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| 1 | Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis显示文摘AIM:To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1 ) gene in patients with spontaneous bacterial peritonitis (SBP).METHODS:MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ascites.RESULTS:The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However,in the subgroup of patients with alcoholic cirrhosis (n=80),carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%,P=0.021). CONCLUSION:In patients with alcoholic liver cirrhosis,the-2518 MCP-1 genotype AA is a risk factor for the development of SBP. | Erwin Gbele Marcus Mhlbauer Hartwig Paulo Monika Johann Christin Meltzer Franz Leidl Norbert Wodarz Reiner Wiest Jrgen Schlmerich Claus Hellerbrand | 2009 | World Journal of Gastroenterology2009，15，44： | 7 |
| 2 | Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension显示文摘AIM:To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension. METHODS: Neuronal nitric oxide synthase (nNOS) and HSP-90 were analyzed by immunofluorescence, western blotting and co-immunoprecipitation in the mesenteric vasculature and isolated nerves of portal-vein-ligated (PVL) rats and sham operated rats. In vitro perfused de-endothelialized mesenteric arterial vasculature was preconstricted with norepinephrine (EC80) and tested for nNOS-mediated vasorelaxation by periarterial nerve stimulation (PNS, 2-12 Hz, 45V) before and after incubation with geldanamycin (specific inhibitor of HSP-90 signalling, 3 μg/mL) or L-NAME (non-specific NOSblocker, 10-4 mol/L). RESULTS: nNOS and HSP-90 expression was significantly increased in mesenteric nerves from PVL as compared to sham rats. Moreover, nNOS and HSP-90 were visualized in mesenteric nerves by immunofluorescence and immunoprecipitation of nNOS co-immunoprecitated HSP-90 in sham and PVL rats. PNS induced a frequencydependent vasorelaxation which was more pronounced in PVL as compared to sham rats. L-NAME and geldanamycin markedly reduced nNOS-mediated vasorelaxation abrogating differences between the study groups. The effect of L-NAME and geldanamycin on nNOS-mediated vasorelaxation was significantly greater in PVL than in sham animals. However, no difference in magnitude of effect between L-NAME and geldanamycin was noted. CONCLUSION: HSP-90 acts as a signalling mediator of nNOS-dependent nerve mediated vascular responses in mesenteric arteries, and the increased nitrergic vasorelaxation observed in portal hypertension is mediated largely by HSP-90. | Lukas Moleda Lars Jurzik Matthias Froh Erwin Gbele Claus Hellerbrand Rainer H Straub Jürgen Schlmerich Reiner Wiest | 2010 | World Journal of Gastroenterology2010，16，15： | 4 |
| 3 | Expression of the tumor markers sialyl Lewis A, Sialyl Lewis X, Lewis Y, Thomsen-Friedenreich antigen, galectin-1 and galectin-3 in human osteoblasts in vitro显示文摘 | Ttibel J Saldamli B Wiest I | 2012 | Anticancer Res2012，32，5： | 1 |
| 4 | Synergy of combining sonoly- sis and pbotocatalysis in the degradation and mineralization of chlorinated aromatic compounds 显示文摘 | Peller J Wiest O Kamat P V | 2003 | Environmental Sci- ence & Technology2003，37，9： | 1 |
| 5 | Designing metallicglass matrix composites with high toughness and tensileductility 显示文摘 | Hofmann D C Suh J Y Wiest A | 2008 | Nature2008，451，7182： | 1 |
| 6 | Adolescent depres- sion: Links toacademic coping and perceived auton- omysuport显示文摘 | Wnog E H Wiest D J | 1999 | Education1999，，4： | 1 |
| 7 | Lesions to primary sensory and posterior parietal cortices impair recovery from hand paresis after stroke 显示文摘 | Abela E Missimer J Wiest R | 2012 | PLoS One2012，7，31： | 1 |
| 8 | Vestibular function in severe bilateral vestibulopathy显示文摘 | WIEST G DEMER J L TIAN J | 2001 | J Neurol Neurosurg Psychiatry2001，71，： | 1 |
| 9 | DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH显示文摘 | Erwin G?bele Karin Dostert Claudia Hofmann Reiner Wiest Jürgen Sch?lmerich Claus Hellerbrand Florian Obermeier | 2011 | Journal of Hepatology2011，，6： | 1 |
| 10 | Some properties of schedules for large projects with limited resources 显示文摘 | WIEST J D | 1964 | Operations Research1964，12，3： | 1 |
| 11 | Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense显示文摘 | Teltschik Z Wiest R Beisner J | 2012 | Hepatology2012，55，4： | 1 |
| 12 | Intestinal bacterial translo- cation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense 显示文摘 | Teltschik Z Wiest R Beisner J | 2012 | Hepatology2012，55，： | 1 |
| 13 | Intestinal bacterial transloca- tion in rats with cirrhosis is related to compromised Paneth cell anti microbial host defense显示文摘 | Teltschik Z Wiest R Beisner J | 2012 | Hepatology2012，55，4： | 1 |
| 14 | Self calibration of a planar dissolved oxygen sensor显示文摘 | Eminaga Y Brischwein M Wiest J | 2013 | Sensors and Actuators B: Chemical2013，177，： | 1 |
| 15 | The paradox of nitric oxide in cirrhosis and portal hypertension:too much,not enough显示文摘 | Wiest R Groszmann R J | 2002 | Hepatology2002，35，2： | 1 |
| 16 | Role of TLR9 in hepatic stellate cells and experimental liver fibrosis 显示文摘 | Ggbele E M/ihlbauer M Dorn C Weiss TS Froh M Schnabl B Wiest R Sch61merich J Obermeier F Hellerbrand C | 2008 | Biochem Biophys Res Commun2008，376，2： | 1 |
| 17 | The paradox of nitric oxide in cirrhosis and portal hypertension: too much, not enough显示文摘 | WIEST R GROSZMANN R J | 2002 | Hepatology2002，35，2： | 1 |
| 18 | Designing metallic glass matrix composites with high toughness and tensile ductility显示文摘 | HOFMANN D C SUH J Y WIEST A DUAN G LIND M L DEMETRIOU M D JOHNSON W L | 2008 | Nat Mater2008，451，： | 1 |
| 19 | Adolescent depression:Links to academic coping and perceived autonomy support显示文摘 | Wong E H Wiest D J | | 0，，04： | 1 |
| 20 | Development of tough, low-density titanium-based bulk metallic glass matrix composites with tensile ductility显示文摘 | HOFMANNL D C SUH J Y WIEST A LIND M L DEMETIOU M D JOHNSON W L | 2008 | PNAS2008，105，20： | 1 |
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