents to obtain superior quality along with grain yield in wheat. | Jieyun Li Jindong Liu Wei'e Wen Pingzhi Zhang Yingxiu Wan Xianchun Xia Yan Zhang Zhonghu He | 2018 | The Crop Journal2018，6，3： | 4 |
| 5 | Efficacy and Safety of Yanggan Jian in Hepatitis B Virusrelated Decompensated Cirrhosis:A Randomized,Doubleblind,Controlled Trial显示文摘Background and Aims:The aim was to evaluate the efficacy and safety of Yanggan Jian(YGJ)in HBV-infected patients with decompensated cirrhosis.Methods:This randomized,double-blind controlled trial enrolled 160 patients with HBV-related decompensated cirrhosis who were already receiving or about to start antiviral therapy.Patients were randomly assigned to receive YGJ or placebo for 24 weeks,and were followed-up to 36 weeks.The primary outcome was the proportion of patients with a≥2 point reduction in Child-Turcotte-Pugh(CTP)score from baseline at week 24.Secondary outcomes were CTP class and score,serum liver function indices,mortality,incidence of hepatocellular carcinoma and variceal bleeding.Results:The proportion of patients with a CTP score reduction≥2 was significantly greater in the YGJ than in the placebo group(p=0.009);the percentage of patients with CTP class C was significantly less than that in the placebo group(p<0.05),and the YGJ group had a significantly greater mean change from baseline in CTP score at week 24(p=0.034).The improvement in measured values and change from baseline of prothrombin time,serum albumin,platelets,cholinesterase,international normalized ratio,and activated partial thromboplastin time were significantly better with YGJ than with placebo.Between-group differences in cumulative rates of variceal bleeding,hepatocellular carcinoma,death,or the frequency of any adverse event(AE),AEs related to treatment,or discontinuation because of AEs were not significant.Conclusions:YGJ significantly improved CTP scores and hepatic synthetic and reserve function in patients with HBV-related decompensated cirrhosis,and was safe and well tolerated. | Long Chen Chaoqun Zhao Weili Yao Wei Liu Hua Zhang Yongping Mu Hong Cai Dongying Xue Chengbao Wang Wan’e Wang Yuehong Lin Jiamei Chen Ping Liu | 2023 | Journal of Clinical and Translational Hepatology2023，11，1： | 3 |
| 6 | Operation Efficiency and Influencing Factors of Listed Companies of Swine Industry:Empirical Analysis Based on Data of 16 Listed Companies in 2010-2014显示文摘Listed companies of the swine industry,as an important form of agricultural industrialized operation,are typical representatives of large-scale production and the level of their operation efficiency exerts a direct influence on the healthy development of the swine industry.Using the DEA-based Malmquist method,this paper made a static and dynamic evaluation of the operation efficiency of 16 listed companies in China's swine industry in 2010-2014. It obtained following results:( i) The overall efficiency of listed companies of China's swine industry remained at high level and the development trend was excellent.( ii) Different types of enterprises had difference in the overall efficiency,pure technical efficiency and scale efficiency. In general,pig feed processing companies had the best performance,followed by slaughtering and deep processing companies,and swine breeding companies were the worst.( iii) The total factor productivity characterized by the Malmquist index declined year by year in 2010-2013 and was improved in 2014,mainly due to technological progress.( iv) The total asset turnover ratio,equity concentration,and R & D management level had a significantly positive impact on the operation efficiency of listed companies in the swine industry,while the human capital had a significantly negative impact. | Mengqi YOU Zhenhong QI Ai’e WANG Xinrui LI Weihong HUANG Wenbin WAN | 2017 | Asian Agricultural Research2017，9，3： | 2 |
