维普期刊资源整合服务平台（V6.5）

150篇 您的检索式：作者名="WEN DR"

选中清除导出查看参考文献查看引证文献引用追踪共8页首页上一页第1页下一页末页 /8 跳转

	题名	作者	年代	出处	被引量
1	Infant cholestasis patient with a novel missense mutation in the AKR1D1 gene successfully treated by early adequate supplementation with chenodeoxycholic acid: A case report and review of the literature显示文摘Steroid 5β-reductase [aldo-keto reductase family 1 member D1(AKR1D1)] is essential for bile acid biosynthesis. Bile acid deficiency caused by genetic defects in AKR1D1 leads to life-threatening neonatal hepatitis and cholestasis. There is still limited experience regarding the treatment of this disease. We describe an infant who presented with hyperbilirubinemia and coagulopathy but normal bile acid and γ-glutamyltransferase. Gene analysis was performed using genomic DNA from peripheral lymphocytes from the patient, his parents, and his elder brother. The patient was compound heterozygous for c.919C>T in exon 8 and exhibited a loss of heterozygosity of the AKR1D1 gene, which led to an amino acid substitution of arginine by cysteine at amino acid position 307(p.R307C). Based on these mutations, the patient was confirmed to have primary 5β-reductase deficiency. Ursodeoxycholic acid(UDCA) treatment did not have any effect on the patient. However, when we changed to chenodeoxycholic acid(CDCA) treatment, his symptoms and laboratory tests gradually improved. It is therefore crucial to supplement with an adequate dose of CDCA early to improve clinical symptoms and to normalize laboratory tests.	Hui-Hui Wang Fei-Qiu Wen Dong-Ling Dai Jian-She Wang Jing Zhao Kenneth DR Setchell Li-Na Shi Shao-Ming Zhou Si-Xi Liu Qing-Hua Yang	2018	World Journal of Gastroenterology2018，24，35：	3
2	Technical details of intraoperative lymphatic mapping for early stage melanoma 显示文摘	Morton DL Wen DR Wong J H	1992	Arch Surg1992，127，3：	1
3	Technical details of intraopenative lymphatic mapping for early stage melanoma显示文摘	Morton DL Wen DR Wong J H	1992	Arch Sura1992，127，4：	1
4	Technical details of intraoperation lymphatic mapping for early stage melanoma显示文摘	Morton DL Wen DR Wong JH	1992	Arch Surg1992，127，：	1
5	Arsenic trioxidereduces the invasive and metastatic properties of nasopharyngeal carcinoma cells in vitro显示文摘	Du CW Wen BG Li DR	2006	Braz J Med Biol Res2006，39，5：	1
6	Technical details of intraoperative lymphatic mapping for early stage melanoma 显示文摘	Morton DI Wen DR Wong JH	1992	Arch Surg1992，127，4：	1
7	Technical details of intraoperative lymphatic mapping for early stage melanoma显示文摘	Morton DL Wen DR Wong JH	1992	Arch Surg1992，127，4：	1
8	Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group 显示文摘	Wen PY Macdonald DR Reardon DA	2010	J Clin Oncol2010，28，11：	1
9	Technical details of intraoperative lymphatic mapping for early stage melanoma 显示文摘	Morton DL Wen DR Wang JH	1992	Arch Surg1992，127，：	1
10	Technical details of intraoperative lymphatic mapping for early stage melanoma 显示文摘	Wen DR Wong JH	1992	Arch Surg1992，127，4：	1
11	Technical details of intraoperative lymphatie mapping for early stage melanoma 显示文摘	Morton DL Wen DR Wong JH	1992	Arch Surg1992，127，4：	1
12	Management of the early stage melanoma by intraoperative lymphatic mapping and selective lymphadenectomy显示文摘	Morton DL Wen DR Cochran	1992	Surg Oncol Clin North Am1992，1，：	1
13	Arsenic trioxide reduces the invasive and metastatic properties of nasopharyngeal carcinoma cells in vitro 显示文摘	Du Cw Wen BG Li DR	2006	Braz J Med Biol Res2006，39，5：	1
14	Technical details of intraoperative lymphatic mapping for early stage melanoma 显示文摘	Morton DL Wen DR Wong JH	1992	Arch Surg1992，127，：	1
15	Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group显示文摘	Wen PY Macdonald DR Reardon DA	2010	J Clin Oneol2010，28，：	1
16	Technical details of intraoperative lymphatic mapping for early-stage melanoma 显示文摘	Morton DL Wen DR Wong JH	1992	Arch Surg1992，127，4：	1
17	Paragangliomas:Assessment of prognosis by histologic,immunohistochemical,and ultrastructural techniques显示文摘	Kliewer KE Wen DR Cancilla PA	1989	Hum Pathol1989，20，1：	1
18	Technical details ofintraoperative lymphatic mapping for early stagemelanoma显示文摘	Morton DL Wen DR’Wong JH	1992	Arch Surg1992，127，4：	1
19	Proteomic identification of potential susceptibility factors in drug-induced liver disease 显示文摘	Welch KD Wen B Goodlett DR	2005	Chem Res Toxicol2005，18，6：	1
20	Technical details of intra- operative lymphatic mapping for early stage melanoma 显示文摘	Morton DL Wen DR Wong JH L	1992	Arch Surg1992，127，4：	1

返回顶部每页显示：

共8页首页上一页第1页下一页末页 /8 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示