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| 1 | Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury显示文摘AIM To investigate the hypothesis that treatment with dimethyl fumarate(D MF) mayame liorate liver ischemia/reperfusion injury(I/RI).METHODS Rats were divided into 3 groups: sham, control(CTL), and DMF. DMF(25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase(ALT) and malondialdehyde(MDA) levels, adenosine triphosphate(ATP), NO × metabolites, anti-oxidant enzyme expression level, antiinflammatory effect, and anti-apoptotic effect were determined.RESULTS Histological tissue damage was significantly reduced in the DMF group(Suzuki scores: sham: 0 ± 0; CTL: 9.3± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT(DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA(DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content(DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity(DMF 7.8 ± 0.4 m U/m L vs CTL 6.0 ± 0.5 m U/m L, P = 0.01) and level of endothelial nitric oxide synthase expression(DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes(catalase and glutamatecysteine ligase modifier subunit and lower levels of key inflammatory mediators(nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group.CONCLUSION DMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI. | Chie Takasu Nosratola D Vaziri Shiri Li Lourdes Robles Kelly Vo Mizuki Takasu Christine Pham Seyed H Farzaneh Mitsuo Shimada Michael J Stamos Hirohito Ichii | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 2 | Performance on a measure of category fluency in cognitively impaired elderly 显示文摘 | Hall J R Harvey M Vo H T | 2011 | Neuropsychol Dev Cogn B Aging Neuropsychol Cogn2011，18，3： | 1 |
| 3 | Blade tip clearanceflow and compressor nonsynchronous vibrations : the jetcore feedback theory as the coupling mechanism显示文摘 | Thomassin J Vo H D Mureithi N W | 2009 | Jour-nal of Turbomachinery2009，131，01： | 1 |
| 4 | The tip clearanceflow resonance behind axial compressor monsynchronousvibration显示文摘 | Thomassin J Vo H D Mureithi N W | 2011 | Journal of Turbomachinery2011，133，04： | 1 |
| 5 | Gamma - secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers 显示文摘 | KONISHI J KAWAGUCHI K VO H | 2007 | Cancer Res2007，67，17： | 1 |
| 6 | Visual Exploration of Big Spatio-Temporal Urban Data: A Study of New York City Taxi Trips 显示文摘 | Ferreira N Poco J Vo H T | 2013 | IEEE Transactions on Visualization and Computer Graphics2013，19，12： | 1 |
| 7 | Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers 显示文摘 | Konishi J Kawaguchi KS Vo H | 2007 | Cancer Res2007，67，17： | 1 |
| 8 | Visual Exploration of Big Spatio-Temporal Urban Data: A Study of New York City Taxi Trips显示文摘 | Ferreira N Poco J Vo H T | 2013 | IEEE Trans Vis Comput Graph2013，19，12： | 1 |
| 9 | Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers显示文摘 | KONISHI J KAWAGUCHI K S VO H | 2007 | Cancer Res2007，67，17： | 1 |
| 10 | Managing potential and realized absorptive capac- ity: How do organizational antecedents matter? 显示文摘 | Jansen J J P Van Den Bosch F A J Vo]berda H W | 2005 | The Academy of Management Journal2005，48，6： | 1 |
| 11 | Gamma- secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers显示文摘 | KONISHI J KAWAGUCHI K S VO H | 2007 | Cancer Res2007，67，17： | 1 |
| 12 | γ-Secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers 显示文摘 | Konisbi J Kawaguchi K S Vo H | 2007 | Cancer Res2007，67，17： | 1 |
| 13 | Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers显示文摘 | Konishi J Kawaguchi KS Vo H | | 0，，17： | 1 |
| 14 | Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers显示文摘 | Konishi J Kawaguchi KS Vo H | | 0，，17： | 1 |
| 15 | Promising ironoxide-based magnetic nanoparticles in biomedical engi-neering显示文摘 | Tran P H Tran T T Vo T V Lee B J | 2012 | Arch Pharm Res2012，35，： | 1 |
| 16 | Visual exploration of big spatio-temporal urban data: a study of new york city taxi trips 显示文摘 | Ferreira N Poco J Vo H T | 2013 | IEEE Transactions on Visualization and Computer Graphics2013，19，12： | 1 |
| 17 | Gamma-secretaseinhibitor prevents Notch3activation and reduces proliferationin human lung cancers显示文摘 | Konishi J Kawaguchi KS Vo H | 2007 | Cancer Res2007，67，17： | 1 |
| 18 | Visual exploration of big spatio-temporal urban data: a study of New York city taxi trips显示文摘 | Ferreira N Poco J Vo H T | 2013 | IEEE Transaction on Visualization and Computer Graphics2013，19，12： | 1 |
| 19 | Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers 显示文摘 | Konishi J Kawaguehi KS Vo H | 2007 | CancerRes2007，67，17： | 1 |
| 20 | Origin and phylogeny of chloroplasts revealed by a simple correlation analysis of complete genomes显示文摘 | Chu K H Qi J Yu Z G Ahn Vo | 2004 | Molecular Biology and Evolution2004，21，： | 1 |
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