| 7 | Genetic transformation of wheat mediated by Agrobacterium tumefaciens显示文摘 | Cheng M Fry J E Pang S Zhou H Hironaka C M Duncan D R Conner T W Wan Y | 1997 | Plant Physiol1997，，： | 2 |
| 8 | The characteristics of Na + , K + and free proline distribution in several drought-resistant plants of the Alxa Desert, China显示文摘 | Suomin Wang Changgui Wan Yanrong Wang Hua Chen Zhiyu Zhou Hua Fu Ronald E Sosebee | 2003 | Journal of Arid Environments2003，，3： | 2 |
| 9 | A preliminary study of level 1A data processing of a low-low satellite to satellite tracking mission显示文摘With the Gravity Recovery and Climate Experiment(GRACE)mission as the prime example,an overview is given on the management and processing of Level 1A data of a low-low satellite to satellite tracking mission.To illustrate the underlying principle and algorithm,a detailed study is made on the K-band ranging(KBR)assembly,which includes the measurement principles,modeling of noises,the generation of Level 1A data from that of Level0 as well as Level 1A to Level 1B data processing. | Xu Peng Qiang Li'e Bian Xing Dong Peng Ju Peng Gao Wei Gong Xuefei Luo Ziren Shao Mingxue Tang Werilin Wan Xiaoyun Lau Yun-Kau | 2015 | Geodesy and Geodynamics2015，6，5： | 2 |
| 10 | Thermally induced structural transformation of polytriazoleimide to polyindoleimide显示文摘包含 bisphenyl-1,2,3-triazole (BPT ) 的 polytriazoleimide 的一种新类型被叠氮化物和炔属羟和 polycondensation (CuAAC ) 的催化铜的 1,3-dipolar cycloaddition 综合。polytriazoleimide 的热稳定性和降级机制被调查。结果证明在 polytriazoleimide 的 BPT 的结构在热处理以后转变到 phenylindole,伴随 N2 的版本。 | Yan Peng E Li Qiang Wan Yu Jing Li Fa Rong Huang Lei Du | 2012 | Chinese Chemical Letters2012，23，9： | 2 |
| 11 | Axial flux modular permanentmagnet generator with a toroidal winding for wind turbine applications显示文摘 | Muljadi E Butterfield C P Wan U H | 1999 | IEEE Transactions on Industry ApplicAtion1999，35，4： | 1 |
| 12 | Automated detection of malignant features in confocal microscopy on superficial spreading melanoma versus nevi显示文摘 | GAREAU D HENNESSY R WAN E | 2010 | Journal of Biomedical Optics2010，15，6： | 1 |
| 13 | Efficacious llbeta- hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model显示文摘 | WAN ZK CHENAIL E XIANG J | 2009 | J Med Chem2009，52，17： | 1 |
| 14 | Wi-Fi based indoor localization and tracking using sigma-point Kalman filtering methods显示文摘 | Paul A S Wan E A | | 0，，： | 1 |
| 15 | Evidence of widespread ozone-induce visible injury on plants in Beijing,China显示文摘 | Feng Z Sun J Wan W Hu E Calatayud V | 2014 | Environmental Pollution2014，193，： | 1 |
| 16 | Molecular correlates of repolarization alternans in cardiac myocytes 显示文摘 | Wan X Laurita KR Provot E J | 2005 | J Mol Cell Cardiol2005，39，3： | 1 |
| 17 | The Unscented Kalman Filter for Nonlinear Estimation 显示文摘 | Wan E A Rudolph V M | 2000 | Adaptive Systems for Signal Processing Communication and Control IEEE2000，45，3： | 1 |
| 18 | Symmetric region growing显示文摘 | Wan S Y Higgins W E | 2003 | IEEE Trans on Image Processing2003，12，9： | 1 |
| 19 | Evaluation of anti- oxidant capacity of root of Scutellaria baicalensis Georgi, in comparison with roots of Polygonum multiflorum Thunb and Panax ginseng CA Meyer显示文摘 | CHAN E WONG C Y WAN Chunwai | 2010 | The American Journal of Chinese Medicine2010，38，4： | 1 |
| 20 | Comparisons of ecosystem services a- mong three conversion systems in Yancheng National Nature Reserve 显示文摘 | Jin' e Liu Hongxia Zhou Pei Qin Jurl Zhou Guoxiang Wan | 2009 | Ecological Engineering2009，，35： | 1 |
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